CY2342B1 - Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product. - Google Patents

Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product.

Info

Publication number: CY2342B1
Authority: CY; Cyprus
Prior art keywords: isoquinolin; benz; azabicyclo; tetrahydro; oct
Prior art date: 1994-07-08

Application number

CY0300029A

Other languages

English (en)

Inventor

Charles Alois Dvorak

Bruce Andrew Kowalczyk

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-08

Filing date

2003-03-18

Publication date

2004-02-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23040964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2342(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-03-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-02-06 Publication of CY2342B1 publication Critical patent/CY2342B1/xx

Links

DIDFYSQVOPVZQB-UHFFFAOYSA-N 2-(1-azabicyclo[2.2.2]octan-3-yl)-5,6-dihydro-4h-benzo[de]isoquinolin-1-one Chemical compound C1N(CC2)CCC2C1N1C(=O)C(C=CC=C2CCC3)=C2C3=C1 DIDFYSQVOPVZQB-UHFFFAOYSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
CPZBLNMUGSZIPR-RDJZCZTQSA-N (3ar)-2-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3h-benzo[de]isoquinolin-1-one Chemical compound C1N(CC2)CCC2[C@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@@H]3C1 CPZBLNMUGSZIPR-RDJZCZTQSA-N 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CY0300029A 1994-07-08 2003-03-18 Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product. CY2342B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/272,715 US5567818A (en)	1994-07-08	1994-07-08	Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein

Publications (1)

Publication Number	Publication Date
CY2342B1 true CY2342B1 (en)	2004-02-06

Family

ID=23040964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0300029A CY2342B1 (en)	1994-07-08	2003-03-18	Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product.

Country Status (16)

Country	Link
US (1)	US5567818A (de)
EP (1)	EP0770077B1 (de)
JP (1)	JP2898758B2 (de)
CN (1)	CN1048727C (de)
AT (1)	ATE205845T1 (de)
AU (1)	AU2979995A (de)
BR (1)	BR9508249A (de)
CL (2)	CL2004001244A1 (de)
CY (1)	CY2342B1 (de)
DE (1)	DE69522808T2 (de)
DK (1)	DK0770077T3 (de)
ES (1)	ES2162929T3 (de)
FI (1)	FI120198B (de)
MX (1)	MX9700157A (de)
PT (1)	PT770077E (de)
WO (1)	WO1996001824A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL201703B1 (pl)	2000-04-20	2009-04-30	Masonite Corp	Wyrób z kompozytu drewna dwukierunkowo ukształtowany i sposób jego wytwarzania oraz zestaw boazerii i dwukierunkowo ukształtowana okładzina drzwiowa, i jej sposób formowania jak również drzwi zawierające okładzinę drzwiową
JO2735B1 (en) *	2003-01-30	2013-09-15	هيلسين هيلث كير أس ايه.	Liquid pharmaceutical formulations of palonosetron
US8598219B2 (en)	2003-01-30	2013-12-03	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
US8614225B2 (en) *	2006-08-30	2013-12-24	Dr. Reddy's Laboratories Limited	Process for the purification of palonosetron or its salt
US20100016593A1 (en) *	2006-10-23	2010-01-21	Pierluigi Rossetto	Crystalline forms of palonosetron hydrochloride
JP2010512333A (ja) *	2006-12-07	2010-04-22	ヘルシンヘルスケアソシエテアノニム	塩酸パロノセトロンの結晶及び非晶質形
EP2155199A4 (de) *	2007-05-29	2011-08-24	Chemagis Ltd	Neue palonosetron-salze und verfahren zu ihrer herstellung und reinigung
WO2009010987A1 (en) *	2007-07-19	2009-01-22	Natco Pharma Limited	An improved process for the preparation of pure palonosetron hydrochloride
AR069625A1 (es) *	2007-12-13	2010-02-03	Glenmark Generics Ltd	Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (en) *	2008-01-11	2009-07-16	Natco Pharma Limited	Novel crystalline forms of palonosetron hydrochloride
WO2009136405A1 (en) *	2008-05-05	2009-11-12	Natco Pharma Limited	High purity palonosetron base and its solid state characteristics
EP2364312A4 (de) *	2008-11-11	2012-05-02	Reddys Lab Ltd Dr	Herstellung von kristallinem palonosetron-hydrochlorid
CN101851233B (zh) *	2009-04-03	2013-03-06	四川滇虹医药开发有限公司	盐酸帕洛诺司琼和其前体化合物及制备
US20120267533A1 (en)	2009-06-30	2012-10-25	Ranbaxy Laboratories Limited	Processes for the preparation of form i and form ii of palonosetron hydrochloride
WO2011013095A1 (en)	2009-07-31	2011-02-03	Ranbaxy Laboratories Limited	Processes for the preparation of palonosetron
JP2014070036A (ja) *	2012-09-28	2014-04-21	Mitsubishi Gas Chemical Co Inc	１，８−テトラリンジカルボン酸無水物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4007191A (en) *	1975-10-14	1977-02-08	E. R. Squibb & Sons, Inc.	2-(Piperidinyl or tetrahydropyridinyl)-alkyl)-2,3-dihydro-3-hydroxy-1H-benz(DE)isoquinolin-1-ones
AU642178B2 (en) *	1989-11-28	1993-10-14	Roche Palo Alto Llc	New tricyclic compounds
US5202318A (en) *	1990-05-14	1993-04-13	Syntex (U.S.A.) Inc.	Tricyclic compounds acting at serotonin receptor subtypes

1994
- 1994-07-08 US US08/272,715 patent/US5567818A/en not_active Expired - Lifetime
1995
- 1995-07-01 MX MX9700157A patent/MX9700157A/es unknown
- 1995-07-01 DK DK95925803T patent/DK0770077T3/da active
- 1995-07-01 AT AT95925803T patent/ATE205845T1/de active
- 1995-07-01 DE DE69522808T patent/DE69522808T2/de not_active Expired - Lifetime
- 1995-07-01 BR BR9508249A patent/BR9508249A/pt active IP Right Grant
- 1995-07-01 WO PCT/EP1995/002556 patent/WO1996001824A1/en not_active Ceased
- 1995-07-01 AU AU29799/95A patent/AU2979995A/en not_active Abandoned
- 1995-07-01 ES ES95925803T patent/ES2162929T3/es not_active Expired - Lifetime
- 1995-07-01 EP EP95925803A patent/EP0770077B1/de not_active Expired - Lifetime
- 1995-07-01 PT PT95925803T patent/PT770077E/pt unknown
- 1995-07-01 CN CN95194002A patent/CN1048727C/zh not_active Expired - Lifetime
- 1995-07-01 JP JP8504091A patent/JP2898758B2/ja not_active Expired - Lifetime
1997
- 1997-01-07 FI FI970068A patent/FI120198B/fi not_active IP Right Cessation
2003
- 2003-03-18 CY CY0300029A patent/CY2342B1/xx unknown
2004
- 2004-05-20 CL CL200401244A patent/CL2004001244A1/es unknown
2007
- 2007-07-05 CL CL200701958A patent/CL2007001958A1/es unknown

Also Published As

Publication number	Publication date
EP0770077B1 (de)	2001-09-19
EP0770077A1 (de)	1997-05-02
CN1152313A (zh)	1997-06-18
CN1048727C (zh)	2000-01-26
US5567818A (en)	1996-10-22
FI970068A7 (fi)	1997-01-07
PT770077E (pt)	2002-02-28
CL2007001958A1 (es)	2008-02-22
JPH09508645A (ja)	1997-09-02
BR9508249A (pt)	1998-01-06
DE69522808T2 (de)	2002-04-04
JP2898758B2 (ja)	1999-06-02
DE69522808D1 (de)	2001-10-25
ES2162929T3 (es)	2002-01-16
DK0770077T3 (da)	2002-01-14
FI120198B (fi)	2009-07-31
WO1996001824A1 (en)	1996-01-25
CL2004001244A1 (es)	2005-04-15
MX9700157A (es)	1997-04-30
ATE205845T1 (de)	2001-10-15
FI970068A0 (fi)	1997-01-07
AU2979995A (en)	1996-02-09

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