CU23429A3 - DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES - Google Patents

DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

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Publication number
CU23429A3
CU23429A3 CU20050112A CU20050112A CU23429A3 CU 23429 A3 CU23429 A3 CU 23429A3 CU 20050112 A CU20050112 A CU 20050112A CU 20050112 A CU20050112 A CU 20050112A CU 23429 A3 CU23429 A3 CU 23429A3
Authority
CU
Cuba
Prior art keywords
treatment
inflammatory diseases
inhibitors
triain
dihidro
Prior art date
Application number
CU20050112A
Other languages
Spanish (es)
Inventor
Allen Jacob Duplantier
Mark Anthony Dombroski
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Priority to CU20050112A priority Critical patent/CU23429A3/en
Publication of CU23429A3 publication Critical patent/CU23429A3/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona inhibidores benzamídicos del receptor P2X7 de fórmula ESPACIO PARA FÓRMULA en la que R1-R3 son como se han definido aquí. Los compuestos de la invención son útiles en el tratamiento de trastornos mediados por IL-1, incluidos, sin limitación, enfermedades inflamatorias tales como osteoartritis y artritis reumatoide, alergias, asma, COPD (enfermedad pulmonar obstructiva crónica), cáncer, reperfusión o isquemia en accidente cerebrovascular o ataque cardíaco, enfermedades autoinmunes y otros trastornos.The present invention provides benzamide inhibitors of the P2X7 receptor of the formula SPACE FOR FORMULA in which R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis, allergies, asthma, COPD (chronic obstructive pulmonary disease), cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

CU20050112A 2005-06-09 2005-06-09 DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES CU23429A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CU20050112A CU23429A3 (en) 2005-06-09 2005-06-09 DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20050112A CU23429A3 (en) 2005-06-09 2005-06-09 DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Publications (1)

Publication Number Publication Date
CU23429A3 true CU23429A3 (en) 2009-10-16

Family

ID=41320033

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20050112A CU23429A3 (en) 2005-06-09 2005-06-09 DERIVATIVES OF 3- (3,5-DIOXO-4,5-DIHIDRO-3H- (1,2,4) TRIAIN-2-IL) BENZAMIDE AS P2X7 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Country Status (1)

Country Link
CU (1) CU23429A3 (en)

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