DD141036A5 - Verfahren zur herstellung von mycophenolsaeure - Google Patents

Verfahren zur herstellung von mycophenolsaeure Download PDF

Info

Publication number: DD141036A5
Authority: DD; German Democratic Republic
Prior art keywords: mycophenolic acid; penicillium; strains; polyene; strain
Prior art date: 1977-03-21

Application number

DD78203108A

Other languages

German (de)

English (en)

Inventor

Stephen W Queener

Iii Claude H Nash

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-21

Filing date

1978-01-05

Publication date

1980-04-09

1978-01-05 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1980-04-09 Publication of DD141036A5 publication Critical patent/DD141036A5/de

Links

HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title claims description 38
HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title claims description 37
229960000951 mycophenolic acid Drugs 0.000 title claims description 37
238000000034 method Methods 0.000 title claims description 13
238000002360 preparation method Methods 0.000 title description 4
241000228143 Penicillium Species 0.000 claims description 13
241000228145 Penicillium brevicompactum Species 0.000 claims description 10
235000015097 nutrients Nutrition 0.000 claims description 10
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
229910052799 carbon Inorganic materials 0.000 claims description 3
229910052757 nitrogen Inorganic materials 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
239000012528 membrane Substances 0.000 description 18
239000002459 polyene antibiotic agent Substances 0.000 description 15
VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 description 12
239000002609 medium Substances 0.000 description 11
VWFJDQUYCIWHTN-UHFFFAOYSA-N Farnesyl pyrophosphate Natural products CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-UHFFFAOYSA-N 0.000 description 10
238000000855 fermentation Methods 0.000 description 8
230000004151 fermentation Effects 0.000 description 8
229930183931 Filipin Natural products 0.000 description 6
229950000152 filipin Drugs 0.000 description 6
IMQSIXYSKPIGPD-NKYUYKLDSA-N filipin Chemical compound CCCCC[C@H](O)[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O IMQSIXYSKPIGPD-NKYUYKLDSA-N 0.000 description 6
IMQSIXYSKPIGPD-UHFFFAOYSA-N filipin III Natural products CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(C)=CC=CC=CC=CC=CC(O)C(C)OC1=O IMQSIXYSKPIGPD-UHFFFAOYSA-N 0.000 description 6
239000003471 mutagenic agent Substances 0.000 description 6
229960000988 nystatin Drugs 0.000 description 5
VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 5
OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 4
RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 4
OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 4
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 4
229930182558 Sterol Natural products 0.000 description 4
DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 4
239000007788 liquid Substances 0.000 description 4
229920006395 saturated elastomer Polymers 0.000 description 4
150000003432 sterols Chemical class 0.000 description 4
235000003702 sterols Nutrition 0.000 description 4
238000012360 testing method Methods 0.000 description 4
229920001817 Agar Polymers 0.000 description 3
241000233866 Fungi Species 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000008272 agar Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
230000002538 fungal effect Effects 0.000 description 3
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 2
239000006285 cell suspension Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
230000008686 ergosterol biosynthesis Effects 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
230000004060 metabolic process Effects 0.000 description 2
244000005700 microbiome Species 0.000 description 2
239000000203 mixture Substances 0.000 description 2
150000004291 polyenes Chemical class 0.000 description 2
229920000053 polysorbate 80 Polymers 0.000 description 2
239000002243 precursor Substances 0.000 description 2
229930000044 secondary metabolite Natural products 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
238000005406 washing Methods 0.000 description 2
HMVYERAUBSAVAX-UHFFFAOYSA-N 1-nitro-1-nitrosoguanidine Chemical compound NC(=N)N(N=O)[N+]([O-])=O HMVYERAUBSAVAX-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
-1 C 15 terpene Chemical class 0.000 description 1
PLUBXMRUUVWRLT-UHFFFAOYSA-N Ethyl methanesulfonate Chemical compound CCOS(C)(=O)=O PLUBXMRUUVWRLT-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
241000864371 Penicillium viridicatum Species 0.000 description 1
240000006928 Persicaria lapathifolia Species 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
241000512728 Protoblastenia szaferi Species 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
238000010564 aerobic fermentation Methods 0.000 description 1
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
229960003942 amphotericin b Drugs 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
230000035772 mutation Effects 0.000 description 1
238000012261 overproduction Methods 0.000 description 1
238000007248 oxidative elimination reaction Methods 0.000 description 1
230000035699 permeability Effects 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
235000007586 terpenes Nutrition 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DD78203108A 1977-03-21 1978-01-05 Verfahren zur herstellung von mycophenolsaeure DD141036A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77967077A	1977-03-21	1977-03-21

Publications (1)

Publication Number	Publication Date
DD141036A5 true DD141036A5 (de)	1980-04-09

Family

ID=25117146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD78203108A DD141036A5 (de)	1977-03-21	1978-01-05	Verfahren zur herstellung von mycophenolsaeure

Country Status (10)

Country	Link
US (1)	US4115197A (fr)
JP (1)	JPS53115880A (fr)
BE (1)	BE862618A (fr)
DD (1)	DD141036A5 (fr)
DE (1)	DE2800071A1 (fr)
ES (1)	ES465821A1 (fr)
FR (1)	FR2384846A1 (fr)
GB (1)	GB1593208A (fr)
IL (1)	IL53741A (fr)
NL (1)	NL7800064A (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5668398A (en) *	1979-11-07	1981-06-09	Nippon Oil Co Ltd	Prduction of uroporphyrin 3
JPS5678595A (en) *	1979-11-29	1981-06-27	Nippon Oil Co Ltd	Preparation of coproporphyrin 3
US4452891A (en) *	1980-09-08	1984-06-05	Ajinomoto Company Incorporated	Method for production of mycophenolic acid by fermentation
US7083642B2 (en) *	2000-12-22	2006-08-01	Avantec Vascular Corporation	Delivery of therapeutic capable agents
US6471980B2 (en)	2000-12-22	2002-10-29	Avantec Vascular Corporation	Intravascular delivery of mycophenolic acid
US20030050692A1 (en) *	2000-12-22	2003-03-13	Avantec Vascular Corporation	Delivery of therapeutic capable agents
US7077859B2 (en)	2000-12-22	2006-07-18	Avantec Vascular Corporation	Apparatus and methods for variably controlled substance delivery from implanted prostheses
US20050203612A1 (en) *	2000-12-22	2005-09-15	Avantec Vascular Corporation	Devices delivering therapeutic agents and methods regarding the same
EP1416884A4 (fr) *	2001-07-26	2007-03-07	Avantec Vascular Corp	Administration d'agents potentiellement therapeutiques
WO2003106690A1 (fr) *	2002-06-18	2003-12-24	Biocon India Limited	Fermentation a l'etat solide a ecoulement discontinu pour la production d'acide mycophenolique
WO2005051229A2 (fr) *	2003-11-24	2005-06-09	Avantec Vascular Corporation	Dispositifs et procedes d'administration d'agents therapeutiques
US7683188B2 (en) *	2004-04-26	2010-03-23	TEVA Gyógyszergyár Zártkōrūen Mūkōdō Részvénytársaság	Process for preparation of mycophenolic acid and ester derivatives thereof
CA2583310A1 (fr) *	2004-10-05	2006-04-13	Biocon Limited	Processus de production d'acide mycophenolique au moyen de la souche bicc7673 de penicillium arenicola
EP2032712B1 (fr) *	2006-06-29	2010-02-10	Ivax Pharmaceuticals S.R.O.	Régulation de la production de métabolites acides
WO2008127663A1 (fr) *	2007-04-11	2008-10-23	Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság	Procédé de réduction du niveau d'impuretés dans une fermentation d'acide mycophénolique
US20230218644A1 (en)	2020-04-16	2023-07-13	Som Innovation Biotech, S.A.	Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1642699C3 (de) *	1966-09-27	1978-08-17	Imperial Chemical Industries Ltd., London	Verfahren zur Herstellung von Mykophenolsäure

1977
- 1977-08-29 US US05/828,392 patent/US4115197A/en not_active Expired - Lifetime
1978
- 1978-01-02 DE DE19782800071 patent/DE2800071A1/de not_active Ceased
- 1978-01-03 IL IL53741A patent/IL53741A/xx unknown
- 1978-01-03 NL NL7800064A patent/NL7800064A/xx not_active Application Discontinuation
- 1978-01-04 GB GB122/78A patent/GB1593208A/en not_active Expired
- 1978-01-04 BE BE1008623A patent/BE862618A/fr unknown
- 1978-01-04 FR FR7800142A patent/FR2384846A1/fr active Granted
- 1978-01-05 DD DD78203108A patent/DD141036A5/de unknown
- 1978-01-05 ES ES465821A patent/ES465821A1/es not_active Expired
- 1978-01-05 JP JP35478A patent/JPS53115880A/ja active Pending

Also Published As

Publication number	Publication date
JPS53115880A (en)	1978-10-09
DE2800071A1 (de)	1978-10-05
BE862618A (fr)	1978-07-04
ES465821A1 (es)	1978-09-16
IL53741A (en)	1981-02-27
NL7800064A (nl)	1978-09-25
FR2384846A1 (fr)	1978-10-20
GB1593208A (en)	1981-07-15
FR2384846B1 (fr)	1980-10-17
US4115197A (en)	1978-09-19

Publication	Publication Date	Title
DE2800071A1 (de)	1978-10-05	Verfahren zur erzeugung von penicilliumstaemmen mit erhoehter mycophenolsaeureproduktion
CH645891A5 (de)	1984-10-31	Verfahren zur herstellung von monacolin k.
CH645890A5 (de)	1984-10-31	Monacolin k, seine herstellung und dieses enthaltendes antihypercholesterinaemisches mittel.
DE2343587A1 (de)	1974-03-07	Verfahren zur herstellung von 2-ketol-gulonsaeure
DE2900591A1 (de)	1980-07-17	Antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel
DE68907608T2 (de)	1994-01-20	Verfahren zur herstellung von lignin-peroxidase durch verwendung von nichtproliferierenden phanerochaete chryosporium-zellen.
DE69013737T2 (de)	1995-03-23	Mevalonsäure produzierender Mikroorganismus.
DE3418187A1 (de)	1985-03-28	Verfahren zur herstellung von aminoglykosid-antibiotica enthaltenden gaerbruehen
DE2004686A1 (de)	1970-09-03	Antibiotica und Verfahren zu ihrer Herstellung
DE2455992C3 (de)	1978-08-10	methoxy-3-thiosulfatomethyl-3- cephem-4carbonsäure
DE2428957A1 (de)	1975-01-09	Verfahren zur herstellung von desacetoxycephalosporin c
DE2417642B2 (de)	1979-08-09	Verfahren zur enzymatischen Isomerisierung von Glucose zu Fructose
DE2715893A1 (de)	1977-10-20	Verfahren zur selektiven inaktivierung von amylase
DE2413961C2 (de)	1982-03-18	Biotechnische Herstellung von Citronensäure
DE102004046024A1 (de)	2006-03-30	Antibiotikum und Verfahren zur Herstellung
DE3878946T2 (de)	1993-06-17	Verfahren zur herstellung von mevalonischer saeure.
DE1793766C3 (de)	1978-11-02	Antibiotikum A 3823
DE2065297C3 (de)	1976-05-26	Makrolid-Antibioticum SF-837-A tief 2 und dessen Diacetylderivat sowie Makrolid-Antibiotica SF-837-A tief 3 und SF-837-A tief 4 und deren Monoacetylderivate sowie pharmakologisch nicht giftige Säureadditionssalze der genannten Antibiotica und Verfahren zur Herstellung der Antibiotica SF-837-A tief 2, SF-837-A tief 3 und SF-837-A tief 4
DE1926458A1 (de)	1970-02-12	Antibiotische Substanzen und Verfahren zu ihrer Herstellung
AT350716B (de)	1979-06-11	Verfahren zur herstellung neuer antibiotika
DE2342404C3 (de)	1979-10-04	3-(5,7-Dimethyl-2-hydroxy-4-oxo-6,8-decadienyI)-glutarimid sowie Verfahren zu dessen Herstellung
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