CU20220049A7 - Forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato, método para su preparación y composiciones farmacéuticas que la comprenden - Google Patents

Forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato, método para su preparación y composiciones farmacéuticas que la comprenden

Info

Publication number
CU20220049A7
CU20220049A7 CU2022000049A CU20220049A CU20220049A7 CU 20220049 A7 CU20220049 A7 CU 20220049A7 CU 2022000049 A CU2022000049 A CU 2022000049A CU 20220049 A CU20220049 A CU 20220049A CU 20220049 A7 CU20220049 A7 CU 20220049A7
Authority
CU
Cuba
Prior art keywords
quinazolin
methoxyphenyl
trifluoromethyl
fluoro
methoxy
Prior art date
Application number
CU2022000049A
Other languages
English (en)
Other versions
CU24749B1 (es
Inventor
Helmut Buschmann
Bertran Jordi Carles Ceron
Thomas Goldner
Original Assignee
Aic246 Ag & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aic246 Ag & Co Kg filed Critical Aic246 Ag & Co Kg
Publication of CU20220049A7 publication Critical patent/CU20220049A7/es
Publication of CU24749B1 publication Critical patent/CU24749B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p><br /> La presente invención se refiere a una forma cristalina de trihidrato de sodio del ácido<br /> 2-[(4S)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4<em>H</em>-quinazolin-4-il]acético de formula I</p> <p>ESPACIO PARA FÓRMULA</p> <p>a un método eficaz para su preparación, así como a composiciones farmacéuticas que comprende a dicho compuesto.</p>
CU2022000049A 2020-02-27 2021-03-01 Método para preparar una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil) fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato CU24749B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20159727 2020-02-27
PCT/EP2021/055045 WO2021170874A1 (en) 2020-02-27 2021-03-01 A method of producing a crystalline form of sodium 2-[(4s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetate trihydrate

Publications (2)

Publication Number Publication Date
CU20220049A7 true CU20220049A7 (es) 2023-04-10
CU24749B1 CU24749B1 (es) 2025-05-05

Family

ID=69742722

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2022000049A CU24749B1 (es) 2020-02-27 2021-03-01 Método para preparar una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil) fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato

Country Status (22)

Country Link
US (1) US12655110B2 (es)
EP (1) EP4110470A1 (es)
JP (2) JP7645276B2 (es)
KR (1) KR102889550B1 (es)
CN (1) CN115581118B (es)
AR (1) AR121439A1 (es)
AU (1) AU2021225363B2 (es)
BR (1) BR112022016929A2 (es)
CA (1) CA3169484A1 (es)
CL (1) CL2022002291A1 (es)
CO (1) CO2022012039A2 (es)
CU (1) CU24749B1 (es)
EC (1) ECSP22066680A (es)
IL (1) IL295795B1 (es)
MX (1) MX429252B (es)
PE (1) PE20230515A1 (es)
PH (1) PH12022552260A1 (es)
PY (1) PY2116983A (es)
TW (1) TWI870559B (es)
UA (1) UA128999C2 (es)
UY (1) UY39096A (es)
WO (1) WO2021170874A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY39097A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR134783A1 (es) 2023-12-21 2026-04-01 Aic246 Ag & Co Kg Sales diastereoméricas de aminoalcohol y aminoéter de ácido 2-[(4r,s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-3,4-dihidroquinazolin-4-il]acético y su uso para separación enantiomérica

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
UY39098A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, su preparación y uso
UY39097A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo

Also Published As

Publication number Publication date
KR102889550B1 (ko) 2025-11-24
US12655110B2 (en) 2026-06-16
PE20230515A1 (es) 2023-03-24
ECSP22066680A (es) 2022-12-30
CN115581118A (zh) 2023-01-06
CO2022012039A2 (es) 2022-11-18
MX429252B (es) 2025-11-13
EP4110470A1 (en) 2023-01-04
IL295795B1 (en) 2026-07-01
WO2021170874A1 (en) 2021-09-02
AU2021225363A1 (en) 2022-10-13
CA3169484A1 (en) 2021-09-02
IL295795A (en) 2022-10-01
US20230219899A1 (en) 2023-07-13
PY2116983A (es) 2022-04-18
BR112022016929A2 (pt) 2022-12-06
UA128999C2 (uk) 2024-12-18
JP7645276B2 (ja) 2025-03-13
KR20220148863A (ko) 2022-11-07
AR121439A1 (es) 2022-06-08
UY39096A (es) 2021-09-30
NZ792583A (en) 2025-07-25
MX2022010441A (es) 2022-10-18
CL2022002291A1 (es) 2023-02-03
JP2023519813A (ja) 2023-05-15
TWI870559B (zh) 2025-01-21
AU2021225363B2 (en) 2024-09-19
JP2025016547A (ja) 2025-02-04
CU24749B1 (es) 2025-05-05
PH12022552260A1 (en) 2023-11-13
TW202140453A (zh) 2021-11-01
CN115581118B (zh) 2025-01-28

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