CY1119082T1 - Συνδυασμος επιλεγμενων αναλγητικων με αναστολεις cox ii - Google Patents

Συνδυασμος επιλεγμενων αναλγητικων με αναστολεις cox ii

Info

Publication number
CY1119082T1
CY1119082T1 CY20171100762T CY171100762T CY1119082T1 CY 1119082 T1 CY1119082 T1 CY 1119082T1 CY 20171100762 T CY20171100762 T CY 20171100762T CY 171100762 T CY171100762 T CY 171100762T CY 1119082 T1 CY1119082 T1 CY 1119082T1
Authority
CY
Cyprus
Prior art keywords
alkyl
hydrogen
optionally substituted
och
hydroxy
Prior art date
Application number
CY20171100762T
Other languages
English (en)
Inventor
Klaus Schiene
Günter Haase
Babette-Yvonne Kögel
Elmar Friderichs
Ulrich Jahnel
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32395002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119082(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10254785A external-priority patent/DE10254785A1/de
Priority claimed from DE2003126103 external-priority patent/DE10326103A1/de
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1119082T1 publication Critical patent/CY1119082T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η εφεύρεση αφορά στον συνδυασμό από αναλγητικά της ομάδας Α με αναστολείς COX II της ομάδας Β, σε φάρμακα, συμπεριλαμβανομένων ευνοϊκών γαληνικών μορφών, τα οποία περιέχουν τον συνδυασμό αυτό και στην χρησιμοποίηση τους ειδικότερα για τη θεραπεία πόνου.
CY20171100762T 2002-11-22 2017-07-18 Συνδυασμος επιλεγμενων αναλγητικων με αναστολεις cox ii CY1119082T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10254785A DE10254785A1 (de) 2002-11-22 2002-11-22 Kombination ausgewählter Analgetika mit COX II-Inhibitoren
DE2003126103 DE10326103A1 (de) 2003-06-06 2003-06-06 Kombination ausgewählter Analgetika mit COX II-Inhibitoren
PCT/EP2003/012882 WO2004047823A1 (de) 2002-11-22 2003-11-18 Kombination ausgewählter analgetika mit cox ii-inhibitoren

Publications (1)

Publication Number Publication Date
CY1119082T1 true CY1119082T1 (el) 2018-01-10

Family

ID=32395002

Family Applications (4)

Application Number Title Priority Date Filing Date
CY20081100631T CY1108141T1 (el) 2002-11-22 2008-06-12 Χρησιμοποιηση (1rs,3rs,6rs)-6-διμεθυλαμινομεθυλο-1-(3-μεθοξυφαινυλο)-κυκλοεξανο-1,3-διολης για τη θεραπεια φλεγμονωδους πονου
CY20101100665T CY1110246T1 (el) 2002-11-22 2010-07-15 Χρησιμοποιηση (1r,2r)-3(3-διμεθυλαμινο-1-αιθυλο-2-μεθυλο-προπυλο)-φαινολης για τη θεραπεια φλεγμονωδους πονου
CY20171100762T CY1119082T1 (el) 2002-11-22 2017-07-18 Συνδυασμος επιλεγμενων αναλγητικων με αναστολεις cox ii
CY20201100793T CY1123286T1 (el) 2002-11-22 2020-08-25 Χρηση (1r,2r)-3-(3-διμεθυλαμινο-1-αιθυλ-2-μεθυλ-προπυλ)-φαινολης για την αγωγη του φλεγμονωδους πονου

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20081100631T CY1108141T1 (el) 2002-11-22 2008-06-12 Χρησιμοποιηση (1rs,3rs,6rs)-6-διμεθυλαμινομεθυλο-1-(3-μεθοξυφαινυλο)-κυκλοεξανο-1,3-διολης για τη θεραπεια φλεγμονωδους πονου
CY20101100665T CY1110246T1 (el) 2002-11-22 2010-07-15 Χρησιμοποιηση (1r,2r)-3(3-διμεθυλαμινο-1-αιθυλο-2-μεθυλο-προπυλο)-φαινολης για τη θεραπεια φλεγμονωδους πονου

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20201100793T CY1123286T1 (el) 2002-11-22 2020-08-25 Χρηση (1r,2r)-3-(3-διμεθυλαμινο-1-αιθυλ-2-μεθυλ-προπυλ)-φαινολης για την αγωγη του φλεγμονωδους πονου

Country Status (13)

Country Link
US (7) US7786160B2 (el)
EP (6) EP1562567B1 (el)
AT (2) ATE465726T1 (el)
AU (1) AU2003283410A1 (el)
CY (4) CY1108141T1 (el)
DE (2) DE50312678D1 (el)
DK (4) DK1685829T3 (el)
ES (4) ES2819854T3 (el)
HU (2) HUE051024T2 (el)
LT (1) LT1562567T (el)
PT (4) PT1685829E (el)
SI (4) SI1685829T1 (el)
WO (1) WO2004047823A1 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE465726T1 (de) 2002-11-22 2010-05-15 Gruenenthal Gmbh Verwendung von (1r, 2r)-3-(3-dimenthylamino-1- ethyl-2-methyl-propyl)-phenol zur behandlung von entzündungsschmerz
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen
CN101431990B (zh) * 2006-04-28 2011-08-03 格吕伦塔尔有限公司 包含3-（3-二甲基氨基-1-乙基-2-甲基-丙基）-酚和对乙酰氨基酚的药物结合
HRP20110271T1 (hr) * 2006-04-28 2011-05-31 Grnenthal Gmbh Farmaceutska kombinacija koja sadrži 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol i nsaid (nesteroidni antiinflamatorni lijek)
US20070254960A1 (en) * 2006-04-28 2007-11-01 Gruenenthal Gmbh Pharmaceutical combination
DE102007012165A1 (de) * 2007-03-12 2008-09-18 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes
DE102007022790A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur Schmerzbehandlung bei Arthrose
EP2219633A2 (en) * 2007-11-23 2010-08-25 Nectid, Inc. Tapentadol compositions
EP2085081A1 (de) 2008-02-04 2009-08-05 Grünenthal GmbH 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz
US20100190752A1 (en) 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
MX2011002117A (es) * 2008-09-05 2011-03-28 Gruenenthal Gmbh Combinacion farmaceutica que comprenden 6-dimetilaminometil-1-(3-m etoxi-fenil)-ciclohexano-1,3-diol y un aines.
BRPI0918566A2 (pt) * 2008-09-05 2016-02-10 Gruenenthal Gmbh combinacao farmacêutica compreendendo 6-dimetilanometil-1-(3-metóxifenil)-ciclo-hexano-1,3-diol e paracetamol
ES2758831T3 (es) * 2008-10-30 2020-05-06 Gruenenthal Gmbh Nuevas y potentes formas de dosificación de tapentadol
JP5993303B2 (ja) * 2009-04-30 2016-09-14 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング リウマチ性痛を治療するための１−フェニル−３−ジメチルアミノプロパン化合物の使用
WO2011023392A1 (en) * 2009-08-28 2011-03-03 Grünenthal GmbH Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic
CN104276960B (zh) * 2014-09-26 2016-09-28 安徽省逸欣铭医药科技有限公司 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5472711A (en) 1992-07-30 1995-12-05 Edward Mendell Co., Inc. Agglomerated hydrophilic complexes with multi-phasic release characteristics
US5330761A (en) 1993-01-29 1994-07-19 Edward Mendell Co. Inc. Bioadhesive tablet for non-systemic use products
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5399362A (en) 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
DE4425459C2 (de) 1994-07-19 1997-11-27 Meinecke Ag H Woltmannzähler
IT1276322B1 (it) 1994-07-21 1997-10-28 Vbc Srl Procedimento per la purificazione dell'idrossido di magnesio
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
EP0945134A1 (de) 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Neue galenische Zubereitungsformen von Meloxicam zur oralen Applikation
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
AU3384200A (en) * 1999-03-01 2000-09-21 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and a selective cox-2 inhibitor drug
CA2362816C (en) 1999-12-08 2007-02-06 Pharmacia Corporation Valdecoxib compositions
DE10000312A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
MY120279A (en) 2000-05-26 2005-09-30 Pharmacia Corp Use of a celecoxib composition for fast pain relief
DE10049483A1 (de) 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10059412A1 (de) 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz
DE10059411A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10109763A1 (de) 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
PE20030527A1 (es) * 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
DE10225315A1 (de) * 2002-06-06 2003-12-24 Gruenenthal Gmbh Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol
DE10250083A1 (de) * 2002-06-17 2003-12-24 Gruenenthal Gmbh Gegen Missbrauch gesicherte Darreichungsform
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
ATE465726T1 (de) * 2002-11-22 2010-05-15 Gruenenthal Gmbh Verwendung von (1r, 2r)-3-(3-dimenthylamino-1- ethyl-2-methyl-propyl)-phenol zur behandlung von entzündungsschmerz

Also Published As

Publication number Publication date
SI1562567T1 (sl) 2017-09-29
EP1839654B9 (de) 2012-01-11
DK1839654T3 (da) 2010-08-16
US7786160B2 (en) 2010-08-31
ES2819854T3 (es) 2021-04-19
EP1839654A2 (de) 2007-10-03
US20130109733A1 (en) 2013-05-02
CY1123286T1 (el) 2021-12-31
EP3241550A1 (de) 2017-11-08
DE50309605D1 (de) 2008-05-21
SI1685829T1 (sl) 2008-08-31
EP1839654B1 (de) 2010-04-28
US8618177B2 (en) 2013-12-31
US20050277687A1 (en) 2005-12-15
US8404749B2 (en) 2013-03-26
ES2640404T3 (es) 2017-11-02
PT3241550T (pt) 2020-08-11
EP3241550B1 (de) 2020-07-22
ES2345062T3 (es) 2010-09-14
PT1562567T (pt) 2017-08-24
ES2304659T3 (es) 2008-10-16
LT1562567T (lt) 2017-08-25
US20100280126A1 (en) 2010-11-04
SI1839654T1 (sl) 2010-08-31
DK3241550T3 (da) 2020-08-24
DE50312678D1 (de) 2010-06-10
EP1839654A3 (de) 2007-11-07
HUE033042T2 (en) 2017-11-28
CY1110246T1 (el) 2015-01-14
SI3241550T1 (sl) 2020-11-30
DK1685829T3 (da) 2008-07-21
US20070249724A1 (en) 2007-10-25
HUE051024T2 (hu) 2021-03-01
EP1685829B1 (de) 2008-04-09
AU2003283410A1 (en) 2004-06-18
EP3662904A1 (de) 2020-06-10
US20100280129A1 (en) 2010-11-04
EP1562567A1 (de) 2005-08-17
US20100280017A1 (en) 2010-11-04
EP1908460A1 (de) 2008-04-09
PT1685829E (pt) 2008-05-15
DK1562567T3 (en) 2017-07-17
US10471079B2 (en) 2019-11-12
US8003701B2 (en) 2011-08-23
PT1839654E (pt) 2010-07-06
ATE391498T1 (de) 2008-04-15
EP1685829A1 (de) 2006-08-02
EP1562567B1 (de) 2017-06-14
CY1108141T1 (el) 2014-04-09
US8420691B2 (en) 2013-04-16
US20160279150A1 (en) 2016-09-29
WO2004047823A1 (de) 2004-06-10
ATE465726T1 (de) 2010-05-15

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