CU23429A3 -
DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
- Google Patents
DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
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Publication number
CU23429A3
CU23429A3CU20050112ACU20050112ACU23429A3CU 23429 A3CU23429 A3CU 23429A3CU 20050112 ACU20050112 ACU 20050112ACU 20050112 ACU20050112 ACU 20050112ACU 23429 A3CU23429 A3CU 23429A3
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Application filed by Pfizer Prod IncfiledCriticalPfizer Prod Inc
Priority to CU20050112ApriorityCriticalpatent/CU23429A3/en
Publication of CU23429A3publicationCriticalpatent/CU23429A3/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
La presente invención proporciona inhibidores benzamídicos del receptor P2X7 de fórmula ESPACIO PARA FÓRMULA en la que R1-R3 son como se han definido aquí. Los compuestos de la invención son útiles en el tratamiento de trastornos mediados por IL-1, incluidos, sin limitación, enfermedades inflamatorias tales como osteoartritis y artritis reumatoide, alergias, asma, COPD (enfermedad pulmonar obstructiva crónica), cáncer, reperfusión o isquemia en accidente cerebrovascular o ataque cardíaco, enfermedades autoinmunes y otros trastornos.The present invention provides benzamide inhibitors of the P2X7 receptor of the formula SPACE FOR FORMULA in which R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis, allergies, asthma, COPD (chronic obstructive pulmonary disease), cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
CU20050112A2005-06-092005-06-09
DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
CU23429A3
(en)
Efficient and scalable synthesis of nicotinoylribosides and reduced nicotinoylribosides, modified derivatives thereof, phosphorylated analogues thereof, adenylyldin nucleotide conjugates thereof and novel crystalline forms thereof
Compounds derived from pyrazolopyridines and pyrazolopyrimidines; pharmaceutical composition and its use as selective inhibitors of janus kinases (jak) in the treatment of diseases such as nasal congestion, asthma, epoc, allergic rhinitis, diabetes among others.
HETEROCICLICAL COMPOUNDS, RECEIVER MODULATORS CB2; PHARMACEUTICAL COMPOSITION, USEFUL FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES SUCH AS LUNG, Rheumatic, Autoimmune and Musculoskeletal, TUMORS AND INFAR DISEASES
COMPOUNDS DERIVED FROM PIRIMIDO-PIRIDONA, INHIBITORS OF PROTEIN KINASES; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT OF DISEASES SUCH AS ARTHRITIS, IRRITABLE COLON SYNDROME, ACUTE ADULT DISEASE SYNDROME, COPD AND FOR
USE OF COMPOUNDS DERIVED FROM TRIAZINE OR REPLACED PYRIMIDINE, TO TREAT OR PREVENT DISEASES MEDIATED BY PROKINETICIN 2 RECEPTORS SUCH AS GASTROINTESTINAL DISORDERS.