CU24546B1 - Composición vacunal que comprende un mutante de la interleucina-15 humana - Google Patents
Composición vacunal que comprende un mutante de la interleucina-15 humanaInfo
- Publication number
- CU24546B1 CU24546B1 CU2016000194A CU20160194A CU24546B1 CU 24546 B1 CU24546 B1 CU 24546B1 CU 2016000194 A CU2016000194 A CU 2016000194A CU 20160194 A CU20160194 A CU 20160194A CU 24546 B1 CU24546 B1 CU 24546B1
- Authority
- CU
- Cuba
- Prior art keywords
- human interleukin
- mutant
- composition including
- vaccinal composition
- composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
- A61K39/00114—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>Se describe una composición vacunal caracterizada porque comprende un polipéptido mutado de interleucina-15 humana identificado como SEQ ID NO: 1 en una concentración de 200-500 µg y un adyuvante vacunal, seleccionado de sales de aluminio a 1,8 mg/mL o de tipo oleoso en una relación 50:50 (v/v). La composición se emplea para la inmunoterapia activa de enfermedades relacionadas con la sobre-expresión de la IL-15 entre las que se encuentran algunas enfermedades autoinmunes y neoplasias hematológicas.</p>
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2016000194A CU24546B1 (es) | 2016-12-30 | 2016-12-30 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
| BR112019013542-1A BR112019013542A2 (pt) | 2016-12-30 | 2017-12-20 | composição de vacina, uso de um polipeptídeo, e, método para o tratamento de doenças associadas à superexpressão da il-15 |
| PCT/CU2017/050008 WO2018121802A1 (es) | 2016-12-30 | 2017-12-20 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
| US16/474,913 US20200181254A1 (en) | 2016-12-30 | 2017-12-20 | Vaccine composition comprising a mutant of human interleukin-15 |
| RU2019122635A RU2745199C2 (ru) | 2016-12-30 | 2017-12-20 | Вакцинная композиция, содержащая мутантный человеческий интерлейкин-15 |
| EP17840472.9A EP3564264B1 (en) | 2016-12-30 | 2017-12-20 | Vaccine composition comprising a mutant of human interleukin-15 |
| ES17840472T ES2892148T3 (es) | 2016-12-30 | 2017-12-20 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
| MX2019007906A MX2019007906A (es) | 2016-12-30 | 2017-12-20 | Composicion vacunal que comprende un mutante de la interleucina-15 humana. |
| CN201780086587.4A CN110300762B (zh) | 2016-12-30 | 2017-12-20 | 包含人白介素-15的突变体的疫苗组合物 |
| US17/531,914 US20220259300A1 (en) | 2016-12-30 | 2021-11-22 | Vaccine composition comprising a mutant of human interleukin-15 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2016000194A CU24546B1 (es) | 2016-12-30 | 2016-12-30 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20160194A7 CU20160194A7 (es) | 2018-08-06 |
| CU24546B1 true CU24546B1 (es) | 2021-09-07 |
Family
ID=61188581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2016000194A CU24546B1 (es) | 2016-12-30 | 2016-12-30 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20200181254A1 (es) |
| EP (1) | EP3564264B1 (es) |
| CN (1) | CN110300762B (es) |
| BR (1) | BR112019013542A2 (es) |
| CU (1) | CU24546B1 (es) |
| ES (1) | ES2892148T3 (es) |
| MX (1) | MX2019007906A (es) |
| RU (1) | RU2745199C2 (es) |
| WO (1) | WO2018121802A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3179066A1 (en) * | 2020-05-18 | 2021-11-25 | Jing DENG | Human il-15 mutant and use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| WO1997041232A1 (en) | 1996-04-26 | 1997-11-06 | Beth Israel Deaconess Medical Center | Antagonists of interleukin-15 |
| CU23093A1 (es) * | 2002-10-09 | 2005-10-19 | Ct Ingenieria Genetica Biotech | Composición vacunal que comprende interleucina-15 (il-15) |
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| ES2367027T3 (es) * | 2004-02-27 | 2011-10-27 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Sitio de unión de la il-15 para il-15ralfa y mutantes específicos de il-15 que tienen actividad agonista/antagonista. |
| TW200613552A (en) * | 2004-08-11 | 2006-05-01 | Hoffmann La Roche | Mutant interleukin-15 polypeptides |
| WO2006063974A2 (en) * | 2004-12-13 | 2006-06-22 | Cytos Biotechnology Ag | Il-15 antigen arrays and uses thereof |
| CU23716A1 (es) * | 2008-09-30 | 2011-10-05 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la actividad de la interleucina-15 |
| EP3810171B1 (en) * | 2018-06-22 | 2025-07-09 | Cugene Inc. | Novel interleukin-15 (1l-15) fusion proteins and uses thereof |
-
2016
- 2016-12-30 CU CU2016000194A patent/CU24546B1/es unknown
-
2017
- 2017-12-20 WO PCT/CU2017/050008 patent/WO2018121802A1/es not_active Ceased
- 2017-12-20 ES ES17840472T patent/ES2892148T3/es active Active
- 2017-12-20 US US16/474,913 patent/US20200181254A1/en not_active Abandoned
- 2017-12-20 EP EP17840472.9A patent/EP3564264B1/en active Active
- 2017-12-20 MX MX2019007906A patent/MX2019007906A/es unknown
- 2017-12-20 CN CN201780086587.4A patent/CN110300762B/zh not_active Expired - Fee Related
- 2017-12-20 BR BR112019013542-1A patent/BR112019013542A2/pt not_active IP Right Cessation
- 2017-12-20 RU RU2019122635A patent/RU2745199C2/ru active
-
2021
- 2021-11-22 US US17/531,914 patent/US20220259300A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019122635A (ru) | 2021-02-01 |
| US20220259300A1 (en) | 2022-08-18 |
| MX2019007906A (es) | 2019-09-04 |
| ES2892148T3 (es) | 2022-02-02 |
| BR112019013542A2 (pt) | 2020-02-04 |
| CU20160194A7 (es) | 2018-08-06 |
| EP3564264A1 (en) | 2019-11-06 |
| WO2018121802A1 (es) | 2018-07-05 |
| RU2019122635A3 (es) | 2021-02-01 |
| EP3564264B1 (en) | 2021-09-08 |
| CN110300762A (zh) | 2019-10-01 |
| RU2745199C2 (ru) | 2021-03-22 |
| US20200181254A1 (en) | 2020-06-11 |
| CN110300762B (zh) | 2023-05-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2016016236A (es) | Anticuerpos dirigidos contra cd127. | |
| EA201991798A1 (ru) | Стабильные при хранении составы | |
| EA201791717A1 (ru) | Стабильные водные составы адалимумаба | |
| MX378319B (es) | Composiciones para el cuidado bucal y metodos de uso. | |
| NZ737046A (en) | Anti-cgrp antibody formulation | |
| AR076973A1 (es) | Composicion tensioactiva reconstituida mejorada que contiene analogos de la proteina tensioactiva b (sp-b) y de la proteina tensioactiva c (sp-c) | |
| PE20151982A1 (es) | Derivados de bencimidazolona como inhibidores del bromodominio | |
| PE20160225A1 (es) | Modulacion de la inmunidad tumoral | |
| PE20180505A1 (es) | Peptidos y combinacion de peptidos y andamiajes novedosos para su uso en inmunoterapia contra carcinoma de celulas renales (rcc) y otros canceres | |
| EA201691259A1 (ru) | РЕГУЛЯТОРЫ Nrf2 | |
| UA103202C2 (ru) | Фармацевтическая композиция опухолеассоциированных пептидов и ее применение для лечения раковых заболеваний | |
| AR074756A1 (es) | Anticuerpos contra la angiopoyetina-2 humana | |
| MX2015013104A (es) | Composiciones y métodos para la inmunoterapia. | |
| PE20140173A1 (es) | Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis | |
| GT201200189A (es) | Antagonistas de pcsk9 | |
| EA201991799A1 (ru) | Диспергируемые в воде составы | |
| PE20180741A1 (es) | Anticuerpo anti-cd154 con caracteristicas de union, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana | |
| PE20131411A1 (es) | Anticuerpos contra la tweak humana y usos de los mismos | |
| MX2019013621A (es) | Agonistas del receptor de interleuquina-15 de accion prolongada y composiciones y metodos inmunoterapeuticos relacionados. | |
| MX2014010664A (es) | Identificacion de mutaciones de channelopsin-2 (chop2) y los metodos de uso. | |
| CY1114716T1 (el) | Ανασυσταθεντα επιφανειοδραστικα τα οποια διαθετουν βελτιωμενες ιδιοτητες | |
| UY38786A (es) | Agonistas de receptores tipo toll | |
| MD3341379T2 (ro) | Inhibitori ai EZH2 | |
| CO2018011819A2 (es) | Inhibidores del potenciador del homólogo zeste 2 | |
| EA202191175A1 (ru) | Сконструированные с цистеином конъюгаты антитело-лекарственное средство, содержащие пептидсодержащие линкеры |