DD140259A5 - Lagerfaehige cholesterinoxidasepraeparation - Google Patents

Lagerfaehige cholesterinoxidasepraeparation Download PDF

Info

Publication number: DD140259A5
Authority: DD; German Democratic Republic
Prior art keywords: preparation; oxidease; storageable; cholesterine; buffer
Prior art date: 1977-12-14

Application number

DD78109434A

Other languages

German (de)

English (en)

Inventor

Waldemar Thum

Gunter Lang

Hellmuth Vetter

Gotthilf Naeher

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-12-14

Filing date

1978-11-30

Publication date

1980-02-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6026143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD140259(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1978-11-30 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1980-02-20 Publication of DD140259A5 publication Critical patent/DD140259A5/de

Links

238000002360 preparation method Methods 0.000 title claims description 10
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 1
239000003381 stabilizer Substances 0.000 claims description 8
239000000337 buffer salt Substances 0.000 claims 1
239000006172 buffering agent Substances 0.000 claims 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 11
229910052921 ammonium sulfate Inorganic materials 0.000 description 11
235000011130 ammonium sulphate Nutrition 0.000 description 11
108090000790 Enzymes Proteins 0.000 description 10
102000004190 Enzymes Human genes 0.000 description 10
229940088598 enzyme Drugs 0.000 description 10
108010089254 Cholesterol oxidase Proteins 0.000 description 7
230000000694 effects Effects 0.000 description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
239000000872 buffer Substances 0.000 description 6
230000000087 stabilizing effect Effects 0.000 description 5
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
239000000243 solution Substances 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
230000006641 stabilisation Effects 0.000 description 3
238000011105 stabilization Methods 0.000 description 3
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
150000001450 anions Chemical class 0.000 description 2
150000001768 cations Chemical class 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
235000011164 potassium chloride Nutrition 0.000 description 2
239000008057 potassium phosphate buffer Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
108010000659 Choline oxidase Proteins 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
239000004365 Protease Substances 0.000 description 1
108091006629 SLC13A2 Proteins 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910001514 alkali metal chloride Inorganic materials 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
150000001805 chlorine compounds Chemical class 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
230000007423 decrease Effects 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000002523 lectin Substances 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000000746 purification Methods 0.000 description 1
-1 quaternary ammonium ions Chemical class 0.000 description 1
230000007017 scission Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007974 sodium acetate buffer Substances 0.000 description 1
239000012064 sodium phosphate buffer Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DD78109434A 1977-12-14 1978-11-30 Lagerfaehige cholesterinoxidasepraeparation DD140259A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2755799A DE2755799B1 (de)	1977-12-14	1977-12-14	Lagerfaehige Cholesterinoxidasepraeparation

Publications (1)

Publication Number	Publication Date
DD140259A5 true DD140259A5 (de)	1980-02-20

Family

ID=6026143

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD78109434A DD140259A5 (de)	1977-12-14	1978-11-30	Lagerfaehige cholesterinoxidasepraeparation

Country Status (13)

Country	Link
US (1)	US4366249A (cs)
EP (1)	EP0002438B1 (cs)
JP (1)	JPS5489015A (cs)
AT (1)	AT363893B (cs)
CA (1)	CA1108050A (cs)
CS (1)	CS215112B2 (cs)
DD (1)	DD140259A5 (cs)
DE (2)	DE2755799B1 (cs)
DK (1)	DK145614C (cs)
HU (1)	HU179431B (cs)
IL (1)	IL55946A (cs)
IT (1)	IT1099545B (cs)
ZA (1)	ZA786974B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047327A (en) *	1982-04-02	1991-09-10	Ivan E. Modrovich	Time-stable liquid cholesterol assay compositions
JPS60194373U (ja) *	1984-06-04	1985-12-24	株式会社ピ−エフユ−	フエライトコアの実装構造
AU2015202990B2 (en) *	1999-06-21	2017-11-02	Sekisui Medical Co., Ltd.	Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same
AU2008201734B2 (en) *	1999-06-21	2012-07-05	Sekisui Medical Co., Ltd.	Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same
JP4542234B2 (ja) *	1999-06-21	2010-09-08	積水メディカル株式会社	コレステロール定量用試料の前処理方法およびこれを利用する特定のリポ蛋白中のコレステロール定量法
CA2375894C (en) *	1999-06-21	2012-05-22	Daiichi Pure Chemicals Co., Ltd.	Reaction accelerator-enchanced activity of cholesterol metabolizing enzymes in methods of quantifying cholesterol
WO2013161676A1 (ja) *	2012-04-27	2013-10-31	協和メデックス株式会社	コレステロールオキシダーゼの安定化方法
WO2022032178A1 (en)	2020-08-06	2022-02-10	Mate Precision Technologies Inc.	Vise assembly
WO2022032148A1 (en)	2020-08-06	2022-02-10	Mate Precision Technologies Inc.	Tooling base assembly

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2344567A1 (fr) *	1976-03-17	1977-10-14	Mitsubishi Chem Ind	Procede de preservation de glucose-isomerase et solution de glucose-isomerase
US4077842A (en) *	1976-03-19	1978-03-07	Cory Robert Paul	Stabilized glucose isomerase enzyme concentrate
JPS52143285A (en) *	1976-05-26	1977-11-29	Kikkoman Corp	Stabilization of cholesterol-oxydase

1977
- 1977-12-14 DE DE2755799A patent/DE2755799B1/de active Granted
1978
- 1978-10-03 AT AT0712678A patent/AT363893B/de not_active IP Right Cessation
- 1978-10-04 DE DE7878101065T patent/DE2860583D1/de not_active Expired
- 1978-10-04 EP EP78101065A patent/EP0002438B1/de not_active Expired
- 1978-10-26 IT IT29156/78A patent/IT1099545B/it active
- 1978-11-02 DK DK489278A patent/DK145614C/da not_active IP Right Cessation
- 1978-11-08 CA CA315,983A patent/CA1108050A/en not_active Expired
- 1978-11-14 IL IL55946A patent/IL55946A/xx unknown
- 1978-11-30 DD DD78109434A patent/DD140259A5/de not_active IP Right Cessation
- 1978-12-08 CS CS788159A patent/CS215112B2/cs unknown
- 1978-12-12 JP JP15275878A patent/JPS5489015A/ja active Granted
- 1978-12-13 ZA ZA00786974A patent/ZA786974B/xx unknown
- 1978-12-13 HU HU78BO1754A patent/HU179431B/hu unknown
1982
- 1982-01-15 US US06/339,760 patent/US4366249A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IT1099545B (it)	1985-09-18
IL55946A (en)	1981-11-30
DE2755799C2 (cs)	1979-04-12
EP0002438A1 (de)	1979-06-27
ATA712678A (de)	1981-02-15
DE2755799B1 (de)	1978-08-03
US4366249A (en)	1982-12-28
DE2860583D1 (en)	1981-04-23
IT7829156A0 (it)	1978-10-26
ZA786974B (en)	1979-12-27
EP0002438B1 (de)	1981-04-01
DK145614C (da)	1983-06-13
JPS5489015A (en)	1979-07-14
CS215112B2 (en)	1982-07-30
CA1108050A (en)	1981-09-01
HU179431B (en)	1982-10-28
DK489278A (da)	1979-06-15
DK145614B (da)	1982-12-27
AT363893B (de)	1981-09-10
JPS5724760B2 (cs)	1982-05-26
IL55946A0 (en)	1979-01-31

Legal Events

Date	Code	Title	Description
1998-07-16	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE68918847T2 (de)	1995-03-16	Stabile pharmazeutische zusammensetzung.
EP0002438B1 (de)	1981-04-01	Lagerfähige Cholesterinoxidasepräparation
DE2609039B2 (de)	1980-02-14	Verfahren zum Herstellen von beständigem Natriumpercarbonat
DE69521520T2 (de)	2002-04-25	Biologisches produkt zur physikalisch-chemischen weinstabilisierung
DE3337566C2 (cs)	1989-07-20
EP0042969B1 (de)	1985-02-13	Verfahren zur Stabilisierung der alkalischen Phosphatase
DE1045377B (de)	1958-12-04	Verfahren zum Stabilisieren von zur Herstellung von Fungiziden geeignetem Selendisulfid, das durch Zusatz eines hydrophilen kolloidalen Suspensionsmittels aktiviert ist
DE69315059T2 (de)	2009-09-10	Enzymatische Zubereitungen die Papain oder Chymotrypsin enthalten zur dauerhafte enzymatische Entfernung von Haaren
DE69807059T2 (de)	2002-12-05	Enzym-konzentrat
DE1642083B1 (de)	1971-08-26	Jodophores Euterdesinfektionsmittel
DE3234761C2 (cs)	1991-07-25
DE68903937T2 (de)	1993-04-22	Waessrige elcatonin-loesung enthaltende arzneizubereitung.
EP1008350A1 (de)	2000-06-14	Stabilisiertes Antithrombin III-Präparat
DE2239210C3 (de)	1978-11-23	Verfahren zur Herstellung von a- Galactosidase, die eine starke a- Galactosidase-Aktivität und eine äußerst geringe Invertase-Aktivität aufweist, und deren Verwendung zur Zerlegung von Raffinose
DE1131360B (de)	1962-06-14	Verfahren zum Stabilisieren von waessrigen Loesungen, die neben Vitamin B noch Vitamin B und Vitamin C enthalten
DE69030798T2 (de)	1997-09-11	Stabilisierung des Glucose-Oxidase-Enzyms in flüssigem Reagenz
DE3404876A1 (de)	1985-09-05	Verfahren zur verbesserung der selektiven aktivitaetshemmung von humaner pankreas- und speichelamylase sowie eine hierfuer geeignete inhibitorzubereitung
DE283061C (cs)
DE1517751C3 (de)	1975-02-27	Verfahren zum Verhindern der Bildung von flockigen Lysozym- und/oder Lysozymsalzniederschlägen in wässrigen Lösungen, die Lysozym und/oder Lysozymsalze enthalten
DE2036113B2 (de)	1979-01-11	Wäßriges Tetramisolpräparat
DE1642582C3 (de)	1976-08-12	Zusatzmittel zur Erhöhung der Lagerfähigkeit von Cftrat-Lyase und Verfahren zur Verbesserung der Lagerfähigkeit von Citrat-Lyase
DE2234412B2 (de)	1980-07-03	Verfahren zur Stabilisierung und Fällung konzentrierter Protease-Lösungen
DE2163062C3 (de)	1974-05-16	Mittel zum Frischhalten von Schnittblumen
DE4041543C2 (de)	1994-06-30	Stabilisierung von Ascorbinsäure in stark saurer Lösung
AT153166B (de)	1938-04-25	Verfahren zum Bleichen von Fasern.