CU24746B1 - Apirasas humanas, solubilizadas y modificadas útiles para prevenir y tratar el daño tisular - Google Patents
Apirasas humanas, solubilizadas y modificadas útiles para prevenir y tratar el daño tisularInfo
- Publication number
- CU24746B1 CU24746B1 CU2021000008A CU20210008A CU24746B1 CU 24746 B1 CU24746 B1 CU 24746B1 CU 2021000008 A CU2021000008 A CU 2021000008A CU 20210008 A CU20210008 A CU 20210008A CU 24746 B1 CU24746 B1 CU 24746B1
- Authority
- CU
- Cuba
- Prior art keywords
- human
- solubilized
- apyrases
- useful
- preventing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
- C12Y306/01005—Apyrase (3.6.1.5), i.e. ATP diphosphohydrolase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
Abstract
<p>La invención se refiere a una apirasa humana solubilizada, tal como el CD39 humano, que comprende modificaciones en la regiones N terminal, C terminal y central, y conducen a una proteína sorprendentemente activa, segura y fácil de fabricar. En la presente solicitud se proporciona una apirasa humana solubilizada que comprende la secuencia de aminoácidos SEQ ID NO: 229.</p> <p> </p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18184269 | 2018-07-18 | ||
| PCT/IB2019/056117 WO2020016804A1 (en) | 2018-07-18 | 2019-07-17 | Solubilized apyrases, methods and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20210008A7 CU20210008A7 (es) | 2021-08-06 |
| CU24746B1 true CU24746B1 (es) | 2025-04-04 |
Family
ID=62985993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2021000008A CU24746B1 (es) | 2018-07-18 | 2019-07-17 | Apirasas humanas, solubilizadas y modificadas útiles para prevenir y tratar el daño tisular |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US12325870B2 (es) |
| EP (1) | EP3824079A1 (es) |
| JP (2) | JP7425784B2 (es) |
| KR (1) | KR102919646B1 (es) |
| CN (6) | CN119162148A (es) |
| AR (1) | AR115790A1 (es) |
| AU (1) | AU2019306821B2 (es) |
| BR (1) | BR112021000586A2 (es) |
| CA (1) | CA3103684A1 (es) |
| CL (1) | CL2021000129A1 (es) |
| CO (1) | CO2021000210A2 (es) |
| CR (1) | CR20210021A (es) |
| CU (1) | CU24746B1 (es) |
| EA (1) | EA202190057A1 (es) |
| EC (1) | ECSP21002804A (es) |
| IL (1) | IL280191A (es) |
| JO (1) | JOP20210008A1 (es) |
| MA (1) | MA53177A (es) |
| MX (1) | MX2021000542A (es) |
| MY (1) | MY203583A (es) |
| PE (1) | PE20210185A1 (es) |
| PH (1) | PH12021550122A1 (es) |
| SG (1) | SG11202011776RA (es) |
| TW (1) | TWI857965B (es) |
| UY (1) | UY38299A (es) |
| WO (1) | WO2020016804A1 (es) |
| ZA (1) | ZA202007187B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY38299A (es) * | 2018-07-18 | 2020-02-28 | Novartis Ag | Apirasas solubilizadas, métodos y usos |
| EP4157131A4 (en) * | 2020-05-28 | 2024-10-02 | Charm Sciences, Inc. | METHODS AND ASSEMBLIES FOR SAMPLE ANALYSIS |
| WO2024023745A1 (en) | 2022-07-29 | 2024-02-01 | Novartis Ag | Treatment for acute organ injury using cd39, recombinant cd39 |
| KR20250044704A (ko) | 2022-07-29 | 2025-04-01 | 노파르티스 아게 | Cd39 변이체의 개선된 생산 |
| WO2025080755A1 (en) * | 2023-10-13 | 2025-04-17 | Nutrition & Biosciences USA 4, Inc. | Methods and compositions for aging and mitochondrial health |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6447771B1 (en) | 1999-03-19 | 2002-09-10 | Hyseq, Inc. | Methods and materials relating to novel CD39-like polypeptides |
| CA2345382A1 (en) * | 1998-10-16 | 2000-04-27 | Immunex Corporation | Inhibitors of platelet activation and recruitment |
| US20020002277A1 (en) * | 1998-10-16 | 2002-01-03 | Maliszewski Charles Richard | Inhibitors of platelet activation and recruitment |
| US6867177B2 (en) | 1999-08-13 | 2005-03-15 | The Trustees Of Columbia University In The City Of New York | CD39/ECTO-adpase as a treatment for thrombotic and ischemic disorders |
| US7247300B1 (en) | 2002-11-07 | 2007-07-24 | Apt Therapeutics, Inc. | Therapeutic use of soluble CD39L3 |
| EP1861498A4 (en) | 2005-03-17 | 2009-06-24 | Ca Nat Research Council | EXPRESSION VECTORS FOR TRANSIENT GENETIC EXPRESSION AND MAMMALIAN CELLS EXPRESSING THE SAME |
| WO2008002157A1 (en) | 2006-06-27 | 2008-01-03 | Agresearch Limited | Apyrases and uses thereof |
| CA2787016C (en) * | 2010-01-13 | 2018-01-23 | Apt Therapeutics, Inc. | Therapeutic apyrase constructs, apyrase agents, and production methods |
| WO2011088231A1 (en) | 2010-01-13 | 2011-07-21 | Apt Therapeutics, Inc. | Apyrase therapy for bleeding conditions |
| JP6708548B2 (ja) | 2013-12-20 | 2020-06-10 | ノバルティス アーゲー | 新規真核細胞および目的の生成物を組換え発現させるための方法 |
| EP3083677B1 (en) | 2013-12-20 | 2019-08-28 | Novartis AG | Novel eukaryotic cells and methods for recombinantly expressing a product of interest |
| UY38299A (es) | 2018-07-18 | 2020-02-28 | Novartis Ag | Apirasas solubilizadas, métodos y usos |
-
2019
- 2019-07-15 UY UY0001038299A patent/UY38299A/es active IP Right Grant
- 2019-07-16 AR ARP190102009A patent/AR115790A1/es unknown
- 2019-07-16 TW TW108125140A patent/TWI857965B/zh active
- 2019-07-17 KR KR1020217001187A patent/KR102919646B1/ko active Active
- 2019-07-17 CN CN202411151692.XA patent/CN119162148A/zh active Pending
- 2019-07-17 CN CN202411151526.XA patent/CN119020319A/zh active Pending
- 2019-07-17 EA EA202190057A patent/EA202190057A1/ru unknown
- 2019-07-17 AU AU2019306821A patent/AU2019306821B2/en active Active
- 2019-07-17 CN CN201980047594.2A patent/CN112424346B/zh active Active
- 2019-07-17 PE PE2021000054A patent/PE20210185A1/es unknown
- 2019-07-17 CN CN202411151636.6A patent/CN119020320A/zh active Pending
- 2019-07-17 CN CN202411151437.5A patent/CN119020318A/zh active Pending
- 2019-07-17 EP EP19769879.8A patent/EP3824079A1/en active Pending
- 2019-07-17 JP JP2021502432A patent/JP7425784B2/ja active Active
- 2019-07-17 SG SG11202011776RA patent/SG11202011776RA/en unknown
- 2019-07-17 BR BR112021000586-2A patent/BR112021000586A2/pt unknown
- 2019-07-17 CN CN202411151809.4A patent/CN119020321A/zh active Pending
- 2019-07-17 MY MYPI2020006171A patent/MY203583A/en unknown
- 2019-07-17 MA MA053177A patent/MA53177A/fr unknown
- 2019-07-17 MX MX2021000542A patent/MX2021000542A/es unknown
- 2019-07-17 CR CR20210021A patent/CR20210021A/es unknown
- 2019-07-17 CA CA3103684A patent/CA3103684A1/en active Pending
- 2019-07-17 US US17/261,533 patent/US12325870B2/en active Active
- 2019-07-17 CU CU2021000008A patent/CU24746B1/es unknown
- 2019-07-17 WO PCT/IB2019/056117 patent/WO2020016804A1/en not_active Ceased
- 2019-07-17 JO JOP/2021/0008A patent/JOP20210008A1/ar unknown
-
2020
- 2020-11-18 ZA ZA2020/07187A patent/ZA202007187B/en unknown
-
2021
- 2021-01-14 IL IL280191A patent/IL280191A/en unknown
- 2021-01-14 EC ECSENADI20212804A patent/ECSP21002804A/es unknown
- 2021-01-14 CO CONC2021/0000210A patent/CO2021000210A2/es unknown
- 2021-01-15 CL CL2021000129A patent/CL2021000129A1/es unknown
- 2021-01-15 PH PH12021550122A patent/PH12021550122A1/en unknown
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2023
- 2023-11-14 JP JP2023193640A patent/JP7853263B2/ja active Active
-
2024
- 2024-09-26 US US18/897,352 patent/US20250179447A1/en active Pending
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