CU20190021A7 - Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva - Google Patents

Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

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Publication number
CU20190021A7
CU20190021A7 CU2019000021A CU20190021A CU20190021A7 CU 20190021 A7 CU20190021 A7 CU 20190021A7 CU 2019000021 A CU2019000021 A CU 2019000021A CU 20190021 A CU20190021 A CU 20190021A CU 20190021 A7 CU20190021 A7 CU 20190021A7
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CU
Cuba
Prior art keywords
cells
lymphocytes
adoptive transfer
differentiation
expansion
Prior art date
Application number
CU2019000021A
Other languages
English (en)
Other versions
CU24712B1 (es
Inventor
Osorio Ángel De Jesús Corria
George Coukos
Elisabetta Cribioli
Melita Irving
Monzón Kalet León
Bereau Galia Magela Montalvo
Miranda Yaquelin Ortiz
Original Assignee
Centre Hospitalier Univ Vaudois
Ct Inmunologia Molecular
Ludwig Inst For Cancer Res Ltd
Univ Of Lausanne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Hospitalier Univ Vaudois, Ct Inmunologia Molecular, Ludwig Inst For Cancer Res Ltd, Univ Of Lausanne filed Critical Centre Hospitalier Univ Vaudois
Priority to CU2019000021A priority Critical patent/CU24712B1/es
Priority to CA3133736A priority patent/CA3133736A1/en
Priority to EA202192447A priority patent/EA202192447A1/ru
Priority to SG11202109574Q priority patent/SG11202109574QA/en
Priority to KR1020217033073A priority patent/KR20220012224A/ko
Priority to CN202080020973.5A priority patent/CN113785048B/zh
Priority to BR112021018100A priority patent/BR112021018100A2/pt
Priority to MYPI2021005276A priority patent/MY206651A/en
Priority to EP20757209.0A priority patent/EP3940063A2/en
Priority to MX2021011120A priority patent/MX2021011120A/es
Priority to PCT/CU2020/050002 priority patent/WO2020187340A2/es
Priority to AU2020242520A priority patent/AU2020242520B2/en
Priority to JP2021555590A priority patent/JP7572371B2/ja
Priority to US17/439,293 priority patent/US20220152107A1/en
Priority to TW109108199A priority patent/TW202102667A/zh
Priority to ARP200100724A priority patent/AR118369A1/es
Publication of CU20190021A7 publication Critical patent/CU20190021A7/es
Priority to CONC2021/0013127A priority patent/CO2021013127A2/es
Priority to ZA2021/07758A priority patent/ZA202107758B/en
Publication of CU24712B1 publication Critical patent/CU24712B1/es

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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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Abstract

<p>En la presente invención se describe un método para obtener linfocitos T y células NK con el fenotipo deseado en la transferencia adoptiva de células para la terapia del cáncer. Especialmente, se basa en estrategias para inducir una señalización preferencial a través del receptor de IL2 de afinidad intermedia, con lo cual se logra expandir las células con el fenotipo de memoria central deseado. El método de la presente invención es útil en la obtención de linfocitos infiltrantes de tumor, TCR o de receptores quiméricos ingenierizados de células T empleados en el tratamiento del cáncer.</p>
CU2019000021A 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva CU24712B1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CU2019000021A CU24712B1 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
MX2021011120A MX2021011120A (es) 2019-03-15 2020-03-09 Metodo para la expansion y diferenciacion de linfocitos t y celulas nk en terapias de transferencia adoptiva.
PCT/CU2020/050002 WO2020187340A2 (es) 2019-03-15 2020-03-09 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
SG11202109574Q SG11202109574QA (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
KR1020217033073A KR20220012224A (ko) 2019-03-15 2020-03-09 입양 전달 요법에서 t 림프구 및 nk 세포의 확장 및 분화를 위한 방법
CN202080020973.5A CN113785048B (zh) 2019-03-15 2020-03-09 用于扩增和分化在过继转移疗法中的t淋巴细胞和nk细胞的方法
BR112021018100A BR112021018100A2 (pt) 2019-03-15 2020-03-09 Métodos para a diferenciação e expansão de linfócitos t e células nk, para enriquecimento e expansão ex vivo de linfócitos e para tratar um câncer, uso do método, células, e, composição de células
MYPI2021005276A MY206651A (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
EP20757209.0A EP3940063A2 (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
CA3133736A CA3133736A1 (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies
EA202192447A EA202192447A1 (ru) 2019-03-15 2020-03-09 Способ размножения и дифференцировки т-лимфоцитов и nk-клеток в методах лечения с адоптивным переносом
AU2020242520A AU2020242520B2 (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of T lymphocytes and NK cells in adoptive transfer therapies
JP2021555590A JP7572371B2 (ja) 2019-03-15 2020-03-09 養子移入療法（Ａｄｏｐｔｉｖｅ ｔｒａｎｓｆｅｒ ｔｈｅｒａｐｉｅｓ）におけるＴリンパ球及びＮＫ細胞の拡大増殖及び分化のための方法
US17/439,293 US20220152107A1 (en) 2019-03-15 2020-03-09 Method for expansion and differentiation of t lymphocytes and nk cells for adoptive transfer therapies
TW109108199A TW202102667A (zh) 2019-03-15 2020-03-12 用於擴增和分化供過繼性細胞治療之ｔ淋巴細胞和天然殺手（ｎｋ）細胞之方法
ARP200100724A AR118369A1 (es) 2019-03-15 2020-03-13 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
CONC2021/0013127A CO2021013127A2 (es) 2019-03-15 2021-09-30 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
ZA2021/07758A ZA202107758B (en) 2019-03-15 2021-10-13 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2019000021A CU24712B1 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Publications (2)

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CU20190021A7 true CU20190021A7 (es) 2020-10-20
CU24712B1 CU24712B1 (es) 2024-07-10

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US (1) US20220152107A1 (es)
EP (1) EP3940063A2 (es)
JP (1) JP7572371B2 (es)
KR (1) KR20220012224A (es)
CN (1) CN113785048B (es)
AR (1) AR118369A1 (es)
AU (1) AU2020242520B2 (es)
BR (1) BR112021018100A2 (es)
CA (1) CA3133736A1 (es)
CO (1) CO2021013127A2 (es)
CU (1) CU24712B1 (es)
EA (1) EA202192447A1 (es)
MX (1) MX2021011120A (es)
MY (1) MY206651A (es)
SG (1) SG11202109574QA (es)
TW (1) TW202102667A (es)
WO (1) WO2020187340A2 (es)
ZA (1) ZA202107758B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3746095A4 (en) 2018-02-01 2021-04-21 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
JP7273421B2 (ja) 2018-02-21 2023-05-15 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用
US12365871B2 (en) 2020-04-28 2025-07-22 Lyell Immunopharma, Inc. Methods for culturing cells
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
US20240309061A1 (en) * 2021-07-23 2024-09-19 Merck Sharp & Dohme Llc Il-2 muteins for treating cancer or infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1941028A2 (en) * 2005-08-08 2008-07-09 Fondazione Centro San Raffaele Del Monte Tabor Use of common gamma chain cytokines for the visualization, isolation and genetic modification of memory t lymphocytes.
US20100254958A1 (en) * 2007-10-24 2010-10-07 Anne Letsch Antigen-Specific T-Cell Preparations from Bone Marrow
CU23923B1 (es) 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
KR20150029714A (ko) * 2012-07-13 2015-03-18 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 이중특이적 항체의 공-도입에 의한 ｃａｒ 세포의 활성 증강
CA3011374A1 (en) * 2016-02-05 2017-08-10 Washington University Compositions and methods for targeted cytokine delivery

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TW202102667A (zh) 2021-01-16
CN113785048B (zh) 2024-09-24
WO2020187340A2 (es) 2020-09-24
CO2021013127A2 (es) 2022-03-18
EP3940063A2 (en) 2022-01-19
BR112021018100A2 (pt) 2022-02-08
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