CU24631B1 - Método para inactivar xenoantígenos en tejidos biológicos - Google Patents

Método para inactivar xenoantígenos en tejidos biológicos

Info

Publication number
CU24631B1
CU24631B1 CU2018000048A CU20180048A CU24631B1 CU 24631 B1 CU24631 B1 CU 24631B1 CU 2018000048 A CU2018000048 A CU 2018000048A CU 20180048 A CU20180048 A CU 20180048A CU 24631 B1 CU24631 B1 CU 24631B1
Authority
CU
Cuba
Prior art keywords
xenoantigens
inactivate
biological tissues
tissues
hydroxytyrosol
Prior art date
Application number
CU2018000048A
Other languages
English (en)
Other versions
CU20180048A7 (es
Inventor
Alessandro Gandaglia
Filippo Naso
Original Assignee
Biocompatibility Innovation Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibility Innovation Srl filed Critical Biocompatibility Innovation Srl
Publication of CU20180048A7 publication Critical patent/CU20180048A7/es
Publication of CU24631B1 publication Critical patent/CU24631B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Prostheses (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

<p>La presente invención se refiere a un método para inactivar xenoantígenos en tejidos biológicos aislados del cuerpo humano, que comprende: proporcionar una solución de ácido cafeico, de ácido tánico o de hidroxitirosol, para la inactivación del epítopo alfa-Gal de dichos tejidos; incubar las muestras y someter los tejidos tratados a tres lavados.</p>
CU2018000048A 2015-11-30 2016-11-25 Método para inactivar xenoantígenos en tejidos biológicos CU24631B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUB2015A006019A ITUB20156019A1 (it) 2015-11-30 2015-11-30 Metodo per l'inattivazione di xenoantigeni in tessuti biologici
PCT/EP2016/078898 WO2017093147A1 (en) 2015-11-30 2016-11-25 Method for inactivating xenoantigens in biological tissues

Publications (2)

Publication Number Publication Date
CU20180048A7 CU20180048A7 (es) 2018-11-06
CU24631B1 true CU24631B1 (es) 2022-12-12

Family

ID=55485194

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2018000048A CU24631B1 (es) 2015-11-30 2016-11-25 Método para inactivar xenoantígenos en tejidos biológicos

Country Status (18)

Country Link
US (1) US12589186B2 (es)
EP (1) EP3383446B1 (es)
JP (1) JP7169645B2 (es)
KR (1) KR20180090816A (es)
CN (1) CN108367098B (es)
AU (1) AU2016363536B2 (es)
BR (1) BR112018011021B1 (es)
CU (1) CU24631B1 (es)
DK (1) DK3383446T3 (es)
ES (1) ES2881603T3 (es)
IL (1) IL259591B (es)
IT (1) ITUB20156019A1 (es)
MX (1) MX385515B (es)
PL (1) PL3383446T3 (es)
RS (1) RS62100B1 (es)
RU (1) RU2754197C2 (es)
WO (1) WO2017093147A1 (es)
ZA (1) ZA201803786B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600115523A1 (it) * 2016-11-16 2018-05-16 Biocompatibility Innovation Srl Metodo per l'inattivazione ed il controllo di avvenuta inattivazione di xenoantigeni in alimenti di origine animale, particolarmente per latte e derivati, e in alimenti di origine vegetale, particolarmente per succedanei di latte a base di soia e/o riso
JP2022534228A (ja) * 2019-05-22 2022-07-28 バイオコンパティビリティ・イノベイション・ソチエタ・ア・レスポンサビリタ・リミタータ 石灰化沈着物の形成を防止し、生物学的マトリックス中の異種抗原を不活化するための方法
KR20260014524A (ko) 2023-03-14 2026-01-30 바이오컴패터빌러티 이노베이션 에스알엘 합성 기질에 항미생물 특성을 부여하는 방법
WO2025257595A1 (en) 2024-06-12 2025-12-18 Biocompatibility Innovation S.r.l. Preserving solution

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003520825A (ja) * 2000-01-25 2003-07-08 ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ネブラスカ 抗ドナー免疫へ抵抗する、移植前に順応された臓器
US20040153145A1 (en) * 2002-11-26 2004-08-05 Clemson University Fixation method for bioprostheses
AU2005223617A1 (en) * 2004-03-17 2005-09-29 Revivicor, Inc. Tissue products from animals lacking functional alpha 1,3 galactosyl transferase
RU2400105C2 (ru) * 2005-11-10 2010-09-27 Хилл`С Пет Ньютришн, Инк. Композиции и способы улучшения состояния кожного покрова и шерстного покрова
WO2007133479A2 (en) * 2006-05-10 2007-11-22 Cook Incorporated Delivery of elastin-stabilizing compound within a body lumen
CN101366979B (zh) * 2008-09-03 2012-08-29 陕西瑞盛生物科技有限公司 一种组织补片及其制备方法
FR2947456B1 (fr) * 2009-07-06 2012-03-09 Univ Bordeaux 1 Procede d'inactivation d'au moins un agent pathogene dans un echantillon de plasma sanguin humain
IL210162A0 (en) * 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
EP2709711B8 (en) * 2011-05-18 2017-03-22 Vatrix Medical, Inc. Coated balloons for blood vessel stabilization
RU2495928C2 (ru) * 2012-01-30 2013-10-20 Сергей Юрьевич Лешков Средство для стимуляции синтеза белков теплового шока hsp 70 в клетках человека и животных; косметическое средство для стимуляции репаративных процессов; косметическое средство для снижения побочных эффектов агрессивных косметологических процедур; биологически активная добавка; пищевой продукт; способ снижения побочных эффектов агрессивных косметологических процедур
ITPD20120029A1 (it) 2012-02-09 2013-08-10 Alessandro Gandaglia Metodo per la rilevazione di uno xenoantigene in tessuti fissati usati come sostituti bioprotesici
US9283241B2 (en) * 2012-07-10 2016-03-15 Clemson University Treatment to render implants resistant to diabetes
US9795573B2 (en) * 2013-09-24 2017-10-24 Clemson University Multi-step connective tissue stabilization method and stabilized tissue formed thereby
US11951078B2 (en) * 2019-05-22 2024-04-09 Biocompatibility Innovation S.r.l. Method for preventing the formation of calcified deposits and for inactivating xenoantigens in biological matrices

Also Published As

Publication number Publication date
RU2018123621A (ru) 2020-01-09
EP3383446B1 (en) 2021-04-28
JP2019503821A (ja) 2019-02-14
ZA201803786B (en) 2019-02-27
CU20180048A7 (es) 2018-11-06
RU2754197C2 (ru) 2021-08-30
ES2881603T3 (es) 2021-11-30
MX385515B (es) 2025-03-18
AU2016363536B2 (en) 2021-04-01
IL259591A (en) 2018-07-31
AU2016363536A1 (en) 2018-06-28
MX2018006577A (es) 2018-09-05
US12589186B2 (en) 2026-03-31
IL259591B (en) 2022-04-01
BR112018011021A2 (pt) 2018-11-21
CN108367098A (zh) 2018-08-03
ITUB20156019A1 (it) 2017-05-30
BR112018011021B1 (pt) 2021-12-07
US20180353647A1 (en) 2018-12-13
KR20180090816A (ko) 2018-08-13
WO2017093147A1 (en) 2017-06-08
JP7169645B2 (ja) 2022-11-11
RS62100B1 (sr) 2021-08-31
CA3006234A1 (en) 2017-06-08
DK3383446T3 (da) 2021-07-26
PL3383446T3 (pl) 2021-11-02
RU2018123621A3 (es) 2020-04-10
CN108367098B (zh) 2021-06-11
EP3383446A1 (en) 2018-10-10

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