CU20070171A7 - CYCLHEXILAMIDS AS ANTAGONISTS OF DOPAMINE D3, D2 AND 5HT1A - Google Patents
CYCLHEXILAMIDS AS ANTAGONISTS OF DOPAMINE D3, D2 AND 5HT1AInfo
- Publication number
- CU20070171A7 CU20070171A7 CU20070171A CU20070171A CU20070171A7 CU 20070171 A7 CU20070171 A7 CU 20070171A7 CU 20070171 A CU20070171 A CU 20070171A CU 20070171 A CU20070171 A CU 20070171A CU 20070171 A7 CU20070171 A7 CU 20070171A7
- Authority
- CU
- Cuba
- Prior art keywords
- dopamine
- formula
- heteroaryl
- cycloalkyl
- alkenyl
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003638 dopamine Drugs 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- 102000017911 HTR1A Human genes 0.000 abstract 2
- 101150015707 HTR1A gene Proteins 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008196 pharmacological composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a nuevos ligandos preferentes del subtipo de los receptores de la dopamina D3 y D2 y de la serotonina 5-HT1A, de fórmula (I), ESPACIO PARA FÓRMULA caracterizados porque A representa alquilo, alquenilo, arilo, heteroarilo, cicloalquilo o un grupo de fórmula -NR1R2 donde R1 y R2 representan, independientemente, un sustituyente seleccionado de entre hidrógeno, alquilo, alquenilo, arilo, heteroarilo o cicloalquilo o R1 yR2 forman, junto con el átomo de nitrógeno adyacente y opcionalmente con otro(s) heteroátomo(s), un anillo heterocíclico; m es un número entero de 0 a 1; n es un número entero de 1 a 2; y/o los isómeros geométricos y/o las sales y/o hidratos y/o solvatos de los mismos; a los procesos para producir estos compuestos, a las composiciones farmacológicas que los contienen y a su utilización en la terapia y/o la prevención de una condición que requiere la modulación de los receptores de la dopamina y/o 5-HT1A.The present invention relates to new preferred ligands of the subtype of dopamine D3 and D2 and serotonin 5-HT1A receptors, of formula (I), FORMULA SPACE characterized in that A represents alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or a group of the formula -NR1R2 where R1 and R2 independently represent a substituent selected from hydrogen, alkyl, alkenyl, aryl, heteroaryl or cycloalkyl or R1 and R2 form, together with the adjacent nitrogen atom and optionally with other (s) heteroatom (s), a heterocyclic ring; m is an integer from 0 to 1; n is an integer from 1 to 2; and / or geometric isomers and / or salts and / or hydrates and / or solvates thereof; to the processes to produce these compounds, to the pharmacological compositions that contain them and to their use in the therapy and / or the prevention of a condition that requires the modulation of the dopamine and / or 5-HT1A receptors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070171A CU20070171A7 (en) | 2007-07-19 | 2007-07-19 | CYCLHEXILAMIDS AS ANTAGONISTS OF DOPAMINE D3, D2 AND 5HT1A |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070171A CU20070171A7 (en) | 2007-07-19 | 2007-07-19 | CYCLHEXILAMIDS AS ANTAGONISTS OF DOPAMINE D3, D2 AND 5HT1A |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20070171A7 true CU20070171A7 (en) | 2010-12-08 |
Family
ID=43401416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20070171A CU20070171A7 (en) | 2007-07-19 | 2007-07-19 | CYCLHEXILAMIDS AS ANTAGONISTS OF DOPAMINE D3, D2 AND 5HT1A |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU20070171A7 (en) |
-
2007
- 2007-07-19 CU CU20070171A patent/CU20070171A7/en unknown
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