CU20080221A7 - STABLE PHARMACEUTICAL COMPOSITION CONTAINING DOCETEXAL AND ITS PREPARATION - Google Patents
STABLE PHARMACEUTICAL COMPOSITION CONTAINING DOCETEXAL AND ITS PREPARATIONInfo
- Publication number
- CU20080221A7 CU20080221A7 CU20080221A CU20080221A CU20080221A7 CU 20080221 A7 CU20080221 A7 CU 20080221A7 CU 20080221 A CU20080221 A CU 20080221A CU 20080221 A CU20080221 A CU 20080221A CU 20080221 A7 CU20080221 A7 CU 20080221A7
- Authority
- CU
- Cuba
- Prior art keywords
- pharmaceutical composition
- stable pharmaceutical
- docetexal
- preparation
- composition containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 3
- 229960003668 docetaxel Drugs 0.000 abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica estable para inyección, que contiene docetaxel y a un método para prepararla. Más en particular, la presente invención se refiere a una composición farmacéutica para inyección que contiene docetaxel que tiene mejor estabilidad durante el almacenamiento, que las medicaciones convencionales; que se prepara disolviendo el docetaxel, un compuesto insoluble en agua, en agua destilada, después de mezclarlo con ciclodextrina (CD) y un polímero soluble en agua, tal como hidroxipropilmetilcelulosa (HPMC), polientilenglicol (PEG) o polivinilpirrolidona (PVP), y liofilizando la mezcla, y a un método para prepararla.The present invention relates to a stable pharmaceutical composition for injection, which contains docetaxel and a method of preparing it. More particularly, the present invention relates to a pharmaceutical composition for injection containing docetaxel that has better storage stability, than conventional medications; which is prepared by dissolving docetaxel, a water insoluble compound, in distilled water, after mixing it with cyclodextrin (CD) and a water soluble polymer, such as hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP), and lyophilizing the mixture, and a method to prepare it.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20080221A CU20080221A7 (en) | 2008-11-24 | 2008-11-24 | STABLE PHARMACEUTICAL COMPOSITION CONTAINING DOCETEXAL AND ITS PREPARATION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20080221A CU20080221A7 (en) | 2008-11-24 | 2008-11-24 | STABLE PHARMACEUTICAL COMPOSITION CONTAINING DOCETEXAL AND ITS PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20080221A7 true CU20080221A7 (en) | 2011-04-26 |
Family
ID=44303520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20080221A CU20080221A7 (en) | 2008-11-24 | 2008-11-24 | STABLE PHARMACEUTICAL COMPOSITION CONTAINING DOCETEXAL AND ITS PREPARATION |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU20080221A7 (en) |
-
2008
- 2008-11-24 CU CU20080221A patent/CU20080221A7/en unknown
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