DD233940A5 - Verfahren zum ueberziehen von arzneiformen - Google Patents

Verfahren zum ueberziehen von arzneiformen Download PDF

Info

Publication number: DD233940A5
Authority: DD; German Democratic Republic
Prior art keywords: coating; film; polymer; water; binder
Prior art date: 1984-06-13

Application number

DD85277211A

Other languages

German (de)

English (en)

Inventor

Klaus Lehmann

Dieter Dreher

Harry Goetz

Original Assignee

Roehm Gmbh Chemische Fabrik,De

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-13

Filing date

1985-06-10

Publication date

1986-03-19

1985-06-10 Application filed by Roehm Gmbh Chemische Fabrik,De filed Critical Roehm Gmbh Chemische Fabrik,De

1986-03-19 Publication of DD233940A5 publication Critical patent/DD233940A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 20
229940126601 medicinal product Drugs 0.000 title 1
239000011248 coating agent Substances 0.000 claims abstract description 57
229920000642 polymer Polymers 0.000 claims abstract description 53
238000000576 coating method Methods 0.000 claims abstract description 39
239000000178 monomer Substances 0.000 claims abstract description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
239000007788 liquid Substances 0.000 claims abstract description 23
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 14
239000008199 coating composition Substances 0.000 claims abstract description 14
239000002552 dosage form Substances 0.000 claims abstract description 13
238000001035 drying Methods 0.000 claims abstract description 8
150000003866 tertiary ammonium salts Chemical group 0.000 claims abstract description 8
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 3
125000005395 methacrylic acid group Chemical group 0.000 claims description 10
229920001577 copolymer Polymers 0.000 claims description 9
239000000470 constituent Substances 0.000 claims description 8
229920001519 homopolymer Polymers 0.000 claims 1
239000011230 binding agent Substances 0.000 abstract description 41
125000001931 aliphatic group Chemical group 0.000 abstract description 4
125000002947 alkylene group Chemical group 0.000 abstract description 4
239000004215 Carbon black (E152) Substances 0.000 abstract description 3
229930195733 hydrocarbon Natural products 0.000 abstract description 3
239000000243 solution Substances 0.000 description 24
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 19
239000000049 pigment Substances 0.000 description 15
239000003814 drug Substances 0.000 description 14
229940079593 drug Drugs 0.000 description 14
239000000203 mixture Substances 0.000 description 13
239000004014 plasticizer Substances 0.000 description 13
239000002253 acid Substances 0.000 description 11
239000007787 solid Substances 0.000 description 10
239000003826 tablet Substances 0.000 description 9
239000004480 active ingredient Substances 0.000 description 8
125000004432 carbon atom Chemical group C* 0.000 description 8
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 7
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 7
125000005907 alkyl ester group Chemical group 0.000 description 7
239000006185 dispersion Substances 0.000 description 7
239000000843 powder Substances 0.000 description 7
125000001302 tertiary amino group Chemical group 0.000 description 7
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 6
150000002148 esters Chemical class 0.000 description 6
239000008187 granular material Substances 0.000 description 6
239000002245 particle Substances 0.000 description 6
239000008188 pellet Substances 0.000 description 6
229920001223 polyethylene glycol Polymers 0.000 description 6
239000007909 solid dosage form Substances 0.000 description 6
239000000725 suspension Substances 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
125000003277 amino group Chemical group 0.000 description 5
239000000945 filler Substances 0.000 description 5
230000007935 neutral effect Effects 0.000 description 5
150000003839 salts Chemical group 0.000 description 5
238000005507 spraying Methods 0.000 description 5
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
238000005299 abrasion Methods 0.000 description 4
150000003863 ammonium salts Chemical class 0.000 description 4
150000001450 anions Chemical class 0.000 description 4
210000004051 gastric juice Anatomy 0.000 description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
229910000403 monosodium phosphate Inorganic materials 0.000 description 4
235000019799 monosodium phosphate Nutrition 0.000 description 4
125000004430 oxygen atom Chemical group O* 0.000 description 4
230000035699 permeability Effects 0.000 description 4
229940093429 polyethylene glycol 6000 Drugs 0.000 description 4
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 4
239000007921 spray Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
210000002784 stomach Anatomy 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000000454 talc Substances 0.000 description 4
229910052623 talc Inorganic materials 0.000 description 4
235000012222 talc Nutrition 0.000 description 4
239000003232 water-soluble binding agent Substances 0.000 description 4
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
239000004908 Emulsion polymer Substances 0.000 description 3
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical group N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
239000002775 capsule Substances 0.000 description 3
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
239000008298 dragée Substances 0.000 description 3
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 3
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 3
238000006116 polymerization reaction Methods 0.000 description 3
229920002451 polyvinyl alcohol Polymers 0.000 description 3
235000019422 polyvinyl alcohol Nutrition 0.000 description 3
229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000010526 radical polymerization reaction Methods 0.000 description 3
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
239000004372 Polyvinyl alcohol Substances 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000013543 active substance Substances 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000013078 crystal Substances 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000007720 emulsion polymerization reaction Methods 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
239000007888 film coating Substances 0.000 description 2
238000009501 film coating Methods 0.000 description 2
238000009472 formulation Methods 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
-1 globules Substances 0.000 description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
125000002768 hydroxyalkyl group Chemical group 0.000 description 2
239000004922 lacquer Substances 0.000 description 2
244000005700 microbiome Species 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
150000007519 polyprotic acids Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000001694 spray drying Methods 0.000 description 2
238000009495 sugar coating Methods 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 description 1
NMBXBBSVGZNJCE-UHFFFAOYSA-N 2-(dimethylamino)propyl prop-2-enoate Chemical compound CN(C)C(C)COC(=O)C=C NMBXBBSVGZNJCE-UHFFFAOYSA-N 0.000 description 1
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
HWNIMFWVBMOWHI-UHFFFAOYSA-N 2-morpholin-4-ylethyl prop-2-enoate Chemical compound C=CC(=O)OCCN1CCOCC1 HWNIMFWVBMOWHI-UHFFFAOYSA-N 0.000 description 1
FGSBZZTYGCQZPD-UHFFFAOYSA-N 2-piperidin-1-ylethyl prop-2-enoate Chemical compound C=CC(=O)OCCN1CCCCC1 FGSBZZTYGCQZPD-UHFFFAOYSA-N 0.000 description 1
FLCAEMBIQVZWIF-UHFFFAOYSA-N 6-(dimethylamino)-2-methylhex-2-enamide Chemical compound CN(C)CCCC=C(C)C(N)=O FLCAEMBIQVZWIF-UHFFFAOYSA-N 0.000 description 1
FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
KNUSQTXJWATMLJ-UHFFFAOYSA-N [1-(dimethylamino)-2,2-dimethylpropyl] prop-2-enoate Chemical compound CN(C)C(C(C)(C)C)OC(=O)C=C KNUSQTXJWATMLJ-UHFFFAOYSA-N 0.000 description 1
BDHURBZBESSTSI-UHFFFAOYSA-N [3-(diethylamino)-2,2-dimethylpropyl] prop-2-enoate Chemical compound CCN(CC)CC(C)(C)COC(=O)C=C BDHURBZBESSTSI-UHFFFAOYSA-N 0.000 description 1
FTIMEUKJNDNRFG-UHFFFAOYSA-N [dimethylamino(phenyl)methyl] prop-2-enoate Chemical compound C=CC(=O)OC(N(C)C)C1=CC=CC=C1 FTIMEUKJNDNRFG-UHFFFAOYSA-N 0.000 description 1
150000008043 acidic salts Chemical class 0.000 description 1
BAPJBEWLBFYGME-UHFFFAOYSA-N acrylic acid methyl ester Natural products COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
238000003915 air pollution Methods 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
CREXVNNSNOKDHW-UHFFFAOYSA-N azaniumylideneazanide Chemical group N[N] CREXVNNSNOKDHW-UHFFFAOYSA-N 0.000 description 1
238000007664 blowing Methods 0.000 description 1
CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
125000005521 carbonamide group Chemical group 0.000 description 1
230000001427 coherent effect Effects 0.000 description 1
238000010276 construction Methods 0.000 description 1
230000006378 damage Effects 0.000 description 1
238000013016 damping Methods 0.000 description 1
238000007872 degassing Methods 0.000 description 1
239000003405 delayed action preparation Substances 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000002360 explosive Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
230000037406 food intake Effects 0.000 description 1
235000012631 food intake Nutrition 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000003999 initiator Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
LVHBHZANLOWSRM-UHFFFAOYSA-N itaconic acid Chemical class OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
ZZSGYARVLIMPBM-UHFFFAOYSA-N n-[3-(dimethylamino)-2,2-dimethylpropyl]prop-2-enamide Chemical compound CN(C)CC(C)(C)CNC(=O)C=C ZZSGYARVLIMPBM-UHFFFAOYSA-N 0.000 description 1
ADTJPOBHAXXXFS-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]prop-2-enamide Chemical compound CN(C)CCCNC(=O)C=C ADTJPOBHAXXXFS-UHFFFAOYSA-N 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
230000019612 pigmentation Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
229920001290 polyvinyl ester Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
229910000342 sodium bisulfate Inorganic materials 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
239000004149 tartrazine Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
229920001567 vinyl ester resin Polymers 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Paints Or Removers (AREA)

DD85277211A 1984-06-13 1985-06-10 Verfahren zum ueberziehen von arzneiformen DD233940A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3421860A DE3421860C2 (de)	1984-06-13	1984-06-13	Verfahren zum Überziehen von Arzneiformen

Publications (1)

Publication Number	Publication Date
DD233940A5 true DD233940A5 (de)	1986-03-19

Family

ID=6238217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD85277211A DD233940A5 (de)	1984-06-13	1985-06-10	Verfahren zum ueberziehen von arzneiformen

Country Status (4)

Country	Link
JP (1)	JPS611624A (cs)
CS (1)	CS259879B2 (cs)
DD (1)	DD233940A5 (cs)
DE (1)	DE3421860C2 (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3426587A1 (de) *	1984-07-19	1986-01-30	Röhm GmbH, 6100 Darmstadt	Verfahren zum ueberziehen von arzneiformen
US4932368A (en) *	1988-01-28	1990-06-12	Mazda Motor Corporation	Suction arrangement for internal combustion engine
HRP970485A2 (en) *	1996-09-13	1998-08-31	Joerg Rosenberg	Process for producing solid pharmaceutical forms
DE19918435A1 (de) *	1998-07-23	2000-01-27	Roehm Gmbh	Überzugs- und Bindemittel für orale oder dermale Arzneiformen
DE19958007A1 (de) *	1999-12-02	2001-06-07	Roehm Gmbh	Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
CN102470175B (zh) *	2009-07-30	2014-06-18	赢创罗姆有限公司	含氨基(甲基)丙烯酸酯聚合物或共聚物的水性碳酸化介质

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3049179A1 (de) *	1975-03-20	1982-07-29	Röhm GmbH, 6100 Darmstadt	Bindemittel fuer arzneimittelueberzuege.
DE3208791A1 (de) *	1982-03-11	1983-09-22	Röhm GmbH, 6100 Darmstadt	Verfahren zum ueberziehen von arzneiformen mittes eines in wasser dispergierten ueberzugsmittels

1984
- 1984-06-13 DE DE3421860A patent/DE3421860C2/de not_active Expired - Lifetime
1985
- 1985-05-20 CS CS853605A patent/CS259879B2/cs unknown
- 1985-06-10 DD DD85277211A patent/DD233940A5/de not_active IP Right Cessation
- 1985-06-12 JP JP60126404A patent/JPS611624A/ja active Pending

Also Published As

Publication number	Publication date
DE3421860C2 (de)	1994-09-15
DE3421860A1 (de)	1986-01-02
CS360585A2 (en)	1988-03-15
JPS611624A (ja)	1986-01-07
CS259879B2 (en)	1988-11-15

Legal Events

Date	Code	Title	Description
1999-03-18	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
EP0164669B1 (de)	1991-01-23	Verfahren zum Überziehen von Arzneiformen
EP0181515B1 (de)	1990-09-05	Verfahren zur Herstellung einer wässrigen Überzugsmitteldispersion und ihre Verwendung zum Überziehen von Arzneimitteln
EP0058765B1 (de)	1985-02-20	In Magensaft lösliche oder quellbare Überzugsmasse und ihre Verwendung in einem Verfahren zum Überziehen von Arzneiformen
DE3049179C2 (cs)	1987-07-02
EP0704208B1 (de)	2004-03-03	Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform
EP0152038B1 (de)	1989-07-12	Arzneimittelüberzug
EP0088951B1 (de)	1987-06-24	Verfahren zum Überziehen von Arzneiformen mittels eines in Wasser dispergierten Überzugsmittels
DE69321538T2 (de)	1999-05-06	Wässrige Dispersionen von Zein und Beschichtungen mit gesteuerter Freisetzung
DE69002604T2 (de)	1993-12-02	Pharmazeutische Zubereitung mit verzögerter Freisetzung und seine Herstellung.
EP0545209B1 (de)	1996-07-03	Redispergierbares Dispersionspulver aus N-Vinylpyrrolidon-Vinylacetat-Copolymerisat, dessen Herstellung und Verwendung
DE2031871C3 (de)	1974-06-27	Überzugsmasse für Arzneiformen
DE2135073C3 (de)	1974-07-11	Überzugsmittel für Arzneiformen
EP0485840B2 (de)	1999-03-03	Orale Arzneiform und Überzugsmittel, enthaltend ein im Colon abbaubares Polysaccharid
DE2721603C3 (de)	1982-03-25	Beschichtete Körnchen aus Alkalimetallsalzen der Polyacrylsäure und Verfahren zu ihrer Herstellung
DE69001487T2 (de)	1993-08-26	Gemfibrozil enthaltende mittel mit verlaengerter freigabe.
DE2741755A1 (de)	1978-03-23	Ueberzugsmassen auf polymerbasis fuer biologisch aktive praeparate und verfahren zur herstellung der ersteren sowie biologisch aktive praeparate und verfahren zur herstellung der letzteren
DD233940A5 (de)	1986-03-19	Verfahren zum ueberziehen von arzneiformen
EP0208213B1 (de)	1989-10-18	Arzneimittelumhüllung
DE3426587A1 (de)	1986-01-30	Verfahren zum ueberziehen von arzneiformen
DE3920082A1 (de)	1991-03-07	Filmbildendes waessriges ueberzugsmittel fuer feste arzneimittel, verfahren zu seiner herstellung und verwendung
DD272999A1 (de)	1989-11-01	Verfahren zur herstellung ueberzogener arzneiformen
DE1617351C (de)	1972-08-03	Überzugsmittel fur Arzneitabletten
DE1467838B (de)		Filmbildendes Überzugsmittel für Arz neitabletten aus amphoteren Mischpolymensa ten