CY2342B1 - Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product. - Google Patents

Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product.

Info

Publication number: CY2342B1
Authority: CY; Cyprus
Prior art keywords: isoquinolin; benz; azabicyclo; tetrahydro; oct
Prior art date: 1994-07-08

Application number

CY0300029A

Other languages

English (en)

Inventor

Charles Alois Dvorak

Bruce Andrew Kowalczyk

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-08

Filing date

2003-03-18

Publication date

2004-02-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23040964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2342(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-03-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-02-06 Publication of CY2342B1 publication Critical patent/CY2342B1/xx

Links

DIDFYSQVOPVZQB-UHFFFAOYSA-N 2-(1-azabicyclo[2.2.2]octan-3-yl)-5,6-dihydro-4h-benzo[de]isoquinolin-1-one Chemical compound C1N(CC2)CCC2C1N1C(=O)C(C=CC=C2CCC3)=C2C3=C1 DIDFYSQVOPVZQB-UHFFFAOYSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
CPZBLNMUGSZIPR-RDJZCZTQSA-N (3ar)-2-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3h-benzo[de]isoquinolin-1-one Chemical compound C1N(CC2)CCC2[C@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@@H]3C1 CPZBLNMUGSZIPR-RDJZCZTQSA-N 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CY0300029A 1994-07-08 2003-03-18 Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product. CY2342B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/272,715 US5567818A (en)	1994-07-08	1994-07-08	Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein

Publications (1)

Publication Number	Publication Date
CY2342B1 true CY2342B1 (en)	2004-02-06

Family

ID=23040964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0300029A CY2342B1 (en)	1994-07-08	2003-03-18	Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1H-benz(de)isoquinolin-1-one and intermediate product.

Country Status (16)

Country	Link
US (1)	US5567818A (de)
EP (1)	EP0770077B1 (de)
JP (1)	JP2898758B2 (de)
CN (1)	CN1048727C (de)
AT (1)	ATE205845T1 (de)
AU (1)	AU2979995A (de)
BR (1)	BR9508249A (de)
CL (2)	CL2004001244A1 (de)
CY (1)	CY2342B1 (de)
DE (1)	DE69522808T2 (de)
DK (1)	DK0770077T3 (de)
ES (1)	ES2162929T3 (de)
FI (1)	FI120198B (de)
MX (1)	MX9700157A (de)
PT (1)	PT770077E (de)
WO (1)	WO1996001824A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1437525B (zh)	2000-04-20	2013-09-04	梅森奈特公司	木材复合制品和制造反向模制的木材复合制品的方法
US8598219B2 (en)	2003-01-30	2013-12-03	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) *	2003-01-30	2013-09-15	هيلسين هيلث كير أس ايه.	Liquid pharmaceutical formulations of palonosetron
US8614225B2 (en) *	2006-08-30	2013-12-24	Dr. Reddy's Laboratories Limited	Process for the purification of palonosetron or its salt
HRPK20100281B3 (hr) *	2006-10-23	2012-01-31	Sicor Inc.	Kristalni oblici palonosetron hidroklorida
JP2010512333A (ja) *	2006-12-07	2010-04-22	ヘルシンヘルスケアソシエテアノニム	塩酸パロノセトロンの結晶及び非晶質形
WO2008146283A2 (en) *	2007-05-29	2008-12-04	Chemagis Ltd.	Novel palonosetron salts and processes for preparation and purification thereof
WO2009010987A1 (en) *	2007-07-19	2009-01-22	Natco Pharma Limited	An improved process for the preparation of pure palonosetron hydrochloride
AR069625A1 (es) *	2007-12-13	2010-02-03	Glenmark Generics Ltd	Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (en) *	2008-01-11	2009-07-16	Natco Pharma Limited	Novel crystalline forms of palonosetron hydrochloride
WO2009136405A1 (en) *	2008-05-05	2009-11-12	Natco Pharma Limited	High purity palonosetron base and its solid state characteristics
EP2364312A4 (de) *	2008-11-11	2012-05-02	Reddys Lab Ltd Dr	Herstellung von kristallinem palonosetron-hydrochlorid
CN101851233B (zh) *	2009-04-03	2013-03-06	四川滇虹医药开发有限公司	盐酸帕洛诺司琼和其前体化合物及制备
EP2448936A2 (de)	2009-06-30	2012-05-09	Ranbaxy Laboratories Limited	Verfahren zur herstellung von palonosetronhydrochlorid form i und form ii
WO2011013095A1 (en)	2009-07-31	2011-02-03	Ranbaxy Laboratories Limited	Processes for the preparation of palonosetron
JP2014070036A (ja) *	2012-09-28	2014-04-21	Mitsubishi Gas Chemical Co Inc	１，８−テトラリンジカルボン酸無水物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4007191A (en) *	1975-10-14	1977-02-08	E. R. Squibb & Sons, Inc.	2-(Piperidinyl or tetrahydropyridinyl)-alkyl)-2,3-dihydro-3-hydroxy-1H-benz(DE)isoquinolin-1-ones
NZ236225A (en) *	1989-11-28	1992-09-25	Syntex Inc	Azabicyclic-substituted isoquinoline derivatives, intermediates and pharmaceutical compositions
US5202318A (en) *	1990-05-14	1993-04-13	Syntex (U.S.A.) Inc.	Tricyclic compounds acting at serotonin receptor subtypes

1994
- 1994-07-08 US US08/272,715 patent/US5567818A/en not_active Expired - Lifetime
1995
- 1995-07-01 CN CN95194002A patent/CN1048727C/zh not_active Expired - Lifetime
- 1995-07-01 PT PT95925803T patent/PT770077E/pt unknown
- 1995-07-01 DK DK95925803T patent/DK0770077T3/da active
- 1995-07-01 ES ES95925803T patent/ES2162929T3/es not_active Expired - Lifetime
- 1995-07-01 MX MX9700157A patent/MX9700157A/es unknown
- 1995-07-01 JP JP8504091A patent/JP2898758B2/ja not_active Expired - Lifetime
- 1995-07-01 WO PCT/EP1995/002556 patent/WO1996001824A1/en not_active Ceased
- 1995-07-01 BR BR9508249A patent/BR9508249A/pt active IP Right Grant
- 1995-07-01 EP EP95925803A patent/EP0770077B1/de not_active Expired - Lifetime
- 1995-07-01 DE DE69522808T patent/DE69522808T2/de not_active Expired - Lifetime
- 1995-07-01 AT AT95925803T patent/ATE205845T1/de active
- 1995-07-01 AU AU29799/95A patent/AU2979995A/en not_active Abandoned
1997
- 1997-01-07 FI FI970068A patent/FI120198B/fi not_active IP Right Cessation
2003
- 2003-03-18 CY CY0300029A patent/CY2342B1/xx unknown
2004
- 2004-05-20 CL CL200401244A patent/CL2004001244A1/es unknown
2007
- 2007-07-05 CL CL200701958A patent/CL2007001958A1/es unknown

Also Published As

Publication number	Publication date
CN1152313A (zh)	1997-06-18
JPH09508645A (ja)	1997-09-02
BR9508249A (pt)	1998-01-06
EP0770077B1 (de)	2001-09-19
MX9700157A (es)	1997-04-30
DE69522808T2 (de)	2002-04-04
US5567818A (en)	1996-10-22
FI970068A7 (fi)	1997-01-07
CN1048727C (zh)	2000-01-26
PT770077E (pt)	2002-02-28
CL2007001958A1 (es)	2008-02-22
WO1996001824A1 (en)	1996-01-25
FI970068A0 (fi)	1997-01-07
ES2162929T3 (es)	2002-01-16
DE69522808D1 (de)	2001-10-25
ATE205845T1 (de)	2001-10-15
AU2979995A (en)	1996-02-09
EP0770077A1 (de)	1997-05-02
JP2898758B2 (ja)	1999-06-02
DK0770077T3 (da)	2002-01-14
CL2004001244A1 (es)	2005-04-15
FI120198B (fi)	2009-07-31

Publication	Publication Date	Title
AU2979995A (en)	1996-02-09	Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1h-benz(de)isoquinolin-1-one and intermediate product
NZ294191A (en)	1998-10-28	Process for preparing 4a,5,9,10,11,12-hexahydro-6h-benzofuro[3a,3,2-ef][2]benzazepine derivatives and intermediates thereof
AU2781997A (en)	1997-12-05	Process for the production of 1,4-butanediol, gamma-butyrolactone and tetrahydrofuran
AU4631596A (en)	1996-09-04	Process for the microbiological production of pha-polymers
SG43113A1 (en)	1997-10-17	Process for the preparation of lactam
HRP960253B1 (en)	2000-10-31	Process for the hydrogenation of imines
EP0673920A3 (de)	1995-11-22	Verfahren zur Herstellung von Ethanolaminen.
SG65610A1 (en)	1999-06-22	Process for the preparation of lactams
AU4729396A (en)	1996-10-08	Process for the preparation of 1,2-benzisothiazolin-3-ones
IL118788A0 (en)	1996-10-31	Process for the hydrogenation of imines
EP0690053A3 (de)	1997-03-05	Verfahren zur Herstellung von 2,5-Dihydrofuran
AU6657296A (en)	1997-02-26	Process for the hydrogenation of imines
GB9516444D0 (en)	1995-10-11	Process for the production of n,n-dimethyl-n'-phenylureas
AU6778796A (en)	1997-03-12	Process for the preparation of 1,4-butenediol
CA2370145A1 (en)	2001-04-19	Process of preparing a high-energy softening agent
EP0430096A3 (en)	1991-12-27	Process for the production of 3,4-epoxybutyrate and intermediate therefor
IL118731A0 (en)	1996-10-16	Process for the preparation of 2,2-dialkyl-arylidene-cycloalkanones
AU1681895A (en)	1995-08-08	Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates
AU6733596A (en)	1997-02-26	Process for the hydrogenation of imines
AU4300397A (en)	1998-04-02	Process for the manufacture of (2'-fluorophenyl)-3-halopyridines
IL120556A (en)	2000-11-21	Process for the preparation of 3,3,5-trichloroglutarimide
IL129511A (en)	2003-03-12	Method of making (1s, 4r)-1-azabicyclo [2.2.1] heptan-3-one and (1r, 4s) 1-azabicyclo [2.2.1] heptan-3-one
HUP9602374A3 (en)	1998-01-28	2-azabicyclo[3,3,0]octan derivates, process for producing them and pharmaceutical compositions containing the same
HUP0100578A3 (en)	2002-08-28	Process for the preparation of 8-azabicyclo[3.2.1]octane derivatives and the novel intermediates
IL119112A0 (en)	1996-11-14	Process for the preparation of 4,6-dichloropyrimidines