CU24012B1 - NEW DERIVATIVES OF NAFTALENO AND ITS OBTAINING PROCEDURES FOR THE LIVE DIAGNOSIS OF ALZHEIMER'S DISEASE THROUGH IMAGE TECHNIQUES - Google Patents
NEW DERIVATIVES OF NAFTALENO AND ITS OBTAINING PROCEDURES FOR THE LIVE DIAGNOSIS OF ALZHEIMER'S DISEASE THROUGH IMAGE TECHNIQUESInfo
- Publication number
- CU24012B1 CU24012B1 CU20100204A CU20100204A CU24012B1 CU 24012 B1 CU24012 B1 CU 24012B1 CU 20100204 A CU20100204 A CU 20100204A CU 20100204 A CU20100204 A CU 20100204A CU 24012 B1 CU24012 B1 CU 24012B1
- Authority
- CU
- Cuba
- Prior art keywords
- alkyl
- alkylene
- compounds
- naftaleno
- alzheimer
- Prior art date
Links
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002790 naphthalenes Chemical class 0.000 abstract 2
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- -1 alkaline earth metal salts Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005466 alkylenyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000012990 dithiocarbamate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000003448 neutrophilic effect Effects 0.000 abstract 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical group O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Esta invención se relaciona con la rama de la química, en particular con el campo de la síntesis orgánica de compuestos que pertenecen a la categoría de aromáticos bicíclicos o naftalénicos, utilizados en la detección de placas amiloideas. Estos nuevos derivados de naftaleno tienen fórmula general: ESPACIO PARA FÓRMULA Donde R representa a grupos independientes entre sí. En I: R1: -alquilenil-C(O)NH-alquilenil-R3, -alquilenil-C(O)O-R4; R3: -COOH, -OH, -SH, -NH2, -alquil-NH, -alquil-N-ditiocarbamato de sales de metales alcalino térreo; R4: H, grupo succinimido; R2: -H, -alquil. Los términos "alquil" y alquilenil" se refieren a cadenas alifáticas lineales o ramificadas, preferentemente de 1 a 4 átomos de carbono. Estos compuestos son néutros, lipofílicos y de bajo peso molecular por lo que atraviesan la barrera hematoencefálica y se adhieren a las placas amiloideas. La presente invención proporciona los procedimientos para la obtención de derivados de naftaleno con buenos rendimientos, que pueden ser prácticos, económicos y ser adaptados a una manufactura a mayor escala. No tenemos conocimiento de que los compuestos presentados en esta invención hayan sido reportados anteriormente.This invention relates to the branch of chemistry, in particular with the field of organic synthesis of compounds belonging to the category of bicyclic or naphthalene aromatics, used in the detection of amyloid plaques. These new naphthalene derivatives have a general formula: SPACE FOR FORMULA Where R represents independent groups from each other. In I: R1: -alkylene-C (O) NH-alkylene-R3, -alkylene-C (O) O-R4; R3: -COOH, -OH, -SH, -NH2, -alkyl-NH, -alkyl-N-dithiocarbamate of alkaline earth metal salts; R4: H, succinimide group; R2: -H, -alkyl. The terms "alkyl" and alkylenyl "refer to linear or branched aliphatic chains, preferably 1 to 4 carbon atoms. These compounds are neutrophilic, lipophilic and of low molecular weight whereby they cross the blood-brain barrier and adhere to the plates amyloid The present invention provides the processes for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger scale manufacturing We are not aware that the compounds presented in this invention have been previously reported .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20100204A CU24012B1 (en) | 2010-10-19 | 2010-10-19 | NEW DERIVATIVES OF NAFTALENO AND ITS OBTAINING PROCEDURES FOR THE LIVE DIAGNOSIS OF ALZHEIMER'S DISEASE THROUGH IMAGE TECHNIQUES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20100204A CU24012B1 (en) | 2010-10-19 | 2010-10-19 | NEW DERIVATIVES OF NAFTALENO AND ITS OBTAINING PROCEDURES FOR THE LIVE DIAGNOSIS OF ALZHEIMER'S DISEASE THROUGH IMAGE TECHNIQUES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20100204A7 CU20100204A7 (en) | 2012-06-21 |
| CU24012B1 true CU24012B1 (en) | 2014-06-27 |
Family
ID=46514996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20100204A CU24012B1 (en) | 2010-10-19 | 2010-10-19 | NEW DERIVATIVES OF NAFTALENO AND ITS OBTAINING PROCEDURES FOR THE LIVE DIAGNOSIS OF ALZHEIMER'S DISEASE THROUGH IMAGE TECHNIQUES |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU24012B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU24583B1 (en) | 2018-11-06 | 2022-02-04 | Centro De Neurociencias De Cuba | METAL OXIDE NANOPARTICLES CONJUGATED WITH NAPHTHALENE DERIVATIVES AS CONTRAST AGENTS FOR THE DETECTION OF AMYLOID PLAQUES BY MAGNETIC RESONANCE (MRI) |
-
2010
- 2010-10-19 CU CU20100204A patent/CU24012B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CU20100204A7 (en) | 2012-06-21 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant of patent |