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Priority to CU20060145ApriorityCriticalpatent/CU23445A3/en
Publication of CU23445A3publicationCriticalpatent/CU23445A3/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Plural Heterocyclic Compounds
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Abstract
La presente invención se refiere a un procedimiento para la preparación de 5-cloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morfolinil)fenil]-1,3-oxazolidin-5il}metil)-2-tiofenocarboxamida a partir de 2-[(2S)-2-oxiranilmetil]-1H-isoindol-1,3(2H)-diona, 4-(4-aminofenil)-3-morfolinona y cloruro de 5-clorotiofeno-2-cartbonilo.The present invention relates to a process for the preparation of 5-chloro-N - ({(5S) -2-oxo-3- [4- (3-oxo-4-morpholinyl) phenyl] -1,3-oxazolidin -5il} methyl) -2-thiophenecarboxamide from 2 - [(2S) -2-oxyranylmethyl] -1H-isoindole-1,3 (2H) -dione, 4- (4-aminophenyl) -3-morpholinone and chloride of 5-chlorothiophene-2-cartbonyl.
Liquid pharmaceutical compositions which can be administered orally and contain 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene carboxamide
A method for polymorphic form of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide preparing in the modification ii
PROCESS FOR THE PREPARATION OF 5-CHLORO-N - ({(5S) -2-OXO-3- [4- (5,6-DIHYDRO-4H- [1,2,4] TRIAZIN-1-YL) DERIVATIVE PHENYL] -1,3-OXAZOLIDIN-5-YL} METHYL) THIOPHEN-2-CARBOXAMIDE AND INTERMEDIATE USED THEREFOR
NEW POLYMORPHIC FORM AND THE AMORPHY FORM OF 5-CHLORINE-N - ({(5S) -2-OXO-3- [4- (3-OXO-4-MORFOLINIL) -FENIL] -1,3-OXAZOLIDIN-5- IL} -METIL) -2-THIOPHENOCARBOXAMIDE