CU20180014A7 - Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h - Google Patents

Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h

Info

Publication number
CU20180014A7
CU20180014A7 CUP2018000014A CU20180014A CU20180014A7 CU 20180014 A7 CU20180014 A7 CU 20180014A7 CU P2018000014 A CUP2018000014 A CU P2018000014A CU 20180014 A CU20180014 A CU 20180014A CU 20180014 A7 CU20180014 A7 CU 20180014A7
Authority
CU
Cuba
Prior art keywords
idh1
inhibitor
muted
isocitrate
dehydrogenase
Prior art date
Application number
CUP2018000014A
Other languages
English (en)
Spanish (es)
Inventor
Heiko Schirmer
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CU20180014A7 publication Critical patent/CU20180014A7/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CUP2018000014A 2015-07-27 2016-07-22 Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h CU20180014A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15178419 2015-07-27
PCT/EP2016/067477 WO2017016992A1 (fr) 2015-07-27 2016-07-22 Inhibiteur d'isocitrate déshydrogénase mutée idh1 r132h

Publications (1)

Publication Number Publication Date
CU20180014A7 true CU20180014A7 (es) 2018-06-05

Family

ID=53758092

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2018000014A CU20180014A7 (es) 2015-07-27 2016-07-22 Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h

Country Status (26)

Country Link
US (1) US10344004B2 (fr)
EP (1) EP3328837B1 (fr)
JP (1) JP6804516B2 (fr)
KR (1) KR20180030789A (fr)
CN (1) CN107810181B (fr)
AR (1) AR105493A1 (fr)
AU (1) AU2016300980B2 (fr)
BR (1) BR112018001534A2 (fr)
CA (1) CA2993473A1 (fr)
CL (1) CL2018000249A1 (fr)
CO (1) CO2018000793A2 (fr)
CR (1) CR20180053A (fr)
CU (1) CU20180014A7 (fr)
DO (1) DOP2018000027A (fr)
EA (1) EA201890386A1 (fr)
EC (1) ECSP18006465A (fr)
ES (1) ES2860693T3 (fr)
HK (1) HK1252449A1 (fr)
IL (1) IL256024A (fr)
MX (1) MX2018001205A (fr)
NI (1) NI201800014A (fr)
PE (1) PE20181038A1 (fr)
SV (1) SV2018005621A (fr)
TN (1) TN2018000038A1 (fr)
TW (1) TW201708193A (fr)
WO (1) WO2017016992A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9951027B2 (en) 2014-02-11 2018-04-24 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as MIDH1 inhibitors
EA031655B1 (ru) 2014-02-11 2019-02-28 Байер Фарма Акциенгезельшафт Бензимидазол-2-амины в качестве ингибиторов midhi
JP6672288B2 (ja) 2014-10-23 2020-03-25 バイエル・ファルマ・アクティエンゲゼルシャフト 腫瘍の治療のためのｍｉｄｈ１阻害剤としての１−シクロヘキシル−２−フェニルアミノベンゾイミダゾール
EP3303302B1 (fr) 2015-06-08 2019-03-20 Bayer Pharma Aktiengesellschaft N-menthylbenzimidazoles à titre d'inhibiteurs de midh1
EP3319945B1 (fr) 2015-07-07 2021-04-28 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts 2-aryl- et 2-arylalkylbenzimidazoles comme inhibiteurs midh1
JP6824954B2 (ja) 2015-07-16 2021-02-03 ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ ｍＩＤＨ１阻害剤としての５−ヒドロキシアルキルベンズイミダゾール
EP3121166A1 (fr) 2015-07-21 2017-01-25 Bayer Pharma Aktiengesellschaft Imidazoles condensés comme inhibiteurs midh1
TW201718513A (zh) 2015-07-27 2017-06-01 拜耳製藥公司 製備經取代之３－（２－苯胺－１－環己基－１ｈ－苯并咪唑－５－基）丙酸衍生物之方法
WO2019015672A1 (fr) * 2017-07-21 2019-01-24 南京明德新药研发股份有限公司 Composé de pyridoimidazole et son utilisation
US20210113598A1 (en) 2017-08-01 2021-04-22 Deutsches Krebsforschungszentrum (DKFZ) Stiftung des öffentlichen Rechts Combination of MIDH1 Inhibitors and DNA Hypomethylating Agents (HMA)
CN108948205B (zh) * 2018-07-13 2021-09-28 北京金岱生物科技有限公司 抗idh1r132h单克隆抗体及其应用
TWI760017B (zh) 2019-12-23 2022-04-01 大陸商昆藥集團股份有限公司 一種ｉｄｈ１突變體抑制劑的鹽型、晶型及其製備方法
EP4186525A4 (fr) 2020-07-21 2024-04-03 Daiichi Sankyo Company, Limited Médicament combiné de témozolomide et d'inhibiteur de l'enzyme idh1 mutée

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010263113B2 (en) * 2009-06-23 2015-11-26 Translational Drug Development, Llc Benzamide derivatives
US9012464B2 (en) * 2010-11-25 2015-04-21 Ratiopharm Gmbh Salts and polymorphic forms of Afatinib
BR112014007310A2 (pt) 2011-09-27 2017-04-04 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante
EA031655B1 (ru) * 2014-02-11 2019-02-28 Байер Фарма Акциенгезельшафт Бензимидазол-2-амины в качестве ингибиторов midhi
US9951027B2 (en) * 2014-02-11 2018-04-24 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as MIDH1 inhibitors
WO2016062677A1 (fr) 2014-10-23 2016-04-28 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines en tant qu'inhibiteurs midh1
JP6672288B2 (ja) * 2014-10-23 2020-03-25 バイエル・ファルマ・アクティエンゲゼルシャフト 腫瘍の治療のためのｍｉｄｈ１阻害剤としての１−シクロヘキシル−２−フェニルアミノベンゾイミダゾール
EP3303302B1 (fr) * 2015-06-08 2019-03-20 Bayer Pharma Aktiengesellschaft N-menthylbenzimidazoles à titre d'inhibiteurs de midh1
EP3319945B1 (fr) 2015-07-07 2021-04-28 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts 2-aryl- et 2-arylalkylbenzimidazoles comme inhibiteurs midh1
JP6824954B2 (ja) 2015-07-16 2021-02-03 ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ ｍＩＤＨ１阻害剤としての５−ヒドロキシアルキルベンズイミダゾール
EP3121166A1 (fr) 2015-07-21 2017-01-25 Bayer Pharma Aktiengesellschaft Imidazoles condensés comme inhibiteurs midh1
TW201718513A (zh) 2015-07-27 2017-06-01 拜耳製藥公司 製備經取代之３－（２－苯胺－１－環己基－１ｈ－苯并咪唑－５－基）丙酸衍生物之方法

Also Published As

Publication number Publication date
EP3328837A1 (fr) 2018-06-06
AU2016300980A1 (en) 2017-12-21
NI201800014A (es) 2018-09-06
AU2016300980B2 (en) 2020-12-24
EA201890386A1 (ru) 2018-08-31
US20180222870A1 (en) 2018-08-09
CR20180053A (es) 2018-03-20
JP6804516B2 (ja) 2020-12-23
CA2993473A1 (fr) 2017-02-02
ECSP18006465A (es) 2018-04-30
CN107810181B (zh) 2021-06-22
US10344004B2 (en) 2019-07-09
IL256024A (en) 2018-01-31
BR112018001534A2 (pt) 2018-09-11
PE20181038A1 (es) 2018-07-03
WO2017016992A1 (fr) 2017-02-02
HK1252449A1 (zh) 2019-05-24
AR105493A1 (es) 2017-10-11
SV2018005621A (es) 2018-12-05
ES2860693T3 (es) 2021-10-05
JP2018521095A (ja) 2018-08-02
CN107810181A (zh) 2018-03-16
CL2018000249A1 (es) 2018-07-06
DOP2018000027A (es) 2018-02-28
EP3328837B1 (fr) 2021-01-06
CO2018000793A2 (es) 2018-05-10
TN2018000038A1 (en) 2019-07-08
TW201708193A (zh) 2017-03-01
KR20180030789A (ko) 2018-03-26
MX2018001205A (es) 2018-04-24

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