CU24554B1 - Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 - Google Patents
Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1Info
- Publication number
- CU24554B1 CU24554B1 CU2018000039A CU20180039A CU24554B1 CU 24554 B1 CU24554 B1 CU 24554B1 CU 2018000039 A CU2018000039 A CU 2018000039A CU 20180039 A CU20180039 A CU 20180039A CU 24554 B1 CU24554 B1 CU 24554B1
- Authority
- CU
- Cuba
- Prior art keywords
- fusion proteins
- mutein
- interferon
- type
- interleukin
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 102000014150 Interferons Human genes 0.000 title abstract 2
- 108010050904 Interferons Proteins 0.000 title abstract 2
- 229940079322 interferon Drugs 0.000 title abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 title 1
- 108010002350 Interleukin-2 Proteins 0.000 title 1
- 108010075254 C-Peptide Proteins 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
<p>La presente invención se relaciona con el campo de Ia Biotecnología y Ia lnmunooncología. Se describen proteínas de fusión basadas en citocinas, denominadas bicitocinas, particularmente formadas por Ia unión de una muteína agonista de IL2 con un interferón tipo 1, enlazados mediante Ia región Fc de una lgG1 humana mutada y un péptido conector. Se describen, además, las composiciones farmacéuticas que comprenden como principio activo las proteínas de fusión aquí descritas.</p>
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2018000039A CU24554B1 (es) | 2018-05-07 | 2018-05-07 | Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 |
| US17/052,912 US11926654B2 (en) | 2018-05-07 | 2019-03-05 | Fusion proteins composed of an interleukin-2 mutein and type I interferon |
| CN201980031020.6A CN112218884A (zh) | 2018-05-07 | 2019-05-03 | 由白介素-2突变蛋白和i型干扰素构成的融合蛋白 |
| PCT/CU2019/050003 WO2019214757A1 (es) | 2018-05-07 | 2019-05-03 | Proteínas de fusión compuestas por una muteina de interleucina-2 e interferon tipo 1 |
| CA3098653A CA3098653A1 (en) | 2018-05-07 | 2019-05-03 | Fusion proteins composed of an interleukin-2 mutein and type i interferon |
| BR112020022511-8A BR112020022511A2 (pt) | 2018-05-07 | 2019-05-03 | proteínas de fusão compostas por uma muteína de interleucina-2 (il-2) e interferon do tipo i |
| JP2021512997A JP7423607B2 (ja) | 2018-05-07 | 2019-05-03 | インターロイキン 2突然変異タンパク質およびi型インターフェロンで構成される融合タンパク質 |
| EP19729611.4A EP3792277A1 (en) | 2018-05-07 | 2019-05-03 | Fusion proteins composed of an interleukin-2 mutein and type i interferon |
| TW108115578A TWI821287B (zh) | 2018-05-07 | 2019-05-06 | 介白素-2突變形成之蛋白質與第i型干擾素所構成之融合蛋白質 |
| ARP190101204A AR115083A1 (es) | 2018-05-07 | 2019-05-07 | Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2018000039A CU24554B1 (es) | 2018-05-07 | 2018-05-07 | Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20180039A7 CU20180039A7 (es) | 2019-12-03 |
| CU24554B1 true CU24554B1 (es) | 2021-11-04 |
Family
ID=68467792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2018000039A CU24554B1 (es) | 2018-05-07 | 2018-05-07 | Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11926654B2 (es) |
| EP (1) | EP3792277A1 (es) |
| JP (1) | JP7423607B2 (es) |
| CN (1) | CN112218884A (es) |
| AR (1) | AR115083A1 (es) |
| BR (1) | BR112020022511A2 (es) |
| CA (1) | CA3098653A1 (es) |
| CU (1) | CU24554B1 (es) |
| TW (1) | TWI821287B (es) |
| WO (1) | WO2019214757A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3794024T5 (da) | 2018-05-14 | 2024-08-19 | Werewolf Therapeutics Inc | Aktiverbare interleukin-2 polypeptider og fremgangsmåder til anvendelse heraf |
| EP3794023A1 (en) | 2018-05-14 | 2021-03-24 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
| US20220002370A1 (en) | 2018-09-27 | 2022-01-06 | Xilio Development, Inc. | Masked cytokine polypeptides |
| MX2021013766A (es) | 2019-05-14 | 2022-02-21 | Werewolf Therapeutics Inc | Restos de separacion y metodos de uso de los mismos. |
| AU2020384375A1 (en) | 2019-11-14 | 2022-05-26 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| TW202136317A (zh) | 2019-12-20 | 2021-10-01 | 美商再生元醫藥公司 | 新穎之il2促效劑及其使用方法(二) |
| WO2022009123A1 (en) * | 2020-07-09 | 2022-01-13 | Eutilex Co., Ltd. | Il-2 variants |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| TW202235431A (zh) | 2020-11-25 | 2022-09-16 | 美商艾希利歐發展股份有限公司 | 腫瘤特異性可裂解連接子 |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| WO2023141555A2 (en) * | 2022-01-21 | 2023-07-27 | Aetio Biotherapy, Inc. | Immunoconjugates of interleukin-2 mutant polypeptides with antibodies |
| CN114853909A (zh) * | 2022-05-13 | 2022-08-05 | 南京吉盛澳玛生物医药有限公司 | 新型IL-2与INFα和Fc融合蛋白的设计、制备及用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610830B1 (en) * | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
| DE60035871T2 (de) * | 1999-05-19 | 2008-06-05 | Merck Patent Gmbh | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
| US6617135B1 (en) * | 1999-08-09 | 2003-09-09 | Emd Lexigen Research Center Corp. | Multiple cytokine protein complexes |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| WO2009152610A1 (en) | 2008-06-20 | 2009-12-23 | The Royal Institution For The Advancement Of Learning/Mcgill University | Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof |
| CN102041263B (zh) * | 2010-02-08 | 2013-01-09 | 河南省动物疫病预防控制中心 | 鸡α干扰素/白细胞介素2嵌合基因 |
| CU23923B1 (es) * | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| JP6093712B2 (ja) * | 2010-12-22 | 2017-03-08 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン2のスーパーアゴニストおよびアンタゴニスト |
| UY34347A (es) * | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| WO2014100014A1 (en) * | 2012-12-17 | 2014-06-26 | The Board Of Trustees Of The Leland Stanford Junior University | Super-2 complexes with antibody to augment il-2 therapy |
| CN104877029A (zh) * | 2015-04-24 | 2015-09-02 | 昆明理工大学 | 一种Vimentin-Fc融合蛋白及其应用 |
| CN106397607A (zh) * | 2016-09-13 | 2017-02-15 | 河南师范大学 | 重组人成纤维细胞生长因子21融合蛋白及其在制备治疗代谢疾病药物中的应用 |
| CN107245108A (zh) * | 2017-08-09 | 2017-10-13 | 芜湖英特菲尔生物制品产业研究院有限公司 | 牛白蛋白‑干扰素α‑白介素2融合蛋白、制备方法及其编码基因、一种牛长效干扰素 |
| CN107286254A (zh) * | 2017-08-09 | 2017-10-24 | 芜湖英特菲尔生物制品产业研究院有限公司 | 犬白蛋白‑干扰素α‑白介素2融合蛋白、制备方法及其编码基因、一种犬长效干扰素 |
-
2018
- 2018-05-07 CU CU2018000039A patent/CU24554B1/es unknown
-
2019
- 2019-03-05 US US17/052,912 patent/US11926654B2/en active Active
- 2019-05-03 CN CN201980031020.6A patent/CN112218884A/zh active Pending
- 2019-05-03 BR BR112020022511-8A patent/BR112020022511A2/pt unknown
- 2019-05-03 WO PCT/CU2019/050003 patent/WO2019214757A1/es not_active Ceased
- 2019-05-03 EP EP19729611.4A patent/EP3792277A1/en active Pending
- 2019-05-03 CA CA3098653A patent/CA3098653A1/en active Pending
- 2019-05-03 JP JP2021512997A patent/JP7423607B2/ja active Active
- 2019-05-06 TW TW108115578A patent/TWI821287B/zh active
- 2019-05-07 AR ARP190101204A patent/AR115083A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3792277A1 (en) | 2021-03-17 |
| US11926654B2 (en) | 2024-03-12 |
| CA3098653A1 (en) | 2019-11-14 |
| JP7423607B2 (ja) | 2024-01-29 |
| US20210238246A1 (en) | 2021-08-05 |
| JP2021522861A (ja) | 2021-09-02 |
| TWI821287B (zh) | 2023-11-11 |
| AR115083A1 (es) | 2020-11-25 |
| BR112020022511A2 (pt) | 2021-02-09 |
| WO2019214757A1 (es) | 2019-11-14 |
| TW202014431A (zh) | 2020-04-16 |
| CN112218884A (zh) | 2021-01-12 |
| CU20180039A7 (es) | 2019-12-03 |
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