CZ2018595A3 - Postnatální epigenetický profil kardiovaskulárních mikroRNA u dětí narozených z komplikovaných gravidit - nové biomarkery kardiovaskulárního rizika - Google Patents

Postnatální epigenetický profil kardiovaskulárních mikroRNA u dětí narozených z komplikovaných gravidit - nové biomarkery kardiovaskulárního rizika

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Publication number
CZ2018595A3
CZ2018595A3 CZ2018-595A CZ2018595A CZ2018595A3 CZ 2018595 A3 CZ2018595 A3 CZ 2018595A3 CZ 2018595 A CZ2018595 A CZ 2018595A CZ 2018595 A3 CZ2018595 A3 CZ 2018595A3
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CZ
Czechia
Prior art keywords
cardiovascular
micrornas
postpartal
children born
new biomarkers
Prior art date
Application number
CZ2018-595A
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English (en)
Other versions
CZ308102B6 (cs
Inventor
Ilona Hromadníková
Original Assignee
Univerzita Karlova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerzita Karlova filed Critical Univerzita Karlova
Priority to CZ2018-595A priority Critical patent/CZ2018595A3/cs
Priority to PCT/CZ2019/050050 priority patent/WO2020088703A1/en
Publication of CZ308102B6 publication Critical patent/CZ308102B6/cs
Publication of CZ2018595A3 publication Critical patent/CZ2018595A3/cs

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Způsob in vitro detekce potenciálního kardiovaskulárního rizika u dětí narozených z komplikovaného těhotenství na základě přítomnosti aberantního expresního profilu vybraných mikroRNA v plné periferní žilní krvi.
CZ2018-595A 2018-10-31 2018-10-31 Postnatální epigenetický profil kardiovaskulárních mikroRNA u dětí narozených z komplikovaných gravidit - nové biomarkery kardiovaskulárního rizika CZ2018595A3 (cs)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CZ2018-595A CZ2018595A3 (cs) 2018-10-31 2018-10-31 Postnatální epigenetický profil kardiovaskulárních mikroRNA u dětí narozených z komplikovaných gravidit - nové biomarkery kardiovaskulárního rizika
PCT/CZ2019/050050 WO2020088703A1 (en) 2018-10-31 2019-10-30 A method of predicting a risk of cardiovascular disease for a child born from a complicated pregnancy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2018-595A CZ2018595A3 (cs) 2018-10-31 2018-10-31 Postnatální epigenetický profil kardiovaskulárních mikroRNA u dětí narozených z komplikovaných gravidit - nové biomarkery kardiovaskulárního rizika

Publications (2)

Publication Number Publication Date
CZ308102B6 CZ308102B6 (cs) 2020-01-02
CZ2018595A3 true CZ2018595A3 (cs) 2020-01-02

Family

ID=69063489

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2018-595A CZ2018595A3 (cs) 2018-10-31 2018-10-31 Postnatální epigenetický profil kardiovaskulárních mikroRNA u dětí narozených z komplikovaných gravidit - nové biomarkery kardiovaskulárního rizika

Country Status (2)

Country Link
CZ (1) CZ2018595A3 (cs)
WO (1) WO2020088703A1 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ309639B6 (cs) 2021-12-13 2023-05-31 GeneSpector Innovations s.r.o Způsob predikce těhotenských komplikací dle expresního profilu kardiovaskulárních miRNA
CN114600832B (zh) * 2022-04-01 2023-07-25 西南医科大学 一种小鼠心衰模型及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK144771C (da) 1979-07-10 1982-10-25 V B K Rasmussen Haengselbeslag til vippevinduer,navnlig skraat indbyggede tagvinduer
US4318157A (en) 1980-06-06 1982-03-02 Control Data Corporation Apparatus for mounting circuit cards
US20140274923A1 (en) * 2013-03-14 2014-09-18 The Regents Of The University Of Colorado, A Body Corporate Mirnas as a prognostic biomarker in pediatric heart failure
WO2017031501A1 (en) * 2015-08-20 2017-02-23 Serenium, Inc. System and method of diagnosing endothelial dysfunction utilizing circulating mirnas as biomarkers
CN108165623A (zh) * 2018-01-02 2018-06-15 青岛大学 miRNA的应用、应用其的产品及检测方法

Also Published As

Publication number Publication date
CZ308102B6 (cs) 2020-01-02
WO2020088703A1 (en) 2020-05-07

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