CS370788A1 - Method of selegiline's hydrochloride production - Google Patents

Method of selegiline's hydrochloride production

Info

Publication number: CS370788A1
Authority: CS; Czechoslovakia
Prior art keywords: hydrochloride; selegiline; phenylpropane; methylamino; temperature
Prior art date: 1988-05-30

Application number

CS883707A

Other languages

English (en)

Other versions

CS269271B1 (en

Inventor

Josef Ing Csc Hajicek

Jiri Pharm Dr Hrbata

Pavel Pihera

Bohumila Ing Csc Brunova

Milan Rndr Ferenc

Jiri Ing Csc Krepelka

Lubomir Rndr Kvapil

Josef Pospisil

Original Assignee

Hajicek Josef

Hrbata Jiri

Pavel Pihera

Brunova Bohumila

Ferenc Milan

Krepelka Jiri

Lubomir Rndr Kvapil

Josef Pospisil

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-30

Filing date

1988-05-30

Publication date

1989-09-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=5377914&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS370788(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-05-30 Application filed by Hajicek Josef, Hrbata Jiri, Pavel Pihera, Brunova Bohumila, Ferenc Milan, Krepelka Jiri, Lubomir Rndr Kvapil, Josef Pospisil filed Critical Hajicek Josef

1988-05-30 Priority to CS883707A priority Critical patent/CS269271B1/cs

1989-05-29 Priority to JP1132947A priority patent/JPH0219348A/ja

1989-05-29 Priority to AT89109635T priority patent/ATE93227T1/de

1989-05-29 Priority to DE68908477T priority patent/DE68908477T3/de

1989-05-29 Priority to EP89109635A priority patent/EP0344675B2/en

1989-09-12 Publication of CS370788A1 publication Critical patent/CS370788A1/cs

1990-04-11 Publication of CS269271B1 publication Critical patent/CS269271B1/cs

Links

238000000034 method Methods 0.000 title abstract 3
229960003678 selegiline hydrochloride Drugs 0.000 title abstract 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
IYETZZCWLLUHIJ-UHFFFAOYSA-N methyl-(1-phenylpropan-2-yl)-prop-2-ynylazanium;chloride Chemical compound Cl.C#CCN(C)C(C)CC1=CC=CC=C1 IYETZZCWLLUHIJ-UHFFFAOYSA-N 0.000 abstract 2
MYWUZJCMWCOHBA-UHFFFAOYSA-N n-methyl-1-phenylpropan-2-amine Chemical compound CNC(C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-UHFFFAOYSA-N 0.000 abstract 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
230000000648 anti-parkinson Effects 0.000 abstract 1
238000009835 boiling Methods 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
YORCIIVHUBAYBQ-UHFFFAOYSA-N propargyl bromide Chemical compound BrCC#C YORCIIVHUBAYBQ-UHFFFAOYSA-N 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CS883707A 1988-05-30 1988-05-30 Method of selegiline's hydrochloride production CS269271B1 (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
CS883707A CS269271B1 (en)	1988-05-30	1988-05-30	Method of selegiline's hydrochloride production
JP1132947A JPH0219348A (ja)	1988-05-30	1989-05-29	セレジリン塩酸塩の製造方法
AT89109635T ATE93227T1 (de)	1988-05-30	1989-05-29	Verfahren zur herstellung von selegilinhydrochlorid.
DE68908477T DE68908477T3 (de)	1988-05-30	1989-05-29	"Verfahren zur Herstellung von Selegilin-hydrochlorid"
EP89109635A EP0344675B2 (en)	1988-05-30	1989-05-29	Method for the production of selegiline hydrochloride

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS883707A CS269271B1 (en)	1988-05-30	1988-05-30	Method of selegiline's hydrochloride production

Publications (2)

Publication Number	Publication Date
CS370788A1 true CS370788A1 (en)	1989-09-12
CS269271B1 CS269271B1 (en)	1990-04-11

Family

ID=5377914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS883707A CS269271B1 (en)	1988-05-30	1988-05-30	Method of selegiline's hydrochloride production

Country Status (5)

Country	Link
EP (1)	EP0344675B2 (cs)
JP (1)	JPH0219348A (cs)
AT (1)	ATE93227T1 (cs)
CS (1)	CS269271B1 (cs)
DE (1)	DE68908477T3 (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4432610C1 (de) *	1994-09-13	1996-02-01	Knoll Ag	Verfahren zur Herstellung von Selegilin-Hydrochlorid
AU2009254927B2 (en)	2008-06-02	2014-03-13	Generics [Uk] Limited	A process for the preparation of enantiomerically pure amines
NZ589470A (en) *	2008-06-02	2012-08-31	Generics Uk Ltd	A process for the preparation of rasagiline and its analogues
IT201700008702A1 (it)	2017-01-26	2018-07-26	Dipharma Francis Srl	Metodo di sintesi di selegilina base

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1227447B (de) *	1962-03-30	1966-10-27	Chinoin Gyogyszer Es Vegyeszet	Verfahren zur Herstellung von Phenylisopropylaminen
HU187775B (en) *	1982-07-14	1986-02-28	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu	New process for producing propargile-amines of pharmaceutical activity
HU197510B (en) *	1986-12-19	1989-04-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing pharmaceutical composition containing phenyl-alkyl-amine derivatives, against motion-sick

1988
- 1988-05-30 CS CS883707A patent/CS269271B1/cs unknown
1989
- 1989-05-29 DE DE68908477T patent/DE68908477T3/de not_active Expired - Fee Related
- 1989-05-29 EP EP89109635A patent/EP0344675B2/en not_active Expired - Lifetime
- 1989-05-29 JP JP1132947A patent/JPH0219348A/ja active Pending
- 1989-05-29 AT AT89109635T patent/ATE93227T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CS269271B1 (en)	1990-04-11
EP0344675A3 (en)	1991-01-09
EP0344675A2 (en)	1989-12-06
ATE93227T1 (de)	1993-09-15
EP0344675B2 (en)	1998-11-11
DE68908477D1 (de)	1993-09-23
JPH0219348A (ja)	1990-01-23
DE68908477T2 (de)	1994-01-13
DE68908477T3 (de)	1999-04-01
EP0344675B1 (en)	1993-08-18

Publication	Publication Date	Title
KR860003215A (ko)	1986-05-21	4-페닐피롤 유도체의 제조방법
EP0358154A3 (en)	1990-09-05	Novel cyclobutane derivative and process for producing same
ATE275822T1 (de)	2004-10-15	Quartäres ammonium und wasserdichtung- /konservierungszusammensetzung
IL68964A (en)	1988-03-31	1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments
KR900014292A (ko)	1990-10-23	1,2,2,2-테트라플루오로에틸 디플루오로메틸 에테르의 제조방법
AU605325B2 (en)	1991-01-10	Synthesis of perfluoroalkyl bromides
DE68908477D1 (de)	1993-09-23	Verfahren zur herstellung von selegilinhydrochlorid.
ES8500277A1 (es)	1984-11-01	Procedimiento de preparar derivados pirrolicidinicos 8 substituidos.
KR860004027A (ko)	1986-06-16	1,3-디메틸-2-이미다졸리디논의 제조방법
KR840007228A (ko)	1984-12-06	트리아졸 유도체의 제조방법
ZA909420B (en)	1991-09-25	Process for the preparation of a perfluoroalkyl bromide
KR840002340A (ko)	1984-06-25	1-(3-벤질옥시페닐)-1,1-디메틸헵탄 및 관련 중간체의 제조방법
KR850008160A (ko)	1985-12-13	이미다졸 유도체의 제조방법
ES8703865A2 (es)	1987-03-16	Perfeccionamientos en la patente de invencion n.544661 por: procedimiento de preparazcion de ascorbatos antagonistas h2-receptores.
KR840009077A (ko)	1984-12-24	벤즈 아미드 유도체
GR3004216T3 (cs)	1993-03-31
ES2019355B3 (es)	1991-06-16	Procedimiento para la fabricacion de halogenalcohol
KR870001172A (ko)	1987-03-11	신규한 벤즈아미드의 제법
JPS56154483A (en)	1981-11-30	Preparation or pyrrole derivative
DE3462031D1 (en)	1987-02-19	Alpha,alpha-dimethylphenylacetanilide derivatives, process for production thereof, and use thereof as insecticide
AU564839B2 (en)	1987-08-27	Preparation of hydrochlorides
JPS5522699A (en)	1980-02-18	Novel 3-amino-1-benzylpyrrolidine derivative
KR850002978A (ko)	1985-05-28	화학적 방법
EP0377750A4 (en)	1991-05-15	Process for preparing thiazolecarboxylic acid chlorides
JPS6426544A (en)	1989-01-27	4-cyanocyclohexanecarboxylic acid amide