CS9100950A2 - Method of n-succinimidylcarbonates production - Google Patents

Method of n-succinimidylcarbonates production

Info

Publication number
CS9100950A2
CS9100950A2 CS91950A CS95091A CS9100950A2 CS 9100950 A2 CS9100950 A2 CS 9100950A2 CS 91950 A CS91950 A CS 91950A CS 95091 A CS95091 A CS 95091A CS 9100950 A2 CS9100950 A2 CS 9100950A2
Authority
CS
Czechoslovakia
Prior art keywords
formula
carbonate
radical
isolating
denotes
Prior art date
Application number
CS91950A
Other languages
Czech (cs)
Inventor
Gerhard Dipl Ing Dr Steinbauer
Wolfgang Mag Dr Huber
Rupert Kogler
Original Assignee
Chemie Linz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3500962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS9100950(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chemie Linz Gmbh filed Critical Chemie Linz Gmbh
Publication of CS9100950A2 publication Critical patent/CS9100950A2/en
Publication of CZ279743B6 publication Critical patent/CZ279743B6/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Process for the preparation of N-succinimidyl carbonates of the formula <IMAGE> in which Ar denotes a 9-fluorenyl radical, a phenyl radical, which is unsubstituted or substituted by halogen, nitro, alkyl having 1 - 4 C atoms or trifluoromethyl, or denotes a 5- or 6-membered heteroaromatic radical having one or two N or S atoms, by reacting an alcohol of the formula Ar - CH2OH II in which Ar has the abovementioned meaning, with phosgene in the presence of an inert water-miscible diluent to give a chloroformic ester of the formula <IMAGE> and reacting the reaction mixture without isolating the compound of the formula III with an aqueous solution of N-hydroxysuccinimide in the presence of an alkali metal bicarbonate or carbonate, alkaline earth metal bicarbonate or carbonate or ammonium bicarbonate or carbonate as neutralising agent, and isolating the compound of the formula I from the organic phase.
CS91950A 1990-04-10 1991-04-05 Process for preparing n-succinimidyl carbonates CZ279743B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0083990A AT394852B (en) 1990-04-10 1990-04-10 METHOD FOR PRODUCING N-SUCCINIMIDYLCARBONATES

Publications (2)

Publication Number Publication Date
CS9100950A2 true CS9100950A2 (en) 1991-11-12
CZ279743B6 CZ279743B6 (en) 1995-06-14

Family

ID=3500962

Country Status (7)

Country Link
EP (1) EP0451519B1 (en)
AT (2) AT394852B (en)
CZ (1) CZ279743B6 (en)
DE (2) DE4014272A1 (en)
HU (1) HU207716B (en)
SK (1) SK277921B6 (en)
YU (1) YU48206B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5426190A (en) * 1994-06-16 1995-06-20 Ppg Industries, Inc. Preparation of N-(organocarbonyloxy)-succinimide derivatives of N-hydroxysuccinimide
US5493031A (en) * 1994-06-16 1996-02-20 Ppg Industries, Inc. N-hydroxysuccinimide monohydrate
CN101096356B (en) * 2007-01-24 2011-11-09 湖南化工研究院 Purification technique of 9-fluorenylmethoxycarbon succinimide ester
CN101817776B (en) * 2009-02-26 2013-03-27 上海宝钢化工有限公司 Method for synthesizing 9-fluorenylmethoxycarbonyloxy succinimide ester
CN120865059B (en) * 2025-09-25 2025-11-25 连云港冠昕医药科技有限公司 A method for preparing 9-fluorenylmethyl-N-succinimide carbonate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932375A (en) * 1971-09-17 1976-01-13 Nitto Boseki Co. Ltd. Use of 2-pyrimidine thiol carbonates as acylating agents for amino or imino containing compounds
US4038282A (en) * 1975-11-26 1977-07-26 Merck & Co., Inc. Pyridyl-4-methyl-succinimidocarbonate and process for its preparation
US4126628A (en) * 1977-03-28 1978-11-21 Canadian Patents And Development Limited Acylation of amino acids
EP0972779A3 (en) * 1987-10-28 2004-10-20 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates

Also Published As

Publication number Publication date
HU207716B (en) 1993-05-28
ATE115563T1 (en) 1994-12-15
EP0451519A1 (en) 1991-10-16
DE4014272A1 (en) 1991-11-07
HUT56819A (en) 1991-10-28
SK277921B6 (en) 1995-08-09
DE59103839D1 (en) 1995-01-26
ATA83990A (en) 1991-12-15
EP0451519B1 (en) 1994-12-14
AT394852B (en) 1992-07-10
YU48206B (en) 1997-08-22
CZ279743B6 (en) 1995-06-14
YU62891A (en) 1994-05-10

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