CU20130106A7 - GLUCAGON RECEIVER MODULATORS - Google Patents
GLUCAGON RECEIVER MODULATORSInfo
- Publication number
- CU20130106A7 CU20130106A7 CU2013000106A CU20130106A CU20130106A7 CU 20130106 A7 CU20130106 A7 CU 20130106A7 CU 2013000106 A CU2013000106 A CU 2013000106A CU 20130106 A CU20130106 A CU 20130106A CU 20130106 A7 CU20130106 A7 CU 20130106A7
- Authority
- CU
- Cuba
- Prior art keywords
- glucagon
- formula
- compounds
- receiver modulators
- modulators
- Prior art date
Links
- 102000051325 Glucagon Human genes 0.000 title abstract 3
- 108060003199 Glucagon Proteins 0.000 title abstract 3
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 3
- 229960004666 glucagon Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención proporciona un compuesto de fórmula( I): o una sal farmacéuticamente aceptable del mismo, en la que R^1, R^2, R^3, A^1, A^2, A^3, A^4, L, B^1, B^2, B^3 y B^4 son como se definen en el presente documento. Se ha encontrado que los compuestos de fórmula I actúan como antagonistas o agonistas inversos de glucagón. En consecuencia, los compuestos de fórmula I y las composiciones farmacéuticas del mismo son útiles para el tratamiento de enfermedades, trastornos o afecciones mediadas por glucagón.The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R ^ 1, R ^ 2, R ^ 3, A ^ 1, A ^ 2, A ^ 3, A ^ 4 , L, B ^ 1, B ^ 2, B ^ 3 and B ^ 4 are as defined herein. It has been found that the compounds of formula I act as glucagon antagonists or inverse agonists. Consequently, the compounds of formula I and the pharmaceutical compositions thereof are useful for the treatment of glucagon-mediated diseases, disorders or conditions.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440578P | 2011-02-08 | 2011-02-08 | |
| US201161441044P | 2011-02-09 | 2011-02-09 | |
| US201261585834P | 2012-01-12 | 2012-01-12 | |
| PCT/IB2012/050349 WO2012107850A1 (en) | 2011-02-08 | 2012-01-25 | Glucagon receptor modulator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20130106A7 true CU20130106A7 (en) | 2013-09-27 |
| CU24135B1 CU24135B1 (en) | 2015-11-27 |
Family
ID=52395351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2013000106A CU24135B1 (en) | 2011-02-08 | 2012-01-25 | GLUCAGON RECEIVER MODULATORS |
Country Status (2)
| Country | Link |
|---|---|
| CU (1) | CU24135B1 (en) |
| TN (1) | TN2013000338A1 (en) |
-
2012
- 2012-01-25 CU CUP2013000106A patent/CU24135B1/en unknown
-
2013
- 2013-08-07 TN TNP2013000338A patent/TN2013000338A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CU24135B1 (en) | 2015-11-27 |
| TN2013000338A1 (en) | 2015-01-20 |
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