CU23721A3 - HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE - Google Patents
HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPEInfo
- Publication number
- CU23721A3 CU23721A3 CU20080033A CU20080033A CU23721A3 CU 23721 A3 CU23721 A3 CU 23721A3 CU 20080033 A CU20080033 A CU 20080033A CU 20080033 A CU20080033 A CU 20080033A CU 23721 A3 CU23721 A3 CU 23721A3
- Authority
- CU
- Cuba
- Prior art keywords
- antibodies
- alk
- relates
- present
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 abstract 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 abstract 1
- 101700032040 SMAD1 Proteins 0.000 abstract 1
- 102000057209 Smad1 Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se relaciona a los anticuerpos que incluyen anticuerpos humanos y las porciones aglutinantes de antígeno de los mismos que aglutinan el dominio extracelular ALK (ECD) b de la quinasa-1 (ALK-1) tipo receptor de activista y esa función que abroga la trayectoria de senalización ALK-1/TGF -beta-1/Smad1. La invención se relaciona también a las inmunoglobulinas de cadenas pesada y liviana procedentes de los anticuerpos anti-ALK-1 humanos y a las moléculas de ácido nucleico que codifican tales inmunoglobulinas. La presente invención se relaciona también a métodos para hacer los anticuerpos anti-ALK-1 humanos, composiciones que consisten de estos anticuerpos y los métodos para el uso de los anticuerpos y las composiciones. La invención se relaciona también a los animales y plantas transgénicos que consisten de moléculas de ácido nucleico de la presente invención.composiciones que consisten de estos anticuerpos y los métodos para el uso de los anticuerpos y las composiciones. La invención se relaciona también a los animales y plantas transgénicos que consisten de moléculas de ácido nucleico de la presente invención.The present invention relates to antibodies that include human antibodies and the antigen binding portions thereof that bind the extracellular domain ALK (ECD) b of kinase-1 (ALK-1) activist receptor type and that function that abrogates the signaling path ALK-1 / TGF -beta-1 / Smad1. The invention also relates to heavy and light chain immunoglobulins from human anti-ALK-1 antibodies and to nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods for making human anti-ALK-1 antibodies, compositions consisting of these antibodies and methods for the use of antibodies and compositions. The invention also relates to transgenic animals and plants consisting of nucleic acid molecules of the present invention, compositions consisting of these antibodies and methods for the use of antibodies and compositions. The invention also relates to transgenic animals and plants consisting of nucleic acid molecules of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20080033A CU23721A3 (en) | 2008-03-06 | 2008-03-06 | HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20080033A CU23721A3 (en) | 2008-03-06 | 2008-03-06 | HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23721A3 true CU23721A3 (en) | 2011-10-14 |
Family
ID=45000041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20080033A CU23721A3 (en) | 2008-03-06 | 2008-03-06 | HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23721A3 (en) |
-
2008
- 2008-03-06 CU CU20080033A patent/CU23721A3/en unknown
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