CU23404A1 - Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes - Google Patents

Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes

Info

Publication number
CU23404A1
CU23404A1 CU20030270A CU20030270A CU23404A1 CU 23404 A1 CU23404 A1 CU 23404A1 CU 20030270 A CU20030270 A CU 20030270A CU 20030270 A CU20030270 A CU 20030270A CU 23404 A1 CU23404 A1 CU 23404A1
Authority
CU
Cuba
Prior art keywords
polysaccharides
formulations
neisseria meningitidis
meningitidis
similar
Prior art date
Application number
CU20030270A
Other languages
English (en)
Inventor
Blanco Sonia Gonzalez
Portilla Tania Carmenate
Espina Maite Delgado
Perez Olivia Niebla
Garcia Gretel Sardinas
Feyt Rolando Pajon
Rubido Julio Cesar Aguilar
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20030270A priority Critical patent/CU23404A1/es
Priority to ARP040104182A priority patent/AR046840A1/es
Priority to PCT/CU2004/000014 priority patent/WO2005049076A1/es
Publication of CU23404A1 publication Critical patent/CU23404A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Uso de polisacáridos capsulares de distintos serogrupos de Neisseria meningitidis, como agentes inmunopotenciadores e inmunomodulares, útiles para el desarrollo de vacunas. En la presente invención se administran dichos polisacáridos para incrementar la respuesta inmune contra antígenos heterólogos que han sido coadministrados por la vía muscusal. Se obtienen formulaciones múltiples de los polisacáridos capsulares de N. Meningitidis y antígenos heterólogos que al ser administradas por vías mucosales, producen niveles de inmunogenicidad similares a los obtenidos después de la administración parenteral de combinaciones similares a los obtenidos después de la administración parenteral de combinaciones similares. El uso de dichos polisacáridos como inmunopotenciadores permite prescindir del empleo de otros adyuvantes mucosales. Este nuevo uso de los polisacáridos capsulares de N. meningitidis y las formulaciones antigénicas resultantes son aplicables en la industria farmacéutica como formulaciones vacúnales preventivas o terapéuticas.
CU20030270A 2003-11-19 2003-11-19 Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes CU23404A1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CU20030270A CU23404A1 (es) 2003-11-19 2003-11-19 Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes
ARP040104182A AR046840A1 (es) 2003-11-19 2004-11-12 Polisacaridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes
PCT/CU2004/000014 WO2005049076A1 (es) 2003-11-19 2004-11-18 Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20030270A CU23404A1 (es) 2003-11-19 2003-11-19 Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes

Publications (1)

Publication Number Publication Date
CU23404A1 true CU23404A1 (es) 2009-08-04

Family

ID=34777988

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20030270A CU23404A1 (es) 2003-11-19 2003-11-19 Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes

Country Status (3)

Country Link
AR (1) AR046840A1 (es)
CU (1) CU23404A1 (es)
WO (1) WO2005049076A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0413558A (pt) 2003-08-12 2006-10-17 3M Innovative Properties Co compostos contendo imidazo substituìdo por hidroxilamina
AU2004268625B2 (en) 2003-08-27 2011-03-31 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
CA2545825A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (en) 2003-12-30 2006-09-13 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides
WO2005094531A2 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
JP2008526752A (ja) * 2004-12-30 2008-07-24 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調節剤化合物の多経路投与
EP1831221B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Substituted chiral fused 1,2 imidazo 4,5-c ring compounds
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
AU2006232375A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
CN101785857B (zh) * 2010-03-05 2012-09-26 成都安特金生物技术有限公司 一种新的肺炎球菌结合疫苗及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20024224A3 (cs) * 2000-06-29 2003-05-14 Glaxosmithkline Biologicals S. A. Farmaceutický prostředek

Also Published As

Publication number Publication date
AR046840A1 (es) 2005-12-28
WO2005049076A1 (es) 2005-06-02

Similar Documents

Publication Publication Date Title
CU23404A1 (es) Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes
CY1115308T1 (el) Συνθεσεις εμβολιου οι οποιες περιεχουν ανοσοενισχυτικο εκδοχο σαπωνινης
EP3058954A3 (en) Immunogenic compositions and methods
ATE503493T1 (de) Influenza vakzinzusammensetzungen zur intradermaler verabreichung
MX2018013640A (es) Liposomas pegiladas y metodos de uso.
MX340096B (es) Formulaciones de vacuna meningococica.
CY1118732T1 (el) Εμβολια κυστιδιων βασει gna1870 για προστασια ευρεως φασματος εναντι νοσων προκαλουμενων απο neisseria meningitidis
PT1187629E (pt) Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador
WO2006060710A3 (en) Vaccine formulations for intradermal delivery comprising adjuvants and antigenic agents
CY1111916T1 (el) Εμβολιο ζωντανου εξασθενημενου ροταϊου για χορηγηση απο του στοματος
CR10559A (es) Vacuna de influenza
DOP2009000239A (es) Vacuna de influenza de emulsion de aceite en agua
PE20190458A1 (es) Composiciones de neisseria meningitidis y metodos de las mismas
AR082952A1 (es) Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis
UY27843A1 (es) Composicion de vacuna
EA200601761A1 (ru) Композиции в качестве адъювантов для усиления иммунных ответов на вакцины и способы их применения
BRPI0510430A (pt) composições e métodos para vacinação mucosal
AR053661A1 (es) Peptido para entregar vacunas via mucosas
RU2008144180A (ru) Вакцина против микоплазмы и prrsv
AR038311A1 (es) Antigeno de superficie del virus de la hepatitis b como inmunopotenciador mucosal, formulaciones resultantes
AR059972A1 (es) Administracion intranasal o inhalacional de virosomas
UY28706A1 (es) Proteoliposomas y sus derivados como adyuvantes inductores de respuesta citotóxica y las formulaciones resultantes
AR046921A1 (es) Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes
TH75448A (th) พอลิแซคคาไรด์ที่เป็นปลอกหุ้มของ Neisseria meningitidis ในการเป็นตัวกระตุ้นภูมิคุ้มกันทางเยื่อบุเมือก และสูตรผสมผลลัพธ์ที่ได้
Fisher et al. Adjuvanted vaccines against influenza in the elderly