CU20120120A7 - PIRROLO-PYRIMIDINE COMPOUNDS AS CDK4 / 6 INHIBITORS - Google Patents
PIRROLO-PYRIMIDINE COMPOUNDS AS CDK4 / 6 INHIBITORSInfo
- Publication number
- CU20120120A7 CU20120120A7 CU2012000120A CU20120120A CU20120120A7 CU 20120120 A7 CU20120120 A7 CU 20120120A7 CU 2012000120 A CU2012000120 A CU 2012000120A CU 20120120 A CU20120120 A CU 20120120A CU 20120120 A7 CU20120120 A7 CU 20120120A7
- Authority
- CU
- Cuba
- Prior art keywords
- cdk4
- compound
- cancer
- inhibitors
- pyrimidine compounds
- Prior art date
Links
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 abstract 2
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000007276 esophageal squamous cell carcinoma Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 206010024627 liposarcoma Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 150000004944 pyrrolopyrimidines Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención se refiere a novedosos compuestos de pirrolo-pirimidina de la fórmula(I):en donde R^1,R^2Y, R^4, R^8- R^11, A y L se definen en la presente, y a las sales, incluyendo las sales farmacéuticamente aceptables de los mismos. Los compuestos de la presente invención son inhibidores de CDK4/6 y podrían ser útiles en el tratamiento de las enfermedades de los trastornos mediados por CDK4/6, tales como cáncer, incluyendo linfoma de células de manto, liposarcoma, cáncer pulmonar no microcelular, melanoma,cáncer esofágico de células escamosas, y cáncer de mama. La invención se refiere además a las composiciones farmacéuticas que comprenden un compuesto de la invención.La invención se refiere todavía adicionalmente a los métodos para inhibir la actividad de CDK4/6, y al tratamiento de los trastornos asociados con la misma, utilizando un compuesto de la invención o una composición farmacéutica que comprenda un compuesto de la invención.The invention relates to novel pyrrolo-pyrimidine compounds of the formula (I): wherein R ^ 1, R ^ 2Y, R ^ 4, R ^ 8- R ^ 11, A and L are defined herein, and the salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4 / 6 inhibitors and could be useful in the treatment of diseases of CDK4 / 6 mediated disorders, such as cancer, including mantle cell lymphoma, liposarcoma, non-microcellular lung cancer, melanoma. , esophageal squamous cell cancer, and breast cancer. The invention further relates to pharmaceutical compositions comprising a compound of the invention. The invention still further relates to methods for inhibiting CDK4 / 6 activity, and to treating disorders associated therewith, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30624810P | 2010-02-19 | 2010-02-19 | |
| US201161429997P | 2011-01-05 | 2011-01-05 | |
| PCT/EP2011/052353 WO2011101409A1 (en) | 2010-02-19 | 2011-02-17 | Pyrrolopyrimidine compounds as inhibitors of cdk4/6 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20120120A7 true CU20120120A7 (en) | 2013-01-30 |
| CU24069B1 CU24069B1 (en) | 2015-01-29 |
Family
ID=53365647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20120120A CU24069B1 (en) | 2010-02-19 | 2011-02-17 | PIRROLO-PYRIMIDINE COMPOUNDS AS CDK4 / 6 INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU24069B1 (en) |
-
2011
- 2011-02-17 CU CU20120120A patent/CU24069B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CU24069B1 (en) | 2015-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant of patent |