CS611586A2 - Process for preparing heat stable crystalline cephalosporines - Google Patents

Process for preparing heat stable crystalline cephalosporines

Info

Publication number
CS611586A2
CS611586A2 CS866115A CS611586A CS611586A2 CS 611586 A2 CS611586 A2 CS 611586A2 CS 866115 A CS866115 A CS 866115A CS 611586 A CS611586 A CS 611586A CS 611586 A2 CS611586 A2 CS 611586A2
Authority
CS
Czechoslovakia
Prior art keywords
cephalosporines
heat stable
stable crystalline
preparing heat
preparing
Prior art date
Application number
CS866115A
Other languages
English (en)
Other versions
CS262674B2 (en
Inventor
Steven Peter Brundidge
Paul Raymond Brodfuehrer
Chet Sapino Jr
Kun Mao Shin
Donald Gilmore Walker
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to CS879686A priority Critical patent/CS262698B2/cs
Priority to CS879687A priority patent/CS262699B2/cs
Publication of CS611586A2 publication Critical patent/CS611586A2/cs
Publication of CS262674B2 publication Critical patent/CS262674B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS866115A 1985-08-20 1986-08-20 Process for preparing heat stable crystalline cephalosporines CS262674B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS879686A CS262698B2 (cs) 1985-08-20 1987-12-22 Způsob výroby teplotně stálých krystalických cefalosporinů
CS879687A CS262699B2 (cs) 1985-08-20 1987-12-22 Způsob výroby stabilních krystalických ceíailospoirinů obecného vzorce I, kde X je chlorovodík nebo jodbvodík, spočívající v reakci sloučeniny vzorce VL s roztokem sloučeniny vzorce IVa v 1,1,2-trichlortrifluore- thanu, v odštěpení sílyfových skupin, působením nižšího alkanolu a v okyselení produktu chlorovodíkem nebo jodovodíkem. Vyrobené sloučeniny slouží jako meziprodukty pro přípravu cefalosporinových antibiotik se širokým spektrem účinku.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76756185A 1985-08-20 1985-08-20
US06/882,107 US4714760A (en) 1985-08-20 1986-07-11 Cephalosporin intermediates

Publications (2)

Publication Number Publication Date
CS611586A2 true CS611586A2 (en) 1988-08-16
CS262674B2 CS262674B2 (en) 1989-03-14

Family

ID=27117927

Family Applications (1)

Application Number Title Priority Date Filing Date
CS866115A CS262674B2 (en) 1985-08-20 1986-08-20 Process for preparing heat stable crystalline cephalosporines

Country Status (15)

Country Link
US (1) US4714760A (cs)
EP (1) EP0233271B1 (cs)
JP (1) JPH0615549B2 (cs)
KR (1) KR910000419B1 (cs)
AR (1) AR241408A1 (cs)
AT (1) ATE87000T1 (cs)
CA (1) CA1282408C (cs)
CS (1) CS262674B2 (cs)
CY (1) CY1848A (cs)
EG (1) EG18205A (cs)
FI (1) FI89051C (cs)
HK (1) HK110295A (cs)
HU (1) HU201080B (cs)
WO (1) WO1987001116A1 (cs)
YU (1) YU44810B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0827520B2 (ja) * 1986-07-12 1996-03-21 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料の処理方法
JP2809711B2 (ja) * 1988-06-22 1998-10-15 イーライ・リリー・アンド・カンパニー １―カルバ（デチア）セファロスポリンの中間体
US4935508A (en) * 1988-08-23 1990-06-19 Bristol-Myers Company Process for cephem prodrug esters
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate
CA2099692C (en) 1992-07-24 2003-09-30 Gary M. F. Lim Process for preparing cephalosporin intermediates
AU2307297A (en) * 1996-04-12 1997-11-07 Takeda Chemical Industries Ltd. Production of 7-aminocephalosporanic acid derivative
WO2006008749A1 (en) * 2004-07-16 2006-01-26 Hetero Drugs Limited Process for preparing pure cephalosporine intermediates
JP2008526944A (ja) * 2005-01-17 2008-07-24 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド セファロスポリン抗生物質中間体を製造するための改善された方法
ITMI20051684A1 (it) * 2005-09-13 2007-03-14 Harvest Lodge Ltd Procedimento per la produzione del dicloridrato di amminoacidi
ITMI20060422A1 (it) * 2006-03-09 2007-09-10 Harvest Lodge Ltd Procedimento diretto per la produzione del dicloridrato di un amminoacido
CN102391288B (zh) * 2011-12-03 2013-09-18 齐鲁安替制药有限公司 头孢匹罗中间体及头孢匹罗的制备方法
CN102391289B (zh) * 2011-12-03 2013-09-18 齐鲁安替制药有限公司 头孢他啶中间体及头孢他啶的合成方法
CN102633813A (zh) * 2012-04-17 2012-08-15 黑龙江豪运精细化工有限公司 一种头孢唑林钠中间体tda的制备方法
CN102627659A (zh) * 2012-04-17 2012-08-08 黑龙江豪运精细化工有限公司 一种头孢哌酮中间体7-tmca的制备方法
CN107201391B (zh) * 2017-07-04 2020-07-07 吉林省爱诺德生物工程有限公司 一种盐酸头孢吡肟的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182863A (en) * 1974-09-03 1980-01-08 Bristol-Myers Company 7-Amino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4093723A (en) * 1976-05-19 1978-06-06 Smithkline Corporation 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
FR2457295A1 (fr) * 1979-05-25 1980-12-19 Glaxo Group Ltd Composes intermediaires pour la preparation de cephalosporines
DE3173529D1 (en) * 1980-11-11 1986-02-27 Takeda Chemical Industries Ltd Improvement in the method for producing 7-aminocephem compounds
IT8026945A0 (it) * 1980-12-24 1980-12-24 Isf Spa Chetoidrossiimminocefalosporine.
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
GR76701B (cs) * 1981-09-08 1984-08-29 Lilly Co Eli
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4499088A (en) * 1983-01-04 1985-02-12 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
US4540779A (en) * 1983-06-20 1985-09-10 Eli Lilly And Company Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound
US4659812A (en) * 1985-08-20 1987-04-21 Bristol-Myers Company Cephalosporin intermediates

Also Published As

Publication number Publication date
FI89051B (fi) 1993-04-30
CS262674B2 (en) 1989-03-14
EP0233271A1 (en) 1987-08-26
JPS62502046A (ja) 1987-08-13
FI871693L (fi) 1987-04-16
FI89051C (fi) 1993-08-10
ATE87000T1 (de) 1993-04-15
EP0233271B1 (en) 1993-03-17
YU160387A (en) 1988-08-31
CY1848A (en) 1996-03-08
WO1987001116A1 (en) 1987-02-26
US4714760A (en) 1987-12-22
CA1282408C (en) 1991-04-02
EP0233271A4 (en) 1988-10-20
KR910000419B1 (ko) 1991-01-25
EG18205A (en) 1993-10-30
HU201080B (en) 1990-09-28
HK110295A (en) 1995-07-14
FI871693A0 (fi) 1987-04-16
HUT43853A (en) 1987-12-28
AR241408A1 (es) 1992-07-31
KR870700628A (ko) 1987-12-30
YU44810B (en) 1991-02-28
JPH0615549B2 (ja) 1994-03-02

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20010820