CU20170120A7 - Compuestos 3-sustituidos de 1 de 1,3,4-oxadiazol y tiadiazol como inmunomoduladores - Google Patents
Compuestos 3-sustituidos de 1 de 1,3,4-oxadiazol y tiadiazol como inmunomoduladoresInfo
- Publication number
- CU20170120A7 CU20170120A7 CUP2017000120A CU20170120A CU20170120A7 CU 20170120 A7 CU20170120 A7 CU 20170120A7 CU P2017000120 A CUP2017000120 A CU P2017000120A CU 20170120 A CU20170120 A CU 20170120A CU 20170120 A7 CU20170120 A7 CU 20170120A7
- Authority
- CU
- Cuba
- Prior art keywords
- tiadiazol
- immunomodulators
- oxadiazol
- substituted compounds
- inhibiting
- Prior art date
Links
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002955 immunomodulating agent Substances 0.000 title 1
- 229940121354 immunomodulator Drugs 0.000 title 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 abstract 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 150000004869 1,3,4-thiadiazoles Chemical class 0.000 abstract 1
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 abstract 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 abstract 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 abstract 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>La presente invención hace referencia a compuestos 1,3,4 - oxadiazol y tiadiazol de fórmula (I)</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>útiles para inhibir la vía de señalización de muerte celular programada 1 (PD-1) y/o para tratar trastornos mediante la inhibición de una señal de inmunosupresión inducida por PD-1, PD-L1 o PD-L2.</p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1179CH2015 | 2015-03-10 | ||
| PCT/IB2016/051299 WO2016142852A1 (en) | 2015-03-10 | 2016-03-08 | 1,3,4-oxadiazole and thiadiazole compounds as immunomodulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20170120A7 true CU20170120A7 (es) | 2018-06-05 |
Family
ID=56879298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2017000120A CU20170120A7 (es) | 2015-03-10 | 2016-03-08 | Compuestos 3-sustituidos de 1 de 1,3,4-oxadiazol y tiadiazol como inmunomoduladores |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20180044304A1 (es) |
| EP (1) | EP3267999A4 (es) |
| JP (1) | JP2018507885A (es) |
| KR (1) | KR20170123680A (es) |
| CN (1) | CN107405336A (es) |
| AU (1) | AU2016230812A1 (es) |
| BR (1) | BR112017019306A2 (es) |
| CA (1) | CA2979145A1 (es) |
| CU (1) | CU20170120A7 (es) |
| EA (1) | EA201791629A1 (es) |
| HK (1) | HK1243339A1 (es) |
| IL (1) | IL254046A0 (es) |
| MX (1) | MX2017011614A (es) |
| PH (1) | PH12017501452A1 (es) |
| SG (1) | SG11201706900YA (es) |
| WO (1) | WO2016142852A1 (es) |
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| CU24362B1 (es) | 2013-09-06 | 2018-10-04 | Aurigene Discovery Tech Ltd | Derivados de 1,2,4-oxadiazol como inmunomoduladores |
| MX384444B (es) | 2015-03-10 | 2025-03-14 | Aurigene Discovery Tech Ltd | Compuestos de 1,2,4-oxadiazol y tiadiazol como inmunomoduladores |
| TWI808938B (zh) | 2016-04-07 | 2023-07-21 | 美商卡默森屈有限公司 | 藉由投予ccr1拮抗劑與pd-1抑制劑或pd-l1抑制劑之組合減少腫瘤負荷 |
| WO2018047139A1 (en) * | 2016-09-12 | 2018-03-15 | Aurigene Discovery Technologies Limited | Compounds as modulators of tigit signalling pathway |
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| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
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| BR112020006669A2 (pt) | 2017-10-11 | 2020-09-24 | Aurigene Discovery Technologies Limited | formas cristalinas de 1,2,4-oxadiazol 3-substituído |
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| EA202090749A1 (ru) | 2017-11-06 | 2020-08-19 | Ориджен Дискавери Текнолоджис Лимитед | Способы совместной терапии для иммуномодуляции |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090264315A1 (en) * | 2007-07-26 | 2009-10-22 | Texas A&M University System | Dipeptide mimics, libraries combining two dipeptide mimics with a third group, and methods for production thereof |
| US8907053B2 (en) * | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| CN103732238A (zh) * | 2011-06-08 | 2014-04-16 | 奥瑞基尼探索技术有限公司 | 用于免疫调节的治疗性化合物 |
| HRP20181251T1 (hr) * | 2013-09-06 | 2018-10-05 | Aurigene Discovery Technologies Limited | Derivati 1,3,4-oksadiazola i 1,3,4-tiadiazola kao imunomodulatori |
-
2016
- 2016-03-08 CA CA2979145A patent/CA2979145A1/en not_active Abandoned
- 2016-03-08 CU CUP2017000120A patent/CU20170120A7/es unknown
- 2016-03-08 AU AU2016230812A patent/AU2016230812A1/en not_active Abandoned
- 2016-03-08 WO PCT/IB2016/051299 patent/WO2016142852A1/en not_active Ceased
- 2016-03-08 EP EP16761174.8A patent/EP3267999A4/en not_active Withdrawn
- 2016-03-08 EA EA201791629A patent/EA201791629A1/ru unknown
- 2016-03-08 KR KR1020177028023A patent/KR20170123680A/ko not_active Withdrawn
- 2016-03-08 CN CN201680020153.XA patent/CN107405336A/zh active Pending
- 2016-03-08 HK HK18102876.5A patent/HK1243339A1/zh unknown
- 2016-03-08 US US15/556,822 patent/US20180044304A1/en not_active Abandoned
- 2016-03-08 BR BR112017019306-0A patent/BR112017019306A2/pt not_active Application Discontinuation
- 2016-03-08 JP JP2017547436A patent/JP2018507885A/ja active Pending
- 2016-03-08 SG SG11201706900YA patent/SG11201706900YA/en unknown
- 2016-03-08 MX MX2017011614A patent/MX2017011614A/es unknown
-
2017
- 2017-08-11 PH PH12017501452A patent/PH12017501452A1/en unknown
- 2017-08-17 IL IL254046A patent/IL254046A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018507885A (ja) | 2018-03-22 |
| EA201791629A1 (ru) | 2018-02-28 |
| EP3267999A1 (en) | 2018-01-17 |
| MX2017011614A (es) | 2018-03-23 |
| WO2016142852A1 (en) | 2016-09-15 |
| PH12017501452A1 (en) | 2018-01-15 |
| EP3267999A4 (en) | 2018-07-25 |
| IL254046A0 (en) | 2017-10-31 |
| CA2979145A1 (en) | 2016-09-15 |
| US20180044304A1 (en) | 2018-02-15 |
| BR112017019306A2 (pt) | 2018-05-08 |
| CN107405336A (zh) | 2017-11-28 |
| AU2016230812A1 (en) | 2017-09-07 |
| KR20170123680A (ko) | 2017-11-08 |
| HK1243339A1 (zh) | 2018-07-13 |
| SG11201706900YA (en) | 2017-09-28 |
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