CS8803635A2 - Method of antiviral substances production - Google Patents

Method of antiviral substances production

Info

Publication number: CS8803635A2
Authority: CS; Czechoslovakia
Prior art keywords: antiviral substances; substances production; production; prophylaxis; compounds
Prior art date: 1987-05-30

Application number

CS883635A

Other languages

English (en)

Other versions

CS277006B6 (en

Inventor

Thomas A Krenitsky

George W Koszalka

Lynda A Jones

Devron R Averett

Allan R Moorman

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-30

Filing date

1988-05-27

Publication date

1990-09-12

1988-05-27 Application filed by Wellcome Found filed Critical Wellcome Found

1990-09-12 Publication of CS8803635A2 publication Critical patent/CS8803635A2/cs

1992-11-18 Publication of CS277006B6 publication Critical patent/CS277006B6/cs

Links

238000000034 method Methods 0.000 title abstract 2
230000000840 anti-viral effect Effects 0.000 title 1
239000000126 substance Substances 0.000 title 1
206010011831 Cytomegalovirus infection Diseases 0.000 abstract 1
241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 1
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
208000005181 Varicella Zoster Virus Infection Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
-1 purine arabinosides Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
208000010531 varicella zoster infection Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Public Health (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)

CS883635A 1987-05-30 1988-05-27 Process for preparing antiviral substances CS277006B6 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878712745A GB8712745D0 (en)	1987-05-30	1987-05-30	Antiviral compounds

Publications (2)

Publication Number	Publication Date
CS8803635A2 true CS8803635A2 (en)	1990-09-12
CS277006B6 CS277006B6 (en)	1992-11-18

Family

ID=10618179

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS883635A CS277006B6 (en)	1987-05-30	1988-05-27	Process for preparing antiviral substances

Country Status (31)

Country	Link
US (2)	US5424295A (cs)
EP (1)	EP0294114B1 (cs)
JP (1)	JP2667873B2 (cs)
KR (1)	KR970009474B1 (cs)
CN (1)	CN1020107C (cs)
AT (1)	ATE142636T1 (cs)
AU (1)	AU622403B2 (cs)
CA (1)	CA1330990C (cs)
CS (1)	CS277006B6 (cs)
CY (2)	CY2001A (cs)
DD (2)	DD293962A5 (cs)
DE (2)	DE122008000003I2 (cs)
DK (1)	DK171670B1 (cs)
ES (1)	ES2091750T3 (cs)
FI (1)	FI89805C (cs)
GB (1)	GB8712745D0 (cs)
GR (1)	GR3021257T3 (cs)
HK (1)	HK78497A (cs)
HU (2)	HU205001B (cs)
IL (1)	IL86531A (cs)
LU (1)	LU91370I2 (cs)
MC (1)	MC1935A1 (cs)
MY (1)	MY103567A (cs)
NL (1)	NL300302I2 (cs)
NO (2)	NO172543C (cs)
NZ (1)	NZ224813A (cs)
PH (1)	PH27292A (cs)
PL (1)	PL157684B1 (cs)
PT (1)	PT87592B (cs)
SA (1)	SA99200688A (cs)
ZA (2)	ZA883829B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8712745D0 (en) *	1987-05-30	1987-07-01	Wellcome Found	Antiviral compounds
US7307166B1 (en) *	1987-10-28	2007-12-11	Wellstat Therapeutics Corporation	Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
DD293498A5 (de) *	1989-07-20	1991-09-05	Zi Fuer Molekularbiologie Der Adw,De	Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB8919607D0 (en) *	1989-08-30	1989-10-11	Wellcome Found	Novel entities for cancer therapy
US6337209B1 (en)	1992-02-26	2002-01-08	Glaxo Wellcome Inc.	Molecular constructs containing a carcinoembryonic antigen regulatory sequence
KR910007655A (ko) *	1989-10-03	1991-05-30	엠. 피. 잭슨	치료용 뉴클레오시드
US5206351A (en) *	1990-06-15	1993-04-27	Ash Stevens, Inc.	Process for the preparation of 2-amino (2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine
GB9015914D0 (en) *	1990-07-19	1990-09-05	Wellcome Found	Heterocyclic compounds
US5283331A (en) *	1990-12-20	1994-02-01	Nippon Kayaku Kabushiki Kaisha	2-halogeno-oxetanocin A and phosphoric ester thereof
GB9104165D0 (en) *	1991-02-27	1991-04-17	Wellcome Found	Novel entities for hiv therapy
US5961987A (en) *	1996-10-31	1999-10-05	University Of Iowa Research Foundation	Ocular protein stimulants
JP3619017B2 (ja)	1998-06-24	2005-02-09	日本臓器製薬株式会社	新規アラビノシルアデニン誘導体
US6653318B1 (en) *	1999-07-21	2003-11-25	Yale University	5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
AU3851601A (en) *	2000-02-18	2001-08-27	Southern Res Inst	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h- purin-6-amine
US6753322B2 (en) *	2000-06-06	2004-06-22	Pfizer Inc	2-aminocarbonyl-9H-purine derivatives
JP3421330B2 (ja) *	2000-11-02	2003-06-30	持田製薬株式会社	ビダラビン注射用乾燥製剤
WO2003045968A1 (en) *	2001-11-27	2003-06-05	Anadys Pharmaceuticals, Inc.	3-β-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
US7321033B2 (en) *	2001-11-27	2008-01-22	Anadys Pharmaceuticals, Inc.	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
TW200418498A (en) *	2002-09-30	2004-10-01	Genelabs Tech Inc	Nucleoside derivatives for treating hepatitis C virus infection
ES2459368T3 (es) *	2004-12-17	2014-05-09	Anadys Pharmaceuticals, Inc.	Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos
US20060178512A1 (en) *	2005-02-04	2006-08-10	Cheruthur Govindan	Method for preparing amino acid esters of nucleoside analogues
CA2630463C (en)	2005-11-21	2015-01-06	Anadys Pharmaceuticals, Inc.	Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2-one
CA2655904C (en) *	2006-06-22	2014-11-18	Anadys Pharmaceuticals, Inc.	Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
EP2040712B1 (en)	2006-07-18	2011-03-02	Anadys Pharmaceuticals, Inc.	Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
CN101092441A (zh) *	2007-07-17	2007-12-26	北京本草天源药物研究院	一种奈拉滨的合成方法
US7846912B2 (en) *	2007-09-13	2010-12-07	Protia, Llc	Deuterium-enriched nelarabine
CN101768197A (zh) *	2008-12-29	2010-07-07	北京德众万全药物技术开发有限公司	一种奈拉滨的制备方法
CN103665076B (zh) *	2012-08-30	2018-01-09	上海阳帆医药科技有限公司	奈拉滨的制备方法
CN104892709B (zh) *	2015-06-04	2018-01-19	新乡学院	一种合成奈拉滨的方法
WO2018133835A1 (en) *	2017-01-20	2018-07-26	National Institute Of Biological Sciences, Beijing	Nucleoside analogue regulating mammalian circadian rhythm
WO2022258014A1 (zh) *	2021-06-09	2022-12-15	正大天晴药业集团股份有限公司	用于制备奈拉滨的重组基因工程菌及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE759011A (fr) *	1969-11-17	1971-05-17	Wellcome Found	Aminopurines
US3758684A (en) *	1971-09-07	1973-09-11	Burroughs Wellcome Co	Treating dna virus infections with amino purine derivatives
US4055717A (en) *	1976-05-17	1977-10-25	Parke, Davis & Company	9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
US4048432A (en) *	1976-05-17	1977-09-13	Parke, Davis & Company	9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production
US4055718A (en) *	1976-05-17	1977-10-25	Parke, Davis & Company	9-(2-O-Acyl-β-D-arabinofuranosyl)-adenine compounds and method for their production
US4371613A (en) *	1977-08-10	1983-02-01	Ajinomoto Company Incorporated	Method for producing purine arabinosides
JPS5515716A (en) *	1978-07-18	1980-02-04	Ajinomoto Co Inc	Production of purine arabinoside
JPS6053941B2 (ja) *	1977-08-10	1985-11-28	日本電気株式会社	バイアスライト駆動方式
GB1573777A (en) *	1977-11-03	1980-08-28	Wellcome Found	9-d-arabinonucleosides and an enzymatic process for their preparation
US4495180A (en) *	1982-06-21	1985-01-22	Merck & Co., Inc.	Prodrugs of Ara-A an antiviral agent
JPS58225097A (ja) *	1982-06-23	1983-12-27	Yamasa Shoyu Co Ltd	ヌクレオシド５′−アルキルもしくはアルケニルりん酸
IE73219B1 (en) *	1985-03-16	1997-05-07	Wellcome Found	Therapeutic nucleosides
GB8712745D0 (en) *	1987-05-30	1987-07-01	Wellcome Found	Antiviral compounds

1987
- 1987-05-30 GB GB878712745A patent/GB8712745D0/en active Pending
1988
- 1988-05-27 PL PL1988272729A patent/PL157684B1/pl unknown
- 1988-05-27 CS CS883635A patent/CS277006B6/cs not_active IP Right Cessation
- 1988-05-27 MY MYPI88000569A patent/MY103567A/en unknown
- 1988-05-27 DE DE122008000003C patent/DE122008000003I2/de active Active
- 1988-05-27 DD DD88340139A patent/DD293962A5/de not_active IP Right Cessation
- 1988-05-27 DE DE3855522T patent/DE3855522T2/de not_active Expired - Lifetime
- 1988-05-27 AU AU16718/88A patent/AU622403B2/en not_active Expired
- 1988-05-27 DD DD88316143A patent/DD282694A5/de not_active IP Right Cessation
- 1988-05-27 HU HU895829A patent/HU205001B/hu unknown
- 1988-05-27 ES ES88304813T patent/ES2091750T3/es not_active Expired - Lifetime
- 1988-05-27 IL IL86531A patent/IL86531A/xx active Protection Beyond IP Right Term
- 1988-05-27 FI FI882511A patent/FI89805C/fi not_active IP Right Cessation
- 1988-05-27 NZ NZ224813A patent/NZ224813A/en unknown
- 1988-05-27 PT PT87592A patent/PT87592B/pt not_active IP Right Cessation
- 1988-05-27 AT AT88304813T patent/ATE142636T1/de active
- 1988-05-27 JP JP63128562A patent/JP2667873B2/ja not_active Expired - Lifetime
- 1988-05-27 ZA ZA883829A patent/ZA883829B/xx unknown
- 1988-05-27 CA CA000567966A patent/CA1330990C/en not_active Expired - Lifetime
- 1988-05-27 HU HU882706A patent/HU199870B/hu active Protection Beyond IP Right Term
- 1988-05-27 NO NO882357A patent/NO172543C/no not_active IP Right Cessation
- 1988-05-27 MC MC881981A patent/MC1935A1/fr unknown
- 1988-05-27 CN CN88103820A patent/CN1020107C/zh not_active Expired - Lifetime
- 1988-05-27 EP EP88304813A patent/EP0294114B1/en not_active Expired - Lifetime
- 1988-05-27 DK DK289788A patent/DK171670B1/da not_active IP Right Cessation
- 1988-05-27 KR KR1019880006295A patent/KR970009474B1/ko not_active Expired - Lifetime
1989
- 1989-09-01 PH PH39191A patent/PH27292A/en unknown
- 1989-10-05 ZA ZA897598A patent/ZA897598B/xx unknown
1993
- 1993-08-23 US US08/110,487 patent/US5424295A/en not_active Expired - Lifetime
1995
- 1995-03-14 US US08/403,363 patent/US5539098A/en not_active Expired - Lifetime
1996
- 1996-10-03 GR GR960402608T patent/GR3021257T3/el unknown
1997
- 1997-06-12 HK HK78497A patent/HK78497A/en not_active IP Right Cessation
- 1997-12-05 CY CY200197A patent/CY2001A/xx unknown
1999
- 1999-10-18 SA SA99200688A patent/SA99200688A/ar unknown
2007
- 2007-10-10 LU LU91370C patent/LU91370I2/fr unknown
- 2007-11-02 NL NL300302C patent/NL300302I2/nl unknown
- 2007-12-21 NO NO2007016C patent/NO2007016I2/no unknown
2008
- 2008-01-25 CY CY200800001C patent/CY2008001I2/el unknown

Also Published As

Publication number	Publication date
EP0294114B1 (en)	1996-09-11
FI89805B (fi)	1993-08-13
KR970009474B1 (ko)	1997-06-13
HK78497A (en)	1997-06-20
NO172543B (no)	1993-04-26
AU622403B2 (en)	1992-04-09
LU91370I2 (fr)	2007-12-10
DD293962A5 (de)	1991-09-19
NO2007016I1 (no)	2008-01-14
CN1020107C (zh)	1993-03-17
CN1031233A (zh)	1989-02-22
JPS63310831A (ja)	1988-12-19
FI882511L (fi)	1988-12-01
ES2091750T3 (es)	1996-11-16
NL300302I2 (nl)	2008-05-01
DE3855522D1 (de)	1996-10-17
CY2008001I1 (el)	2009-11-04
PL157684B1 (pl)	1992-06-30
GB8712745D0 (en)	1987-07-01
FI89805C (fi)	1993-11-25
HUT47129A (en)	1989-01-30
FI882511A0 (fi)	1988-05-27
DE122008000003I2 (de)	2010-02-04
NZ224813A (en)	1991-04-26
NO172543C (no)	1993-08-04
US5424295A (en)	1995-06-13
PH27292A (en)	1993-05-04
MY103567A (en)	1993-08-28
MC1935A1 (fr)	1989-05-19
US5539098A (en)	1996-07-23
DK171670B1 (da)	1997-03-10
HU895829D0 (en)	1990-01-28
IL86531A (en)	1993-07-08
PL272729A1 (en)	1989-02-06
IL86531A0 (en)	1988-11-15
NO882357D0 (no)	1988-05-27
CY2008001I2 (el)	2009-11-04
NO882357L (no)	1988-12-01
EP0294114A3 (en)	1990-01-24
CS277006B6 (en)	1992-11-18
DE122008000003I1 (de)	2008-04-17
DK289788A (da)	1988-12-01
ZA897598B (en)	1990-01-31
ATE142636T1 (de)	1996-09-15
ZA883829B (en)	1990-01-31
JP2667873B2 (ja)	1997-10-27
DD282694A5 (de)	1990-09-19
PT87592B (pt)	1992-09-30
DE3855522T2 (de)	1997-02-06
AU1671888A (en)	1988-12-01
KR880013967A (ko)	1988-12-22
SA99200688A (ar)	2005-12-03
NO2007016I2 (no)	2008-06-23
HU199870B (en)	1990-03-28
GR3021257T3 (en)	1997-01-31
EP0294114A2 (en)	1988-12-07
CY2001A (en)	1997-12-05
PT87592A (pt)	1989-05-31
HU205001B (en)	1992-03-30
CA1330990C (en)	1994-07-26
DK289788D0 (da)	1988-05-27
NL300302I1 (nl)	2008-01-02

Legal Events

Date	Code	Title	Description
2000-06-30	IF00	In force as of 2000-06-30 in czech republic
2009-01-21	MK4A	Patent expired	Effective date: 20080527

Publication	Publication Date	Title
PL272729A1 (en)	1989-02-06	Method of obtaining novel derivatives of arabinofuranozylpurine
CY2058B1 (en)	1998-04-30	Antiviral pyrimidine and purine compounds process for their preparation and pharmaceutical compositions containing them
MY103760A (en)	1993-09-30	Therapeutic nucleosides
PL269462A1 (en)	1989-06-26	Method for manufacturing 5-substituted pyrimydine nucleosides
AU581329B2 (en)	1989-02-16	Antiviral compounds