CU23698B7 - PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- CU23698B7 CU23698B7 CU20060195A CU20060195A CU23698B7 CU 23698 B7 CU23698 B7 CU 23698B7 CU 20060195 A CU20060195 A CU 20060195A CU 20060195 A CU20060195 A CU 20060195A CU 23698 B7 CU23698 B7 CU 23698B7
- Authority
- CU
- Cuba
- Prior art keywords
- delta
- cristalina
- procedure
- preparation
- ivabradine
- Prior art date
Links
- 229960003825 ivabradine Drugs 0.000 title abstract 2
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 6
- HLUKNZUABFFNQS-ZMBIFBSDSA-N ivabradine hydrochloride Chemical compound Cl.C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 HLUKNZUABFFNQS-ZMBIFBSDSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 229960000504 ivabradine hydrochloride Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento de preparación de la forma cristalina delta d del clorhidrato de ivabradina de fórmula (I) (ESPACIO PARA FÓRMULA) consistiendo en el precalentamientio del acetonitrilo o una mezcla de acetonitrilo y agua, seguidamente se anade el clorhidrato de ivabradina y se enfría la solución obtenida a temperatura ambiente, y se mantiene a esta temperatura hasta la completa cristalización, luego se deshidratan los cristales obtenidos.The present invention relates to a process for preparing the delta d crystalline form of the ivabradine hydrochloride of formula (I) (SPACE FOR FORMULA) consisting of the preheating of acetonitrile or a mixture of acetonitrile and water, then the hydrochloride of Ivabradine and the solution obtained is cooled to room temperature, and is maintained at this temperature until complete crystallization, then the crystals obtained are dehydrated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060195A CU23698B7 (en) | 2006-10-11 | 2006-10-11 | PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060195A CU23698B7 (en) | 2006-10-11 | 2006-10-11 | PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20060195A7 CU20060195A7 (en) | 2010-05-19 |
| CU23698B7 true CU23698B7 (en) | 2011-09-21 |
Family
ID=44280807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20060195A CU23698B7 (en) | 2006-10-11 | 2006-10-11 | PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23698B7 (en) |
-
2006
- 2006-10-11 CU CU20060195A patent/CU23698B7/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CU20060195A7 (en) | 2010-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant of patent |