DD146248A5 - Verfahren zur herstellung von presssuppositorien - Google Patents

Verfahren zur herstellung von presssuppositorien Download PDF

Info

Publication number: DD146248A5
Authority: DD; German Democratic Republic
Prior art keywords: suppositories; pressed; suppository; temperature; mass
Prior art date: 1978-09-29

Application number

DD79215888A

Other languages

German (de)

English (en)

Inventor

Buman Alain De

Aldo Riva

Heinz Sucker

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-09-29

Filing date

1979-09-28

Publication date

1981-02-04

1979-09-28 Application filed by Sandoz Ag filed Critical Sandoz Ag

1981-02-04 Publication of DD146248A5 publication Critical patent/DD146248A5/de

Links

239000000829 suppository Substances 0.000 title claims abstract description 54
238000004519 manufacturing process Methods 0.000 title claims description 5
238000000034 method Methods 0.000 claims abstract description 17
239000000203 mixture Substances 0.000 claims abstract description 16
150000001875 compounds Chemical class 0.000 claims abstract description 12
239000011230 binding agent Substances 0.000 claims abstract description 11
238000002360 preparation method Methods 0.000 claims abstract description 7
AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical class OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 claims abstract description 3
235000003441 saturated fatty acids Nutrition 0.000 claims abstract description 3
150000004671 saturated fatty acids Chemical class 0.000 claims abstract description 3
229960003133 ergot alkaloid Drugs 0.000 claims description 2
238000002788 crimping Methods 0.000 abstract 1
238000003825 pressing Methods 0.000 description 13
239000004480 active ingredient Substances 0.000 description 10
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 8
UZVHFVZFNXBMQJ-UHFFFAOYSA-N butalbital Chemical compound CC(C)CC1(CC=C)C(=O)NC(=O)NC1=O UZVHFVZFNXBMQJ-UHFFFAOYSA-N 0.000 description 6
229960002546 butalbital Drugs 0.000 description 6
229960001948 caffeine Drugs 0.000 description 6
239000008187 granular material Substances 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
238000001816 cooling Methods 0.000 description 5
PXWLVJLKJGVOKE-UHFFFAOYSA-N propyphenazone Chemical compound O=C1C(C(C)C)=C(C)N(C)N1C1=CC=CC=C1 PXWLVJLKJGVOKE-UHFFFAOYSA-N 0.000 description 5
229960002189 propyphenazone Drugs 0.000 description 5
-1 Teflon Chemical class 0.000 description 4
JTIGKVIOEQASGT-UHFFFAOYSA-N proquazone Chemical compound N=1C(=O)N(C(C)C)C2=CC(C)=CC=C2C=1C1=CC=CC=C1 JTIGKVIOEQASGT-UHFFFAOYSA-N 0.000 description 4
229960002466 proquazone Drugs 0.000 description 4
238000005266 casting Methods 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
239000001267 polyvinylpyrrolidone Substances 0.000 description 3
229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
235000014347 soups Nutrition 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
FMBVHKPWDJQLNO-UHFFFAOYSA-N 1-[(3-fluorophenyl)methyl]-5-nitroindazole Chemical compound N1=CC2=CC([N+](=O)[O-])=CC=C2N1CC1=CC=CC(F)=C1 FMBVHKPWDJQLNO-UHFFFAOYSA-N 0.000 description 1
LBFGQUCAQWAFNN-UHFFFAOYSA-N 4-ethyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1h-pyrazol-3-one Chemical compound O=C1C(CC)=C(C=2C=CC=CC=2)NN1C1CCN(C)CC1 LBFGQUCAQWAFNN-UHFFFAOYSA-N 0.000 description 1
VCCNKWWXYVWTLT-CYZBKYQRSA-N 7-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 VCCNKWWXYVWTLT-CYZBKYQRSA-N 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical class CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
241000208011 Digitalis Species 0.000 description 1
229940123907 Disease modifying antirheumatic drug Drugs 0.000 description 1
QZXATCCPQKOEIH-UHFFFAOYSA-N Florasulam Chemical compound N=1N2C(OC)=NC=C(F)C2=NC=1S(=O)(=O)NC1=C(F)C=CC=C1F QZXATCCPQKOEIH-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
JAYAGJDXJIDEKI-PTGWOZRBSA-N Lanatoside C Chemical compound O([C@H]1[C@@H](OC(C)=O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(CC[C@@H]([C@@]4(C)[C@H](O)C3)C=3COC(=O)C=3)O)CC2)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JAYAGJDXJIDEKI-PTGWOZRBSA-N 0.000 description 1
JAYAGJDXJIDEKI-UHFFFAOYSA-N Lanatoside C Natural products CC1OC(OC2CC3C(C4C(C5(CCC(C5(C)C(O)C4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(OC(C)=O)C1OC1OC(CO)C(O)C(O)C1O JAYAGJDXJIDEKI-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000003570 air Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229930013930 alkaloid Natural products 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
239000012080 ambient air Substances 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000003356 anti-rheumatic effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical class CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 description 1
239000003435 antirheumatic agent Substances 0.000 description 1
229940125717 barbiturate Drugs 0.000 description 1
229940092732 belladonna alkaloid Drugs 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
GERIGMSHTUAXSI-UHFFFAOYSA-N bis(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 4-phenyl-2,3-dihydro-1h-naphthalene-1,4-dicarboxylate Chemical compound CN1C(C2)CCC1CC2OC(=O)C(C1=CC=CC=C11)CCC1(C(=O)OC1CC2CCC(N2C)C1)C1=CC=CC=C1 GERIGMSHTUAXSI-UHFFFAOYSA-N 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
239000000498 cooling water Substances 0.000 description 1
238000010586 diagram Methods 0.000 description 1
229960004704 dihydroergotamine Drugs 0.000 description 1
HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 description 1
ADYPXRFPBQGGAH-UMYZUSPBSA-N dihydroergotamine mesylate Chemical compound CS(O)(=O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C)C1=CC=CC=C1 ADYPXRFPBQGGAH-UMYZUSPBSA-N 0.000 description 1
238000009826 distribution Methods 0.000 description 1
229960004943 ergotamine Drugs 0.000 description 1
OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 1
229960001903 ergotamine tartrate Drugs 0.000 description 1
XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 1
239000003925 fat Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
MSVZUEGLXXVUJS-UHFFFAOYSA-N hydron;n-(2-piperidin-1-ylethyl)-n-(pyridin-2-ylmethyl)aniline;chloride Chemical compound Cl.C=1C=CC=NC=1CN(C=1C=CC=CC=1)CCN1CCCCC1 MSVZUEGLXXVUJS-UHFFFAOYSA-N 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
238000004898 kneading Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229960002614 lanatoside c Drugs 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000000465 moulding Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
150000003246 quinazolines Chemical class 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
239000013049 sediment Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
JZLOKWGVGHYBKD-UHFFFAOYSA-M sodium;2-acetyloxybenzoate Chemical class [Na+].CC(=O)OC1=CC=CC=C1C([O-])=O JZLOKWGVGHYBKD-UHFFFAOYSA-M 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000002048 spasmolytic effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/08—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of suppositories or sticks

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Auxiliary Devices For And Details Of Packaging Control (AREA)
Basic Packing Technique (AREA)
Fodder In General (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

DD79215888A 1978-09-29 1979-09-28 Verfahren zur herstellung von presssuppositorien DD146248A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1019478A CH637014A5 (de)	1978-09-29	1978-09-29	Verfahren zur herstellung von suppositorien.

Publications (1)

Publication Number	Publication Date
DD146248A5 true DD146248A5 (de)	1981-02-04

Family

ID=4360430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD79215888A DD146248A5 (de)	1978-09-29	1979-09-28	Verfahren zur herstellung von presssuppositorien

Country Status (28)

Country	Link
US (1)	US4369784A (fr)
JP (1)	JPS5549310A (fr)
KR (1)	KR830000308B1 (fr)
AR (1)	AR228729A1 (fr)
AT (1)	AT374680B (fr)
AU (1)	AU530954B2 (fr)
BE (1)	BE875506A (fr)
CA (1)	CA1134268A (fr)
CH (1)	CH637014A5 (fr)
CS (1)	CS219258B2 (fr)
DD (1)	DD146248A5 (fr)
DE (1)	DE2914163C2 (fr)
DK (1)	DK393379A (fr)
ES (1)	ES479565A1 (fr)
FI (1)	FI68762C (fr)
FR (1)	FR2437204B1 (fr)
GB (1)	GB2030861B (fr)
HU (1)	HU180291B (fr)
IE (1)	IE48405B1 (fr)
IL (1)	IL58342A (fr)
IT (1)	IT1116178B (fr)
NL (1)	NL7903065A (fr)
NO (1)	NO153553C (fr)
NZ (1)	NZ191674A (fr)
PH (1)	PH16955A (fr)
PT (1)	PT70234A (fr)
SE (1)	SE439243B (fr)
ZA (1)	ZA795180B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4483807A (en) *	1981-01-27	1984-11-20	Japan Atomic Energy Research Institute	Process for producing a slow release composite
US5137669A (en) *	1988-03-02	1992-08-11	Endocon, Inc.	Manufacture of partially fused peptide pellet
KR100354702B1 (ko)	1993-11-23	2002-12-28	유로-셀티크 소시에떼 아노뉨	약학조성물의제조방법및서방형조성물
US5891471A (en)	1993-11-23	1999-04-06	Euro-Celtique, S.A.	Pharmaceutical multiparticulates
US5843480A (en)	1994-03-14	1998-12-01	Euro-Celtique, S.A.	Controlled release diamorphine formulation
GB9422154D0 (en)	1994-11-03	1994-12-21	Euro Celtique Sa	Pharmaceutical compositions and method of producing the same
US5965161A (en)	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
ES2155594T3 (es) *	1995-12-12	2001-05-16	Alusuisse Tech & Man Ag	Procedimiento para fabricar envases blister.
DE19918325A1 (de)	1999-04-22	2000-10-26	Euro Celtique Sa	Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
GB0015617D0 (en) *	2000-06-26	2000-08-16	Vectura Ltd	Improved preparations for dermal delivery of active substances
JP2003095923A (ja) *	2001-09-26	2003-04-03	Tendou Seiyaku Kk	油脂類成形物の製造法
EP1506035A1 (fr) *	2002-05-06	2005-02-16	Vectura Limited	Dispositif d'application destine a l'administration topique d'agents pharmaceutiques

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2307371A (en) *	1941-08-13	1943-01-05	Ray O Vac Co	Molding process
US2874417A (en) *	1954-06-28	1959-02-24	Elektrokemisk As	Method of forming thermoplastic briquettes
DE2553026A1 (de) *	1974-12-04	1976-06-10	Schlueter Edelfett	Neue formulierungen
SU572269A1 (ru) *	1975-07-14	1977-09-15	Львовский государственный медицинский институт	Способ получени суппозиториев
DE2551446B2 (de) *	1975-11-15	1977-09-15	Karl Werner Schlüter GmbH, 2000 Ham burg	Verfahren zur herstellung von suppositorien
DE2556561C2 (de) *	1975-12-16	1983-04-14	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur Herstellung von porösen Tabletten

1978
- 1978-09-29 CH CH1019478A patent/CH637014A5/de not_active IP Right Cessation
1979
- 1979-04-05 GB GB7911927A patent/GB2030861B/en not_active Expired
- 1979-04-07 DE DE2914163A patent/DE2914163C2/de not_active Expired
- 1979-04-09 IT IT48667/79A patent/IT1116178B/it active
- 1979-04-11 ES ES479565A patent/ES479565A1/es not_active Expired
- 1979-04-11 AT AT0269979A patent/AT374680B/de active
- 1979-04-11 FR FR797909158A patent/FR2437204B1/fr not_active Expired
- 1979-04-11 BE BE0/194551A patent/BE875506A/fr not_active IP Right Cessation
- 1979-04-19 NL NL7903065A patent/NL7903065A/nl not_active Application Discontinuation
- 1979-04-25 JP JP5199779A patent/JPS5549310A/ja active Granted
- 1979-09-20 DK DK393379A patent/DK393379A/da not_active Application Discontinuation
- 1979-09-20 FI FI792927A patent/FI68762C/fi not_active IP Right Cessation
- 1979-09-20 SE SE7907795A patent/SE439243B/sv not_active IP Right Cessation
- 1979-09-21 NO NO793034A patent/NO153553C/no unknown
- 1979-09-26 NZ NZ191674A patent/NZ191674A/xx unknown
- 1979-09-27 IL IL58342A patent/IL58342A/xx unknown
- 1979-09-27 PT PT70234A patent/PT70234A/pt unknown
- 1979-09-27 IE IE1842/79A patent/IE48405B1/en unknown
- 1979-09-27 CA CA336,504A patent/CA1134268A/fr not_active Expired
- 1979-09-28 CS CS796590A patent/CS219258B2/cs unknown
- 1979-09-28 PH PH23076A patent/PH16955A/en unknown
- 1979-09-28 KR KR1019790003364A patent/KR830000308B1/ko not_active Expired
- 1979-09-28 AR AR278252A patent/AR228729A1/es active
- 1979-09-28 ZA ZA00795180A patent/ZA795180B/xx unknown
- 1979-09-28 HU HU79SA3201A patent/HU180291B/hu unknown
- 1979-09-28 DD DD79215888A patent/DD146248A5/de unknown
- 1979-09-28 AU AU51287/79A patent/AU530954B2/en not_active Ceased
1980
- 1980-12-09 US US06/214,747 patent/US4369784A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GB2030861B (en)	1983-04-27
PH16955A (en)	1984-04-27
JPS6227046B2 (fr)	1987-06-12
HU180291B (en)	1983-02-28
ZA795180B (en)	1981-06-24
AR228729A1 (es)	1983-04-15
IE48405B1 (en)	1985-01-09
IL58342A (en)	1983-03-31
SE7907795L (sv)	1980-03-30
DK393379A (da)	1980-03-30
IT7948667A0 (it)	1979-04-09
CA1134268A (fr)	1982-10-26
CS219258B2 (en)	1983-03-25
NO793034L (no)	1980-04-01
NZ191674A (en)	1982-02-23
GB2030861A (en)	1980-04-16
AU5128779A (en)	1980-04-03
AU530954B2 (en)	1983-08-04
SE439243B (sv)	1985-06-10
ATA269979A (de)	1983-10-15
NL7903065A (nl)	1980-04-01
AT374680B (de)	1984-05-25
KR830000308B1 (ko)	1983-03-02
JPS5549310A (en)	1980-04-09
NO153553B (no)	1986-01-06
FR2437204B1 (fr)	1985-07-26
FI792927A7 (fi)	1980-03-30
CH637014A5 (de)	1983-07-15
IE791842L (en)	1980-03-29
IL58342A0 (en)	1979-12-30
ES479565A1 (es)	1979-07-16
IT1116178B (it)	1986-02-10
PT70234A (en)	1979-10-01
FI68762C (fi)	1985-11-11
FR2437204A1 (fr)	1980-04-25
NO153553C (no)	1986-04-16
DE2914163C2 (de)	1982-11-18
US4369784A (en)	1983-01-25
BE875506A (fr)	1979-10-11
DE2914163A1 (de)	1980-04-10
FI68762B (fi)	1985-07-31

Publication	Publication Date	Title
DE3024416C2 (de)	1982-04-15	Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
DE60008912T2 (de)	2004-08-19	Direktverpressbare, ultrafeine acetaminophenzusammensetzungen und verfahren zu ihrer herstellung
DE3811114C2 (de)	1996-05-30	Zweischichtige Dosierungsform zur Abgabe eines Wirkstoffs
DE60004649T2 (de)	2004-03-18	Verfahren zur herstellung nicht-hygroscopische l (-) - carnitine salze
DE69414046T3 (de)	2004-08-26	Morphinenthaltende Arzneizusammensetzungen mit verzögerter Wirkstoffabgabe
DE3877764T2 (de)	1993-05-13	Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren.
DE3687848T2 (de)	1993-06-17	Verfahren zum gleitfaehigmachen wasserloeslicher vitaminpulver.
DE69530308T2 (de)	2003-10-16	Verfahren zur herstellung von dosierungsformen durch feuchtgranulierung
DE2224534A1 (de)	1972-12-14	Pharmazeutisches Präparat mit langsamer Wirkstoffabgabe
AT3413U2 (de)	2000-03-27	Arzneimittel mit kontrollierter freisetzung von tramadol
DE69020541T2 (de)	1995-11-02	Granulate mit hohem ibuprofengehalt.
DE69919155T2 (de)	2005-08-04	Formulierungen zur mehrfachfreisetzung
DE2433285A1 (de)	1975-01-30	(verzoegerungs-)mikrokapseln enthaltende tabletten und verfahren zur herstellung derselben
DE2914163C2 (de)	1982-11-18	Verfahren zur Herstellung von Pressuppositorien und Verwendung eines Gemisches zu deren Herstellung
DE2426812A1 (de)	1976-01-02	Verfahren zur herstellung von granulaten
DE3936112C2 (de)	1999-02-18	Arzneimittelpräparate, die Piroxicam enthalten und Verfahren zu deren Herstellung
EP0068450A2 (fr)	1983-01-05	Formes pharmaceutiques pour administration orale
DE69827484T2 (de)	2005-03-17	Stabilisierte Tibolon-Zubereitungen
CH621063A5 (en)	1981-01-15	Process for the production of a pharmaceutical multizone tablet and tablet produced by this process
DE3871791T2 (de)	1993-01-21	Verwendung von homo- und copolymeren des vinylalkohols zum tablettieren von wirkstoffen.
EP0208144B1 (fr)	1989-09-20	Granulé pharmaceutique contenant de l'ambroxol ou de la bromhexine
DE2439538C3 (de)	1980-07-17	Verfahren zur Herstellung von oral zu verabreichenden Arzneimitteln mit verzögerter Wirkungsfreigabe
DE69917446T2 (de)	2005-05-25	Verfahren zum Herstellen von Kapseln und Tabletten aus Naturstoffen pflanzlichen Ursprungs
DD263232A5 (de)	1988-12-28	Therapeutische mittel
WO1999032090A1 (fr)	1999-07-01	Procede pour produire des formulations pharmaceutiques contenant un extrait