CU20110043A7 - PICOLINAMIDE DERIVATIVES AS CINASA INHIBITORS - Google Patents
PICOLINAMIDE DERIVATIVES AS CINASA INHIBITORSInfo
- Publication number
- CU20110043A7 CU20110043A7 CU20110043A CU20110043A CU20110043A7 CU 20110043 A7 CU20110043 A7 CU 20110043A7 CU 20110043 A CU20110043 A CU 20110043A CU 20110043 A CU20110043 A CU 20110043A CU 20110043 A7 CU20110043 A7 CU 20110043A7
- Authority
- CU
- Cuba
- Prior art keywords
- kinase
- compositions
- inhibiting
- activity
- picolinamide derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 102100036077 Serine/threonine-protein kinase pim-1 Human genes 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 208000005623 Carcinogenesis Diseases 0.000 abstract 1
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000036952 cancer formation Effects 0.000 abstract 1
- 231100000504 carcinogenesis Toxicity 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Se proporcionan nuevos compuestos, composiciones y métodos de inhibición de la integración de la actividad del provirus de la cinasa Maloney (Cinasa PIM) asociada con tumorigénesis en un sujeto humano o animal. En ciertas modalidades, los compuestos y composiciones son efectivos para inhibir la actividad de cuando menos una cinasa PIM. Los nuevos compuestos y composiciones se pueden utilizar ya sea solos o bien en combinación con cuando menos un agente adicional para el tratamiento de un trastorno mediado por una cinasa de serina/treonina o por un receptor de cinasa de tirosina, tal como cáncer.New compounds, compositions and methods of inhibiting the integration of Maloney kinase provirus activity (PIM kinase) associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective in inhibiting the activity of at least one PIM kinase. The new compounds and compositions can be used either alone or in combination with at least one additional agent for the treatment of a serine / threonine kinase mediated disorder or a tyrosine kinase receptor, such as cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22509P | 2009-07-15 | 2009-07-15 | |
| PCT/EP2009/061204 WO2010023309A2 (en) | 2008-08-29 | 2009-08-31 | Airbag arrangements for vehicle-occupant restraining systems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20110043A7 true CU20110043A7 (en) | 2011-12-28 |
| CU23997B1 CU23997B1 (en) | 2014-04-24 |
Family
ID=45508745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2011000043A CU23997B1 (en) | 2009-07-15 | 2011-02-28 | PICOLINAMIDE DERIVATIVES AS CINASA INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23997B1 (en) |
-
2011
- 2011-02-28 CU CU2011000043A patent/CU23997B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CU23997B1 (en) | 2014-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant of patent |