CY2531B1 - Guanine derivative - Google Patents

Guanine derivative

Info

Publication number: CY2531B1
Authority: CY; Cyprus
Prior art keywords: guanine derivative; guanine; derivative
Prior art date: 1995-01-20

Application number

CY0500061A

Other languages

English (en)

Inventor

Barry Howard Carter

Jane Muse Partin

Peter Gregory Varlashkin

Richard Augustus Winnike

William Bayne Grubb Iii

Gregory Alan Conway

Philip George Lake

David Michael Skinner

David James Whatrup

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-20

Filing date

2005-11-16

Publication date

2006-04-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2531(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-11-16 Application filed by Wellcome Found filed Critical Wellcome Found

2006-04-12 Publication of CY2531B1 publication Critical patent/CY2531B1/xx

Links

WJSVJNDMOQTICG-UHFFFAOYSA-N 2-amino-1-[(2-methyl-4-methylidene-5-oxooxolan-2-yl)methyl]-7h-purin-6-one Chemical compound NC1=NC=2N=CNC=2C(=O)N1CC1(C)CC(=C)C(=O)O1 WJSVJNDMOQTICG-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

CY0500061A 1995-01-20 2005-11-16 Guanine derivative CY2531B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9501178.9A GB9501178D0 (en)	1995-01-20	1995-01-20	Guanine derivative

Publications (1)

Publication Number	Publication Date
CY2531B1 true CY2531B1 (en)	2006-04-12

Family

ID=10768347

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0500061A CY2531B1 (en)	1995-01-20	2005-11-16	Guanine derivative

Country Status (40)

Country	Link
US (1)	US6107302A (cs)
EP (1)	EP0804436B1 (cs)
JP (1)	JP3176633B2 (cs)
KR (1)	KR100376074B1 (cs)
CN (1)	CN1049893C (cs)
AP (1)	AP662A (cs)
AR (1)	AR002270A1 (cs)
AT (1)	ATE302777T1 (cs)
AU (1)	AU702794B2 (cs)
BG (1)	BG63393B1 (cs)
BR (1)	BR9606768A (cs)
CA (1)	CA2210799C (cs)
CY (1)	CY2531B1 (cs)
CZ (1)	CZ297065B6 (cs)
DE (1)	DE69635106T2 (cs)
DK (1)	DK0804436T3 (cs)
EA (1)	EA000364B1 (cs)
EE (1)	EE03528B1 (cs)
ES (1)	ES2248806T3 (cs)
FI (1)	FI973063L (cs)
GB (1)	GB9501178D0 (cs)
GE (1)	GEP20001940B (cs)
HR (1)	HRP960024B1 (cs)
HU (1)	HU222993B1 (cs)
IL (1)	IL116831A (cs)
IN (1)	IN182468B (cs)
IS (1)	IS2268B (cs)
NO (1)	NO315558B1 (cs)
NZ (1)	NZ298851A (cs)
OA (1)	OA10499A (cs)
PL (1)	PL182175B1 (cs)
RO (1)	RO118693B1 (cs)
RS (1)	RS49518B (cs)
SI (1)	SI0804436T1 (cs)
SK (1)	SK285329B6 (cs)
TR (1)	TR199700656T1 (cs)
UA (1)	UA46001C2 (cs)
UY (1)	UY25779A1 (cs)
WO (1)	WO1996022291A1 (cs)
ZA (1)	ZA96449B (cs)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative
ATE254463T1 (de) *	1996-01-19	2003-12-15	Glaxo Group Ltd	Verwendung von valaciclovir zur herstellung eines arzneimittels zur behandlung von genitalherpes durch einmal tägliche verabreichung
IT1283447B1 (it) *	1996-07-18	1998-04-21	Ind Chimica Srl	Processo di preparazione del valaciclovir e relativi intermedi
EP0976750A4 (en) *	1997-01-17	2001-05-30	Ajinomoto Kk	NEW Z-VALACYCLOVIR CRYSTALS
GB0010446D0 (en) *	2000-04-28	2000-06-14	Glaxo Wellcome Kk	Pharmaceutical formulation
EE05643B1 (et) *	2001-02-24	2013-04-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina
EP1436295A4 (en) *	2001-09-07	2007-07-11	Teva Pharma	CRISTALLINE FORMS OF VALACYCLOVIR HYDROCHLORIDE
AU2002348022B2 (en) *	2001-11-05	2006-06-15	Glaxo Group Limited	Anhydrous crystal form of valaciclovir hydrochloride
CA2649826A1 (en) *	2001-11-14	2003-05-22	Teva Pharmaceutical Industries Ltd.	Synthesis and purification of valacyclovir
US20060147519A1 (en) *	2002-06-24	2006-07-06	Ashish Gogia	Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050043329A1 (en) *	2002-09-06	2005-02-24	Shlomit Wizel	Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) *	2002-10-16	2005-03-17	Ben-Zion Dolitzky	Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
ATE335743T1 (de) *	2002-10-16	2006-09-15	Teva Pharma	Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid
CA2548608A1 (en) *	2002-12-09	2004-06-24	Texcontor Etablissement	Anhydrous crystalline form of valacyclovir hydrochloride
US7786302B2 (en)	2003-05-30	2010-08-31	Eczacibasi-Zentiva Kimyasal Urunler Sanayi Ve Ticaret A.S.	Crystalline forms of valacyclovir hydrochloride
EP1638972A2 (en) *	2003-06-02	2006-03-29	Teva Pharmaceutical Industries Limited	Novel crystalline forms of valacyclovir hydrochloride
MXPA06008197A (es) *	2004-01-21	2007-04-02	Teva Pharma	Proceso para la preparacion de clorhidrato de valaciclovir.
US7501426B2 (en)	2004-02-18	2009-03-10	Boehringer Ingelheim International Gmbh	8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
EP1761535A1 (en) *	2004-06-30	2007-03-14	Teva Pharmaceutical Industries Ltd	Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20060178512A1 (en) *	2005-02-04	2006-08-10	Cheruthur Govindan	Method for preparing amino acid esters of nucleoside analogues
ES2379804T3 (es) *	2005-05-25	2012-05-03	Eli Lilly And Company	Ésteres de ciclopropanocarboxilato de aciclovir
EP1746098A1 (en)	2005-07-21	2007-01-24	SOLMAG S.p.A.	Valacyclovir polymorphs and a process for the preparation thereof
DE102005035891A1 (de) *	2005-07-30	2007-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20070112193A1 (en) *	2005-11-14	2007-05-17	Khunt Mayur D	Valacyclovir process
CN102838599A (zh)	2006-05-04	2012-12-26	贝林格尔.英格海姆国际有限公司	多晶型
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
EP1852108A1 (en)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	DPP IV inhibitor formulations
CN1903854B (zh) *	2006-08-09	2012-05-23	丽珠医药集团股份有限公司	一种合成盐酸伐昔洛韦的方法
US20080167325A1 (en) *	2006-12-27	2008-07-10	Bs Praveen Kumar	Valacyclovir compositions
US20080281099A1 (en) *	2007-05-07	2008-11-13	Mayur Devjibhai Khunt	Process for purifying valacyclovir hydrochloride and intermediates thereof
GB0710277D0 (en) *	2007-05-30	2007-07-11	Univ Birmingham	Use of antivirals in the treatment of medical disorders
AU2008290582B2 (en) *	2007-08-17	2014-08-14	Boehringer Ingelheim International Gmbh	Purin derivatives for use in the treatment of fab-related diseases
JPWO2009031576A1 (ja) *	2007-09-03	2010-12-16	味の素株式会社	バラシクロビル塩酸塩結晶の製造方法
US20090076039A1 (en) *	2007-09-14	2009-03-19	Protia, Llc	Deuterium-enriched valacyclovir
PE20091730A1 (es)	2008-04-03	2009-12-10	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) *	2008-06-03	2010-02-23	Boehringer Ingelheim Int	Tratamiento de nafld
KR20200118243A (ko)	2008-08-06	2020-10-14	베링거 인겔하임 인터내셔날 게엠베하	메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
MX370599B (es) *	2008-08-15	2019-12-18	Boehringer Ingelheim Int	Derivados de purina para su uso en el tratamiento de enfermedades relacionadas con fab.
BRPI0919288A2 (pt)	2008-09-10	2015-12-15	Boehring Ingelheim Internat Gmbh	teriapia de combinação para tratamento de diabetes e condições relacionadas.
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EA022310B1 (ru)	2008-12-23	2015-12-30	Бёрингер Ингельхайм Интернациональ Гмбх	Солевые формы органического соединения
AR074990A1 (es)	2009-01-07	2011-03-02	Boehringer Ingelheim Int	Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
NZ599298A (en)	2009-11-27	2014-11-28	Boehringer Ingelheim Int	Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
WO2011138421A1 (en)	2010-05-05	2011-11-10	Boehringer Ingelheim International Gmbh	Combination therapy
WO2011158252A1 (en)	2010-06-15	2011-12-22	Matrix Laboratories Ltd	Process for the preparation of valacyclovir hydrochloride polymorphic form ii
NZ603319A (en)	2010-06-24	2015-04-24	Boehringer Ingelheim Int	Diabetes therapy
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CN102584825B (zh) *	2011-01-17	2014-04-02	四川科伦药物研究有限公司	一种合成盐酸伐昔洛韦的方法
CA2841552C (en)	2011-07-15	2020-06-23	Boehringer Ingelheim International Gmbh	Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
EP2852592A4 (en) *	2011-11-25	2015-12-23	Piramal Entpr Ltd	PROCESS FOR THE PREPARATION OF VALACYCLOVIR CHLORHYDRATE
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US20130303554A1 (en)	2012-05-14	2013-11-14	Boehringer Ingelheim International Gmbh	Use of a dpp-4 inhibitor in sirs and/or sepsis
EP3685839A1 (en)	2012-05-14	2020-07-29	Boehringer Ingelheim International GmbH	Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es)	2014-02-28	2023-10-09	Boehringer Ingelheim Int	Uso médico de un inhibidor de DPP-4
WO2017211979A1 (en)	2016-06-10	2017-12-14	Boehringer Ingelheim International Gmbh	Combinations of linagliptin and metformin
CN110437231B (zh) *	2019-09-04	2022-04-29	上药康丽（常州）药业有限公司	一种盐酸伐昔洛韦无水晶型ⅰ的制备方法
US20230218644A1 (en)	2020-04-16	2023-07-13	Som Innovation Biotech, S.A.	Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP55A (en) *	1987-08-15	1989-09-26	The Wellcome Foundation Ltd	Therapeutic Acyclic Nucleosides
ES2157259T3 (es) *	1993-06-10	2001-08-16	Rolabo Sl	Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos.
GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative

1995
- 1995-01-20 GB GBGB9501178.9A patent/GB9501178D0/en active Pending
1996
- 1996-01-19 CN CN96192662A patent/CN1049893C/zh not_active Expired - Fee Related
- 1996-01-19 KR KR1019970704916A patent/KR100376074B1/ko not_active Expired - Lifetime
- 1996-01-19 SK SK965-97A patent/SK285329B6/sk not_active IP Right Cessation
- 1996-01-19 CA CA002210799A patent/CA2210799C/en not_active Expired - Fee Related
- 1996-01-19 ES ES96900631T patent/ES2248806T3/es not_active Expired - Lifetime
- 1996-01-19 PL PL96321326A patent/PL182175B1/pl not_active IP Right Cessation
- 1996-01-19 RO RO97-01334A patent/RO118693B1/ro unknown
- 1996-01-19 NZ NZ298851A patent/NZ298851A/xx not_active IP Right Cessation
- 1996-01-19 FI FI973063A patent/FI973063L/fi not_active Application Discontinuation
- 1996-01-19 DE DE69635106T patent/DE69635106T2/de not_active Expired - Lifetime
- 1996-01-19 AU AU44539/96A patent/AU702794B2/en not_active Ceased
- 1996-01-19 IL IL11683196A patent/IL116831A/en not_active IP Right Cessation
- 1996-01-19 DK DK96900631T patent/DK0804436T3/da active
- 1996-01-19 CZ CZ0229497A patent/CZ297065B6/cs not_active IP Right Cessation
- 1996-01-19 ZA ZA96449A patent/ZA96449B/xx unknown
- 1996-01-19 WO PCT/GB1996/000117 patent/WO1996022291A1/en not_active Ceased
- 1996-01-19 US US08/875,173 patent/US6107302A/en not_active Expired - Lifetime
- 1996-01-19 UA UA97084268A patent/UA46001C2/uk unknown
- 1996-01-19 HU HU9801836A patent/HU222993B1/hu not_active IP Right Cessation
- 1996-01-19 TR TR97/00656T patent/TR199700656T1/xx unknown
- 1996-01-19 SI SI9630717T patent/SI0804436T1/sl unknown
- 1996-01-19 JP JP52213196A patent/JP3176633B2/ja not_active Expired - Fee Related
- 1996-01-19 RS YU3396A patent/RS49518B/sr unknown
- 1996-01-19 EP EP96900631A patent/EP0804436B1/en not_active Expired - Lifetime
- 1996-01-19 AR ARP960101082A patent/AR002270A1/es not_active Application Discontinuation
- 1996-01-19 AP APAP/P/1997/001058A patent/AP662A/en active
- 1996-01-19 GE GEAP19963845A patent/GEP20001940B/en unknown
- 1996-01-19 HR HR960024A patent/HRP960024B1/xx not_active IP Right Cessation
- 1996-01-19 EE EE9700175A patent/EE03528B1/xx not_active IP Right Cessation
- 1996-01-19 BR BR9606768A patent/BR9606768A/pt active IP Right Grant
- 1996-01-19 EA EA199700124A patent/EA000364B1/ru not_active IP Right Cessation
- 1996-01-19 IN IN102MA1996 patent/IN182468B/en unknown
- 1996-01-19 AT AT96900631T patent/ATE302777T1/de not_active IP Right Cessation
1997
- 1997-07-15 IS IS4527A patent/IS2268B/is unknown
- 1997-07-16 OA OA70051A patent/OA10499A/en unknown
- 1997-07-18 NO NO19973326A patent/NO315558B1/no not_active IP Right Cessation
- 1997-08-14 BG BG101833A patent/BG63393B1/bg unknown
1999
- 1999-10-29 UY UY25779A patent/UY25779A1/es not_active IP Right Cessation
2005
- 2005-11-16 CY CY0500061A patent/CY2531B1/xx unknown

Also Published As

Publication number	Publication date
HU222993B1 (hu)	2004-01-28
CN1179159A (zh)	1998-04-15
KR100376074B1 (ko)	2003-06-02
AP662A (en)	1998-08-19
HRP960024B1 (en)	2005-08-31
PL182175B1 (pl)	2001-11-30
DK0804436T3 (da)	2005-12-27
EP0804436B1 (en)	2005-08-24
CA2210799A1 (en)	1996-07-25
EE03528B1 (et)	2001-10-15
EA199700124A1 (ru)	1997-12-30
OA10499A (en)	2002-04-10
MX9705462A (es)	1997-10-31
DE69635106D1 (de)	2005-09-29
EE9700175A (et)	1998-02-16
BG63393B1 (bg)	2001-12-29
CN1049893C (zh)	2000-03-01
NZ298851A (en)	1999-01-28
FI973063A7 (fi)	1997-09-18
HRP960024A2 (en)	1997-10-31
JP3176633B2 (ja)	2001-06-18
IL116831A0 (en)	1996-05-14
AR002270A1 (es)	1998-03-11
PL321326A1 (en)	1997-12-08
AU702794B2 (en)	1999-03-04
ATE302777T1 (de)	2005-09-15
TR199700656T1 (xx)	1998-03-21
BR9606768A (pt)	1997-12-30
SI0804436T1 (sl)	2006-02-28
YU3396A (sh)	1998-12-23
BG101833A (bg)	1998-04-30
RO118693B1 (ro)	2003-09-30
DE69635106T2 (de)	2006-06-08
IL116831A (en)	1998-10-30
NO973326L (no)	1997-09-16
US6107302A (en)	2000-08-22
KR19980701525A (ko)	1998-05-15
NO315558B1 (no)	2003-09-22
CA2210799C (en)	2008-06-10
SK96597A3 (en)	1998-02-04
GEP20001940B (en)	2000-02-05
AP9701058A0 (en)	1997-10-31
IS4527A (is)	1997-07-15
GB9501178D0 (en)	1995-03-08
ES2248806T3 (es)	2006-03-16
NO973326D0 (no)	1997-07-18
EP0804436A1 (en)	1997-11-05
CZ297065B6 (cs)	2006-08-16
UY25779A1 (es)	2000-08-21
RS49518B (sr)	2006-10-27
ZA96449B (en)	1996-08-07
IN182468B (cs)	1999-04-17
HUP9801836A2 (hu)	1999-05-28
WO1996022291A1 (en)	1996-07-25
FI973063L (fi)	1997-09-18
UA46001C2 (uk)	2002-05-15
EA000364B1 (ru)	1999-06-24
JPH11503718A (ja)	1999-03-30
SK285329B6 (sk)	2006-11-03
HUP9801836A3 (en)	1999-06-28
AU4453996A (en)	1996-08-07
FI973063A0 (fi)	1997-07-18
CZ229497A3 (en)	1997-12-17
IS2268B (is)	2007-07-15

Publication	Publication Date	Title
HRP960024B1 (en)	2005-08-31	Guanine derivative
GB9508565D0 (en)	1995-06-14	Quiazoline derivative
NZ305444A (en)	1999-03-29	4-anilino-7-alkoxy-quinazoline derivatives
IL152383A0 (en)	2003-05-29	5-amino-3-cyano-4-ethylsulfinyl-1- phenyl-pyrazole derivatives
IL135376A0 (en)	2001-05-20	Hydroxyalkyl-phenyl derivatives
GB2306473A8 (en)	1997-05-28	Glucoxide derivatives
ZA96228B (en)	1996-07-26	Indolepiperidine derivatives
ZA969278B (en)	1997-06-02	Purin-6-one derivatives
HU9600876D0 (en)	1996-05-28	Benzonitril- and -fluoride derivatives
HU9600107D0 (en)	1996-03-28	9-substituted-2-(2-n-alkoxy-phenyl)-purin-6-one derivatives
NZ332395A (en)	1999-02-25	Benzonthiazole derivatives
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