CU20140021A7 - DERIVATIVES OF 2- AMINO-4- (PIRIDIN-2-IL) -5,6- DIHIDRO-4H-1,3- OXACINE AND ITS USE AS BACE -1 AND / OR BACE-2 INHIBITORS - Google Patents

DERIVATIVES OF 2- AMINO-4- (PIRIDIN-2-IL) -5,6- DIHIDRO-4H-1,3- OXACINE AND ITS USE AS BACE -1 AND / OR BACE-2 INHIBITORS

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Publication number
CU20140021A7
CU20140021A7 CU2014000021A CU20140021A CU20140021A7 CU 20140021 A7 CU20140021 A7 CU 20140021A7 CU 2014000021 A CU2014000021 A CU 2014000021A CU 20140021 A CU20140021 A CU 20140021A CU 20140021 A7 CU20140021 A7 CU 20140021A7
Authority
CU
Cuba
Prior art keywords
bace
derivatives
oxacine
piridin
dihidro
Prior art date
Application number
CU2014000021A
Other languages
Spanish (es)
Inventor
Rainer Martin Lueoend
Rainer Machauer
Heinrich Rueeger
Siem Jacob Veenstra
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2012/054269 external-priority patent/WO2013027188A1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20140021A7 publication Critical patent/CU20140021A7/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a novedosos derivados de oxacina de la fórmula( I), y las sales farmacéuticamente aceptables de los mismos: En donde todas las variables son como se definen en la memoria descriptiva, a composiciones farmacéuticas de los mismos, a combinaciones de los mismos, y a su uso como medicamentos, en particular para el tratamiento de enfermedad de Alzheimer o de diabetes por medio de la inhibición de BACE-1 o BACE-2.The invention relates to novel oxacin derivatives of the formula (I), and pharmaceutically acceptable salts thereof: Where all the variables are as defined in the specification, to pharmaceutical compositions thereof, to combinations thereof. themselves, and their use as medicines, in particular for the treatment of Alzheimer's disease or diabetes by means of the inhibition of BACE-1 or BACE-2.

CU2014000021A 2012-06-28 2014-02-25 DERIVATIVES OF 2- AMINO-4- (PIRIDIN-2-IL) -5,6- DIHIDRO-4H-1,3- OXACINE AND ITS USE AS BACE -1 AND / OR BACE-2 INHIBITORS CU20140021A7 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261665395P 2012-06-28 2012-06-28
PCT/IB2012/054269 WO2013027188A1 (en) 2011-08-25 2012-08-23 2 -amino-4 - (pyridin- 2 -yl) - 5, 6 -dihydro-4h- 1, 3 -oxazine derivatives and their use as bace-1 and/or bace - 2 inhibitors

Publications (1)

Publication Number Publication Date
CU20140021A7 true CU20140021A7 (en) 2014-04-24

Family

ID=52394776

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2014000021A CU20140021A7 (en) 2012-06-28 2014-02-25 DERIVATIVES OF 2- AMINO-4- (PIRIDIN-2-IL) -5,6- DIHIDRO-4H-1,3- OXACINE AND ITS USE AS BACE -1 AND / OR BACE-2 INHIBITORS

Country Status (1)

Country Link
CU (1) CU20140021A7 (en)

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