CU23560A3 - 4-PHENYLAMINE-QUINAZOLIN-6-IL-AMIDAS - Google Patents
4-PHENYLAMINE-QUINAZOLIN-6-IL-AMIDASInfo
- Publication number
- CU23560A3 CU23560A3 CU20060210A CU20060210A CU23560A3 CU 23560 A3 CU23560 A3 CU 23560A3 CU 20060210 A CU20060210 A CU 20060210A CU 20060210 A CU20060210 A CU 20060210A CU 23560 A3 CU23560 A3 CU 23560A3
- Authority
- CU
- Cuba
- Prior art keywords
- alkyl
- halo
- piperazine
- pyrrolidine
- piperidine
- Prior art date
Links
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- HFVRFBSLWSSEIA-UHFFFAOYSA-N 3,4-dihydro-2h-pyridine Chemical compound C1C[N]C=CC1 HFVRFBSLWSSEIA-UHFFFAOYSA-N 0.000 abstract 1
- REEHSAJWGAOIIW-UHFFFAOYSA-N 3,6-dihydro-2h-pyridine Chemical compound C1CC=CC[N]1 REEHSAJWGAOIIW-UHFFFAOYSA-N 0.000 abstract 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención proporciona compuestos de quinazolina de la fórmula: ESPACIO PARA FÓRMULA en la que: R1 es halo; R2 es H o halo; R3 es a) alquilo C1-C3 opcionalmente sustituido con halo; o b) -(CH2)n-morfolino, -(CH2)n-piperidina, -(CH2)n-piperazina-, -(CH2)npiperacina-N-(alquilo C1-C3), -(CH2)n-pirrolidina- o, -CH2)-imidazol; n es un número entero de 1 a 4; R4 es -(CH2)mHet; Het es morfolina, piperidina, piperazina, piperazina-N-(alquilo C1-C3), imidazol, pirrolidina, azepan, 3,4-dihidro-2H-piridina, o 3,6-dihidro-2h-piridina, cada uno opcionalmente sustituido con alquilo, halo, OH, NH2, NH(alquilo C1-C3o N(alquilo C1-C3)2; m es 1,3; y X es O, S o NH; o una sal farmacéuticamente aceptable del mismo, así como los procedimientos y los compuestos intermedios para prepararlos, composiciones farmacéuticas útiles y procedimientos para usar los compuestos en el tratamiento de enfermedades proliferativasThis invention provides quinazoline compounds of the formula: FORMULA SPACE in which: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl optionally substituted with halo; ob) - (CH2) n-morpholino, - (CH2) n-piperidine, - (CH2) n-piperazine-, - (CH2) npiperacin-N- (C1-C3 alkyl), - (CH2) n-pyrrolidine- or, -CH2) -imidazole; n is an integer from 1 to 4; R4 is - (CH2) mHet; Het is morpholine, piperidine, piperazine, piperazine-N- (C1-C3 alkyl), imidazole, pyrrolidine, azepan, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2h-pyridine, each optionally substituted with alkyl, halo, OH, NH2, NH (C1-C3o N alkyl (C1-C3 alkyl) 2; m is 1.3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as procedures and intermediates for preparing them, useful pharmaceutical compositions and procedures for using the compounds in the treatment of proliferative diseases
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060210A CU23560A3 (en) | 2006-11-03 | 2006-11-03 | 4-PHENYLAMINE-QUINAZOLIN-6-IL-AMIDAS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060210A CU23560A3 (en) | 2006-11-03 | 2006-11-03 | 4-PHENYLAMINE-QUINAZOLIN-6-IL-AMIDAS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23560A3 true CU23560A3 (en) | 2010-08-30 |
Family
ID=43302546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20060210A CU23560A3 (en) | 2006-11-03 | 2006-11-03 | 4-PHENYLAMINE-QUINAZOLIN-6-IL-AMIDAS |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23560A3 (en) |
-
2006
- 2006-11-03 CU CU20060210A patent/CU23560A3/en active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant of patent |