CU20130165A7 - MODIFIED RELEASE OF 4-METHYL-3 - [[- 4- (3- PIRIDINIL) -2-PYRIMIDINYL] AMINO] -N-5- (4- METHYL-1H-IMIDAZOL-1- IL) -3- (TRIFLUOROMETIL) FENIL] SOLUBILIZED BENZAMIDE USING ORGANIC ACIDS - Google Patents

MODIFIED RELEASE OF 4-METHYL-3 - [[- 4- (3- PIRIDINIL) -2-PYRIMIDINYL] AMINO] -N-5- (4- METHYL-1H-IMIDAZOL-1- IL) -3- (TRIFLUOROMETIL) FENIL] SOLUBILIZED BENZAMIDE USING ORGANIC ACIDS

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Publication number
CU20130165A7
CU20130165A7 CU2013000165A CU20130165A CU20130165A7 CU 20130165 A7 CU20130165 A7 CU 20130165A7 CU 2013000165 A CU2013000165 A CU 2013000165A CU 20130165 A CU20130165 A CU 20130165A CU 20130165 A7 CU20130165 A7 CU 20130165A7
Authority
CU
Cuba
Prior art keywords
methyl
organic acids
piridinil
trifluorometil
fenil
Prior art date
Application number
CU2013000165A
Other languages
Spanish (es)
Inventor
Shoufeng Li
Saran Kumar
Nickil Javant Kavimandan
Enxian Lu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/042205 external-priority patent/WO2012174082A1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20130165A7 publication Critical patent/CU20130165A7/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se inventaron composiciones farmacéuticas solubles de nilotinib, o de una sal farmacéuticamente aceptable del mismo, utilizando uno o más ácidos orgánicos que funcionan como un agente solubilizante, que aumentan la biodisponibilidad del nilotinib, y que suprimen el efecto del alimento asociado con ciertas composiciones de nilotinib. Las composiciones farmacéuticas están en la forma de formas de dosificación oral sólidas, incluyendo cápsulas y tabletas.Soluble pharmaceutical compositions of nilotinib, or a pharmaceutically acceptable salt thereof, were invented, using one or more organic acids that function as a solubilizing agent, which increase the bioavailability of nilotinib, and which suppress the effect of the food associated with certain nilotinib compositions. . The pharmaceutical compositions are in the form of solid oral dosage forms, including capsules and tablets.

CU2013000165A 2011-09-30 2013-12-16 MODIFIED RELEASE OF 4-METHYL-3 - [[- 4- (3- PIRIDINIL) -2-PYRIMIDINYL] AMINO] -N-5- (4- METHYL-1H-IMIDAZOL-1- IL) -3- (TRIFLUOROMETIL) FENIL] SOLUBILIZED BENZAMIDE USING ORGANIC ACIDS CU20130165A7 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161541306P 2011-09-30 2011-09-30
PCT/US2012/042205 WO2012174082A1 (en) 2011-06-14 2012-06-13 Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids

Publications (1)

Publication Number Publication Date
CU20130165A7 true CU20130165A7 (en) 2014-04-24

Family

ID=52394773

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2013000165A CU20130165A7 (en) 2011-09-30 2013-12-16 MODIFIED RELEASE OF 4-METHYL-3 - [[- 4- (3- PIRIDINIL) -2-PYRIMIDINYL] AMINO] -N-5- (4- METHYL-1H-IMIDAZOL-1- IL) -3- (TRIFLUOROMETIL) FENIL] SOLUBILIZED BENZAMIDE USING ORGANIC ACIDS

Country Status (2)

Country Link
CU (1) CU20130165A7 (en)
TN (1) TN2013000440A1 (en)

Also Published As

Publication number Publication date
TN2013000440A1 (en) 2015-03-30

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