CY1111978T1 - Συζυγη μακρολιδων με αντιφλεγμονωδη δραση - Google Patents

Συζυγη μακρολιδων με αντιφλεγμονωδη δραση

Info

Publication number
CY1111978T1
CY1111978T1 CY20111101008T CY111101008T CY1111978T1 CY 1111978 T1 CY1111978 T1 CY 1111978T1 CY 20111101008 T CY20111101008 T CY 20111101008T CY 111101008 T CY111101008 T CY 111101008T CY 1111978 T1 CY1111978 T1 CY 1111978T1
Authority
CY
Cyprus
Prior art keywords
macrolides
consumption
inflammatory action
inflammatory
action
Prior art date
Application number
CY20111101008T
Other languages
English (en)
Inventor
Mladen Mercep
Milan Mesic
Linda Tomaskovic
Stribor Markovic
Boska Hrvacic
Oresta Makaruha
Vionja Poljak
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of CY1111978T1 publication Critical patent/CY1111978T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέες ενώσεις παριστώμενες από τον Τύπο (Ι),
CY20111101008T 2003-04-24 2011-10-25 Συζυγη μακρολιδων με αντιφλεγμονωδη δραση CY1111978T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20030324A HRP20030324A2 (en) 2003-04-24 2003-04-24 Compounds of antiinflammatory effect
EP09075145A EP2070940B1 (en) 2003-04-24 2004-04-23 Macrolide-conjugates with anti-inflammatory activity

Publications (1)

Publication Number Publication Date
CY1111978T1 true CY1111978T1 (el) 2015-11-04

Family

ID=33307078

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091101070T CY1109491T1 (el) 2003-04-24 2009-10-14 Συζυγη μακρολιδων με αντιφλεγμονωδη δραση
CY20111101008T CY1111978T1 (el) 2003-04-24 2011-10-25 Συζυγη μακρολιδων με αντιφλεγμονωδη δραση

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20091101070T CY1109491T1 (el) 2003-04-24 2009-10-14 Συζυγη μακρολιδων με αντιφλεγμονωδη δραση

Country Status (27)

Country Link
US (1) US7579334B2 (el)
EP (2) EP1633771B1 (el)
JP (1) JP4613366B2 (el)
KR (1) KR101107336B1 (el)
CN (1) CN100393741C (el)
AR (1) AR044083A1 (el)
AT (1) ATE518876T1 (el)
AU (1) AU2004232546B2 (el)
BR (1) BRPI0410490A (el)
CA (1) CA2523081C (el)
CL (1) CL2004000872A1 (el)
CY (2) CY1109491T1 (el)
DE (1) DE602004022047D1 (el)
DK (2) DK1633771T3 (el)
ES (2) ES2370371T3 (el)
HR (3) HRP20030324A2 (el)
IS (2) IS2736B (el)
ME (1) MEP34708A (el)
MX (1) MXPA05011359A (el)
NO (2) NO333909B1 (el)
PL (2) PL2070940T3 (el)
PT (2) PT1633771E (el)
RS (1) RS52621B (el)
RU (1) RU2355699C2 (el)
SI (2) SI2070940T1 (el)
WO (1) WO2004094449A1 (el)
ZA (1) ZA200508388B (el)

Families Citing this family (16)

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US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
MX2007001669A (es) * 2004-08-12 2007-04-10 Glaxosmithkline Zagreb Uso de conjugados especificos celulares para el tratamiento de enfermedades inflamatorias del tracto gastrointestinal.
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
DE602005018672D1 (de) * 2004-10-27 2010-02-11 Glaxosmithkline Zagreb Konjugate mit entzündungshemmender aktivität
EP1962855B1 (en) * 2005-12-22 2013-08-21 Hydra Biosciences, Inc. Trpa1 inhibitors for treating pain
WO2007093840A2 (en) * 2006-02-15 2007-08-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
CN101969931A (zh) * 2008-03-05 2011-02-09 万能药生物有限公司 包含霉酚酸的调节释放药物组合物及其方法
CN102838660B (zh) * 2011-06-23 2016-11-02 上海市第一人民医院 一种抑制炎症免疫反应的小肽及其应用
WO2014115167A2 (en) * 2013-01-23 2014-07-31 Sphaera Pharma Pvt. Ltd. Novel compounds of 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion
KR20150128856A (ko) * 2013-03-08 2015-11-18 알러간, 인코포레이티드 스테로이드 약물과 결합된 항생제 컨쥬게이트
US20140256666A1 (en) * 2013-03-08 2014-09-11 Allergan, Inc. Antibiotic conjugates with nonsteroidal anti-inflammatory drugs
WO2014138359A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid antibiotic conjugates
BR112015021836A2 (pt) 2013-03-08 2017-07-18 Allergan Inc conjugados de antibióticos diretamente ligados com drogas esteroides
WO2016013030A2 (en) 2014-07-23 2016-01-28 Sphaera Pharma Pvt. Ltd. Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof

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SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
DK0675897T3 (da) 1992-12-24 1998-01-26 Rhone Poulenc Rorer Ltd Nye steroider
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JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
EP1126838A4 (en) * 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
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HRP20000310A2 (en) 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
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CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
WO2004005309A2 (en) 2002-07-08 2004-01-15 Pliva - Istrazivacki Institut D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect

Also Published As

Publication number Publication date
MXPA05011359A (es) 2006-05-12
PT1633771E (pt) 2009-10-20
DE602004022047D1 (de) 2009-08-27
EP2070940A1 (en) 2009-06-17
US7579334B2 (en) 2009-08-25
CN100393741C (zh) 2008-06-11
NO20130898L (no) 2006-01-16
ES2330109T3 (es) 2009-12-04
HRP20110763T1 (hr) 2011-11-30
JP4613366B2 (ja) 2011-01-19
US20050080003A1 (en) 2005-04-14
EP2070940B1 (en) 2011-08-03
CL2004000872A1 (es) 2005-03-18
NO333909B1 (no) 2013-10-14
ES2370371T3 (es) 2011-12-14
EP1633771A1 (en) 2006-03-15
NO335552B1 (no) 2014-12-29
KR20060024770A (ko) 2006-03-17
SI1633771T1 (sl) 2009-12-31
RU2005131937A (ru) 2006-06-27
RS52621B (sr) 2013-06-28
AU2004232546B2 (en) 2011-06-09
IS2736B (is) 2011-06-15
HK1086842A1 (zh) 2006-09-29
PL1633771T3 (pl) 2009-12-31
PL2070940T3 (pl) 2011-12-30
PT2070940E (pt) 2011-11-14
IS8141A (is) 2005-11-22
ZA200508388B (en) 2006-07-26
MEP34708A (en) 2011-05-10
IS8941A (is) 2010-12-29
CN1777619A (zh) 2006-05-24
RS20050873A (sr) 2007-08-03
NO20055535L (no) 2006-01-16
EP1633771B1 (en) 2009-07-15
JP2006524221A (ja) 2006-10-26
EP2070940A3 (en) 2009-11-25
AR044083A1 (es) 2005-08-24
NO20055535D0 (no) 2005-11-23
BRPI0410490A (pt) 2006-06-13
ATE518876T1 (de) 2011-08-15
CA2523081A1 (en) 2004-11-04
RU2355699C2 (ru) 2009-05-20
HRP20030324A2 (en) 2005-02-28
DK2070940T3 (da) 2011-10-31
CY1109491T1 (el) 2014-08-13
KR101107336B1 (ko) 2012-01-19
WO2004094449A8 (en) 2005-03-31
AU2004232546A1 (en) 2004-11-04
DK1633771T3 (da) 2009-11-16
SI2070940T1 (sl) 2011-12-30
HK1129681A1 (en) 2009-12-04
HRP20090551T1 (hr) 2010-01-31
CA2523081C (en) 2010-08-03
WO2004094449A1 (en) 2004-11-04

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