CU20160058A7 - Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular - Google Patents

Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular

Info

Publication number
CU20160058A7
CU20160058A7 CUP2016000058A CU20160058A CU20160058A7 CU 20160058 A7 CU20160058 A7 CU 20160058A7 CU P2016000058 A CUP2016000058 A CU P2016000058A CU 20160058 A CU20160058 A CU 20160058A CU 20160058 A7 CU20160058 A7 CU 20160058A7
Authority
CU
Cuba
Prior art keywords
central
nervous system
benzodiazepina
activity
derived
Prior art date
Application number
CUP2016000058A
Other languages
English (en)
Inventor
Fernández Pedro Gilberto Bárzaga
Hernández René Delgado
Fonseca Luis Arturo Fonseca
Suárez Bárbara Beatriz Garrido
Alfonso Nicté González
Figueredo Yanier Nuñez
Rodríguez Estael Ochoa
Yaquis Alejandro Saúl Padrón
Andreu Gilberto Lázaro Pardo
Sánchez Jeney Ramírez
Reyes Yamila Verdecia
Guerra Maylin Wong
Original Assignee
Centro De Investigación Y Desarrollo De Medicamentos (Cidem) Organizacion Superior De Desarrollo Emp
Facultad De Química Univ De La Habana Ministerio De Educacion Superior (Mes)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro De Investigación Y Desarrollo De Medicamentos (Cidem) Organizacion Superior De Desarrollo Emp, Facultad De Química Univ De La Habana Ministerio De Educacion Superior (Mes) filed Critical Centro De Investigación Y Desarrollo De Medicamentos (Cidem) Organizacion Superior De Desarrollo Emp
Priority to CUP2016000058A priority Critical patent/CU20160058A7/es
Priority to EA201892461A priority patent/EA201892461A1/ru
Priority to CN201780041572.6A priority patent/CN110114356B/zh
Priority to SG11201809845TA priority patent/SG11201809845TA/en
Priority to BR112018072588-9A priority patent/BR112018072588B1/pt
Priority to SI201731044T priority patent/SI3470414T1/sl
Priority to AU2017259748A priority patent/AU2017259748B2/en
Priority to JP2019510748A priority patent/JP7078959B2/ja
Priority to MYPI2018704116A priority patent/MY199288A/en
Priority to DK17732729.3T priority patent/DK3470414T3/da
Priority to ES17732729T priority patent/ES2902992T3/es
Priority to NZ748959A priority patent/NZ748959B2/en
Priority to PCT/CU2017/050002 priority patent/WO2017190713A1/es
Priority to CA3023105A priority patent/CA3023105C/en
Priority to US16/099,116 priority patent/US11098039B2/en
Priority to EP17732729.3A priority patent/EP3470414B1/en
Priority to MX2018013405A priority patent/MX385439B/es
Priority to KR1020187035040A priority patent/KR102428383B1/ko
Priority to ARP170101152A priority patent/AR108369A1/es
Publication of CU20160058A7 publication Critical patent/CU20160058A7/es
Priority to CL2018003113A priority patent/CL2018003113A1/es
Priority to ZA2018/08162A priority patent/ZA201808162B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>Compuesto de fórmula I, sus derivados y composiciones farmacéuticas que los contienen para el tratamiento de enfermedades del sistema nervioso central y vascular, especialmente trastornos neurodegenerativos, con deterioro cognitivo, enfermedades asociadas al estres oxidativo, enfermedades que cursan con disfunción mitocondrial, enfermedad de Parkinson y dolor neuropático, así como procesos patológicos asociados con el envejecimiento. ESPACIO PARA FÓRMULA</p>
CUP2016000058A 2016-05-04 2016-05-04 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular CU20160058A7 (es)

Priority Applications (21)

Application Number Priority Date Filing Date Title
CUP2016000058A CU20160058A7 (es) 2016-05-04 2016-05-04 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular
DK17732729.3T DK3470414T3 (da) 2016-05-04 2017-05-03 Benzodiazepinderivat med aktivitet på centralnerve- og karsystemerne
PCT/CU2017/050002 WO2017190713A1 (es) 2016-05-04 2017-05-03 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular
SG11201809845TA SG11201809845TA (en) 2016-05-04 2017-05-03 Benzodiazepine product with activity on the central nervous and vascular systems
BR112018072588-9A BR112018072588B1 (pt) 2016-05-04 2017-05-03 Uso de um composto de benzodiacepina
SI201731044T SI3470414T1 (sl) 2016-05-04 2017-05-03 Derivat benzodiazepina, ki deluje na centralni živčni in žilni sistem
AU2017259748A AU2017259748B2 (en) 2016-05-04 2017-05-03 Benzodiazepine derivative with activity on the central nervous and vascular systems
JP2019510748A JP7078959B2 (ja) 2016-05-04 2017-05-03 中枢神経系及び血管系での活性を持つベンゾジアゼピン誘導体
MYPI2018704116A MY199288A (en) 2016-05-04 2017-05-03 Benzodiazepine derivative with activity on the central nervous and vascular systems
EA201892461A EA201892461A1 (ru) 2016-05-04 2017-05-03 Продукт бензодиазепина с активностью на центральную нервную и сердечно-сосудистую системы
ES17732729T ES2902992T3 (es) 2016-05-04 2017-05-03 Derivado de benzodiazepina con actividad sobre los sistemas vascular y nervioso central
NZ748959A NZ748959B2 (en) 2017-05-03 Benzodiazepine derivative with activity on the central nervous and vascular systems
CN201780041572.6A CN110114356B (zh) 2016-05-04 2017-05-03 具有对中枢神经系统和血管系统的活性的苯并二氮卓衍生物
CA3023105A CA3023105C (en) 2016-05-04 2017-05-03 Benzodiazepine derivative with activity on the central nervous and vascular systems
US16/099,116 US11098039B2 (en) 2016-05-04 2017-05-03 Benzodiazepine product with activity on the central nervous and vascular systems
EP17732729.3A EP3470414B1 (en) 2016-05-04 2017-05-03 Benzodiazepine derivative with activity on the central nervous and vascular systems
MX2018013405A MX385439B (es) 2016-05-04 2017-05-03 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular
KR1020187035040A KR102428383B1 (ko) 2016-05-04 2017-05-03 중추신경계 및 혈관계에 대한 활성을 가진 벤조디아제핀 생성물
ARP170101152A AR108369A1 (es) 2016-05-04 2017-05-04 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular
CL2018003113A CL2018003113A1 (es) 2016-05-04 2018-10-31 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular.
ZA2018/08162A ZA201808162B (en) 2016-05-04 2018-12-03 Benzodiazepine derivative with activity on the central nervous and vascular systems

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CUP2016000058A CU20160058A7 (es) 2016-05-04 2016-05-04 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular

Publications (1)

Publication Number Publication Date
CU20160058A7 true CU20160058A7 (es) 2017-12-08

Family

ID=59215419

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2016000058A CU20160058A7 (es) 2016-05-04 2016-05-04 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular

Country Status (20)

Country Link
US (1) US11098039B2 (es)
EP (1) EP3470414B1 (es)
JP (1) JP7078959B2 (es)
KR (1) KR102428383B1 (es)
CN (1) CN110114356B (es)
AR (1) AR108369A1 (es)
AU (1) AU2017259748B2 (es)
BR (1) BR112018072588B1 (es)
CA (1) CA3023105C (es)
CL (1) CL2018003113A1 (es)
CU (1) CU20160058A7 (es)
DK (1) DK3470414T3 (es)
EA (1) EA201892461A1 (es)
ES (1) ES2902992T3 (es)
MX (1) MX385439B (es)
MY (1) MY199288A (es)
SG (1) SG11201809845TA (es)
SI (1) SI3470414T1 (es)
WO (1) WO2017190713A1 (es)
ZA (1) ZA201808162B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022012699A2 (pt) * 2019-12-26 2022-09-06 Centro De Investig Y Desarrollo De Medicamentos Cidem Uso de um derivado de benzodiazepina e método de tratamento de lesão cerebral traumática
CU20190114A7 (es) * 2019-12-26 2021-08-06 Centro De Investig Y Desarrollo De Medicamentos Cidem Combinación para simultáneamente incrementar la eficacia analgésica de la morfina y reducir su dependencia física

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110288070A1 (en) 2008-05-05 2011-11-24 ROGERS Kathryn Methods for treating cognitive disorders using inhibitors of histone deacetylase
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
CU24576B1 (es) 2016-05-04 2022-02-04 Centro De Investig Y Desarrollo De Medicamentos Cidem Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular

Also Published As

Publication number Publication date
BR112018072588A2 (pt) 2019-02-19
JP2019519600A (ja) 2019-07-11
WO2017190713A1 (es) 2017-11-09
EP3470414A1 (en) 2019-04-17
CL2018003113A1 (es) 2019-04-12
BR112018072588B1 (pt) 2024-02-20
AU2017259748B2 (en) 2021-08-05
MY199288A (en) 2023-10-24
CA3023105C (en) 2023-07-18
EA201892461A1 (ru) 2019-04-30
US20190270738A1 (en) 2019-09-05
CN110114356A (zh) 2019-08-09
EP3470414B1 (en) 2021-10-13
KR20210025137A (ko) 2021-03-09
KR102428383B1 (ko) 2022-08-02
CA3023105A1 (en) 2017-11-09
NZ748959A (en) 2024-02-23
ZA201808162B (en) 2021-08-25
AR108369A1 (es) 2018-08-15
SI3470414T1 (sl) 2022-03-31
ES2902992T3 (es) 2022-03-30
MX2018013405A (es) 2019-08-16
CN110114356B (zh) 2021-09-24
MX385439B (es) 2025-03-18
US11098039B2 (en) 2021-08-24
AU2017259748A1 (en) 2018-12-20
JP7078959B2 (ja) 2022-06-01
SG11201809845TA (en) 2018-12-28
DK3470414T3 (da) 2022-01-17

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