CU23680B7 - SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE - Google Patents

SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

Info

Publication number
CU23680B7
CU23680B7 CU20070222A CU20070222A CU23680B7 CU 23680 B7 CU23680 B7 CU 23680B7 CU 20070222 A CU20070222 A CU 20070222A CU 20070222 A CU20070222 A CU 20070222A CU 23680 B7 CU23680 B7 CU 23680B7
Authority
CU
Cuba
Prior art keywords
inhibitors
substituted oxazol
thyrosine kinase
derivatives
oxazol derivatives
Prior art date
Application number
CU20070222A
Other languages
Spanish (es)
Other versions
CU20070222A7 (en
Inventor
Martine Croisy
Alain Moussy
David Grierson
Abdellah Benjahad
Original Assignee
Inst Curie
Centre Nat Rech Scient
Ab Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Curie, Centre Nat Rech Scient, Ab Science filed Critical Inst Curie
Priority to CU20070222A priority Critical patent/CU23680B7/en
Publication of CU20070222A7 publication Critical patent/CU20070222A7/en
Publication of CU23680B7 publication Critical patent/CU23680B7/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención concierne a nuevos compuestos seleccionados entre derivados de oxazol sustituidos de fórmula (I) que, de manera selectiva, modulan, regulan, y/o inhiben la transducción de senales mediada por ciertas tirosina quinasas nativas y/o mutantes implicadas en una variedad de enfermedades humanas y animales como los trastornos celulares poliferativos, metabólicos, alérgicos y degenerativos. Más específicamente, estos compuestos son inhibidores potentes y selectivos de c-kit, bcr-abl y Flt-3.The present invention concerns new compounds selected from substituted oxazole derivatives of formula (I) that, selectively, modulate, regulate, and / or inhibit signal transduction mediated by certain native tyrosine kinases and / or mutants involved in a variety of human and animal diseases such as poliferative, metabolic, allergic and degenerative cell disorders. More specifically, these compounds are potent and selective inhibitors of c-kit, bcr-abl and Flt-3.

CU20070222A 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE CU23680B7 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CU20070222A CU23680B7 (en) 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20070222A CU23680B7 (en) 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

Publications (2)

Publication Number Publication Date
CU20070222A7 CU20070222A7 (en) 2010-12-08
CU23680B7 true CU23680B7 (en) 2011-07-11

Family

ID=43401419

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20070222A CU23680B7 (en) 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

Country Status (1)

Country Link
CU (1) CU23680B7 (en)

Also Published As

Publication number Publication date
CU20070222A7 (en) 2010-12-08

Similar Documents

Publication Publication Date Title
DK1684750T3 (en) 2-aminoaryloxazole compounds as tyrosine kinase inhibitors
NI200900093A (en) COMPOUNDS THAT MODULATE THE ACTIVITY OF C-FMS AND / OR C-KIT AND USE OF THE SAME.
MX2012008083A (en) Thiazole and oxazole kinase inhibitors.
NO20075627L (en) Inhibitors of cytosolic phospholipase A2
NO20051115L (en) 2- (3-aminoaryl) amino-4-arylthiazoles and their use as c-kit inhibitors
NO20075553L (en) Substituted oxazole derivatives and their use as tyrosine kinase inhibitors
MX2022016051A (en) COMPOUNDS FOR THE TREATMENT OF KINASE DEPENDENT DISORDERS.
ECSP077985A (en) PROTEIN CINASE INHIBITORS DERIVED FROM PIRROL (2,3-B) PIRIDINE
GT200600394A (en) SUBSTITUTED BENZIMIDAZOLS AND METHODS TO USE THEM AS INHIBITORS OF KINASES ASSOCIATED WITH TUMORIGENESIS.
NO20063861L (en) 2- (3-substituted aryl) amine-4-arylthiazoles as tyrosine kinase inhibitors
CR20120510A (en) DERIVATIVES OF PIPERIDIN-4-IL AZETIDINE AS INHIBITORS OF JAK1
ECSP099378A (en) COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF PROTEIN QUINASA
ECSP10010044A (en) COMPOUNDS OF 5- (4- (HALO-ALCOXI) -PENYL) -PIRIMIDIN-2-AMINA AND COMPOSITIONS AS KINASE INHIBITORS
UY29176A1 (en) SUBSTITUTED DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA, COMPOSITIONS THAT CONTAIN THEM, METHODS FOR THEIR PREPARATION AND ITS USES.
EA200901488A1 (en) SUBSTITUTED IMIDAZOLOPIRIDAZINES AS LIPIDKINASE INHIBITORS
PH12015501955A1 (en) Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases
CY1110663T1 (en) 2-AMINOARYLOXAZOLATE COMPOUNDS AS TYROSINE CHINESE BREAKERS
PH12014500168A1 (en) Selective protein kinase inhibitors
HK1222396A1 (en) Benzimidazole derivatives as selective proteine kinase inhibitors
GT200600253A (en) AMINOPIRIMIDINS AS KINASE MODULATORS
NI200700312A (en) USEFUL INTERMEDIARIES IN THE SYNTHESIS OF MODULATORS OF THE ALQUILQUINOLEÍA AND ALQUILQUINAZOLINA KINASA AND RELATED SYNTHESIS METHODS.
CU23680B7 (en) SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE
CY1115288T1 (en) UNITS MODIFYING THE ACTIVITY OF C-FMS AND / OR C-KIT AND THEIR USES
UY28460A1 (en) USEFUL AMINOTRIAZOL COMPOUNDS AS INHIBITORS OF PROTEIN KINASES

Legal Events

Date Code Title Description
FG Grant of patent
FD Lapse (for not paying fees)