CZ363997A3 - Polysiloxan-polyolové makromery, způsob jejich přípravy a jejich použití - Google Patents

Polysiloxan-polyolové makromery, způsob jejich přípravy a jejich použití Download PDF

Info

Publication number: CZ363997A3
Authority: CZ; Czechia
Prior art keywords: group; segment; formula; macromers; groups
Prior art date: 1995-05-19

Application number

CZ973639A

Other languages

Czech (cs)

English (en)

Inventor

Angelika Domschke

Dieter Lohmann

Jens Höpken

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-19

Filing date

1996-05-07

Publication date

1998-03-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25687828&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CZ363997(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-12-08 Priority claimed from US08569816 external-priority patent/US5760100B1/en

1996-05-07 Application filed by Novartis Ag filed Critical Novartis Ag

1998-03-18 Publication of CZ363997A3 publication Critical patent/CZ363997A3/cs

Links

229920005862 polyol Polymers 0.000 title claims abstract description 66
238000000034 method Methods 0.000 title claims abstract description 32
238000002360 preparation method Methods 0.000 title claims abstract description 18
230000008569 process Effects 0.000 title claims abstract description 15
229920000642 polymer Polymers 0.000 claims abstract description 77
150000003077 polyols Chemical class 0.000 claims abstract description 59
239000007943 implant Substances 0.000 claims abstract description 45
238000006116 polymerization reaction Methods 0.000 claims abstract description 27
238000000465 moulding Methods 0.000 claims abstract description 19
239000000758 substrate Substances 0.000 claims abstract description 7
-1 polysiloxane Polymers 0.000 claims description 126
125000000217 alkyl group Chemical group 0.000 claims description 84
150000001875 compounds Chemical class 0.000 claims description 77
125000004432 carbon atom Chemical group C* 0.000 claims description 65
150000001720 carbohydrates Chemical class 0.000 claims description 56
239000000203 mixture Substances 0.000 claims description 54
JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 51
XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 50
229920001296 polysiloxane Polymers 0.000 claims description 49
125000002947 alkylene group Chemical group 0.000 claims description 48
125000003368 amide group Chemical group 0.000 claims description 46
125000004185 ester group Chemical group 0.000 claims description 38
125000004103 aminoalkyl group Chemical group 0.000 claims description 36
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 29
125000002768 hydroxyalkyl group Chemical group 0.000 claims description 29
125000003342 alkenyl group Chemical group 0.000 claims description 27
239000000178 monomer Substances 0.000 claims description 26
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 19
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 18
150000001408 amides Chemical class 0.000 claims description 17
125000000732 arylene group Chemical group 0.000 claims description 17
230000002209 hydrophobic effect Effects 0.000 claims description 17
150000002148 esters Chemical class 0.000 claims description 16
150000002596 lactones Chemical class 0.000 claims description 16
229920006395 saturated elastomer Polymers 0.000 claims description 16
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 15
239000007789 gas Substances 0.000 claims description 15
239000001301 oxygen Substances 0.000 claims description 15
229910052760 oxygen Inorganic materials 0.000 claims description 15
125000003277 amino group Chemical group 0.000 claims description 14
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 13
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 12
239000011148 porous material Substances 0.000 claims description 12
229920002554 vinyl polymer Polymers 0.000 claims description 12
125000003118 aryl group Chemical group 0.000 claims description 11
210000004087 cornea Anatomy 0.000 claims description 11
125000000686 lactone group Chemical group 0.000 claims description 11
229910052757 nitrogen Inorganic materials 0.000 claims description 11
RBQRWNWVPQDTJJ-UHFFFAOYSA-N methacryloyloxyethyl isocyanate Chemical compound CC(=C)C(=O)OCCN=C=O RBQRWNWVPQDTJJ-UHFFFAOYSA-N 0.000 claims description 10
229910052786 argon Inorganic materials 0.000 claims description 9
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 8
239000002253 acid Substances 0.000 claims description 8
125000003545 alkoxy group Chemical group 0.000 claims description 8
239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
239000012530 fluid Substances 0.000 claims description 7
229920002451 polyvinyl alcohol Polymers 0.000 claims description 7
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 6
PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 6
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 6
150000001252 acrylic acid derivatives Chemical class 0.000 claims description 6
XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 claims description 6
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 5
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 5
239000004202 carbamide Substances 0.000 claims description 5
125000005587 carbonate group Chemical group 0.000 claims description 5
235000012209 glucono delta-lactone Nutrition 0.000 claims description 5
229960003681 gluconolactone Drugs 0.000 claims description 5
150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 5
150000002772 monosaccharides Chemical class 0.000 claims description 5
229920001542 oligosaccharide Polymers 0.000 claims description 5
150000002482 oligosaccharides Chemical class 0.000 claims description 5
150000004043 trisaccharides Chemical class 0.000 claims description 5
QRFNDAVXJCGLFB-GJPGBQJBSA-N (3r,3ar,6s,6ar)-3,6-dihydroxy-3,3a,6,6a-tetrahydrofuro[3,2-b]furan-2,5-dione Chemical compound O1C(=O)[C@H](O)[C@H]2OC(=O)[C@@H](O)[C@H]21 QRFNDAVXJCGLFB-GJPGBQJBSA-N 0.000 claims description 4
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 4
150000001335 aliphatic alkanes Chemical class 0.000 claims description 4
125000005024 alkenyl aryl group Chemical group 0.000 claims description 4
125000003282 alkyl amino group Chemical group 0.000 claims description 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
238000004113 cell culture Methods 0.000 claims description 4
150000002016 disaccharides Chemical class 0.000 claims description 4
150000004676 glycans Chemical class 0.000 claims description 4
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 4
150000002894 organic compounds Chemical class 0.000 claims description 4
229920001282 polysaccharide Polymers 0.000 claims description 4
239000005017 polysaccharide Substances 0.000 claims description 4
CTXUTPWZJZHRJC-UHFFFAOYSA-N 1-ethenylpyrrole Chemical compound C=CN1C=CC=C1 CTXUTPWZJZHRJC-UHFFFAOYSA-N 0.000 claims description 3
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 claims description 3
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 3
GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 claims description 3
125000005442 diisocyanate group Chemical group 0.000 claims description 3
NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 claims description 3
FSICMNGKCHFHGP-AMTLMPIISA-N lactobiono-1,5-lactone Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(=O)[C@H](O)[C@H]1O FSICMNGKCHFHGP-AMTLMPIISA-N 0.000 claims description 3
239000003446 ligand Substances 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
150000004044 tetrasaccharides Chemical class 0.000 claims description 3
DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims description 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
NNKCVJYUFBVOMM-MJCJSMLMSA-N (1s,2s,5s,8s)-2,3,8-trihydroxy-4,7-dioxabicyclo[3.2.1]octan-6-one Chemical compound O[C@@H]1C(O)O[C@@H]2C(=O)O[C@H]1[C@@H]2O NNKCVJYUFBVOMM-MJCJSMLMSA-N 0.000 claims description 2
ALQLPWJFHRMHIU-UHFFFAOYSA-N 1,4-diisocyanatobenzene Chemical compound O=C=NC1=CC=C(N=C=O)C=C1 ALQLPWJFHRMHIU-UHFFFAOYSA-N 0.000 claims description 2
OVBFMUAFNIIQAL-UHFFFAOYSA-N 1,4-diisocyanatobutane Chemical compound O=C=NCCCCN=C=O OVBFMUAFNIIQAL-UHFFFAOYSA-N 0.000 claims description 2
CDMDQYCEEKCBGR-UHFFFAOYSA-N 1,4-diisocyanatocyclohexane Chemical compound O=C=NC1CCC(N=C=O)CC1 CDMDQYCEEKCBGR-UHFFFAOYSA-N 0.000 claims description 2
ATOUXIOKEJWULN-UHFFFAOYSA-N 1,6-diisocyanato-2,2,4-trimethylhexane Chemical compound O=C=NCCC(C)CC(C)(C)CN=C=O ATOUXIOKEJWULN-UHFFFAOYSA-N 0.000 claims description 2
GNEPBTGCKNEPNE-UHFFFAOYSA-N 1-isocyanatoprop-2-enylbenzene Chemical class O=C=NC(C=C)C1=CC=CC=C1 GNEPBTGCKNEPNE-UHFFFAOYSA-N 0.000 claims description 2
JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 2
BQBSIHIZDSHADD-UHFFFAOYSA-N 2-ethenyl-4,5-dihydro-1,3-oxazole Chemical compound C=CC1=NCCO1 BQBSIHIZDSHADD-UHFFFAOYSA-N 0.000 claims description 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 claims description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
UYUXSRADSPPKRZ-SKNVOMKLSA-N D-glucurono-6,3-lactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 claims description 2
KXTCDGRHGVMZOH-SLVMBWJPSA-N D-maltoheptaono-1,5-lactone Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)C(=O)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O KXTCDGRHGVMZOH-SLVMBWJPSA-N 0.000 claims description 2
239000004641 Diallyl-phthalate Substances 0.000 claims description 2
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 2
239000005058 Isophorone diisocyanate Substances 0.000 claims description 2
229930195725 Mannitol Natural products 0.000 claims description 2
150000001336 alkenes Chemical class 0.000 claims description 2
HXBPYFMVGFDZFT-UHFFFAOYSA-N allyl isocyanate Chemical compound C=CCN=C=O HXBPYFMVGFDZFT-UHFFFAOYSA-N 0.000 claims description 2
150000004263 amino monosaccharides Chemical class 0.000 claims description 2
QUDWYFHPNIMBFC-UHFFFAOYSA-N bis(prop-2-enyl) benzene-1,2-dicarboxylate Chemical compound C=CCOC(=O)C1=CC=CC=C1C(=O)OCC=C QUDWYFHPNIMBFC-UHFFFAOYSA-N 0.000 claims description 2
150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
230000021164 cell adhesion Effects 0.000 claims description 2
239000001530 fumaric acid Substances 0.000 claims description 2
WTXGYGWMPUGBAL-MGCNEYSASA-N galactonolactone Chemical compound O[C@@H]1COC(=O)[C@H](O)[C@@H](O)[C@H]1O WTXGYGWMPUGBAL-MGCNEYSASA-N 0.000 claims description 2
RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 claims description 2
238000002513 implantation Methods 0.000 claims description 2
WARQUFORVQESFF-UHFFFAOYSA-N isocyanatoethene Chemical compound C=CN=C=O WARQUFORVQESFF-UHFFFAOYSA-N 0.000 claims description 2
239000000594 mannitol Substances 0.000 claims description 2
235000010355 mannitol Nutrition 0.000 claims description 2
HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 claims description 2
VHRYZQNGTZXDNX-UHFFFAOYSA-N methacryloyl chloride Chemical compound CC(=C)C(Cl)=O VHRYZQNGTZXDNX-UHFFFAOYSA-N 0.000 claims description 2
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 2
HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 claims description 2
KKFHAJHLJHVUDM-UHFFFAOYSA-N n-vinylcarbazole Chemical compound C1=CC=C2N(C=C)C3=CC=CC=C3C2=C1 KKFHAJHLJHVUDM-UHFFFAOYSA-N 0.000 claims description 2
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 2
229920002689 polyvinyl acetate Polymers 0.000 claims description 2
239000011118 polyvinyl acetate Substances 0.000 claims description 2
125000001453 quaternary ammonium group Chemical group 0.000 claims description 2
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
MNCGMVDMOKPCSQ-UHFFFAOYSA-M sodium;2-phenylethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 MNCGMVDMOKPCSQ-UHFFFAOYSA-M 0.000 claims description 2
BWYYYTVSBPRQCN-UHFFFAOYSA-M sodium;ethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=C BWYYYTVSBPRQCN-UHFFFAOYSA-M 0.000 claims description 2
239000000600 sorbitol Substances 0.000 claims description 2
230000008467 tissue growth Effects 0.000 claims description 2
RUELTTOHQODFPA-UHFFFAOYSA-N toluene 2,6-diisocyanate Chemical compound CC1=C(N=C=O)C=CC=C1N=C=O RUELTTOHQODFPA-UHFFFAOYSA-N 0.000 claims description 2
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims 2
QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 2
125000005250 alkyl acrylate group Chemical group 0.000 claims 2
IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 claims 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
WVAFEFUPWRPQSY-UHFFFAOYSA-N 1,2,3-tris(ethenyl)benzene Chemical compound C=CC1=CC=CC(C=C)=C1C=C WVAFEFUPWRPQSY-UHFFFAOYSA-N 0.000 claims 1
KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 claims 1
BRXKVEIJEXJBFF-UHFFFAOYSA-N 2,2-bis(hydroxymethyl)-3-methylbutane-1,4-diol Chemical compound OCC(C)C(CO)(CO)CO BRXKVEIJEXJBFF-UHFFFAOYSA-N 0.000 claims 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
241001465754 Metazoa Species 0.000 claims 1
JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
239000004305 biphenyl Substances 0.000 claims 1
235000010290 biphenyl Nutrition 0.000 claims 1
125000006267 biphenyl group Chemical group 0.000 claims 1
230000001413 cellular effect Effects 0.000 claims 1
230000008878 coupling Effects 0.000 claims 1
238000010168 coupling process Methods 0.000 claims 1
238000005859 coupling reaction Methods 0.000 claims 1
229960001271 desloratadine Drugs 0.000 claims 1
AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
230000002708 enhancing effect Effects 0.000 claims 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
239000011976 maleic acid Substances 0.000 claims 1
230000000149 penetrating effect Effects 0.000 claims 1
230000035515 penetration Effects 0.000 claims 1
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 1
ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
235000004252 protein component Nutrition 0.000 claims 1
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
229960000834 vinyl ether Drugs 0.000 claims 1
230000004304 visual acuity Effects 0.000 claims 1
238000000576 coating method Methods 0.000 abstract description 10
239000011248 coating agent Substances 0.000 abstract description 9
239000000543 intermediate Substances 0.000 abstract description 8
125000002348 vinylic group Chemical group 0.000 abstract 1
150000003254 radicals Chemical class 0.000 description 62
235000014633 carbohydrates Nutrition 0.000 description 46
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 36
239000000047 product Substances 0.000 description 29
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
238000006243 chemical reaction Methods 0.000 description 24
239000000243 solution Substances 0.000 description 20
239000000463 material Substances 0.000 description 18
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 18
230000003287 optical effect Effects 0.000 description 16
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 16
239000004205 dimethyl polysiloxane Substances 0.000 description 15
235000013870 dimethyl polysiloxane Nutrition 0.000 description 14
CFVWNXQPGQOHRJ-UHFFFAOYSA-N 2-methylpropyl prop-2-enoate Chemical compound CC(C)COC(=O)C=C CFVWNXQPGQOHRJ-UHFFFAOYSA-N 0.000 description 12
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
239000007983 Tris buffer Substances 0.000 description 11
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 description 9
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
230000035699 permeability Effects 0.000 description 9
239000002904 solvent Substances 0.000 description 9
IUVCFHHAEHNCFT-INIZCTEOSA-N 2-[(1s)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one Chemical compound C1=C(F)C(OC(C)C)=CC=C1C(C1=C(N)N=CN=C11)=NN1[C@@H](C)C1=C(C=2C=C(F)C=CC=2)C(=O)C2=CC(F)=CC=C2O1 IUVCFHHAEHNCFT-INIZCTEOSA-N 0.000 description 8
210000001519 tissue Anatomy 0.000 description 8
150000001412 amines Chemical class 0.000 description 7
210000004027 cell Anatomy 0.000 description 7
238000009792 diffusion process Methods 0.000 description 7
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 6
102000004169 proteins and genes Human genes 0.000 description 6
108090000623 proteins and genes Proteins 0.000 description 6
BUBVLQDEIIUIQG-UHFFFAOYSA-N 3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-one Chemical compound C=1C=CC=CC=1COC1C(OCC=2C=CC=CC=2)C(OCC=2C=CC=CC=2)C(=O)OC1COCC1=CC=CC=C1 BUBVLQDEIIUIQG-UHFFFAOYSA-N 0.000 description 5
229920000858 Cyclodextrin Polymers 0.000 description 5
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 5
UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 5
239000012975 dibutyltin dilaurate Substances 0.000 description 5
CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 5
238000004987 plasma desorption mass spectroscopy Methods 0.000 description 5
239000000126 substance Substances 0.000 description 5
239000000725 suspension Substances 0.000 description 5
238000003786 synthesis reaction Methods 0.000 description 5
JCZPMGDSEAFWDY-SQOUGZDYSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanamide Chemical compound NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO JCZPMGDSEAFWDY-SQOUGZDYSA-N 0.000 description 4
QWFMDSOYEQHWMF-UHFFFAOYSA-N 2,3-bis(ethenyl)benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC(C=C)=C1C=C QWFMDSOYEQHWMF-UHFFFAOYSA-N 0.000 description 4
VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 4
239000004743 Polypropylene Substances 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 4
150000001735 carboxylic acids Chemical class 0.000 description 4
239000003054 catalyst Substances 0.000 description 4
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 4
239000012528 membrane Substances 0.000 description 4
238000009832 plasma treatment Methods 0.000 description 4
230000000379 polymerizing effect Effects 0.000 description 4
229920001155 polypropylene Polymers 0.000 description 4
150000003141 primary amines Chemical group 0.000 description 4
238000012545 processing Methods 0.000 description 4
239000000741 silica gel Substances 0.000 description 4
229910002027 silica gel Inorganic materials 0.000 description 4
238000004381 surface treatment Methods 0.000 description 4
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 3
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 3
SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 3
239000012298 atmosphere Substances 0.000 description 3
238000004132 cross linking Methods 0.000 description 3
229940097362 cyclodextrins Drugs 0.000 description 3
229920001519 homopolymer Polymers 0.000 description 3
239000011261 inert gas Substances 0.000 description 3
239000012948 isocyanate Substances 0.000 description 3
150000002513 isocyanates Chemical group 0.000 description 3
239000010410 layer Substances 0.000 description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
DQCSJGUXTUJMAA-UHFFFAOYSA-N n,n-dimethylmethanamine;2-hydroxypropyl 2-methylprop-2-enoate;hydrochloride Chemical compound Cl.CN(C)C.CC(O)COC(=O)C(C)=C DQCSJGUXTUJMAA-UHFFFAOYSA-N 0.000 description 3
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 3
229920006294 polydialkylsiloxane Polymers 0.000 description 3
239000011541 reaction mixture Substances 0.000 description 3
230000035484 reaction time Effects 0.000 description 3
238000004809 thin layer chromatography Methods 0.000 description 3
238000004448 titration Methods 0.000 description 3
WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 2
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 2
LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 2
GZCGUPFRVQAUEE-UHFFFAOYSA-N 2,3,4,5,6-pentahydroxyhexanal Chemical compound OCC(O)C(O)C(O)C(O)C=O GZCGUPFRVQAUEE-UHFFFAOYSA-N 0.000 description 2
RIWRBSMFKVOJMN-UHFFFAOYSA-N 2-methyl-1-phenylpropan-2-ol Chemical compound CC(C)(O)CC1=CC=CC=C1 RIWRBSMFKVOJMN-UHFFFAOYSA-N 0.000 description 2
AEMOLEFTQBMNLQ-UHFFFAOYSA-N 3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 2
UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 description 2
BESKSSIEODQWBP-UHFFFAOYSA-N 3-tris(trimethylsilyloxy)silylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C BESKSSIEODQWBP-UHFFFAOYSA-N 0.000 description 2
DXPPIEDUBFUSEZ-UHFFFAOYSA-N 6-methylheptyl prop-2-enoate Chemical compound CC(C)CCCCCOC(=O)C=C DXPPIEDUBFUSEZ-UHFFFAOYSA-N 0.000 description 2
LVGFPWDANALGOY-UHFFFAOYSA-N 8-methylnonyl prop-2-enoate Chemical compound CC(C)CCCCCCCOC(=O)C=C LVGFPWDANALGOY-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
102000018386 EGF Family of Proteins Human genes 0.000 description 2
108010066486 EGF Family of Proteins Proteins 0.000 description 2
102000016359 Fibronectins Human genes 0.000 description 2
108010067306 Fibronectins Proteins 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 2
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
239000000010 aprotic solvent Substances 0.000 description 2
239000012300 argon atmosphere Substances 0.000 description 2
230000008901 benefit Effects 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
230000003197 catalytic effect Effects 0.000 description 2
OZECDDHOAMNMQI-UHFFFAOYSA-H cerium(3+);trisulfate Chemical compound [Ce+3].[Ce+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O OZECDDHOAMNMQI-UHFFFAOYSA-H 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000001816 cooling Methods 0.000 description 2
239000003431 cross linking reagent Substances 0.000 description 2
JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
125000004956 cyclohexylene group Chemical group 0.000 description 2
238000001514 detection method Methods 0.000 description 2
125000004386 diacrylate group Chemical group 0.000 description 2
239000012972 dimethylethanolamine Substances 0.000 description 2
238000004821 distillation Methods 0.000 description 2
FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 2
150000002170 ethers Chemical class 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
239000012634 fragment Substances 0.000 description 2
150000008282 halocarbons Chemical class 0.000 description 2
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
229940088597 hormone Drugs 0.000 description 2
239000005556 hormone Substances 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
150000002430 hydrocarbons Chemical class 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000003999 initiator Substances 0.000 description 2
IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 2
229940099563 lactobionic acid Drugs 0.000 description 2
229920002521 macromolecule Polymers 0.000 description 2
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 2
DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
210000001747 pupil Anatomy 0.000 description 2
230000005855 radiation Effects 0.000 description 2
230000009257 reactivity Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
238000003860 storage Methods 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
GPVGUNIIVWJTLK-UHFFFAOYSA-N 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-8-prop-2-enoxyoctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCOCC=C GPVGUNIIVWJTLK-UHFFFAOYSA-N 0.000 description 1
UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 1
125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 description 1
125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 description 1
FKJFNEUTFJAOQZ-UHFFFAOYSA-N 1-ethenylpyrrole pyrrolidin-2-one Chemical compound N1C(CCC1)=O.C(=C)N1C=CC=C1 FKJFNEUTFJAOQZ-UHFFFAOYSA-N 0.000 description 1
UDJZTGMLYITLIQ-UHFFFAOYSA-N 1-ethenylpyrrolidine Chemical compound C=CN1CCCC1 UDJZTGMLYITLIQ-UHFFFAOYSA-N 0.000 description 1
239000012956 1-hydroxycyclohexylphenyl-ketone Substances 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
LMVLEDTVXAGBJV-UHFFFAOYSA-N 2,2,3,4,4,4-hexafluorobutyl prop-2-enoate Chemical compound FC(F)(F)C(F)C(F)(F)COC(=O)C=C LMVLEDTVXAGBJV-UHFFFAOYSA-N 0.000 description 1
QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 1
OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 description 1
229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 1
GJKGAPPUXSSCFI-UHFFFAOYSA-N 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone Chemical compound CC(C)(O)C(=O)C1=CC=C(OCCO)C=C1 GJKGAPPUXSSCFI-UHFFFAOYSA-N 0.000 description 1
XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 1
OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
BQZJOQXSCSZQPS-UHFFFAOYSA-N 2-methoxy-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(OC)C(=O)C1=CC=CC=C1 BQZJOQXSCSZQPS-UHFFFAOYSA-N 0.000 description 1
TURITJIWSQEMDB-UHFFFAOYSA-N 2-methyl-n-[(2-methylprop-2-enoylamino)methyl]prop-2-enamide Chemical compound CC(=C)C(=O)NCNC(=O)C(C)=C TURITJIWSQEMDB-UHFFFAOYSA-N 0.000 description 1
ZIFLDVXQTMSDJE-UHFFFAOYSA-N 3-[[dimethyl-[3-(2-methylprop-2-enoyloxy)propyl]silyl]oxy-dimethylsilyl]propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](C)(C)O[Si](C)(C)CCCOC(=O)C(C)=C ZIFLDVXQTMSDJE-UHFFFAOYSA-N 0.000 description 1
NWBTXZPDTSKZJU-UHFFFAOYSA-N 3-[dimethyl(trimethylsilyloxy)silyl]propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](C)(C)O[Si](C)(C)C NWBTXZPDTSKZJU-UHFFFAOYSA-N 0.000 description 1
MDGWPHCHEKVBDM-UHFFFAOYSA-N 3-[methyl-[3-(2-methylprop-2-enoyloxy)propyl]-trimethylsilyloxysilyl]propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](C)(O[Si](C)(C)C)CCCOC(=O)C(C)=C MDGWPHCHEKVBDM-UHFFFAOYSA-N 0.000 description 1
QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 description 1
DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
229920001287 Chondroitin sulfate Polymers 0.000 description 1
208000030275 Chondronectin Diseases 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 1
WQZGKKKJIJFFOK-CBPJZXOFSA-N D-Gulose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O WQZGKKKJIJFFOK-CBPJZXOFSA-N 0.000 description 1
125000003863 D-allosyl group Chemical group 0.000 description 1
WQZGKKKJIJFFOK-RSVSWTKNSA-N D-altro-hexose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O WQZGKKKJIJFFOK-RSVSWTKNSA-N 0.000 description 1
RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
BJHIKXHVCXFQLS-PUFIMZNGSA-N D-psicose group Chemical group OCC(=O)[C@H](O)[C@H](O)[C@H](O)CO BJHIKXHVCXFQLS-PUFIMZNGSA-N 0.000 description 1
ZAQJHHRNXZUBTE-NQXXGFSBSA-N D-ribulose Chemical compound OC[C@@H](O)[C@@H](O)C(=O)CO ZAQJHHRNXZUBTE-NQXXGFSBSA-N 0.000 description 1
LKDRXBCSQODPBY-IANNHFEVSA-N D-sorbose Chemical compound OCC1(O)OC[C@@H](O)[C@H](O)[C@H]1O LKDRXBCSQODPBY-IANNHFEVSA-N 0.000 description 1
LKDRXBCSQODPBY-OEXCPVAWSA-N D-tagatose Chemical compound OCC1(O)OC[C@@H](O)[C@H](O)[C@@H]1O LKDRXBCSQODPBY-OEXCPVAWSA-N 0.000 description 1
ZAQJHHRNXZUBTE-UHFFFAOYSA-N D-threo-2-Pentulose Natural products OCC(O)C(O)C(=O)CO ZAQJHHRNXZUBTE-UHFFFAOYSA-N 0.000 description 1
YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 1
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
ZAQJHHRNXZUBTE-WUJLRWPWSA-N D-xylulose Chemical compound OC[C@@H](O)[C@H](O)C(=O)CO ZAQJHHRNXZUBTE-WUJLRWPWSA-N 0.000 description 1
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
101710145505 Fiber protein Proteins 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
238000004566 IR spectroscopy Methods 0.000 description 1
AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 1
SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 description 1
SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
SRBFZHDQGSBBOR-OWMBCFKOSA-N L-ribopyranose Chemical compound O[C@H]1COC(O)[C@@H](O)[C@H]1O SRBFZHDQGSBBOR-OWMBCFKOSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
AYRXSINWFIIFAE-UHFFFAOYSA-N O6-alpha-D-Galactopyranosyl-D-galactose Natural products OCC1OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C1O AYRXSINWFIIFAE-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
LUEWUZLMQUOBSB-UHFFFAOYSA-N UNPD55895 Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(OC3C(OC(O)C(O)C3O)CO)C(O)C2O)CO)C(O)C1O LUEWUZLMQUOBSB-UHFFFAOYSA-N 0.000 description 1
BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
IAXXETNIOYFMLW-COPLHBTASA-N [(1s,3s,4s)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] 2-methylprop-2-enoate Chemical compound C1C[C@]2(C)[C@@H](OC(=O)C(=C)C)C[C@H]1C2(C)C IAXXETNIOYFMLW-COPLHBTASA-N 0.000 description 1
FHLPGTXWCFQMIU-UHFFFAOYSA-N [4-[2-(4-prop-2-enoyloxyphenyl)propan-2-yl]phenyl] prop-2-enoate Chemical compound C=1C=C(OC(=O)C=C)C=CC=1C(C)(C)C1=CC=C(OC(=O)C=C)C=C1 FHLPGTXWCFQMIU-UHFFFAOYSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
GZCGUPFRVQAUEE-ZXXMMSQZSA-N aldehydo-D-idose Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)C=O GZCGUPFRVQAUEE-ZXXMMSQZSA-N 0.000 description 1
GZCGUPFRVQAUEE-KAZBKCHUSA-N aldehydo-D-talose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)C=O GZCGUPFRVQAUEE-KAZBKCHUSA-N 0.000 description 1
150000001320 aldopentoses Chemical class 0.000 description 1
150000001330 aldotetroses Chemical class 0.000 description 1
125000005529 alkyleneoxy group Chemical group 0.000 description 1
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
SRBFZHDQGSBBOR-STGXQOJASA-N alpha-D-lyxopyranose Chemical compound O[C@@H]1CO[C@H](O)[C@@H](O)[C@H]1O SRBFZHDQGSBBOR-STGXQOJASA-N 0.000 description 1
OCIBBXPLUVYKCH-QXVNYKTNSA-N alpha-maltohexaose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](O[C@H](O[C@@H]3[C@H](O[C@H](O[C@@H]4[C@H](O[C@H](O[C@@H]5[C@H](O[C@H](O)[C@H](O)[C@H]5O)CO)[C@H](O)[C@H]4O)CO)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O OCIBBXPLUVYKCH-QXVNYKTNSA-N 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
238000004873 anchoring Methods 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
238000013459 approach Methods 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
235000019400 benzoyl peroxide Nutrition 0.000 description 1
QLTSDROPCWIKKY-PMCTYKHCSA-N beta-D-glucosaminyl-(1->4)-beta-D-glucosamine Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O)[C@@H](CO)O1 QLTSDROPCWIKKY-PMCTYKHCSA-N 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
229920000249 biocompatible polymer Polymers 0.000 description 1
MQDJYUACMFCOFT-UHFFFAOYSA-N bis[2-(1-hydroxycyclohexyl)phenyl]methanone Chemical compound C=1C=CC=C(C(=O)C=2C(=CC=CC=2)C2(O)CCCCC2)C=1C1(O)CCCCC1 MQDJYUACMFCOFT-UHFFFAOYSA-N 0.000 description 1
QUZSUMLPWDHKCJ-UHFFFAOYSA-N bisphenol A dimethacrylate Chemical compound C1=CC(OC(=O)C(=C)C)=CC=C1C(C)(C)C1=CC=C(OC(=O)C(C)=C)C=C1 QUZSUMLPWDHKCJ-UHFFFAOYSA-N 0.000 description 1
210000004045 bowman membrane Anatomy 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
239000001273 butane Substances 0.000 description 1
IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 1
125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
230000008859 change Effects 0.000 description 1
125000003636 chemical group Chemical group 0.000 description 1
YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 1
229940059329 chondroitin sulfate Drugs 0.000 description 1
238000011097 chromatography purification Methods 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
239000002131 composite material Substances 0.000 description 1
238000012937 correction Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000002316 cosmetic surgery Methods 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
125000004966 cyanoalkyl group Chemical group 0.000 description 1
125000002993 cycloalkylene group Chemical group 0.000 description 1
KBLWLMPSVYBVDK-UHFFFAOYSA-N cyclohexyl prop-2-enoate Chemical compound C=CC(=O)OC1CCCCC1 KBLWLMPSVYBVDK-UHFFFAOYSA-N 0.000 description 1
125000003493 decenyl group Chemical group [H]C([*])=C([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000007547 defect Effects 0.000 description 1
125000000422 delta-lactone group Chemical group 0.000 description 1
230000008021 deposition Effects 0.000 description 1
SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003480 eluent Substances 0.000 description 1
230000003511 endothelial effect Effects 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
238000005530 etching Methods 0.000 description 1
MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
BLZSRIYYOIZLJL-UHFFFAOYSA-N ethenyl pentanoate Chemical compound CCCCC(=O)OC=C BLZSRIYYOIZLJL-UHFFFAOYSA-N 0.000 description 1
UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 1
WUFIZLJHBHJOHX-UHFFFAOYSA-N ethyl acetate;propan-1-ol;hydrate Chemical compound O.CCCO.CCOC(C)=O WUFIZLJHBHJOHX-UHFFFAOYSA-N 0.000 description 1
GIGAVEHCPDOYLJ-UHFFFAOYSA-N ethyl acetate;propan-2-ol;hydrate Chemical compound O.CC(C)O.CCOC(C)=O GIGAVEHCPDOYLJ-UHFFFAOYSA-N 0.000 description 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
239000003925 fat Substances 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
230000008014 freezing Effects 0.000 description 1
238000007710 freezing Methods 0.000 description 1
DLRVVLDZNNYCBX-CQUJWQHSSA-N gentiobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-CQUJWQHSSA-N 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
210000003709 heart valve Anatomy 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000006038 hexenyl group Chemical group 0.000 description 1
125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
102000043667 human chondronectin Human genes 0.000 description 1
108700020610 human chondronectin Proteins 0.000 description 1
238000006459 hydrosilylation reaction Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000001788 irregular Effects 0.000 description 1
229940119545 isobornyl methacrylate Drugs 0.000 description 1
125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
150000002581 ketopentoses Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
150000002688 maleic acid derivatives Chemical class 0.000 description 1
DJMVHSOAUQHPSN-UHFFFAOYSA-N malto-hexaose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(OC4C(C(O)C(O)C(CO)O4)O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 DJMVHSOAUQHPSN-UHFFFAOYSA-N 0.000 description 1
UYQJCPNSAVWAFU-UHFFFAOYSA-N malto-tetraose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 UYQJCPNSAVWAFU-UHFFFAOYSA-N 0.000 description 1
LUEWUZLMQUOBSB-OUBHKODOSA-N maltotetraose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O[C@@H]3[C@@H](O[C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-OUBHKODOSA-N 0.000 description 1
FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
125000005395 methacrylic acid group Chemical group 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
238000001471 micro-filtration Methods 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
238000005065 mining Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
238000000199 molecular distillation Methods 0.000 description 1
210000001087 myotubule Anatomy 0.000 description 1
ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
DCBBWYIVFRLKCD-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2-methylprop-2-enamide Chemical compound CN(C)CCNC(=O)C(C)=C DCBBWYIVFRLKCD-UHFFFAOYSA-N 0.000 description 1
IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
125000004957 naphthylene group Chemical group 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
230000005501 phase interface Effects 0.000 description 1
125000005561 phenanthryl group Chemical group 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
229920002120 photoresistant polymer Polymers 0.000 description 1
230000010399 physical interaction Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000007639 printing Methods 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 description 1
QTECDUFMBMSHKR-UHFFFAOYSA-N prop-2-enyl prop-2-enoate Chemical compound C=CCOC(=O)C=C QTECDUFMBMSHKR-UHFFFAOYSA-N 0.000 description 1
HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
LYBIZMNPXTXVMV-UHFFFAOYSA-N propan-2-yl prop-2-enoate Chemical compound CC(C)OC(=O)C=C LYBIZMNPXTXVMV-UHFFFAOYSA-N 0.000 description 1
239000001294 propane Substances 0.000 description 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 description 1
238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
238000010526 radical polymerization reaction Methods 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
229910052703 rhodium Inorganic materials 0.000 description 1
239000010948 rhodium Substances 0.000 description 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
230000035939 shock Effects 0.000 description 1
239000002356 single layer Substances 0.000 description 1
238000002791 soaking Methods 0.000 description 1
229940045872 sodium percarbonate Drugs 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
238000005507 spraying Methods 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002536 stromal cell Anatomy 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
102000055501 telomere Human genes 0.000 description 1
108091035539 telomere Proteins 0.000 description 1
210000003411 telomere Anatomy 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003538 tetroses Chemical class 0.000 description 1
IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
125000005065 undecenyl group Chemical group C(=CCCCCCCCCC)* 0.000 description 1
210000003556 vascular endothelial cell Anatomy 0.000 description 1
230000035899 viability Effects 0.000 description 1
229920001567 vinyl ester resin Polymers 0.000 description 1
239000008096 xylene Substances 0.000 description 1
125000005023 xylyl group Chemical group 0.000 description 1
FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
- B29D11/00076—Production of contact lenses enabling passage of fluids, e.g. oxygen, tears, between the area under the lens and the lens exterior
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/62—Plasma-deposition of organic layers
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/22—Component parts, details or accessories; Auxiliary operations
- B29C39/42—Casting under special conditions, e.g. vacuum
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4833—Polyethers containing oxyethylene units
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/50—Polyethers having heteroatoms other than oxygen
- C08G18/5003—Polyethers having heteroatoms other than oxygen having halogens
- C08G18/5015—Polyethers having heteroatoms other than oxygen having halogens having fluorine atoms
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/61—Polysiloxanes
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/67—Unsaturated compounds having active hydrogen
- C08G18/671—Unsaturated compounds having only one group containing active hydrogen
- C08G18/672—Esters of acrylic or alkyl acrylic acid having only one group containing active hydrogen
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/81—Unsaturated isocyanates or isothiocyanates
- C08G18/8108—Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group
- C08G18/8116—Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group esters of acrylic or alkylacrylic acid having only one isocyanate or isothiocyanate group
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/81—Unsaturated isocyanates or isothiocyanates
- C08G18/8141—Unsaturated isocyanates or isothiocyanates masked
- C08G18/815—Polyisocyanates or polyisothiocyanates masked with unsaturated compounds having active hydrogen
- C08G18/8158—Polyisocyanates or polyisothiocyanates masked with unsaturated compounds having active hydrogen with unsaturated compounds having only one group containing active hydrogen
- C08G18/8175—Polyisocyanates or polyisothiocyanates masked with unsaturated compounds having active hydrogen with unsaturated compounds having only one group containing active hydrogen with esters of acrylic or alkylacrylic acid having only one group containing active hydrogen
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2011/00—Optical elements, e.g. lenses, prisms
- B29L2011/0016—Lenses
- B29L2011/0041—Contact lenses
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/903—Interpenetrating network
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/936—Encapsulated chemical agent
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/937—Utility as body contact e.g. implant, contact lens or I.U.D.

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Physics & Mathematics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Animal Behavior & Ethology (AREA)
Mechanical Engineering (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Optics & Photonics (AREA)
General Physics & Mathematics (AREA)
Plasma & Fusion (AREA)
Manufacturing & Machinery (AREA)
Ophthalmology & Optometry (AREA)
Macromonomer-Based Addition Polymer (AREA)
Silicon Polymers (AREA)
Eyeglasses (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

CZ973639A 1995-05-19 1996-05-07 Polysiloxan-polyolové makromery, způsob jejich přípravy a jejich použití CZ363997A3 (cs)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH149695		1995-05-19
US08569816 US5760100B1 (en)	1994-09-06	1995-12-08	Extended wear ophthalmic lens

Publications (1)

Publication Number	Publication Date
CZ363997A3 true CZ363997A3 (cs)	1998-03-18

Family

ID=25687828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ973639A CZ363997A3 (cs)	1995-05-19	1996-05-07	Polysiloxan-polyolové makromery, způsob jejich přípravy a jejich použití

Country Status (19)

Country	Link
US (1)	US6043328A (2)
EP (1)	EP0826158B1 (2)
JP (2)	JP5048173B2 (2)
KR (1)	KR19990021832A (2)
CN (1)	CN1186550A (2)
AR (1)	AR001497A1 (2)
AT (1)	ATE184708T1 (2)
AU (1)	AU5814496A (2)
BR (1)	BR9608824A (2)
CA (1)	CA2220217A1 (2)
CZ (1)	CZ363997A3 (2)
DE (2)	DE29624309U1 (2)
HU (1)	HUP9801139A3 (2)
IL (1)	IL118237A0 (2)
NO (1)	NO975289L (2)
PL (1)	PL323350A1 (2)
SI (1)	SI0819258T1 (2)
WO (1)	WO1996036890A1 (2)
ZA (1)	ZA963937B (2)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6357854A (ja) *	1986-08-29	1988-03-12	Aisin Seiki Co Ltd	スタ−リング機関の作動ガス圧力制御装置
US7468398B2 (en)	1994-09-06	2008-12-23	Ciba Vision Corporation	Extended wear ophthalmic lens
US5760100B1 (en)	1994-09-06	2000-11-14	Ciba Vision Corp	Extended wear ophthalmic lens
US6001067A (en)	1997-03-04	1999-12-14	Shults; Mark C.	Device and method for determining analyte levels
US8527026B2 (en)	1997-03-04	2013-09-03	Dexcom, Inc.	Device and method for determining analyte levels
US6200626B1 (en) *	1999-05-20	2001-03-13	Bausch & Lomb Incorporated	Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization
CA2386659C (en) *	1999-10-07	2009-11-10	Johnson & Johnson Vision Care, Inc.	Soft contact lenses
JP2001163933A (ja) *	1999-10-27	2001-06-19	Novartis Ag	材料表面を改質する方法
US7521519B1 (en) *	2000-03-14	2009-04-21	Novartis Ag	Organic compounds
US6770721B1 (en) *	2000-11-02	2004-08-03	Surface Logix, Inc.	Polymer gel contact masks and methods and molds for making same
WO2002052045A1 (en) *	2000-12-26	2002-07-04	Aviva Biosciences	Active and biocompatible platforms prepared by polymerization of surface coating films
US20050276858A1 (en) *	2001-04-23	2005-12-15	Kao Weiyuan J	Bifunctional-modified hydrogels
AU2002258913A1 (en)	2001-04-23	2002-11-05	Wisconsin Alumni Research Foundation	Bifunctional-modified hydrogels
US20030032874A1 (en)	2001-07-27	2003-02-13	Dexcom, Inc.	Sensor head for use with implantable devices
US8364229B2 (en)	2003-07-25	2013-01-29	Dexcom, Inc.	Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7613491B2 (en)	2002-05-22	2009-11-03	Dexcom, Inc.	Silicone based membranes for use in implantable glucose sensors
US7226978B2 (en) *	2002-05-22	2007-06-05	Dexcom, Inc.	Techniques to improve polyurethane membranes for implantable glucose sensors
US7163292B2 (en) *	2002-09-06	2007-01-16	Synergeyes, Inc.	Hybrid contact lens system and method
US7322694B2 (en) *	2002-09-06	2008-01-29	Synergeyes, Inc.	Hybrid contact lens system and method
WO2004023374A1 (en) *	2002-09-06	2004-03-18	Quarter Lambda Technologies, Inc.	Hybrid contact lens system and method
US7104648B2 (en) *	2002-09-06	2006-09-12	Synergeyes, Inc.	Hybrid contact lens system and method
US9763609B2 (en)	2003-07-25	2017-09-19	Dexcom, Inc.	Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
JP4708342B2 (ja)	2003-07-25	2011-06-22	デックスコム・インコーポレーテッド	埋設可能な装置に用いる酸素増大膜システム
US9135402B2 (en)	2007-12-17	2015-09-15	Dexcom, Inc.	Systems and methods for processing sensor data
US7591801B2 (en)	2004-02-26	2009-09-22	Dexcom, Inc.	Integrated delivery device for continuous glucose sensor
US7920906B2 (en)	2005-03-10	2011-04-05	Dexcom, Inc.	System and methods for processing analyte sensor data for sensor calibration
US20050090607A1 (en) *	2003-10-28	2005-04-28	Dexcom, Inc.	Silicone composition for biocompatible membrane
US20050096446A1 (en) *	2003-10-29	2005-05-05	Council Of Scientific And Industrial	Tri-block copolymers and a process for the preparation of the same
US7109280B2 (en) *	2003-10-29	2006-09-19	Council Of Scientific And Industrial Research	Block copolymers and preparation thereof
US7018039B2 (en) *	2003-11-14	2006-03-28	Synergeyes,Inc.	Contact lens
US9247900B2 (en)	2004-07-13	2016-02-02	Dexcom, Inc.	Analyte sensor
US8808228B2 (en)	2004-02-26	2014-08-19	Dexcom, Inc.	Integrated medicament delivery device for use with continuous analyte sensor
US7354980B1 (en)	2004-03-12	2008-04-08	Key Medical Technologies, Inc.	High refractive index polymers for ophthalmic applications
US8277713B2 (en)	2004-05-03	2012-10-02	Dexcom, Inc.	Implantable analyte sensor
DE102004025130A1 (de) *	2004-05-18	2005-12-08	Universitätsklinikum Hamburg-Eppendorf Körperschaft des Öffentlichen Rechts	Verfahren und Vorrichtung zur Untersuchung von Sludgeablagerungen auf Materialien für Endoprothesen sowie Endoprothese
US9248614B2 (en) *	2004-06-30	2016-02-02	Novartis Ag	Method for lathing silicone hydrogel lenses
US20060004165A1 (en) *	2004-06-30	2006-01-05	Phelan John C	Silicone hydrogels with lathability at room temperature
US8989833B2 (en)	2004-07-13	2015-03-24	Dexcom, Inc.	Transcutaneous analyte sensor
ES2732439T3 (es)	2004-08-27	2019-11-22	Coopervision Int Holding Co Lp	Lentes de contacto de hidrogel de silicona
US9322958B2 (en)	2004-08-27	2016-04-26	Coopervision International Holding Company, Lp	Silicone hydrogel contact lenses
US7446157B2 (en)	2004-12-07	2008-11-04	Key Medical Technologies, Inc.	Nanohybrid polymers for ophthalmic applications
US8133178B2 (en)	2006-02-22	2012-03-13	Dexcom, Inc.	Analyte sensor
WO2006098408A1 (ja) *	2005-03-17	2006-09-21	Dow Corning Toray Co., Ltd.	ジヒドロキシカルボン酸アミド基含有オルガノポリシロキサンおよびその製造方法
US8744546B2 (en)	2005-05-05	2014-06-03	Dexcom, Inc.	Cellulosic-based resistance domain for an analyte sensor
US7543936B2 (en) *	2005-05-06	2009-06-09	Synergeyes, Inc.	Hybrid contact lens system and method of fitting
JP5122444B2 (ja) *	2005-05-23	2013-01-16	ダウ・コーニング・コーポレイション	サッカリド−シロキサンコポリマーを含むパーソナルケア組成物
KR101292027B1 (ko) *	2005-05-23	2013-08-05	다우 코닝 코포레이션	사카라이드-실록산 공중합체를 포함하는 표면처리 조성물
US7377637B2 (en) *	2005-10-11	2008-05-27	Synergeyes, Inc.	Hybrid contact lens system and method of fitting
US20070092830A1 (en) *	2005-10-24	2007-04-26	Bausch & Lomb Incorporated	Polymeric radiation-absorbing materials and ophthalmic devices comprising same
US20070092831A1 (en) *	2005-10-24	2007-04-26	Bausch & Lomb Incorporated	Radiation-absorbing polymeric materials and ophthalmic devices comprising same
WO2007120381A2 (en)	2006-04-14	2007-10-25	Dexcom, Inc.	Analyte sensor
JP2013076097A (ja) *	2006-04-25	2013-04-25	Hitachi Chemical Co Ltd	硬化性樹脂組成物及び光学部材
JP5239169B2 (ja) *	2006-04-25	2013-07-17	日立化成株式会社	光学部材
US7576159B2 (en) *	2006-04-28	2009-08-18	Bausch & Lomb Incorporated	Gas-permeable materials and medical devices
US7537339B2 (en) *	2006-05-25	2009-05-26	Synergeyes, Inc.	Hybrid contact lens system and method of fitting
US7468397B2 (en) *	2006-06-30	2008-12-23	Bausch & Lomb Incorporated	Polymerizable siloxane-quaternary amine copolymers
ATE416526T1 (de) *	2006-08-25	2008-12-15	Alcatel Lucent	Digitalsignalempfänger mit q-faktorüberwachung
US20080074611A1 (en) *	2006-09-22	2008-03-27	Meyers William E	Hybrid contact lens with improved resistance to flexure and method for designing the same
US8071703B2 (en) *	2007-03-22	2011-12-06	Novartis Ag	Silicone-containing prepolymers with dangling hydrophilic polymer chains
US20200037875A1 (en)	2007-05-18	2020-02-06	Dexcom, Inc.	Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7828432B2 (en) *	2007-05-25	2010-11-09	Synergeyes, Inc.	Hybrid contact lenses prepared with expansion controlled polymeric materials
CA2688184A1 (en)	2007-06-08	2008-12-18	Dexcom, Inc.	Integrated medicament delivery device for use with continuous analyte sensor
EP4159114B1 (en)	2007-10-09	2024-04-10	DexCom, Inc.	Integrated insulin delivery system with continuous glucose sensor
US8417312B2 (en)	2007-10-25	2013-04-09	Dexcom, Inc.	Systems and methods for processing sensor data
US9839395B2 (en)	2007-12-17	2017-12-12	Dexcom, Inc.	Systems and methods for processing sensor data
US8682408B2 (en)	2008-03-28	2014-03-25	Dexcom, Inc.	Polymer membranes for continuous analyte sensors
US8583204B2 (en)	2008-03-28	2013-11-12	Dexcom, Inc.	Polymer membranes for continuous analyte sensors
US11730407B2 (en)	2008-03-28	2023-08-22	Dexcom, Inc.	Polymer membranes for continuous analyte sensors
US8560039B2 (en)	2008-09-19	2013-10-15	Dexcom, Inc.	Particle-containing membrane and particulate electrode for analyte sensors
US8672475B2 (en) *	2009-10-01	2014-03-18	Coopervision International Holding Company, LLC	Silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses
ES2693499T3 (es)	2010-02-16	2018-12-12	Toray Industries, Inc.	Lentilla ocular blanda que tiene contenido bajo de humedad y procedimiento para producir la misma
AU2011282603B2 (en)	2010-07-30	2014-01-30	Novartis Ag	Amphiphilic polysiloxane prepolymers and uses thereof
ES2423914T3 (es)	2010-07-30	2013-09-25	Novartis Ag	Lentes de hidrogel de silicona con superficies ricas en agua
WO2012027073A1 (en)	2010-08-23	2012-03-01	Dow Corning Corporation	Saccharide siloxanes stable in aqueous environments and methods for the preparation and use of such saccharide siloxanes
US8835525B2 (en)	2010-10-06	2014-09-16	Novartis Ag	Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains
CN103168067B (zh)	2010-10-06	2015-08-05	诺华股份有限公司	可水处理的含硅氧烷预聚物及其用途
EP2625216B1 (en)	2010-10-06	2019-06-05	Novartis AG	Polymerisable chain-extended polysiloxanes with pendant hydrophilic groups
ES2449709T3 (es)	2011-02-28	2014-03-20	Coopervision International Holding Company, Lp	Lentes de contacto de hidrogel de silicona
TWI509313B (zh)	2011-02-28	2015-11-21	Coopervision Int Holding Co Lp	聚矽氧水凝膠隱形眼鏡
KR101528997B1 (ko)	2011-02-28	2015-06-15	쿠퍼비젼 인터내셔날 홀딩 캄파니, 엘피	치수 안정한 실리콘 히드로겔 콘택트 렌즈
KR101736534B1 (ko)	2011-02-28	2017-05-16	쿠퍼비젼 인터내셔날 홀딩 캄파니, 엘피	습윤성 실리콘 히드로겔 콘택트 렌즈
AU2012223582B2 (en)	2011-02-28	2014-10-23	Coopervision International Limited	Phosphine-containing hydrogel contact lenses
TWI512355B (zh)	2011-02-28	2015-12-11	Coopervision Int Holding Co Lp	聚矽氧水凝膠隱形眼鏡及相關組合物及方法
CN103620480B (zh)	2011-02-28	2015-12-09	库柏维景国际控股公司	具有可接受水平的能量损失的硅酮水凝胶隐形眼镜
CN102199270B (zh) *	2011-04-08	2012-07-25	江苏君锐高新材料有限公司	聚氨酯树脂预聚体溶液及其制备的人造革雾洗亮涂饰剂
CN103635219B (zh) *	2011-06-30	2017-04-26	皇家飞利浦有限公司	具有湿气控制和微气候控制的皮肤‑接触产品
WO2013024880A1 (ja) *	2011-08-17	2013-02-21	東レ株式会社	低含水性軟質眼用レンズおよびその製造方法
SG11201400228WA (en)	2011-10-12	2014-05-29	Novartis Ag	Method for making uv-absorbing ophthalmic lenses by coating
DE102011055683A1 (de)	2011-11-24	2013-05-29	Götz von Foerster	Synthetisches Schmiermittel zur Verwendung als Synovialflüssigkeitsersatz
WO2014039495A1 (en)	2012-09-05	2014-03-13	University Of Miami	Novel keratoprosthesis, and system and method of corneal repair using same
WO2014093751A2 (en)	2012-12-14	2014-06-19	Novartis Ag	Amphiphilic siloxane-containing vinylic monomers and uses thereof
JP6065988B2 (ja)	2012-12-14	2017-01-25	ノバルティスアーゲー	トリス（トリメチルシロキシ）シランビニル系モノマー及びその用途
EP2931767B1 (en)	2012-12-14	2017-11-08	Novartis AG	Amphiphilic siloxane-containing (meth)acrylamides and uses thereof
CN104871036B (zh)	2012-12-17	2019-12-10	诺华股份有限公司	制备改进的uv吸收性眼用透镜的方法
US9486311B2 (en)	2013-02-14	2016-11-08	Shifamed Holdings, Llc	Hydrophilic AIOL with bonding
JP6241042B2 (ja) *	2013-02-21	2017-12-06	東レ株式会社	医療デバイス
CA3193600A1 (en)	2013-03-21	2014-09-25	Shifamed Holdings, Llc	Accommodating intraocular lens
US10195018B2 (en)	2013-03-21	2019-02-05	Shifamed Holdings, Llc	Accommodating intraocular lens
WO2015052229A1 (en) *	2013-10-08	2015-04-16	Momentive Performance Materials Gmbh	Reactive functional siloxane compositions
US9505778B2 (en)	2013-11-27	2016-11-29	Regents Of The University Of Minnesota	Monomers, polymers and articles containing the same from sugar derived compounds
HUE038809T2 (hu)	2013-12-17	2018-11-28	Novartis Ag	Térhálósított hidrofíl bevonattal ellátott szilikon hidrogél lencse
WO2015164630A1 (en)	2014-04-25	2015-10-29	Novartis Ag	Carbosiloxane vinylic monomers
EP3134461B1 (en)	2014-04-25	2018-02-14	Novartis AG	Hydrophilized carbosiloxane vinylic monomers
JP6173260B2 (ja) *	2014-06-12	2017-08-02	信越化学工業株式会社	眼科デバイス製造用モノマー
JP6356635B2 (ja) *	2014-06-12	2018-07-11	信越化学工業株式会社	眼科デバイス製造用モノマー
AU2015306613B2 (en)	2014-08-26	2018-01-25	Shifamed Holdings, Llc	Accommodating intraocular lens
EP3186070B1 (en)	2014-08-26	2019-09-25	Novartis AG	Method for applying stable coating on silicone hydrogel contact lenses
NZ728772A (en)	2014-09-26	2018-10-26	Novartis Ag	Polymerizable polysiloxanes with hydrophilic substituents
CN106032400A (zh) *	2015-03-17	2016-10-19	专力国际开发股份有限公司	网状高分子、用于制作生医装置的组成物及生医装置
US11141263B2 (en)	2015-11-18	2021-10-12	Shifamed Holdings, Llc	Multi-piece accommodating intraocular lens
JP6934197B2 (ja)	2015-11-18	2021-09-15	シファメド・ホールディングス・エルエルシー	複数片の調節式眼内レンズ
KR102604468B1 (ko)	2015-12-15	2023-11-22	알콘 인코포레이티드	실리콘 하이드로겔 콘택트 렌즈 상에 안정한 코팅을 적용하기 위한 방법
JP6615349B2 (ja)	2015-12-15	2019-12-04	ノバルティスアーゲー	両親媒性分枝鎖状ポリジオルガノシロキサンマクロマー
CN105949692A (zh) *	2016-07-22	2016-09-21	上海洛法化工有限公司	一种改性聚乙烯醇及其制备工艺
JP6816264B2 (ja) *	2016-09-19	2021-01-20	ダウシリコーンズコーポレーション	ポリウレタン−ポリオルガノシロキサンコポリマー及びその調製方法
WO2018078543A1 (en)	2016-10-26	2018-05-03	Novartis Ag	Amphiphilic branched polydiorganosiloxane macromers
PT3553840T (pt) *	2016-12-09	2022-02-22	Momentive Performance Mat Korea Co Ltd	Composição para um agente de encapsulação de um elemento orgânico eletrónico e o agente de encapsulação formado por essa composição
CN120000379A (zh)	2016-12-23	2025-05-16	施菲姆德控股有限责任公司	多片式调节性人工晶状体及其制造和使用方法
US10350056B2 (en)	2016-12-23	2019-07-16	Shifamed Holdings, Llc	Multi-piece accommodating intraocular lenses and methods for making and using same
CN110996848B (zh)	2017-05-30	2023-08-04	施菲姆德控股有限责任公司	调节性人工晶状体的表面处理以及相关方法和装置
EP4205702B1 (en)	2017-06-07	2025-09-10	Shifamed Holdings, LLC	Adjustable optical power intraocular lenses
US11331022B2 (en)	2017-10-24	2022-05-17	Dexcom, Inc.	Pre-connected analyte sensors
DK3928687T3 (da)	2017-10-24	2024-09-30	Dexcom Inc	Bærbar indretning med på forhånd forbundet analytsensor
US10830923B2 (en)	2017-12-13	2020-11-10	Alcon Inc.	Method for producing MPS-compatible water gradient contact lenses
KR20210053935A (ko) *	2018-12-29	2021-05-12	와커 헤미 아게	친수성 사이클로덱스트린-함유 실리콘 젤
EP3996629A4 (en)	2019-07-11	2023-08-09	Shifamed Holdings, LLC	ACCOMMODATING INTRAOCULAR LENSES AND RELATED PROCEDURES
US20230100274A1 (en) *	2020-02-25	2023-03-30	Shiseido Company, Ltd.	Resin material including siloxane-bond-containing polymer having host group and/or guest group
KR102899294B1 (ko)	2022-09-09	2025-12-15	다우 실리콘즈 코포레이션	폴리에스테르 골격과 가교결합제 사이에 C-O-Si 결합을 갖는 탄성중합체

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE104988C (2) *
US4777276A (en) *	1981-10-29	1988-10-11	Minnesota Mining And Manufacturing Company	Acrylamidoacylated oligomers
US4820302A (en) *	1982-04-22	1989-04-11	Sterling Drug Inc.	Bio compatible and blood compatible materials and methods
DE3219220A1 (de) *	1982-05-21	1983-11-24	Wacker-Chemie GmbH, 8000 München	Waessrige, organosiliciumverbindung enthaltende zusammensetzungen
JPS5982212A (ja) *	1982-11-03	1984-05-12	Sanshin Shokai:Kk	フリ−フロ−コンベヤ
GB2166654A (en) *	1984-09-22	1986-05-14	Olusola Olumide Akindele Oni	Shoulder joint prosthesis
US4605712A (en) *	1984-09-24	1986-08-12	Ciba-Geigy Corporation	Unsaturated polysiloxanes and polymers thereof
US4591652A (en) *	1985-04-12	1986-05-27	Scm Corporation	Polyhydroxyl silanes or siloxanes
US4623697A (en) *	1985-04-30	1986-11-18	Ppg Industries, Inc.	Ungelled resins containing hydrolyzable moieties from organosilane compounds
JPS6268820A (ja) *	1985-09-19	1987-03-28	Kao Corp	糖残基を含有するオルガノポリシロキサンの製造法
JPS63139106A (ja) *	1986-12-02	1988-06-10	Kao Corp	化粧料
DE3641436A1 (de) *	1986-12-04	1988-06-09	Schmalbach Lubeca	Loesungsmittelfreie, monomerarme bzw. -freie, polymerisierbare schmelzmasse, verfahren zu deren herstellung und verarbeitung
FR2622201B1 (fr) *	1987-10-23	1990-03-23	Essilor Int	Elastomere de silicones mouillable convenant a la fabrication de lentilles de contact
DE3803628A1 (de) *	1988-02-06	1989-08-17	Bayer Ag	Verwendung von aminogruppen aufweisenden polysiloxanen als zusatzmittel in kunststofflacken
DE3832089A1 (de) *	1988-09-21	1990-03-29	Rotta Gmbh & Co Dr	Textilveredelungsmittel und verfahren zur ausruestung von cellulosehaltigem textilgut
US4983702A (en) *	1988-09-28	1991-01-08	Ciba-Geigy Corporation	Crosslinked siloxane-urethane polymer contact lens
US4962178A (en) *	1988-11-03	1990-10-09	Ciba-Geigy Corporation	Novel polysiloxane-polyurethanes and contact lens thereof
US5010141A (en) *	1989-10-25	1991-04-23	Ciba-Geigy Corporation	Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
JPH06102796B2 (ja) *	1990-01-10	1994-12-14	花王株式会社	衣料用液体洗浄剤組成物
US5057377A (en) *	1990-05-16	1991-10-15	Ciba-Geigy Corporation	Fluorinated silicon polymers
CA2065923C (en) *	1992-04-13	1997-06-24	Richard Nolin	Method and apparatus for harvesting and dewatering peat moss material
JPH05339087A (ja) *	1992-06-05	1993-12-21	Japan Steel Works Ltd:The	堆肥化装置の曝気方法
ES2097482T3 (es) *	1992-08-05	1997-04-01	Ciba Geigy Ag	Lentes de contacto de ciclodextrinas lipofilizadas.
JP3195662B2 (ja) *	1992-08-24	2001-08-06	株式会社メニコン	眼用レンズ材料
DE4318536A1 (de) *	1993-06-04	1994-12-08	Bayer Ag	Siloxanylmodifizierte polyhydroxylierte Kohlenwasserstoffe
DE4318537A1 (de) *	1993-06-04	1994-12-08	Bayer Ag	Kationische siloxanylmodifizierte polyhydroxylierte Kohlenwasserstoffe
DE4318539A1 (de) *	1993-06-04	1994-12-08	Bayer Ag	Anionische siloxanylmodifizierte polyhydroxylierte Kohlenwasserstoffe
US5603774A (en) *	1993-09-27	1997-02-18	Alcon Laboratories, Inc.	Method for reducing tackiness of soft acrylic polymers
JPH08269204A (ja) *	1995-03-29	1996-10-15	Chiba Seifun Kk	新規シリコーン誘導体、その製造法および用途
US5648402A (en) *	1995-06-01	1997-07-15	Nunez; Ivan M.	Contact lenses from highly permeable siloxane polyol material

1996
- 1996-03-22 DE DE29624309U patent/DE29624309U1/de not_active Expired - Lifetime
- 1996-03-22 SI SI9630391T patent/SI0819258T1/xx unknown
- 1996-04-02 AR AR33601496A patent/AR001497A1/es unknown
- 1996-05-07 CZ CZ973639A patent/CZ363997A3/cs unknown
- 1996-05-07 CA CA002220217A patent/CA2220217A1/en not_active Abandoned
- 1996-05-07 EP EP96919684A patent/EP0826158B1/en not_active Expired - Lifetime
- 1996-05-07 HU HU9801139A patent/HUP9801139A3/hu unknown
- 1996-05-07 KR KR1019970708306A patent/KR19990021832A/ko not_active Withdrawn
- 1996-05-07 AT AT96919684T patent/ATE184708T1/de not_active IP Right Cessation
- 1996-05-07 PL PL96323350A patent/PL323350A1/xx unknown
- 1996-05-07 JP JP53451396A patent/JP5048173B2/ja not_active Expired - Fee Related
- 1996-05-07 BR BR9608824A patent/BR9608824A/pt not_active Application Discontinuation
- 1996-05-07 CN CN96194388A patent/CN1186550A/zh active Pending
- 1996-05-07 US US08/952,416 patent/US6043328A/en not_active Expired - Lifetime
- 1996-05-07 WO PCT/EP1996/001888 patent/WO1996036890A1/en not_active Ceased
- 1996-05-07 DE DE69604285T patent/DE69604285T2/de not_active Expired - Lifetime
- 1996-05-07 AU AU58144/96A patent/AU5814496A/en not_active Abandoned
- 1996-05-13 IL IL11823796A patent/IL118237A0/xx unknown
- 1996-05-17 ZA ZA963937A patent/ZA963937B/xx unknown
1997
- 1997-11-18 NO NO975289A patent/NO975289L/no unknown
2011
- 2011-05-18 JP JP2011111611A patent/JP2011225884A/ja active Pending

Also Published As

Publication number	Publication date
PL323350A1 (en)	1998-03-30
ZA963937B (en)	1997-01-06
HUP9801139A3 (en)	1998-10-28
AU5814496A (en)	1996-11-29
HUP9801139A2 (hu)	1998-09-28
CN1186550A (zh)	1998-07-01
WO1996036890A1 (en)	1996-11-21
US6043328A (en)	2000-03-28
CA2220217A1 (en)	1996-11-21
DE29624309U1 (de)	2002-01-03
NO975289D0 (no)	1997-11-18
EP0826158B1 (en)	1999-09-15
EP0826158A1 (en)	1998-03-04
AR001497A1 (es)	1997-10-22
JP2011225884A (ja)	2011-11-10
DE69604285T2 (de)	2000-03-23
DE69604285D1 (de)	1999-10-21
KR19990021832A (ko)	1999-03-25
JP5048173B2 (ja)	2012-10-17
SI0819258T1 (en)	2002-04-30
MX9708910A (es)	1998-03-31
ATE184708T1 (de)	1999-10-15
NO975289L (no)	1998-01-16
JPH11505564A (ja)	1999-05-21
BR9608824A (pt)	1999-06-15
IL118237A0 (en)	1996-09-12

Publication	Publication Date	Title
US6043328A (en)	2000-03-28	Polysiloxane-polyol macromers, their preparation and their use
EP0868457B1 (en)	2002-09-11	Polyurethanes made from polysiloxane/polyol macromers
JP4216332B2 (ja)	2009-01-28	長期装着用の眼のレンズ
JP3892903B2 (ja)	2007-03-14	重合しうるシロキサンマクロモノマー
JP3967377B2 (ja)	2007-08-29	ポリシロキサン−含有ペルフルオロアルキルエーテル、並びにその製法及び用途
US8415404B2 (en)	2013-04-09	Extended wear ophthalmic lens
AU695525B2 (en)	1998-08-13	Unsaturated carbohydrate derivatives, polymers thereof and their use
JP2000501853A (ja)	2000-02-15	コンタクトレンズを製造する方法
MXPA97008910A (en)	1998-10-15	Macisters polisiloxano-poliol, its preparation and its