CS370788A1 - Method of selegiline's hydrochloride production - Google Patents

Method of selegiline's hydrochloride production

Info

Publication number: CS370788A1
Authority: CS; Czechoslovakia
Prior art keywords: hydrochloride; selegiline; phenylpropane; methylamino; temperature
Prior art date: 1988-05-30

Application number

CS883707A

Other languages

English (en)

Other versions

CS269271B1 (en

Inventor

Josef Ing Csc Hajicek

Jiri Pharm Dr Hrbata

Pavel Pihera

Bohumila Ing Csc Brunova

Milan Rndr Ferenc

Jiri Ing Csc Krepelka

Lubomir Rndr Kvapil

Josef Pospisil

Original Assignee

Hajicek Josef

Hrbata Jiri

Pavel Pihera

Brunova Bohumila

Ferenc Milan

Krepelka Jiri

Lubomir Rndr Kvapil

Josef Pospisil

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-30

Filing date

1988-05-30

Publication date

1989-09-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=5377914&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS370788(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-05-30 Application filed by Hajicek Josef, Hrbata Jiri, Pavel Pihera, Brunova Bohumila, Ferenc Milan, Krepelka Jiri, Lubomir Rndr Kvapil, Josef Pospisil filed Critical Hajicek Josef

1988-05-30 Priority to CS883707A priority Critical patent/CS269271B1/cs

1989-05-29 Priority to DE68908477T priority patent/DE68908477T3/de

1989-05-29 Priority to EP89109635A priority patent/EP0344675B2/en

1989-05-29 Priority to AT89109635T priority patent/ATE93227T1/de

1989-05-29 Priority to JP1132947A priority patent/JPH0219348A/ja

1989-09-12 Publication of CS370788A1 publication Critical patent/CS370788A1/cs

1990-04-11 Publication of CS269271B1 publication Critical patent/CS269271B1/cs

Links

238000000034 method Methods 0.000 title abstract 3
229960003678 selegiline hydrochloride Drugs 0.000 title abstract 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
IYETZZCWLLUHIJ-UHFFFAOYSA-N methyl-(1-phenylpropan-2-yl)-prop-2-ynylazanium;chloride Chemical compound Cl.C#CCN(C)C(C)CC1=CC=CC=C1 IYETZZCWLLUHIJ-UHFFFAOYSA-N 0.000 abstract 2
MYWUZJCMWCOHBA-UHFFFAOYSA-N n-methyl-1-phenylpropan-2-amine Chemical compound CNC(C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-UHFFFAOYSA-N 0.000 abstract 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
230000000648 anti-parkinson Effects 0.000 abstract 1
238000009835 boiling Methods 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
YORCIIVHUBAYBQ-UHFFFAOYSA-N propargyl bromide Chemical compound BrCC#C YORCIIVHUBAYBQ-UHFFFAOYSA-N 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CS883707A 1988-05-30 1988-05-30 Method of selegiline's hydrochloride production CS269271B1 (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
CS883707A CS269271B1 (en)	1988-05-30	1988-05-30	Method of selegiline's hydrochloride production
DE68908477T DE68908477T3 (de)	1988-05-30	1989-05-29	"Verfahren zur Herstellung von Selegilin-hydrochlorid"
EP89109635A EP0344675B2 (en)	1988-05-30	1989-05-29	Method for the production of selegiline hydrochloride
AT89109635T ATE93227T1 (de)	1988-05-30	1989-05-29	Verfahren zur herstellung von selegilinhydrochlorid.
JP1132947A JPH0219348A (ja)	1988-05-30	1989-05-29	セレジリン塩酸塩の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS883707A CS269271B1 (en)	1988-05-30	1988-05-30	Method of selegiline's hydrochloride production

Publications (2)

Publication Number	Publication Date
CS370788A1 true CS370788A1 (en)	1989-09-12
CS269271B1 CS269271B1 (en)	1990-04-11

Family

ID=5377914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS883707A CS269271B1 (en)	1988-05-30	1988-05-30	Method of selegiline's hydrochloride production

Country Status (5)

Country	Link
EP (1)	EP0344675B2 (cs)
JP (1)	JPH0219348A (cs)
AT (1)	ATE93227T1 (cs)
CS (1)	CS269271B1 (cs)
DE (1)	DE68908477T3 (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4432610C1 (de) *	1994-09-13	1996-02-01	Knoll Ag	Verfahren zur Herstellung von Selegilin-Hydrochlorid
WO2009147432A1 (en) *	2008-06-02	2009-12-10	Generics [Uk] Limited	An improved process for the preparation of amines
CN103896779B (zh)	2008-06-02	2015-12-30	基因里克斯(英国)有限公司	用于制备对映异构纯胺的方法
IT201700008702A1 (it) *	2017-01-26	2018-07-26	Dipharma Francis Srl	Metodo di sintesi di selegilina base

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1227447B (de) *	1962-03-30	1966-10-27	Chinoin Gyogyszer Es Vegyeszet	Verfahren zur Herstellung von Phenylisopropylaminen
HU187775B (en) *	1982-07-14	1986-02-28	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu	New process for producing propargile-amines of pharmaceutical activity
HU197510B (en) *	1986-12-19	1989-04-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing pharmaceutical composition containing phenyl-alkyl-amine derivatives, against motion-sick

1988
- 1988-05-30 CS CS883707A patent/CS269271B1/cs unknown
1989
- 1989-05-29 AT AT89109635T patent/ATE93227T1/de not_active IP Right Cessation
- 1989-05-29 EP EP89109635A patent/EP0344675B2/en not_active Expired - Lifetime
- 1989-05-29 DE DE68908477T patent/DE68908477T3/de not_active Expired - Fee Related
- 1989-05-29 JP JP1132947A patent/JPH0219348A/ja active Pending

Also Published As

Publication number	Publication date
EP0344675B1 (en)	1993-08-18
ATE93227T1 (de)	1993-09-15
DE68908477D1 (de)	1993-09-23
EP0344675B2 (en)	1998-11-11
EP0344675A2 (en)	1989-12-06
DE68908477T2 (de)	1994-01-13
JPH0219348A (ja)	1990-01-23
DE68908477T3 (de)	1999-04-01
EP0344675A3 (en)	1991-01-09
CS269271B1 (en)	1990-04-11

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