DD210285A5 - Verfahren zur herstellung von a-21978c-cyclopeptidderivaten - Google Patents

Verfahren zur herstellung von a-21978c-cyclopeptidderivaten Download PDF

Info

Publication number: DD210285A5
Authority: DD; German Democratic Republic
Prior art keywords: amino; hydrogen; formula; protecting group; nrrl
Prior art date: 1982-05-21

Application number

DD83251129A

Other languages

German (de)

English (en)

Inventor

Bernard J Abbott

Manuel Debono

David Sh Fukuda

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-21

Filing date

1983-05-20

Publication date

1984-06-06

1983-05-20 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1984-06-06 Publication of DD210285A5 publication Critical patent/DD210285A5/de

Links

102000001189 Cyclic Peptides Human genes 0.000 title abstract description 32
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238000004519 manufacturing process Methods 0.000 title description 7
-1 8-methyl decanoyl Chemical group 0.000 claims abstract description 90
150000001875 compounds Chemical class 0.000 claims abstract description 83
238000000034 method Methods 0.000 claims abstract description 65
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239000001257 hydrogen Substances 0.000 claims abstract description 44
238000005947 deacylation reaction Methods 0.000 claims abstract description 36
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238000002360 preparation method Methods 0.000 claims abstract description 27
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125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 20
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230000008569 process Effects 0.000 claims abstract description 8
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125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 description 1
239000002773 nucleotide Substances 0.000 description 1
125000003729 nucleotide group Chemical group 0.000 description 1
239000006916 nutrient agar Substances 0.000 description 1
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
244000052769 pathogen Species 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
NKHJDLXPDQTDFI-UHFFFAOYSA-N phenyl-(2,5,6-trichloro-6-dodecoxy-3-hydroxycyclohexa-2,4-dien-1-yl)methanone Chemical compound CCCCCCCCCCCCOC1(C(C(=C(C=C1Cl)O)Cl)C(=O)C2=CC=CC=C2)Cl NKHJDLXPDQTDFI-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
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235000019833 protease Nutrition 0.000 description 1
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GAPYKZAARZMMGP-UHFFFAOYSA-N pyridin-1-ium;acetate Chemical compound CC(O)=O.C1=CC=NC=C1 GAPYKZAARZMMGP-UHFFFAOYSA-N 0.000 description 1
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229910052701 rubidium Inorganic materials 0.000 description 1
IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
230000007017 scission Effects 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
BHRZNVHARXXAHW-UHFFFAOYSA-N sec-butylamine Chemical compound CCC(C)N BHRZNVHARXXAHW-UHFFFAOYSA-N 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
238000000527 sonication Methods 0.000 description 1
WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
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229940031000 streptococcus pneumoniae Drugs 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
231100000048 toxicity data Toxicity 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DD83251129A 1982-05-21 1983-05-20 Verfahren zur herstellung von a-21978c-cyclopeptidderivaten DD210285A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US38049782A	1982-05-21	1982-05-21

Publications (1)

Publication Number	Publication Date
DD210285A5 true DD210285A5 (de)	1984-06-06

Family

ID=23501396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD83251129A DD210285A5 (de)	1982-05-21	1983-05-20	Verfahren zur herstellung von a-21978c-cyclopeptidderivaten

Country Status (16)

Country	Link
KR (1)	KR860001285B1 (fr)
AR (1)	AR241943A1 (fr)
AT (1)	AT381103B (fr)
CA (1)	CA1200777A (fr)
DD (1)	DD210285A5 (fr)
DK (1)	DK221083A (fr)
EG (1)	EG16043A (fr)
ES (2)	ES8502731A1 (fr)
FI (1)	FI79545C (fr)
GR (1)	GR78567B (fr)
HU (1)	HU195839B (fr)
PH (1)	PH22066A (fr)
PL (1)	PL242099A1 (fr)
PT (1)	PT76700B (fr)
RO (1)	RO86724B (fr)
ZA (1)	ZA833451B (fr)

1983
- 1983-05-13 ZA ZA833451A patent/ZA833451B/xx unknown
- 1983-05-13 CA CA000428102A patent/CA1200777A/fr not_active Expired
- 1983-05-16 RO RO110960A patent/RO86724B/ro unknown
- 1983-05-16 AT AT0178283A patent/AT381103B/de not_active IP Right Cessation
- 1983-05-16 AR AR83293026A patent/AR241943A1/es active
- 1983-05-16 PH PH28906A patent/PH22066A/en unknown
- 1983-05-16 PT PT76700A patent/PT76700B/pt unknown
- 1983-05-18 FI FI831748A patent/FI79545C/fi not_active IP Right Cessation
- 1983-05-18 EG EG297/83A patent/EG16043A/xx active
- 1983-05-18 DK DK221083A patent/DK221083A/da not_active Application Discontinuation
- 1983-05-19 ES ES522560A patent/ES8502731A1/es not_active Expired
- 1983-05-19 GR GR71398A patent/GR78567B/el unknown
- 1983-05-19 KR KR1019830002221A patent/KR860001285B1/ko not_active Expired
- 1983-05-20 DD DD83251129A patent/DD210285A5/de unknown
- 1983-05-20 PL PL24209983A patent/PL242099A1/xx unknown
- 1983-05-20 HU HU831795A patent/HU195839B/hu unknown
1984
- 1984-09-14 ES ES535958A patent/ES535958A0/es active Granted

Also Published As

Publication number	Publication date
DK221083D0 (da)	1983-05-18
FI831748L (fi)	1983-11-22
RO86724B (ro)	1985-05-01
KR860001285B1 (ko)	1986-09-05
DK221083A (da)	1983-11-22
AR241943A1 (es)	1993-01-29
RO86724A (fr)	1985-04-17
ES522560A0 (es)	1985-01-16
HU195839B (en)	1988-07-28
GR78567B (fr)	1984-09-27
KR840005075A (ko)	1984-11-03
ATA178283A (de)	1986-01-15
FI831748A0 (fi)	1983-05-18
PT76700B (en)	1986-03-27
ES8502731A1 (es)	1985-01-16
FI79545C (fi)	1990-01-10
ES8506097A1 (es)	1985-06-16
PL242099A1 (en)	1984-07-30
EG16043A (en)	1987-05-30
PT76700A (en)	1983-06-01
ZA833451B (en)	1984-12-24
AT381103B (de)	1986-08-25
FI79545B (fi)	1989-09-29
ES535958A0 (es)	1985-06-16
CA1200777A (fr)	1986-02-18
PH22066A (en)	1988-05-20

Legal Events

Date	Code	Title	Description
1984-06-06	A5	Published as prov. exclusive patent

Publication	Publication Date	Title
US4482487A (en)	1984-11-13	A-21978C cyclic peptides
US4524135A (en)	1985-06-18	A-21978C cyclic peptides
US4293482A (en)	1981-10-06	A-30912A Nucleus
US5039789A (en)	1991-08-13	A54145 cyclic peptides
US4304716A (en)	1981-12-08	S 31794/F-1 Nucleus
USRE32311E (en)	1986-12-16	Derivatives of A-21978C cyclic peptides
JPH0819155B2 (ja)	1996-02-28	脱マンノシルテイコプラニン誘導体
DD146618A5 (de)	1981-02-18	Verfahren zur herstellung des antibiotikums
DD209810A5 (de)	1984-05-23	Verfahren zur herstellung von a-21978c-cyclopeptidderivaten
EP0095295B1 (fr)	1987-01-14	Dérivés de peptides cycliques
US4293485A (en)	1981-10-06	Derivatives of S31794/F-1 nucleus
US4299763A (en)	1981-11-10	A-30912B Nucleus
US5028590A (en)	1991-07-02	Derivatives of A54145 cyclic peptides
EP0031221B1 (fr)	1983-03-02	Noyaux de peptides cycliques
US4293488A (en)	1981-10-06	Derivatives of A-30912B nucleus
EP0032009A1 (fr)	1981-07-15	Dérivés de noyaux de peptides cycliques
EP0916680B1 (fr)	2004-01-28	Lantibiotique apparenté à l'actagardine, son procédé de préparation et utilisation
IE892638L (en)	1990-02-17	A new antibiotic, mersacidin, a process for the preparation¹thereof and the use thereof as a pharmaceutical
DD210258A5 (de)	1984-06-06	Verfahren zur herstellung von a-21978c-cyclopeptidderivaten
DE68925540T2 (de)	1996-06-13	Peptid-Antibiotika
US4293487A (en)	1981-10-06	Derivatives of A-30912D nucleus
DD210285A5 (de)	1984-06-06	Verfahren zur herstellung von a-21978c-cyclopeptidderivaten
DE69709802T2 (de)	2002-08-22	Amythiamicin Amid-Derivate
US4341768A (en)	1982-07-27	Antibiotic compounds
DE2638766A1 (de)	1977-07-14	Antibiotischer glykopeptidkomplex, verfahren zu seiner herstellung und diese enthaltende mittel