CZ2003308A3 - Farmaceutický přípravek pro léčení virové nebo neoplastické nemoci hepatocitu - Google Patents
Farmaceutický přípravek pro léčení virové nebo neoplastické nemoci hepatocitu Download PDFInfo
- Publication number
- CZ2003308A3 CZ2003308A3 CZ2003308A CZ2003308A CZ2003308A3 CZ 2003308 A3 CZ2003308 A3 CZ 2003308A3 CZ 2003308 A CZ2003308 A CZ 2003308A CZ 2003308 A CZ2003308 A CZ 2003308A CZ 2003308 A3 CZ2003308 A3 CZ 2003308A3
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- CZ
- Czechia
- Prior art keywords
- hepatocyte
- substance
- virus
- carboxamidine
- transporter
- Prior art date
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- 206010027599 migraine Diseases 0.000 description 1
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 1
- RJMUSRYZPJIFPJ-UHFFFAOYSA-N niclosamide Chemical compound OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl RJMUSRYZPJIFPJ-UHFFFAOYSA-N 0.000 description 1
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- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 229940097191 phazyme Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229960003171 plicamycin Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
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- 238000009877 rendering Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- SDWIOXKHTFOULX-PDNLFSCWSA-N ribavirin monophosphate Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](COP(O)(O)=O)O1 SDWIOXKHTFOULX-PDNLFSCWSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
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- 238000003345 scintillation counting Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 150000003431 steroids Chemical class 0.000 description 1
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
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- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22686900P | 2000-08-22 | 2000-08-22 | |
| US24062700P | 2000-10-13 | 2000-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ2003308A3 true CZ2003308A3 (cs) | 2004-03-17 |
Family
ID=26920944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2003308A CZ2003308A3 (cs) | 2000-08-22 | 2001-08-21 | Farmaceutický přípravek pro léčení virové nebo neoplastické nemoci hepatocitu |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1313469A1 (pl) |
| JP (1) | JP2004506684A (pl) |
| KR (1) | KR20030040416A (pl) |
| CN (1) | CN1447692A (pl) |
| AU (1) | AU2001292557A1 (pl) |
| BR (1) | BR0113388A (pl) |
| CA (1) | CA2415793A1 (pl) |
| CZ (1) | CZ2003308A3 (pl) |
| HU (1) | HUP0302884A2 (pl) |
| IL (1) | IL154167A0 (pl) |
| MX (1) | MXPA03001529A (pl) |
| NO (1) | NO20030794L (pl) |
| PL (1) | PL365744A1 (pl) |
| RU (1) | RU2003102607A (pl) |
| WO (1) | WO2002015904A1 (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003037908A1 (en) * | 2001-10-31 | 2003-05-08 | Ribapharm Inc. | Antiviral combination therapy and compositions |
| US7608258B2 (en) | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
| US6811777B2 (en) * | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| WO2010042658A1 (en) | 2008-10-07 | 2010-04-15 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
| US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3984396A (en) * | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
| US5959077A (en) * | 1993-05-26 | 1999-09-28 | Laboratori Balducci S.P.A. | Hepatotropic conjugates of antiviral drugs carriers thereof and pharmaceutical compositions containing them |
-
2001
- 2001-08-21 CZ CZ2003308A patent/CZ2003308A3/cs unknown
- 2001-08-21 HU HU0302884A patent/HUP0302884A2/hu unknown
- 2001-08-21 WO PCT/US2001/026057 patent/WO2002015904A1/en not_active Ceased
- 2001-08-21 BR BR0113388-8A patent/BR0113388A/pt not_active IP Right Cessation
- 2001-08-21 KR KR10-2003-7002539A patent/KR20030040416A/ko not_active Ceased
- 2001-08-21 RU RU2003102607/15A patent/RU2003102607A/ru not_active Application Discontinuation
- 2001-08-21 EP EP01972926A patent/EP1313469A1/en not_active Withdrawn
- 2001-08-21 CA CA002415793A patent/CA2415793A1/en not_active Abandoned
- 2001-08-21 CN CN01814399A patent/CN1447692A/zh active Pending
- 2001-08-21 PL PL01365744A patent/PL365744A1/pl unknown
- 2001-08-21 MX MXPA03001529A patent/MXPA03001529A/es unknown
- 2001-08-21 IL IL15416701A patent/IL154167A0/xx unknown
- 2001-08-21 AU AU2001292557A patent/AU2001292557A1/en not_active Abandoned
- 2001-08-21 JP JP2002520825A patent/JP2004506684A/ja not_active Withdrawn
-
2003
- 2003-02-20 NO NO20030794A patent/NO20030794L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030040416A (ko) | 2003-05-22 |
| EP1313469A1 (en) | 2003-05-28 |
| CA2415793A1 (en) | 2002-02-28 |
| PL365744A1 (pl) | 2005-01-10 |
| MXPA03001529A (es) | 2004-04-02 |
| WO2002015904B1 (en) | 2002-07-04 |
| CN1447692A (zh) | 2003-10-08 |
| BR0113388A (pt) | 2004-02-25 |
| AU2001292557A1 (en) | 2002-03-04 |
| NO20030794L (no) | 2003-04-22 |
| NO20030794D0 (no) | 2003-02-20 |
| HUP0302884A2 (hu) | 2003-12-29 |
| WO2002015904A1 (en) | 2002-02-28 |
| RU2003102607A (ru) | 2004-07-27 |
| JP2004506684A (ja) | 2004-03-04 |
| IL154167A0 (en) | 2003-07-31 |
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