CU23718B7 - DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. - Google Patents
DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX.Info
- Publication number
- CU23718B7 CU23718B7 CU20070198A CU20070198A CU23718B7 CU 23718 B7 CU23718 B7 CU 23718B7 CU 20070198 A CU20070198 A CU 20070198A CU 20070198 A CU20070198 A CU 20070198A CU 23718 B7 CU23718 B7 CU 23718B7
- Authority
- CU
- Cuba
- Prior art keywords
- matrix
- compounds
- metaloproteinase
- inhibitors
- phenyl
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 2
- BYHDDXPKOZIZRV-UHFFFAOYSA-N 5-phenylpentanoic acid Chemical class OC(=O)CCCCC1=CC=CC=C1 BYHDDXPKOZIZRV-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 239000008196 pharmacological composition Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000001185 psoriatic effect Effects 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 206010039083 rhinitis Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a ciertos B-hidroxi-ácidos y a los procesos para la síntesis de los mismos. Esta invención también se refiere a composiciones farmacológicas que contienen los compuestos de la presente invención, y a métodos para el tratamiento del asma, artritis reumatoide, COPD, rinitis, osteoartritis psoriásica, psoriasis, fibrosis pulmunar, inflamación pulmunar, síndrome de diestres respiratorio agudo, periodontitis, esclerosis múltiple, gingivitis, ateroesclerosis, proliferación neo-intimal, los cuales conducen a restenosis y a falla isquémica del corazón, ataques, enfermedades renales, metástasis tumoral y otros desórdenes inflamatorios caracterizados por la sobre-expresión y la sobre-activación de una metaloproteinasa de la matriz, utilizando los compuestos.The present invention relates to certain B-hydroxy acids and the processes for their synthesis. This invention also relates to pharmacological compositions containing the compounds of the present invention, and to methods for the treatment of asthma, rheumatoid arthritis, COPD, rhinitis, psoriatic osteoarthritis, psoriasis, pulmonary fibrosis, lung inflammation, acute respiratory dieteres syndrome, periodontitis , multiple sclerosis, gingivitis, atherosclerosis, neo-intimal proliferation, which lead to restenosis and ischemic heart failure, seizures, kidney diseases, tumor metastases and other inflammatory disorders characterized by over-expression and over-activation of a metalloproteinase of the matrix, using the compounds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070198A CU23718B7 (en) | 2007-08-21 | 2007-08-21 | DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070198A CU23718B7 (en) | 2007-08-21 | 2007-08-21 | DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23718B7 true CU23718B7 (en) | 2011-10-14 |
Family
ID=45000137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20070198A CU23718B7 (en) | 2007-08-21 | 2007-08-21 | DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23718B7 (en) |
-
2007
- 2007-08-21 CU CU20070198A patent/CU23718B7/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2013001240A (en) | METALOPROTEIN MATRIX INHIBITORS. | |
| BR112013006929A2 (en) | compound of formula I, pharmaceutical composition, process for preparing compounds of formula 9, 16, 20, 27 and 30 | |
| BR112013006932A2 (en) | compound pharmaceutical composition and process for preparing a compound | |
| CU20110134A7 (en) | INHIBITORS OF THE METALOPROTEINASE MATRIX | |
| BRPI0915692B8 (en) | compounds derived from 1,2,5-oxadiazoles, their solid form, their composition, as well as their uses | |
| CL2015002301A1 (en) | 2-aza-bicyclo [2.2.1] heptane-3-carboxylic acid (benzyl-cyano-methyl) -amides substituted cathepsin inhibitors c. | |
| MX2014007254A (en) | Pharmaceutical compositions comprising glitazones and nrf2 activators. | |
| BR112012019367A2 (en) | heat integration process for ethanol production and purification process. | |
| CY1120660T1 (en) | NEW TOY RIG-I SUBSTITUTES AND METHODS OF THEIR PRODUCTION | |
| MX374414B (en) | NEW ANTI-INFLAMMATORY AGENTS. | |
| ECSP12011910A (en) | IMIDAZOPIRIDINE DERIVATIVES AS JAK INHIBITORS | |
| BR112012017448A2 (en) | method for the preparation of tetrazole methanesulfonic acid salts and a new compound employed therein | |
| CL2007001282A1 (en) | Compounds derived from 2-pyridone; Preparation process; pharmaceutical composition; Preparation process; and use for the treatment of diseases such as pulmonary emphysema, bronchitis, asthma, psoriasis, atherosclerosis, rheumatoid arthritis, among others. | |
| BRPI0713559A2 (en) | CYCLOBUTENE-1,2-DIONES 3,4-DI-REPLACED COMPOUND, PHARMACEUTICAL COMPOSITION UNDERSTANDING AND USES OF THE SAME | |
| UY29839A1 (en) | PHENOXYACETIC ACIDS REPLACED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION AND APPLICATIONS. | |
| BRPI0715691B8 (en) | method for the production of acetic acid | |
| BR112013030264A2 (en) | benzocycloheptene acetic acids | |
| CU24103B1 (en) | SPIRITS DERIVED AMIDO SPIROCYCLES AND SALTS PHARMACEUTICALLY ACCEPTABLE OF THE SAME | |
| CU20090009A7 (en) | BENCILAMINS, A PROCESS FOR ITS PRODUCTION AND ITS USE AS ANTI-INFLAMMATORY AGENTS | |
| CL2011000296A1 (en) | Process for preparing 4-oxo-octahydro-indole-1-carboxylic acid methyl ester and intermediate compounds used. | |
| CO2017002982A2 (en) | Pyrazolothiazole compound and medicine comprising the same | |
| PA8799201A1 (en) | TIGECICLINE AND METHODS TO PREPARE INTERMEDIATES | |
| BR112012030532A2 (en) | new processes | |
| PA8642801A1 (en) | SUBSTITUTED AMIDAS OF TIENOPIRROLCARBOXILICO ACID, AMIDAS OF THE PIRROLOTIAZOLCARBOXILICO ACID AND RELATED ANALOGS AS INHIBITORS OF CASEINA CINASA I | |
| MX385381B (en) | CRYSTAL OF COMPOUND THAT HAS JANUS KINASE (JAK) INHIBITORY ACTIVITY. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Lapse (for not paying fees) |