CU20060177A7 - STABILIZED SUPERSATURED SOLID SOLUTIONS OF STEROID DRUGS - Google Patents
STABILIZED SUPERSATURED SOLID SOLUTIONS OF STEROID DRUGSInfo
- Publication number
- CU20060177A7 CU20060177A7 CU20060177A CU20060177A CU20060177A7 CU 20060177 A7 CU20060177 A7 CU 20060177A7 CU 20060177 A CU20060177 A CU 20060177A CU 20060177 A CU20060177 A CU 20060177A CU 20060177 A7 CU20060177 A7 CU 20060177A7
- Authority
- CU
- Cuba
- Prior art keywords
- supersatured
- stabilized
- solid solutions
- steroid drugs
- lipophilic
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 150000003431 steroids Chemical class 0.000 title abstract 2
- 239000006104 solid solution Substances 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 4
- -1 hormones Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 235000012239 silicon dioxide Nutrition 0.000 abstract 2
- 239000000377 silicon dioxide Substances 0.000 abstract 2
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 abstract 1
- 229960004845 drospirenone Drugs 0.000 abstract 1
- 229960004766 estradiol valerate Drugs 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 150000002634 lipophilic molecules Chemical class 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica con disolución de drogas lipofílicas mejoradas en un medio acuoso. Se comprobó que composiciones farmacéuticas que comprenden un polvo de compuestos lipofílicos tales como hormonas, y esteroides (por ejemplo, drospirenona y valerato de estradiol) en forma dispersa a nivel molecular junto a un vehículo que posee un área superficial específica de al menos 250 m2/g, tal como dióxido de silicio, por ejemplo, dióxido de silicio comercializado bajo la denominación Aeroperl, posee mejores propiedades de disolución de la droga lipofílica.The present invention relates to a pharmaceutical composition with dissolution of lipophilic drugs improved in an aqueous medium. It was found that pharmaceutical compositions comprising a powder of lipophilic compounds such as hormones, and steroids (for example, drospirenone and estradiol valerate) in a molecularly dispersed form together with a vehicle having a specific surface area of at least 250 m2 / g, such as silicon dioxide, for example, silicon dioxide sold under the name Aeroperl, has better dissolving properties of the lipophilic drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060177A CU20060177A7 (en) | 2006-09-11 | 2006-09-11 | STABILIZED SUPERSATURED SOLID SOLUTIONS OF STEROID DRUGS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060177A CU20060177A7 (en) | 2006-09-11 | 2006-09-11 | STABILIZED SUPERSATURED SOLID SOLUTIONS OF STEROID DRUGS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20060177A7 true CU20060177A7 (en) | 2010-04-13 |
Family
ID=44280804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20060177A CU20060177A7 (en) | 2006-09-11 | 2006-09-11 | STABILIZED SUPERSATURED SOLID SOLUTIONS OF STEROID DRUGS |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU20060177A7 (en) |
-
2006
- 2006-09-11 CU CU20060177A patent/CU20060177A7/en unknown
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