CU20070183A7 - OXINDOL DERIVATIVES - Google Patents
OXINDOL DERIVATIVESInfo
- Publication number
- CU20070183A7 CU20070183A7 CU20070183A CU20070183A CU20070183A7 CU 20070183 A7 CU20070183 A7 CU 20070183A7 CU 20070183 A CU20070183 A CU 20070183A CU 20070183 A CU20070183 A CU 20070183A CU 20070183 A7 CU20070183 A7 CU 20070183A7
- Authority
- CU
- Cuba
- Prior art keywords
- disease
- compounds
- dyspepsia
- disorder
- pharmaceutically acceptable
- Prior art date
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000006549 dyspepsia Diseases 0.000 abstract 3
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 206010030216 Oesophagitis Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000006881 esophagitis Diseases 0.000 abstract 1
- 230000030135 gastric motility Effects 0.000 abstract 1
- 208000029493 gastroesophageal disease Diseases 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 208000018685 gastrointestinal system disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere a compuestos de la fórmula (I) ESPACIO PARA FÓRMULA (I) o una sal farmacéuticamente aceptable del mismo, en la que: cada uno de A, R1, R2, R3, R4 y R5 es como se describe en este documento o una sal farmacéuticvamente aceptable, y composiciones que contienen dichos compuestos y el uso de dichos compuestos en el tratamiento de una afección mediada por la actividad agonista de 5-HT4 tales como, aunque sin limitación, enfermedad de reflujo gastroesofágeo, enfermedad gastrointestinal, trastorno de motilidad gástrica, dispepsia no ulcerosa, dispepsia funcional, síndrome del intestino irritable (IBS), estrenimiento, dispepsia, esofagitis, enfermedad gasatroesofágea, náuseas, enfermedad del sistema nervioso central, enfermedad de Alzheimer, trastorno cognitivo, emesis, migrana, enfermedad neurológica, dolor, trastorno cardiovasculares, insufiencia cardiaca, arritmia cardiaca, diabetes o síndrome de apnea.This invention relates to compounds of the formula (I) FORMULA SPACE (I) or a pharmaceutically acceptable salt thereof, in which: each of A, R1, R2, R3, R4 and R5 is as described herein. document or a pharmaceutically acceptable salt, and compositions containing said compounds and the use of said compounds in the treatment of a condition mediated by the agonist activity of 5-HT4 such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, disorder of gastric motility, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorder, heart failure, cardiac arrhythmia, diabetes or apnea syndrome.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070183A CU20070183A7 (en) | 2007-08-06 | 2007-08-06 | OXINDOL DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070183A CU20070183A7 (en) | 2007-08-06 | 2007-08-06 | OXINDOL DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20070183A7 true CU20070183A7 (en) | 2009-03-16 |
Family
ID=44280833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20070183A CU20070183A7 (en) | 2007-08-06 | 2007-08-06 | OXINDOL DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU20070183A7 (en) |
-
2007
- 2007-08-06 CU CU20070183A patent/CU20070183A7/en unknown
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