DD143662A5 - Diagnostisches mittel zur bestimmung von ammoniak oder unter bildung von ammoniak reagierenden substraten - Google Patents

Diagnostisches mittel zur bestimmung von ammoniak oder unter bildung von ammoniak reagierenden substraten Download PDF

Info

Publication number: DD143662A5
Authority: DD; German Democratic Republic
Prior art keywords: ammonia; layer; urea; reaction; reaction layer
Prior art date: 1978-05-17

Application number

DD79212892A

Other languages

German (de)

English (en)

Inventor

Anselm Rothe

Adolf K Selle

Hans-Rudolf Lange

Walter Rittersdorf

Wolfgang Werner

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-05-17

Filing date

1979-05-15

Publication date

1980-09-03

1979-05-15 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1980-09-03 Publication of DD143662A5 publication Critical patent/DD143662A5/de

Links

QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 title claims description 72
229910021529 ammonia Inorganic materials 0.000 title claims description 35
239000000758 substrate Substances 0.000 title claims description 16
229940039227 diagnostic agent Drugs 0.000 title claims description 12
239000000032 diagnostic agent Substances 0.000 title claims description 12
230000015572 biosynthetic process Effects 0.000 title description 4
239000004202 carbamide Substances 0.000 claims description 44
XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 44
238000006243 chemical reaction Methods 0.000 claims description 37
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical group CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 20
125000006850 spacer group Chemical group 0.000 claims description 20
108010046334 Urease Proteins 0.000 claims description 15
239000000243 solution Substances 0.000 claims description 13
239000000872 buffer Substances 0.000 claims description 12
229940109239 creatinine Drugs 0.000 claims description 10
238000001514 detection method Methods 0.000 claims description 10
238000000034 method Methods 0.000 claims description 10
239000003153 chemical reaction reagent Substances 0.000 claims description 7
238000002845 discoloration Methods 0.000 claims description 7
239000011888 foil Substances 0.000 claims description 7
239000007864 aqueous solution Substances 0.000 claims description 5
108010029444 creatinine deiminase Proteins 0.000 claims description 5
239000012070 reactive reagent Substances 0.000 claims description 3
239000003381 stabilizer Substances 0.000 claims description 3
239000004033 plastic Substances 0.000 claims description 2
239000000080 wetting agent Substances 0.000 claims description 2
238000012360 testing method Methods 0.000 description 36
210000004369 blood Anatomy 0.000 description 19
239000008280 blood Substances 0.000 description 19
210000002966 serum Anatomy 0.000 description 13
230000035484 reaction time Effects 0.000 description 12
210000001124 body fluid Anatomy 0.000 description 9
239000010839 body fluid Substances 0.000 description 9
239000000203 mixture Substances 0.000 description 7
210000002381 plasma Anatomy 0.000 description 6
150000001413 amino acids Chemical class 0.000 description 5
230000002209 hydrophobic effect Effects 0.000 description 5
238000005259 measurement Methods 0.000 description 5
-1 phosphoramidate hexose Chemical class 0.000 description 5
239000004831 Hot glue Substances 0.000 description 4
239000003086 colorant Substances 0.000 description 4
239000004744 fabric Substances 0.000 description 4
239000007793 ph indicator Substances 0.000 description 4
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
230000000007 visual effect Effects 0.000 description 4
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 3
ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 3
102000004316 Oxidoreductases Human genes 0.000 description 3
108090000854 Oxidoreductases Proteins 0.000 description 3
239000002250 absorbent Substances 0.000 description 3
230000002745 absorbent Effects 0.000 description 3
239000000853 adhesive Substances 0.000 description 3
230000001070 adhesive effect Effects 0.000 description 3
235000012501 ammonium carbonate Nutrition 0.000 description 3
239000001099 ammonium carbonate Substances 0.000 description 3
238000009792 diffusion process Methods 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
229920002050 silicone resin Polymers 0.000 description 3
238000012546 transfer Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
POKOASTYJWUQJG-UHFFFAOYSA-M 1-butylpyridin-1-ium;chloride Chemical compound [Cl-].CCCC[N+]1=CC=CC=C1 POKOASTYJWUQJG-UHFFFAOYSA-M 0.000 description 2
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 2
239000004677 Nylon Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 description 2
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229920001778 nylon Polymers 0.000 description 2
229920000058 polyacrylate Polymers 0.000 description 2
229920006267 polyester film Polymers 0.000 description 2
238000012545 processing Methods 0.000 description 2
238000007650 screen-printing Methods 0.000 description 2
VADKRMSMGWJZCF-UHFFFAOYSA-N 2-bromophenol Chemical compound OC1=CC=CC=C1Br VADKRMSMGWJZCF-UHFFFAOYSA-N 0.000 description 1
BYPAWIIGMSJURK-UHFFFAOYSA-N 4-tert-butylpyridine;hydrochloride Chemical compound [Cl-].CC(C)(C)C1=CC=[NH+]C=C1 BYPAWIIGMSJURK-UHFFFAOYSA-N 0.000 description 1
108010082072 ATP Synthetase Complexes Proteins 0.000 description 1
102000004118 Ammonia-Lyases Human genes 0.000 description 1
108090000673 Ammonia-Lyases Proteins 0.000 description 1
101000588924 Anthopleura elegantissima Delta-actitoxin-Ael1a Proteins 0.000 description 1
241000974482 Aricia saepiolus Species 0.000 description 1
108020004827 Carbamate kinase Proteins 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
206010010082 Coma uraemic Diseases 0.000 description 1
101710088194 Dehydrogenase Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
102000004867 Hydro-Lyases Human genes 0.000 description 1
108090001042 Hydro-Lyases Proteins 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
108090000992 Transferases Proteins 0.000 description 1
102000004357 Transferases Human genes 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000012670 alkaline solution Substances 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
230000008033 biological extinction Effects 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000009614 chemical analysis method Methods 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
229960003624 creatine Drugs 0.000 description 1
239000006046 creatine Substances 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000012943 hotmelt Substances 0.000 description 1
RSAZYXZUJROYKR-UHFFFAOYSA-N indophenol Chemical compound C1=CC(O)=CC=C1N=C1C=CC(=O)C=C1 RSAZYXZUJROYKR-UHFFFAOYSA-N 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000036651 mood Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000002777 nucleoside Substances 0.000 description 1
150000003833 nucleoside derivatives Chemical class 0.000 description 1
239000002773 nucleotide Substances 0.000 description 1
125000003729 nucleotide group Chemical group 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 1
238000005375 photometry Methods 0.000 description 1
229920006255 plastic film Polymers 0.000 description 1
239000002985 plastic film Substances 0.000 description 1
229920006289 polycarbonate film Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000002791 soaking Methods 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
ZJHHPAUQMCHPRB-UHFFFAOYSA-N urea urea Chemical compound NC(N)=O.NC(N)=O ZJHHPAUQMCHPRB-UHFFFAOYSA-N 0.000 description 1
239000002759 woven fabric Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/10—Quaternary compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/171538—Urea or blood urea nitrogen
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/173845—Amine and quaternary ammonium
- Y10T436/175383—Ammonia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

DD79212892A 1978-05-17 1979-05-15 Diagnostisches mittel zur bestimmung von ammoniak oder unter bildung von ammoniak reagierenden substraten DD143662A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19782821469 DE2821469A1 (de)	1978-05-17	1978-05-17	Diagnostisches mittel zur bestimmung von harnstoff

Publications (1)

Publication Number	Publication Date
DD143662A5 true DD143662A5 (de)	1980-09-03

Family

ID=6039528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD79212892A DD143662A5 (de)	1978-05-17	1979-05-15	Diagnostisches mittel zur bestimmung von ammoniak oder unter bildung von ammoniak reagierenden substraten

Country Status (16)

Country	Link
US (1)	US4223089A (da)
EP (1)	EP0005519B1 (da)
JP (1)	JPS54151096A (da)
AR (1)	AR217373A1 (da)
AT (1)	ATE3086T1 (da)
AU (1)	AU521129B2 (da)
BR (1)	BR7903035A (da)
CA (1)	CA1113356A (da)
DD (1)	DD143662A5 (da)
DE (2)	DE2821469A1 (da)
DK (1)	DK199579A (da)
ES (1)	ES480618A1 (da)
FI (1)	FI791533A7 (da)
IL (1)	IL57259A0 (da)
PL (3)	PL120537B1 (da)
ZA (1)	ZA792362B (da)

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* Cited by examiner, † Cited by third party
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DE3029579C2 (de) *	1980-08-05	1985-12-12	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US4816224A (en) *	1980-08-05	1989-03-28	Boehringer Mannheim Gmbh	Device for separating plasma or serum from whole blood and analyzing the same
DE3048799A1 (de) *	1980-12-23	1982-07-08	Boehringer Mannheim Gmbh, 6800 Mannheim	Reagenzstreifen fuer analytische zwecke
JPS5877661A (ja) *	1981-11-02	1983-05-11	Fuji Photo Film Co Ltd	アンモニアまたはアンモニア生成基質分析用一体型多層分析材料および検出法
JPH0616033B2 (ja) *	1982-04-19	1994-03-02	株式会社京都第一科学	アンモニアおよび尿素の分析具
US4839296A (en) *	1985-10-18	1989-06-13	Chem-Elec, Inc.	Blood plasma test method
US4719085A (en) *	1985-12-24	1988-01-12	Eastman Kodak Company	Mount for ammonia-sensitive test elements
DE3630999A1 (de) *	1986-09-12	1988-03-17	Boehringer Mannheim Gmbh	Mehrschichtiger testtraeger
DE3638654A1 (de) *	1986-11-12	1988-05-26	Boehringer Mannheim Gmbh	Testtraeger zur analytischen bestimmung eines bestandteils einer koerperfluessigkeit
US5047206A (en) *	1987-03-11	1991-09-10	Wayne State University	Reagent test strip
US4952516A (en) *	1987-06-12	1990-08-28	Pall Corporation	Self-venting diagnostic test device
US5340539A (en) *	1989-03-16	1994-08-23	Chemtrak, Inc.	Non-instrumented cholesterol assay
DE3919946A1 (de) *	1989-06-19	1991-01-17	Brinkhaus H Gmbh Co Kg	Verfahren zur bestimmung der gebrauchsintensitaet von textilstuecken und vorrichtung zur durchfuehrung des verfahrens
CA2031975A1 (en) *	1990-01-12	1991-07-13	Brian R. Barkes	Device and method of separating and assaying whole blood
US5183763A (en) *	1990-06-06	1993-02-02	Southwest Research Institute	Composition and method for detecting vapor and liquid reactants
US5877028A (en) *	1991-05-29	1999-03-02	Smithkline Diagnostics, Inc.	Immunochromatographic assay device
US5607863A (en) *	1991-05-29	1997-03-04	Smithkline Diagnostics, Inc.	Barrier-controlled assay device
US5998220A (en) *	1991-05-29	1999-12-07	Beckman Coulter, Inc.	Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en)	1991-05-29	2001-01-02	Beckman Coulter, Inc.	Multiple component chromatographic assay device
US5468648A (en) *	1991-05-29	1995-11-21	Smithkline Diagnostics, Inc.	Interrupted-flow assay device
US5869345A (en) *	1991-05-29	1999-02-09	Smithkline Diagnostics, Inc.	Opposable-element assay device employing conductive barrier
US5186843A (en) *	1991-07-22	1993-02-16	Ahlstrom Filtration, Inc.	Blood separation media and method for separating plasma from whole blood
US5314804A (en) *	1992-03-24	1994-05-24	Serim Research Corporation	Test for Helicobacter pylori
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1978
- 1978-05-17 DE DE19782821469 patent/DE2821469A1/de not_active Withdrawn
1979
- 1979-04-30 US US06/034,719 patent/US4223089A/en not_active Expired - Lifetime
- 1979-05-08 CA CA327,187A patent/CA1113356A/en not_active Expired
- 1979-05-11 EP EP79101446A patent/EP0005519B1/de not_active Expired
- 1979-05-11 DE DE7979101446T patent/DE2965181D1/de not_active Expired
- 1979-05-11 IL IL57259A patent/IL57259A0/xx unknown
- 1979-05-11 AT AT79101446T patent/ATE3086T1/de active
- 1979-05-11 AU AU46929/79A patent/AU521129B2/en not_active Ceased
- 1979-05-11 AR AR276482A patent/AR217373A1/es active
- 1979-05-14 FI FI791533A patent/FI791533A7/fi not_active Application Discontinuation
- 1979-05-15 DK DK199579A patent/DK199579A/da not_active Application Discontinuation
- 1979-05-15 DD DD79212892A patent/DD143662A5/de unknown
- 1979-05-16 PL PL1979215622A patent/PL120537B1/pl unknown
- 1979-05-16 PL PL21566279A patent/PL215662A1/xx unknown
- 1979-05-16 ES ES480618A patent/ES480618A1/es not_active Expired
- 1979-05-16 PL PL1979227316A patent/PL118524B1/pl unknown
- 1979-05-16 BR BR7903035A patent/BR7903035A/pt unknown
- 1979-05-16 ZA ZA792362A patent/ZA792362B/xx unknown
- 1979-05-16 JP JP5920579A patent/JPS54151096A/ja active Granted

Also Published As

Publication number	Publication date
ZA792362B (en)	1980-06-25
US4223089A (en)	1980-09-16
DE2965181D1 (en)	1983-05-19
AR217373A1 (es)	1980-03-14
FI791533A7 (fi)	1981-01-01
PL120537B1 (en)	1982-03-31
PL215662A1 (da)	1980-02-11
AU4692979A (en)	1979-11-22
ATE3086T1 (de)	1983-04-15
JPS54151096A (en)	1979-11-27
EP0005519A3 (en)	1980-09-17
DE2821469A1 (de)	1979-11-22
DK199579A (da)	1979-11-18
ES480618A1 (es)	1980-01-16
BR7903035A (pt)	1979-12-04
CA1113356A (en)	1981-12-01
PL118524B1 (en)	1981-10-31
EP0005519A2 (de)	1979-11-28
IL57259A0 (en)	1979-09-30
EP0005519B1 (de)	1983-04-13
AU521129B2 (en)	1982-03-18
JPS6243500B2 (da)	1987-09-14

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EP0105211A1 (de)	1984-04-11	Küvette zur Bestimmung chemischer Verbindungen in Flüssigkeiten
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EP0825264A1 (de)	1998-02-25	Stabile Mischung zum Nachweis alkalischer Phosphatase mit einem Salz der o-Kresolphthaleinmonophosphorsäure