DD210843A5 - METHOD FOR THE PRODUCTION OF A MEDICAMENT FOR THE TREATMENT OF NEOPLASMA DISEASES - Google Patents

Abstract

The invention relates to a process for the preparation of an agent against neoplasm diseases. There are three different forms of administration prepared, of which two must be taken by the patient, resulting in a synergistic effect. These are: a) hydroquinone with metol in a mixing ratio of 50: 1 in the form of hard gelatine capsules b) an infusion of 0.200 g of Herba Coridalis per 100 ml of fluid, the infusion subsequently being fed methylene blue leaching and uranyl nitrate c) an extract of Herba Potentilla reptans , Radix Helleborns niger and Herba medicago satina in weight ratio (dried plants of 10 g: 3g: 3g in 40% ethyl alcohol, which was macerated in 20 days, after which the extraction liquid was separated.

Description

15-632 55

Process for the preparation of a medicament for the treatment of Ifeoplasma diseases

Field of application of the invention:

The invention relates to a process for the preparation of a medicament for the treatment of neoplasmal diseases, such as acute leukemia, Hodgkin's disease, Kahl's disease and thromboitic purpura.

Characteristic of the known technical solutions;

Treating Heoplasmen takes place at the time in the same way as the treatment of cancer and cancerous diseases _s namely medication, surgery and / or radiotherapy "therapeutically, depending on the type and stage of leoplasmas"

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The main groups of the drugs used are hormones, alchemizing agents such as azoiperites, ethyleneimines, esters of methanol sulfonic acid and antimetabolites such as derivatives of pyrrine and pyrimidine, amino acids, etc. as well as various products of natural origin (colchicine, vincristin, etc.).

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Recently, the methods of cancer immunotherapy were also used. Some of the methods developed have a nonspecific character, and others that have a specific character have been insufficiently tested. The results obtained were not significant, so that these methods were hardly used.

Brfindungs

With the invention, the fight against overeoplasma diseases should be improved.

Explanation of the essence of the invention;

The invention has for its object to provide a method for producing an improved medicament for the treatment of neoplasms diseases.

According to the invention, the process for the preparation of a medicament for the treatment of Heoplasma diseases is characterized in that in order to produce a series of three forms of presentation with synergistic effects in the treatment of the above diseases,

a) Hydroquinone is combined with para-ammonium phenol sulfate (Metol) in a ratio of 50: 1 in the form of a homogeneous powder formulated as hard gelatin capsules?

b) preparing an infusion of Herba Coridalis Marchaliana ausc-200 g of dry plants in 100 ml, and adding to the infusion 0.01 ml of 1 % aqueous methylene blue solution, whereupon in the solution uranyl nitrate is dissolved in a ratio of 1: 100;

c) Herba Potentilla reptans, Radix Helleborus niger and Herba Medicago satiyta are macerated in a weight ratio of dry plants of 10: 3: 3 in 40% ethyl alcohol for 20 days, and the plants are separated from the extraction liquid without the active principle.

The medicament produced according to the invention has the following advantages:

Increased efficacy over the known antineoplastic agents, determining the absorption of the neoplasm formations;

- Bs can also be used in postoperative treatment;

- Ss is not toxic;

- It is applicable to all ages. Embodiment:

As already stated, the drug is produced in the form of a set of three drug forms, namely

a) Closed capsules containing 0.5 g of hydroquinone and 0.01 g of para-ammonium phenol sulphate (Metol) or closed capsules containing 0.5 g of hydroquinone, 0.01 g of metole and 0.02 g of aluminum potassium alum »

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b) A solution of 1 % uranyl nitrate in an aqueous infusion of Coridalis Marchaliama, the infusion containing 0.010 ml solution and 1 % methylene blue. (Solution UEO g)

c) An alcoholic vegetable tincture in 1 liter of 40% alcohol obtained by extraction from the plants Potentilla reptans, Helleborus niger and Medicago sativa

, is, in a mixing ratio (based on the weight of the dried plants) of 10 g: 3g: 3g per liter of 40% alcohol (tincture Hbp).

The closed capsules containing a composition C ₁ ~ or V are prepared as usual. C. gamma is the composition prepared from hydroquinone, para-ammonium phenol sulphate (Metoi) and aluminum potassium alum.

The infusion of Coridalis marchaliamain is prepared from ^ 200 g of dried plants and 100 ml of water. To this infusion, at cold temperature, add a solution of 1 % methylene blue and then dissolve the uranyl nitrate.

The tincture Hbp is prepared by maceration of the crushed dried plants used in the above ratios in 40% ethyl alcohol over a period of 20 days.

Each of the maceration deposits the resulting liquid, and this is the actual vegetable tincture Hbp.

The medicament according to the invention is administered to the patient daily one capsule C-y or V and, in parallel thereto, one infusion of Coridalis marchaliama (25 ml).

For tumors in muscle tissue, dilute each 5 ml of Hbp alcoholic herbal tincture with 25 ml of water or coridal infusion administered 2 to 3 times a day for a period of 1 to 6 months.

This solution is called UPOq. The respective dose is one drop per 10 kg body weight. The administration is also carried out together with the tincture Hbp. For underweight patients, the capsules C. γ or V are administered only once every other day.

In colon cancer, it is particularly effective to take the capsules C. ~ daily in the morning before breakfast, dissolved in 25 ml Coridalis marchalianainfusion. At the same time, however, the tincture Hbp must be taken in a quantity of 5-10 ml, diluted with 25 ml of water, for lunch and in the evening. The administration time is between 6 months and one year «

In the case of systemic neoplasm (lymphogranulomatosis, Hodgkin's disease, malignant reticulosis, thrombocytopenic lymphoid leukemia, bald disease), the use of closed capsules V is particularly effective. In these cases, the presence of aluminum potassium alum is required because the potassium ions make an exogenous contribution to the proetbic group of mitocondial enzymes. Also, the capsules V are administered for the treatment of chronic aggressive hepatitis, one capsule every other day.

In Hepatitiafällen with Colssstazaphenomenen open a broth from Herba helorisium arenarium in a ratio of 0.5 g to 1 g of dried plants is added to 250 ml of water as auxiliaries with Coleretic- and liquefaction-effecting effect with good results. It is taken in the morning before breakfast, periodically for seven days.

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In the treatment of Miastenia gravis, the ingestion of the capsules V, contained in an amount of 0.04 g per capsule, is particularly effective. One capsule is given daily.

In case of ovarian and thyroid cancer, alternate use of the capsules C. ™ and the solution UEOg over a period of 4 to 5 months (per.os) is recommended. The same treatment is also effective in liver cancer.

In the case of thyroid, ovarian, lung and ganglionic tumors, take the solution UEOo per os, one drop per 10 kg of body weight, in the morning before breakfast in 50 ml of water or coridal infusion. The administration takes place for 5 days, then 2 days break, lasting 5 to 6 months,

In the treatment of angiosarcoma Kaposi, the capsules C-γ are taken by mouth, at the same time local treatment with wet dressings, which have been immersed in UEOg.

The solution UEOg can also be used for topical treatment for cancerous peritoneal diseases and pleurisy, as it results in a very rapid absorption of the carcinomatous fluid »In this case, the solution UEO _{Q is} sterilized, after dilution with distilled water in the ratio 1: 5. During this treatment, the patient should take one capsule daily C ₁ per os.

For hepatic keratitis, cutaneous herpes and genital herpes, the local application of the solution UEOg or a daily ocular instilation is very effective * The treatment duration is 1 to 2 months.

In all the cases described, the tincture Hbp, together with the other medicinal forms of the composition of the medicament produced according to the invention, effects an immunological reinforcing effect of the organism. In obstructive chronic bronchopaties and obliterating arteritis and retinal detachment in diabetes, the simple use of this tincture results in a regulation of the metabolism of lipids and hydrocarbons.

Claims (1)

- 8 claim for invention: Process for the preparation of a medicament for the treatment of neoplasmic diseases, characterized in that three dosage forms are produced which together produce a synergistic effect, the first dosage form being a mixture of hydroquinone and metol in a mixing ratio of 50: 1 in the form of a homogeneous, prepare the powder formulated as hard gelatin capsules, then infuse Herba Coridalis Marchaliana as a second dosage form with dried plants and 100 ml of liquid, add 0.01 ml of 1 % aqueous methylene blue solution to this infusion and then add 1: 1 in the solution. 100 UrayfnyInitrat dissolves and finally produces the third administration form by Herba Potentilla reptans, Radix Helleborus niger and Herba Medicago satina in a mixing ratio of the dried plants of 10 g: 3g: 3g in 1 liter of 40 #igem ethyl alcohol for 20 days macerated and the plants there after separating from the extraction liquid.