DD149421A5 - Verfahren und reagenz zur bestimmung der creatinkinase mb - Google Patents

Verfahren und reagenz zur bestimmung der creatinkinase mb Download PDF

Info

Publication number: DD149421A5
Authority: DD; German Democratic Republic
Prior art keywords: subunit; creatine kinase; antibodies; fragments; determination
Prior art date: 1979-03-02

Application number

DD80219298A

Other languages

German (de)

English (en)

Inventor

Wolfgang Gruber

Helmut Lenz

Siegfried Looser

Hans-Ralf Linke

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-02

Filing date

1980-02-27

Publication date

1981-07-08

1980-02-27 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1981-07-08 Publication of DD149421A5 publication Critical patent/DD149421A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 36
102000004420 Creatine Kinase Human genes 0.000 title claims abstract description 15
108010042126 Creatine kinase Proteins 0.000 title claims abstract description 15
239000003153 chemical reaction reagent Substances 0.000 title abstract description 6
239000012634 fragment Substances 0.000 claims abstract description 26
210000002966 serum Anatomy 0.000 claims abstract description 15
230000008030 elimination Effects 0.000 claims abstract description 7
238000003379 elimination reaction Methods 0.000 claims abstract description 7
230000001900 immune effect Effects 0.000 claims abstract description 7
230000006337 proteolytic cleavage Effects 0.000 claims abstract description 4
238000005259 measurement Methods 0.000 claims abstract description 3
239000011541 reaction mixture Substances 0.000 claims abstract description 3
102000004190 Enzymes Human genes 0.000 claims description 17
108090000790 Enzymes Proteins 0.000 claims description 17
108010044467 Isoenzymes Proteins 0.000 claims description 5
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 4
PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims description 4
239000005089 Luciferase Substances 0.000 claims description 2
238000006243 chemical reaction Methods 0.000 claims description 2
229960003624 creatine Drugs 0.000 claims description 2
239000006046 creatine Substances 0.000 claims description 2
JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 claims description 2
229940088598 enzyme Drugs 0.000 description 15
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 10
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 10
230000005764 inhibitory process Effects 0.000 description 10
238000003776 cleavage reaction Methods 0.000 description 7
230000007017 scission Effects 0.000 description 7
230000003053 immunization Effects 0.000 description 6
238000002649 immunization Methods 0.000 description 6
230000002401 inhibitory effect Effects 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
238000005119 centrifugation Methods 0.000 description 5
230000000694 effects Effects 0.000 description 5
210000003205 muscle Anatomy 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
108090000526 Papain Proteins 0.000 description 4
241001494479 Pecora Species 0.000 description 4
239000004365 Protease Substances 0.000 description 4
239000000872 buffer Substances 0.000 description 4
208000010125 myocardial infarction Diseases 0.000 description 4
229940055729 papain Drugs 0.000 description 4
235000019834 papain Nutrition 0.000 description 4
235000018102 proteins Nutrition 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
238000012360 testing method Methods 0.000 description 4
241001465754 Metazoa Species 0.000 description 3
108091005804 Peptidases Proteins 0.000 description 3
102000035195 Peptidases Human genes 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
239000000427 antigen Substances 0.000 description 3
102000036639 antigens Human genes 0.000 description 3
108091007433 antigens Proteins 0.000 description 3
238000000502 dialysis Methods 0.000 description 3
238000011534 incubation Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
238000000746 purification Methods 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
238000000108 ultra-filtration Methods 0.000 description 3
102000006395 Globulins Human genes 0.000 description 2
108010044091 Globulins Proteins 0.000 description 2
DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 description 2
239000007983 Tris buffer Substances 0.000 description 2
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
229910052921 ammonium sulfate Inorganic materials 0.000 description 2
235000011130 ammonium sulphate Nutrition 0.000 description 2
210000004556 brain Anatomy 0.000 description 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
235000018417 cysteine Nutrition 0.000 description 2
238000005227 gel permeation chromatography Methods 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
230000001376 precipitating effect Effects 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
229960001763 zinc sulfate Drugs 0.000 description 2
229910000368 zinc sulfate Inorganic materials 0.000 description 2
VHJLVAABSRFDPM-UHFFFAOYSA-N 1,4-dithiothreitol Chemical compound SCC(O)C(O)CS VHJLVAABSRFDPM-UHFFFAOYSA-N 0.000 description 1
229910002012 Aerosil® Inorganic materials 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
239000002168 alkylating agent Substances 0.000 description 1
229940100198 alkylating agent Drugs 0.000 description 1
230000029936 alkylation Effects 0.000 description 1
238000005804 alkylation reaction Methods 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
230000004992 fission Effects 0.000 description 1
108010074605 gamma-Globulins Proteins 0.000 description 1
238000007429 general method Methods 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
210000004165 myocardium Anatomy 0.000 description 1
230000018791 negative regulation of catalytic activity Effects 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Urology & Nephrology (AREA)
Analytical Chemistry (AREA)
Wood Science & Technology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)

DD80219298A 1979-03-02 1980-02-27 Verfahren und reagenz zur bestimmung der creatinkinase mb DD149421A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2908053A DE2908053C2 (de)	1979-03-02	1979-03-02	Verfahren und Reagenz zur Bestimmung der Creatinkinase MB

Publications (1)

Publication Number	Publication Date
DD149421A5 true DD149421A5 (de)	1981-07-08

Family

ID=6064229

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD80219298A DD149421A5 (de)	1979-03-02	1980-02-27	Verfahren und reagenz zur bestimmung der creatinkinase mb

Country Status (18)

Country	Link
US (1)	US4330620A (da)
EP (1)	EP0015508B1 (da)
JP (1)	JPS5820274B2 (da)
AR (1)	AR219440A1 (da)
AT (1)	ATE263T1 (da)
AU (1)	AU515930B2 (da)
CA (1)	CA1160942A (da)
CS (1)	CS226407B2 (da)
DD (1)	DD149421A5 (da)
DE (2)	DE2908053C2 (da)
DK (1)	DK154459C (da)
ES (1)	ES488774A1 (da)
FI (1)	FI72145C (da)
HU (1)	HU181684B (da)
IE (1)	IE49158B1 (da)
SU (1)	SU1336941A3 (da)
YU (1)	YU42965B (da)
ZA (1)	ZA801158B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4614712A (en) *	1983-02-25	1986-09-30	The Upjohn Company	Immunoassays with luciferase labeled ligands or receptors
CA1260828A (en) *	1983-07-04	1989-09-26	Masakazu Iwai	Therapeutic and prophylactic agent for gastrointestinal ulcers
JPS60125565A (ja) *	1983-12-12	1985-07-04	Amano Pharmaceut Co Ltd	エノラ−ゼサブユニット量の分別定量法
US4810639A (en) *	1985-12-20	1989-03-07	E. I. Du Pont De Nemours And Company	Immunoassay for CK-MB using bound and soluble antibodies
JPS63131065A (ja) *	1986-11-20	1988-06-03	Yatoron:Kk	抗体の精製法とアイソザイムの測定法及び試薬
CN110133265B (zh) *	2019-06-10	2022-03-15	天津市宝坻区人民医院	血清中肌酸激酶试剂盒及测定方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2128670B2 (de) *	1971-06-09	1977-06-30	Merck Patent Gmbh, 6100 Darmstadt	Immunologische isoenzym-bestimmungsmethode
US4001088A (en) *	1974-08-02	1977-01-04	Antonik Alan S	Method for the determination of creatine phosphokinase enzyme
DE2548962C2 (de) *	1975-11-03	1985-11-21	Merck Patent Gmbh, 6100 Darmstadt	Antikörper gegen die Untereinheit M von Creatinkinase-Isoenzymen
DE2548963C3 (de) *	1975-11-03	1982-03-11	Merck Patent Gmbh, 6100 Darmstadt	Verfahren und Mittel zur Bestimmung der Aktivität von Creatinkinase-MB
JPS5344622A (en) *	1976-09-30	1978-04-21	Mochida Pharm Co Ltd	Immunologically measuring method
DE2828658C3 (de) *	1978-06-29	1981-10-22	Lkb-Produkter Ab, Stockholm	Verfahren zur photometrischen Bestimmung der Untereinheit B der Creatinkinase und Reagens hierfür

1979
- 1979-03-02 DE DE2908053A patent/DE2908053C2/de not_active Expired
1980
- 1980-02-05 IE IE221/80A patent/IE49158B1/en not_active IP Right Cessation
- 1980-02-11 CS CS80907A patent/CS226407B2/cs unknown
- 1980-02-13 AU AU55496/80A patent/AU515930B2/en not_active Expired
- 1980-02-14 DK DK063680A patent/DK154459C/da not_active IP Right Cessation
- 1980-02-20 ES ES488774A patent/ES488774A1/es not_active Expired
- 1980-02-26 AR AR280091A patent/AR219440A1/es active
- 1980-02-27 DD DD80219298A patent/DD149421A5/de not_active IP Right Cessation
- 1980-02-27 FI FI800577A patent/FI72145C/fi not_active IP Right Cessation
- 1980-02-27 CA CA000346572A patent/CA1160942A/en not_active Expired
- 1980-02-28 US US06/125,318 patent/US4330620A/en not_active Expired - Lifetime
- 1980-02-28 AT AT80100995T patent/ATE263T1/de not_active IP Right Cessation
- 1980-02-28 YU YU542/80A patent/YU42965B/xx unknown
- 1980-02-28 EP EP80100995A patent/EP0015508B1/de not_active Expired
- 1980-02-28 DE DE8080100995T patent/DE3060050D1/de not_active Expired
- 1980-02-29 ZA ZA00801158A patent/ZA801158B/xx unknown
- 1980-02-29 HU HU80475A patent/HU181684B/hu unknown
- 1980-02-29 JP JP55024219A patent/JPS5820274B2/ja not_active Expired
- 1980-02-29 SU SU802891744A patent/SU1336941A3/ru active

Also Published As

Publication number	Publication date
AU5549680A (en)	1981-03-12
YU42965B (en)	1989-02-28
US4330620A (en)	1982-05-18
ATE263T1 (de)	1981-10-15
FI72145C (fi)	1987-04-13
CS226407B2 (en)	1984-03-19
YU54280A (en)	1984-10-31
JPS5820274B2 (ja)	1983-04-22
FI800577A7 (fi)	1980-09-03
ZA801158B (en)	1981-03-25
DK154459B (da)	1988-11-14
DK154459C (da)	1989-05-22
IE800221L (en)	1980-09-02
HU181684B (en)	1983-11-28
DE2908053C2 (de)	1982-08-19
DE2908053A1 (de)	1980-09-11
DE3060050D1 (en)	1981-12-10
CA1160942A (en)	1984-01-24
EP0015508A1 (de)	1980-09-17
JPS55120797A (en)	1980-09-17
DK63680A (da)	1980-09-03
IE49158B1 (en)	1985-08-07
SU1336941A3 (ru)	1987-09-07
EP0015508B1 (de)	1981-09-30
AU515930B2 (en)	1981-05-07
ES488774A1 (es)	1980-09-16
AR219440A1 (es)	1980-08-15
FI72145B (fi)	1986-12-31

Legal Events

Date	Code	Title	Description
1996-05-09	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE2548963C3 (de)	1982-03-11	Verfahren und Mittel zur Bestimmung der Aktivität von Creatinkinase-MB
EP0021152B1 (de)	1984-02-15	Verfahren zur immunologischen Bestimmung von Basalmembranmaterial, hierfür geeignete Basalmembranfragmente und Verfahren zu deren Herstellung, bzw. Gewinnung
DE3785038T2 (de)	1993-11-04	Monoklonale antikoerper gegen nicht reduzierte, nicht enzymatisch glykolysierte proteine.
DE2128670B2 (de)	1977-06-30	Immunologische isoenzym-bestimmungsmethode
DE2258822A1 (de)	1974-06-06	Verfahren und mittel zur analyse von isoenzymmustern
EP1381628B1 (de)	2005-11-23	Entzündungsspezifische peptide und deren verwendungen
DE3425186C2 (de)	1995-04-20	Reines pI 6,3 und pI 6,5 L1-Protein, deren Herstellungsverfahren und deren Verwendung
DE3025078A1 (de)	1981-02-05	Gereinigtes immunserumglobulin- praeparat
DE2641840C2 (de)	1986-07-24	Verfahren zum Reinigen eines Antiserums
DE3205301A1 (de)	1982-09-16	Immunochemische enzymbestimmung
EP0015508B1 (de)	1981-09-30	Verfahren und Reagenz zur Bestimmung der Creatinkinase-MB
DE68912477T2 (de)	1994-06-30	Verfahren zum messen der biologischen wirkung von antithrombin iii und reagenzien zu dessen messung.
DE68909995T2 (de)	1994-02-10	Reagenz zur Bestimmung von Kreatinkinase und Messverfahren dafür.
DE2548962C2 (de)	1985-11-21	Antikörper gegen die Untereinheit M von Creatinkinase-Isoenzymen
EP0598329B1 (de)	2002-02-06	Simultane Bestimmung von HbA1c und Hämoglobinvarianten mit einer HbA1c-analogen Glykierung
DE69800080T2 (de)	2000-08-24	Antikörper gegen das Prorenin Profragment, reninaktive Substanz die diese enthält und Prorenintest die diese verwendet
DE3743402C2 (de)	1994-04-14	Verfahren zur Krebsdiagnose beim Menschen
DE69900283T2 (de)	2002-06-27	Reninaktive Substanz enthaltend humanes Prorenin und Antikörper gegen das Prorenin Profragment
DE69730223T2 (de)	2005-09-15	Diagnostische methode zum nachweis von isoformen des eosinophilen kationischen proteins
DE68911574T2 (de)	1994-05-11	Reagenzsystem zur Bestimmung des Komplexes des menschlichen Plasminogenaktivator-Inhibitors und des menschlichen Gewebeplasminogenaktivators und Testsatz dafür.
Orlans et al.	1960	Clostridium welchii: Epsilon-Toxin and Antitoxin
DE3915344A1 (de)	1989-11-23	Serumdiagnose-verfahren
EP1130402B1 (de)	2006-03-01	Gebrauchsfertiges langzeitstabiles Ristocetin Cofactor Testreagenz
DE19916242C2 (de)	2003-04-10	PSA-haltige Substanz und deren Verwendung
DE3783840T2 (de)	1993-07-22	Verfahren zur bestimmung von plasma-protein und testsatz dafuer.