DD224491A5 - Verfahren zur herstellung eines resorbierbaren antibiotika-depots - Google Patents

Verfahren zur herstellung eines resorbierbaren antibiotika-depots Download PDF

Info

Publication number: DD224491A5
Authority: DD; German Democratic Republic
Prior art keywords: collagen; antibiotic; depot; polysaccharide; salt
Prior art date: 1983-09-24

Application number

DD84267494A

Other languages

German (de)

English (en)

Inventor

Peter Fleckenstein

Helmut Wahlig

Elvira Dingeldein

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-24

Filing date

1984-09-21

Publication date

1985-07-10

1984-09-21 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1985-07-10 Publication of DD224491A5 publication Critical patent/DD224491A5/de

Links

230000003115 biocidal effect Effects 0.000 title claims abstract description 17
238000004519 manufacturing process Methods 0.000 title abstract description 7
VIQCGTZFEYDQMR-UHFFFAOYSA-N fluphenazine decanoate Chemical compound C1CN(CCOC(=O)CCCCCCCCC)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 VIQCGTZFEYDQMR-UHFFFAOYSA-N 0.000 title 1
102000008186 Collagen Human genes 0.000 claims abstract description 30
108010035532 Collagen Proteins 0.000 claims abstract description 30
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239000011148 porous material Substances 0.000 claims abstract description 15
239000002647 aminoglycoside antibiotic agent Substances 0.000 claims abstract description 13
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239000005445 natural material Substances 0.000 claims abstract description 4
229920000642 polymer Polymers 0.000 claims abstract 2
239000011159 matrix material Substances 0.000 claims description 17
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238000000034 method Methods 0.000 claims description 12
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CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 10
229930182566 Gentamicin Natural products 0.000 claims description 10
150000003839 salts Chemical class 0.000 claims description 9
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
-1 acidic polysaccharide sodium alginate Chemical class 0.000 claims description 6
AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 claims description 2
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SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
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241000195493 Cryptophyta Species 0.000 description 1
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JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
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Classifications

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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A61K9/2004—Excipients; Inactive ingredients
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- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A61K9/2063—Proteins, e.g. gelatin
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics

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Animal Behavior & Ethology (AREA)
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Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Materials Engineering (AREA)
Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
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Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

DD84267494A 1983-09-24 1984-09-21 Verfahren zur herstellung eines resorbierbaren antibiotika-depots DD224491A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19833334595 DE3334595A1 (de)	1983-09-24	1983-09-24	Wirkstoffdepot

Publications (1)

Publication Number	Publication Date
DD224491A5 true DD224491A5 (de)	1985-07-10

Family

ID=6209951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD84267494A DD224491A5 (de)	1983-09-24	1984-09-21	Verfahren zur herstellung eines resorbierbaren antibiotika-depots

Country Status (13)

Country	Link
EP (1)	EP0137297A3 (da)
JP (1)	JPS6087219A (da)
AU (1)	AU3339684A (da)
DD (1)	DD224491A5 (da)
DE (1)	DE3334595A1 (da)
DK (1)	DK454084A (da)
ES (1)	ES8607012A1 (da)
FI (1)	FI843710A7 (da)
GR (1)	GR80449B (da)
HU (1)	HUT37036A (da)
NO (1)	NO843806L (da)
PT (1)	PT79254B (da)
ZA (1)	ZA847472B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1229075B (it) *	1985-04-05	1991-07-17	Fidia Farmaceutici	Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
US5128326A (en) *	1984-12-06	1992-07-07	Biomatrix, Inc.	Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
JPS6440418A (en) *	1987-08-07	1989-02-10	Arusu Japan Kk	Sustained release material for drug
DE19856668A1 (de) *	1998-12-09	2000-06-15	Aesculap Ag & Co Kg	Wirkstoffmatrix in Form eines biologisch resorbierbaren porösen Vlieses, Verfahren zu ihrer Herstellung und Verwendung
WO2003084571A1 (en) *	2002-04-08	2003-10-16	Denki Kagaku Kogyo Kabushiki Kaisha	Therapeutic composition for bone infectious disease
DE102018218429A1 (de)	2018-10-29	2020-04-30	Heraeus Medical Gmbh	Vorrichtung zur temporären, lokalen Applikation von Fluiden
CA3091601A1 (en)	2019-09-18	2021-03-18	Heraeus Medical Gmbh	Device for temporarily, locally applying fluids
EP3854437B1 (de)	2020-01-27	2022-01-19	Heraeus Medical GmbH	Vorrichtung zur temporären, lokalen applikation von fluiden
EP3795196B1 (de)	2019-09-18	2022-05-11	Heraeus Medical GmbH	Vorrichtung zur temporären, lokalen applikation von fluiden
EP3831426B1 (de)	2019-12-05	2025-07-09	Heraeus Medical GmbH	Vorrichtung zur lokalen applikation von pharmazeutischen fluiden
EP4094797B1 (de)	2021-05-28	2023-04-05	Heraeus Medical GmbH	Vorrichtung zur applikation eines pharmazeutischen fluids
EP4649987A1 (de)	2024-05-17	2025-11-19	Heraeus Medical GmbH	Medizinisches abgabesystem mit selbstschliessenden schlitzventilen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1302118A (da) *	1970-04-17	1973-01-04
DE2319852A1 (de) *	1972-04-21	1973-10-25	Biological Concepts Inc	Verfahren zur herstellung einer zur aufnahme von arzneimitteln geeigneten, saugfaehigen fasermasse aus protein, insbesondere aus kollagen
DE2843963A1 (de) *	1978-10-09	1980-04-24	Merck Patent Gmbh	Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin

1983
- 1983-09-24 DE DE19833334595 patent/DE3334595A1/de not_active Withdrawn
1984
- 1984-09-04 EP EP84110486A patent/EP0137297A3/de not_active Withdrawn
- 1984-09-21 NO NO843806A patent/NO843806L/no unknown
- 1984-09-21 FI FI843710A patent/FI843710A7/fi not_active Application Discontinuation
- 1984-09-21 PT PT79254A patent/PT79254B/pt unknown
- 1984-09-21 JP JP59196960A patent/JPS6087219A/ja active Pending
- 1984-09-21 AU AU33396/84A patent/AU3339684A/en not_active Abandoned
- 1984-09-21 DK DK454084A patent/DK454084A/da not_active Application Discontinuation
- 1984-09-21 ES ES536133A patent/ES8607012A1/es not_active Expired
- 1984-09-21 ZA ZA847472A patent/ZA847472B/xx unknown
- 1984-09-21 DD DD84267494A patent/DD224491A5/de unknown
- 1984-09-21 GR GR80449A patent/GR80449B/el unknown
- 1984-09-24 HU HU843600A patent/HUT37036A/hu unknown

Also Published As

Publication number	Publication date
PT79254A (en)	1984-10-01
DK454084D0 (da)	1984-09-21
FI843710L (fi)	1985-03-25
AU3339684A (en)	1985-03-28
EP0137297A2 (de)	1985-04-17
GR80449B (en)	1985-01-14
HUT37036A (en)	1985-11-28
ES536133A0 (es)	1986-05-16
PT79254B (en)	1986-08-08
DK454084A (da)	1985-03-25
DE3334595A1 (de)	1985-04-18
FI843710A0 (fi)	1984-09-21
ZA847472B (en)	1985-04-24
JPS6087219A (ja)	1985-05-16
ES8607012A1 (es)	1986-05-16
NO843806L (no)	1985-03-25
EP0137297A3 (de)	1986-10-15
FI843710A7 (fi)	1985-03-25

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