CU20160142A7 - PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM - Google Patents

PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM

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Publication number
CU20160142A7
CU20160142A7 CUP2016000142A CU20160142A CU20160142A7 CU 20160142 A7 CU20160142 A7 CU 20160142A7 CU P2016000142 A CUP2016000142 A CU P2016000142A CU 20160142 A CU20160142 A CU 20160142A CU 20160142 A7 CU20160142 A7 CU 20160142A7
Authority
CU
Cuba
Prior art keywords
central
treatment
nervous system
fused
dihydropiridine
Prior art date
Application number
CUP2016000142A
Other languages
Spanish (es)
Inventor
Fernández Pedro Gilberto Bárzaga
Navarro Claudia Amanda Canaán-Haden
Hernández René Delgado
Fonseca Luis Arturo Fonseca
Alfonso Nicté González
Rodríguez Abel Mondelo
Figueredo Yanier Nuñez
Rodríguez Estael Ochoa
Yaquis Alejandro Saúl Padrón
Andreu Gilberto Lázaro Pardo
Sánchez Jeney Ramírez
Reyes Yamila Verdecia
Guerra Maylin Wong
Original Assignee
Centro De Investig Y Desarrollo De Medicamentos Cidem Organizacion Superior De Direccion Empresarial
Facultad De Quimica Univ De La Habana Ministerio De Educacion Superior Mes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro De Investig Y Desarrollo De Medicamentos Cidem Organizacion Superior De Direccion Empresarial, Facultad De Quimica Univ De La Habana Ministerio De Educacion Superior Mes filed Critical Centro De Investig Y Desarrollo De Medicamentos Cidem Organizacion Superior De Direccion Empresarial
Priority to CUP2016000142A priority Critical patent/CU20160142A7/en
Publication of CU20160142A7 publication Critical patent/CU20160142A7/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>La presente invención se relaciona con Ia Química, Ia Farmacéutica y en particular con Ia obtención de formulaciones a partir de derivados de compuestos fenólicos o polifenólicos y a partir de derivados de compuestos fenólicos o polifenólicos combinados con sistemas tricíclicos del tipo benzodiazepinas fusionadas a derivados de 1,4-dihidropiridinas con acción sobre el Sistema Nervioso Central y Vascular. Estas composiciones farmacéuticas presentan acción GABAérgica, antiglutamatérgica, moduladora de los canales de calcio, mitoprotectora, antioxidante, antiinflamatoria, y antiapoptótica, utilizables en el tratamiento de las enfermedades cardiovasculares, cerebrovasculares, neurodegenerativas, neuropsiquiátricas y neurológicas.</p><p> The present invention relates to Chemistry, Pharmaceutical and in particular to obtaining formulations from derivatives of phenolic or polyphenolic compounds and from derivatives of phenolic or polyphenolic compounds combined with tricyclic systems of the benzodiazepine type fused to derivatives of 1,4-dihydropyridines with action on the Central and Vascular Nervous System. These pharmaceutical compositions have GABAergic, antiglutamatergic, calcium channel modulator, mitoprotective, antioxidant, anti-inflammatory, and antiapoptotic action, usable in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological diseases. </p>

CUP2016000142A 2016-09-27 2016-09-27 PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM CU20160142A7 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CUP2016000142A CU20160142A7 (en) 2016-09-27 2016-09-27 PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CUP2016000142A CU20160142A7 (en) 2016-09-27 2016-09-27 PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM

Publications (1)

Publication Number Publication Date
CU20160142A7 true CU20160142A7 (en) 2018-05-08

Family

ID=62104049

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2016000142A CU20160142A7 (en) 2016-09-27 2016-09-27 PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM

Country Status (1)

Country Link
CU (1) CU20160142A7 (en)

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