CZ297347B6 - Zpusob prípravy rosiglitazonu - Google Patents

Zpusob prípravy rosiglitazonu

Info

Publication number
CZ297347B6
CZ297347B6 CZ20040983A CZ2004983A CZ297347B6 CZ 297347 B6 CZ297347 B6 CZ 297347B6 CZ 20040983 A CZ20040983 A CZ 20040983A CZ 2004983 A CZ2004983 A CZ 2004983A CZ 297347 B6 CZ297347 B6 CZ 297347B6
Authority
CZ
Czechia
Prior art keywords
general formula
formic acid
rosiglitazone
preparing rosiglitazone
preparing
Prior art date
Application number
CZ20040983A
Other languages
English (en)
Other versions
CZ2004983A3 (cs
Inventor
Halama@Ales
Jirman@Josef
Original Assignee
Zentiva, A. S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, A. S. filed Critical Zentiva, A. S.
Priority to CZ20040983A priority Critical patent/CZ297347B6/cs
Priority to PCT/CZ2005/000066 priority patent/WO2006032218A1/en
Publication of CZ2004983A3 publication Critical patent/CZ2004983A3/cs
Publication of CZ297347B6 publication Critical patent/CZ297347B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Príprava rosiglitazonu vzorce I redukcí 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyliden]thiazolidin-2,4-dionu vzorce II za pouzití smesi kyseliny mravencí vzorce III a bazického aminu vzorce IV nebo amoniové soli kyseliny mravencí vzorce V, kde R.sub.1.n., R.sub.2.n. a R.sub.3.n. znací vodíknebo alkyl (C1-C5), za katalýzy prechodovým kovem.
CZ20040983A 2004-09-21 2004-09-21 Zpusob prípravy rosiglitazonu CZ297347B6 (cs)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CZ20040983A CZ297347B6 (cs) 2004-09-21 2004-09-21 Zpusob prípravy rosiglitazonu
PCT/CZ2005/000066 WO2006032218A1 (en) 2004-09-21 2005-08-31 Method for the preparation of rosiglitazone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20040983A CZ297347B6 (cs) 2004-09-21 2004-09-21 Zpusob prípravy rosiglitazonu

Publications (2)

Publication Number Publication Date
CZ2004983A3 CZ2004983A3 (cs) 2006-05-17
CZ297347B6 true CZ297347B6 (cs) 2006-11-15

Family

ID=35520548

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20040983A CZ297347B6 (cs) 2004-09-21 2004-09-21 Zpusob prípravy rosiglitazonu

Country Status (2)

Country Link
CZ (1) CZ297347B6 (cs)
WO (1) WO2006032218A1 (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1887006A1 (en) * 2006-08-07 2008-02-13 Krka Polymorphic forms of rosiglitazone base

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306228A1 (en) * 1987-09-04 1989-03-08 Beecham Group Plc Substituted thiazolidinedione derivatives
US5726055A (en) * 1991-11-19 1998-03-10 Smithkline Beecham Plc Process for the preparation of pharmaceutically active thiazolidine compounds by a yeast reductase
WO1998037073A1 (en) * 1997-02-18 1998-08-27 Smithkline Beecham Plc Process for the preparation of substituted thiazolidinedione
WO1999023095A1 (en) * 1997-11-04 1999-05-14 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
EP1231211A1 (en) * 1999-11-18 2002-08-14 Vita-Invest, S.A. Thiazolidinedione derivatives as antidiabetic agents
WO2003053367A2 (en) * 2001-12-20 2003-07-03 Teva Pharmaceutical Industries Ltd. Hydrogenation of precursors to thiazolidinedione antihyperglycemics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2820742B1 (fr) * 2001-02-14 2005-03-11 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306228A1 (en) * 1987-09-04 1989-03-08 Beecham Group Plc Substituted thiazolidinedione derivatives
US5726055A (en) * 1991-11-19 1998-03-10 Smithkline Beecham Plc Process for the preparation of pharmaceutically active thiazolidine compounds by a yeast reductase
WO1998037073A1 (en) * 1997-02-18 1998-08-27 Smithkline Beecham Plc Process for the preparation of substituted thiazolidinedione
WO1999023095A1 (en) * 1997-11-04 1999-05-14 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
EP1231211A1 (en) * 1999-11-18 2002-08-14 Vita-Invest, S.A. Thiazolidinedione derivatives as antidiabetic agents
WO2003053367A2 (en) * 2001-12-20 2003-07-03 Teva Pharmaceutical Industries Ltd. Hydrogenation of precursors to thiazolidinedione antihyperglycemics

Also Published As

Publication number Publication date
CZ2004983A3 (cs) 2006-05-17
WO2006032218A1 (en) 2006-03-30

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of fee

Effective date: 20120921