DD258940A5 - Verfahren zur herstellung von arzneipillen-formulierungen mit langzeitwirkung - Google Patents

Verfahren zur herstellung von arzneipillen-formulierungen mit langzeitwirkung Download PDF

Info

Publication number: DD258940A5
Authority: DD; German Democratic Republic
Prior art keywords: mixture; drug; wax; weight; mold
Prior art date: 1986-03-10

Application number

DD87300634A

Other languages

German (de)

English (en)

Inventor

Joseph Ch Dietz

Richard B Toothill

Original Assignee

��@��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-10

Filing date

1987-03-10

Publication date

1988-08-10

1987-03-10 Application filed by ��@��@��k�� filed Critical ��@��@��k��

1988-08-10 Publication of DD258940A5 publication Critical patent/DD258940A5/de

Links

238000004519 manufacturing process Methods 0.000 title abstract description 7
230000007774 longterm Effects 0.000 title abstract description 6
239000013583 drug formulation Substances 0.000 title description 5
239000000203 mixture Substances 0.000 claims abstract description 41
238000000034 method Methods 0.000 claims abstract description 24
239000003814 drug Substances 0.000 claims abstract description 22
229940079593 drug Drugs 0.000 claims abstract description 21
238000001746 injection moulding Methods 0.000 claims abstract description 17
238000013268 sustained release Methods 0.000 claims abstract description 9
239000012730 sustained-release form Substances 0.000 claims abstract description 9
238000002360 preparation method Methods 0.000 claims abstract description 7
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical group [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 23
239000010428 baryte Substances 0.000 claims description 12
229910052601 baryte Inorganic materials 0.000 claims description 12
239000000945 filler Substances 0.000 claims description 8
239000004184 Avoparcin Substances 0.000 claims description 7
235000019377 avoparcin Nutrition 0.000 claims description 7
JWFVWARSGMYXRN-HTQQBIQNSA-N avoparcin Chemical compound O([C@H]1[C@H](C(N[C@H](C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(N[C@H](C4=CC(O)=CC(O)=C4C=4C(O)=CC=C3C=4)C(O)=O)=O)CC3=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@H](N)C4)C=C(C(=C3)Cl)OC=3C=C2C=C(C=3O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@H](N)C2)OC2=CC=C1C=C2)C=1C=CC(O)=CC=1)=O)NC(=O)[C@@H](NC)C=1C=CC(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)=CC=1)[C@@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@H]1O JWFVWARSGMYXRN-HTQQBIQNSA-N 0.000 claims description 7
229950001335 avoparcin Drugs 0.000 claims description 7
108010053278 avoparcin Proteins 0.000 claims description 7
239000005893 Diflubenzuron Substances 0.000 claims description 5
239000004480 active ingredient Substances 0.000 claims description 5
QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical group FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 claims description 5
229940019503 diflubenzuron Drugs 0.000 claims description 5
239000008194 pharmaceutical composition Substances 0.000 claims description 5
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 4
229960001614 levamisole Drugs 0.000 claims description 4
241000238631 Hexapoda Species 0.000 claims description 3
229940124339 anthelmintic agent Drugs 0.000 claims description 3
239000000921 anthelmintic agent Substances 0.000 claims description 3
230000003115 biocidal effect Effects 0.000 claims description 3
239000003630 growth substance Substances 0.000 claims description 3
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 2
SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 2
239000004098 Tetracycline Substances 0.000 claims description 2
239000004182 Tylosin Substances 0.000 claims description 2
229930194936 Tylosin Natural products 0.000 claims description 2
238000001816 cooling Methods 0.000 claims description 2
238000011049 filling Methods 0.000 claims description 2
238000010438 heat treatment Methods 0.000 claims description 2
229960002418 ivermectin Drugs 0.000 claims description 2
238000003825 pressing Methods 0.000 claims description 2
229960002135 sulfadimidine Drugs 0.000 claims description 2
ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 claims description 2
235000019364 tetracycline Nutrition 0.000 claims description 2
229960002180 tetracycline Drugs 0.000 claims description 2
229930101283 tetracycline Natural products 0.000 claims description 2
150000003522 tetracyclines Chemical class 0.000 claims description 2
229960004059 tylosin Drugs 0.000 claims description 2
235000019375 tylosin Nutrition 0.000 claims description 2
WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 claims description 2
WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims 1
239000004721 Polyphenylene oxide Substances 0.000 claims 1
239000002555 ionophore Substances 0.000 claims 1
230000000236 ionophoric effect Effects 0.000 claims 1
229950000688 phenothiazine Drugs 0.000 claims 1
229920000570 polyether Polymers 0.000 claims 1
239000006187 pill Substances 0.000 abstract description 21
238000009472 formulation Methods 0.000 abstract description 7
241001465754 Metazoa Species 0.000 abstract description 4
239000002949 juvenile hormone Substances 0.000 abstract description 4
239000001993 wax Substances 0.000 description 23
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 8
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
239000004203 carnauba wax Substances 0.000 description 5
235000013869 carnauba wax Nutrition 0.000 description 5
239000003925 fat Substances 0.000 description 5
238000002844 melting Methods 0.000 description 5
230000008018 melting Effects 0.000 description 5
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
230000003628 erosive effect Effects 0.000 description 4
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 4
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 4
239000000463 material Substances 0.000 description 4
239000008187 granular material Substances 0.000 description 3
238000005469 granulation Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
238000002156 mixing Methods 0.000 description 3
239000008188 pellet Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
230000007704 transition Effects 0.000 description 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
230000003311 flocculating effect Effects 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
229910052742 iron Inorganic materials 0.000 description 2
238000000465 moulding Methods 0.000 description 2
UTOPWMOLSKOLTQ-UHFFFAOYSA-N octacosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O UTOPWMOLSKOLTQ-UHFFFAOYSA-N 0.000 description 2
239000008247 solid mixture Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
241000238421 Arthropoda Species 0.000 description 1
229930182504 Lasalocid Natural products 0.000 description 1
229930191564 Monensin Natural products 0.000 description 1
GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 1
240000005125 Myrtus communis Species 0.000 description 1
235000013418 Myrtus communis Nutrition 0.000 description 1
239000004189 Salinomycin Substances 0.000 description 1
KQXDHUJYNAXLNZ-XQSDOZFQSA-N Salinomycin Chemical compound O1[C@@H]([C@@H](CC)C(O)=O)CC[C@H](C)[C@@H]1[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(C=C[C@@H](O)[C@@]3(O[C@@](C)(CC3)[C@@H]3O[C@@H](C)[C@@](O)(CC)CC3)O2)O1 KQXDHUJYNAXLNZ-XQSDOZFQSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
238000005299 abrasion Methods 0.000 description 1
239000012164 animal wax Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229920002988 biodegradable polymer Polymers 0.000 description 1
239000004621 biodegradable polymer Substances 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
239000004067 bulking agent Substances 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000004204 candelilla wax Substances 0.000 description 1
235000013868 candelilla wax Nutrition 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000000748 compression moulding Methods 0.000 description 1
230000001186 cumulative effect Effects 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
238000000227 grinding Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229960000320 lasalocid Drugs 0.000 description 1
BBMULGJBVDDDNI-OWKLGTHSSA-N lasalocid Chemical compound C([C@@H]1[C@@]2(CC)O[C@@H]([C@H](C2)C)[C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCC=2C(=C(O)C(C)=CC=2)C(O)=O)C[C@](O)(CC)[C@H](C)O1 BBMULGJBVDDDNI-OWKLGTHSSA-N 0.000 description 1
239000003077 lignite Substances 0.000 description 1
239000010871 livestock manure Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229950006915 maduramicin Drugs 0.000 description 1
RWVUEZAROXKXRT-VQLSFVLHSA-N maduramicin Chemical compound O1[C@@H](C)[C@H](OC)[C@@H](OC)C[C@H]1O[C@@H]1[C@H]([C@@]2(C)O[C@H](CC2)[C@@]2(C)O[C@]3(O[C@@H]([C@H](C)[C@@H](O)C3)[C@@H](C)[C@H]3[C@@H]([C@@H](OC)[C@H](C)[C@@](O)(CC(O)=O)O3)OC)CC2)O[C@@H]([C@@H]2[C@H](C[C@@H](C)[C@@](C)(O)O2)C)C1 RWVUEZAROXKXRT-VQLSFVLHSA-N 0.000 description 1
229950003442 methoprene Drugs 0.000 description 1
229930002897 methoprene Natural products 0.000 description 1
239000012184 mineral wax Substances 0.000 description 1
229960005358 monensin Drugs 0.000 description 1
GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical compound C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 description 1
239000012170 montan wax Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000003415 peat Substances 0.000 description 1
229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 1
239000000622 polydioxanone Substances 0.000 description 1
238000004064 recycling Methods 0.000 description 1
239000012744 reinforcing agent Substances 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
210000004767 rumen Anatomy 0.000 description 1
229960001548 salinomycin Drugs 0.000 description 1
235000019378 salinomycin Nutrition 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
238000011282 treatment Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
239000012178 vegetable wax Substances 0.000 description 1
239000010456 wollastonite Substances 0.000 description 1
229910052882 wollastonite Inorganic materials 0.000 description 1
239000010457 zeolite Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pest Control & Pesticides (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Environmental Sciences (AREA)
Agronomy & Crop Science (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measurement Of Radiation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DD87300634A 1986-03-10 1987-03-10 Verfahren zur herstellung von arzneipillen-formulierungen mit langzeitwirkung DD258940A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US83763686A	1986-03-10	1986-03-10

Publications (1)

Publication Number	Publication Date
DD258940A5 true DD258940A5 (de)	1988-08-10

Family

ID=25275025

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD87300634A DD258940A5 (de)	1986-03-10	1987-03-10	Verfahren zur herstellung von arzneipillen-formulierungen mit langzeitwirkung

Country Status (19)

Country	Link
EP (1)	EP0236901B1 (fr)
JP (1)	JP2512736B2 (fr)
KR (1)	KR950007203B1 (fr)
AT (1)	ATE66600T1 (fr)
AU (1)	AU596401B2 (fr)
CA (1)	CA1297019C (fr)
DD (1)	DD258940A5 (fr)
DE (1)	DE3772415D1 (fr)
DK (1)	DK166946B1 (fr)
ES (1)	ES2024444B3 (fr)
FI (1)	FI87314C (fr)
GR (1)	GR3002614T3 (fr)
HU (1)	HU199284B (fr)
IE (1)	IE59745B1 (fr)
IL (1)	IL81750A (fr)
NO (1)	NO172728C (fr)
NZ (1)	NZ219493A (fr)
PT (1)	PT84433B (fr)
ZA (1)	ZA871694B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0324521A3 (fr) *	1988-01-11	1991-11-27	Duphar International Research B.V	Méthode de traitement des maladies hématologiques et compositions pharmaceutiques pour cet usage
US5322692A (en) *	1989-02-28	1994-06-21	American Cyanamid Company	Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
DE69007515T2 (de) *	1989-02-28	1994-11-03	American Cyanamid Co	Bolus mit lang andauernder Wirkstoffabgabe, wirksam bei der Prophylaxe, Behandlung oder Bekämpfung des Befalls bei Wiederkäuern durch Fadenwürmer, Milben und Endo- und Ektoparasiten.
MX9200339A (es) *	1991-01-28	1992-08-01	Hoechst Ag	Preparado para la liberacion controlada de sustancias activas, que son apropiadas como terapeuticos o para mejorar el crecimiento y el aprovechamiento de los piensos en rumiantes
GB9306106D0 (en) *	1993-03-24	1993-05-12	Norbrook Lab Ltd	Sustained release veterinary composition
WO1995028835A1 (fr) *	1994-04-21	1995-11-02	Nippon Shinyaku Co., Ltd.	Procede pour produire une matrice de cire contenant un pesticide, et preparation utilisable en agriculture
HUE067496T2 (hu)	2020-12-08	2024-10-28	Ruminant Biotech Corp Ltd	Az állatoknak szánt anyagok bejuttatására szolgáló eszközök és módszerek fejlesztése

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3535419A (en) *	1965-12-15	1970-10-20	Syntex Corp	Veterinary compositions and methods
US4166107A (en) *	1978-07-25	1979-08-28	The United States Of America As Represented By The Secretary Of Agriculture	Sustained release bolus formulations containing insect growth regulators for control of livestock pests
GR78492B (fr) *	1982-03-26	1984-09-27	Warner Lambert Co
EP0201792A3 (fr) *	1985-05-09	1988-07-20	American Cyanamid Company	Compositions larvicides

1987
- 1987-03-02 AT AT87102920T patent/ATE66600T1/de not_active IP Right Cessation
- 1987-03-02 EP EP87102920A patent/EP0236901B1/fr not_active Expired - Lifetime
- 1987-03-02 ES ES87102920T patent/ES2024444B3/es not_active Expired - Lifetime
- 1987-03-02 DE DE8787102920T patent/DE3772415D1/de not_active Expired - Fee Related
- 1987-03-03 IL IL81750A patent/IL81750A/xx not_active IP Right Cessation
- 1987-03-04 NZ NZ219493A patent/NZ219493A/xx unknown
- 1987-03-06 DK DK116587A patent/DK166946B1/da not_active IP Right Cessation
- 1987-03-06 CA CA000531313A patent/CA1297019C/fr not_active Expired - Fee Related
- 1987-03-09 IE IE59287A patent/IE59745B1/en not_active IP Right Cessation
- 1987-03-09 NO NO870971A patent/NO172728C/no unknown
- 1987-03-09 ZA ZA871694A patent/ZA871694B/xx unknown
- 1987-03-09 HU HU87993A patent/HU199284B/hu not_active IP Right Cessation
- 1987-03-09 PT PT84433A patent/PT84433B/pt unknown
- 1987-03-09 AU AU69819/87A patent/AU596401B2/en not_active Ceased
- 1987-03-09 FI FI871016A patent/FI87314C/fi not_active IP Right Cessation
- 1987-03-09 KR KR1019870002083A patent/KR950007203B1/ko not_active Expired - Fee Related
- 1987-03-10 JP JP62053187A patent/JP2512736B2/ja not_active Expired - Fee Related
- 1987-03-10 DD DD87300634A patent/DD258940A5/de unknown
1991
- 1991-08-29 GR GR91400178T patent/GR3002614T3/el unknown

Also Published As

Publication number	Publication date
IE870592L (en)	1987-09-10
KR950007203B1 (ko)	1995-07-04
PT84433A (en)	1987-04-01
FI87314B (fi)	1992-09-15
GR3002614T3 (en)	1993-01-25
CA1297019C (fr)	1992-03-10
JPS62265217A (ja)	1987-11-18
AU6981987A (en)	1987-09-17
JP2512736B2 (ja)	1996-07-03
DK116587A (da)	1987-09-11
ES2024444B3 (es)	1992-03-01
ATE66600T1 (de)	1991-09-15
IE59745B1 (en)	1994-03-23
HUT43949A (en)	1988-01-28
NO870971D0 (no)	1987-03-09
AU596401B2 (en)	1990-05-03
DK116587D0 (da)	1987-03-06
FI871016A0 (fi)	1987-03-09
NO870971L (no)	1987-09-11
ZA871694B (en)	1987-08-28
EP0236901B1 (fr)	1991-08-28
NO172728C (no)	1993-09-01
FI87314C (fi)	1992-12-28
IL81750A0 (en)	1987-10-20
IL81750A (en)	1990-08-31
PT84433B (pt)	1989-10-04
DE3772415D1 (de)	1991-10-02
FI871016L (fi)	1987-09-11
EP0236901A2 (fr)	1987-09-16
DK166946B1 (da)	1993-08-09
KR870008511A (ko)	1987-10-19
HU199284B (en)	1990-02-28
EP0236901A3 (en)	1988-01-27
NZ219493A (en)	1990-09-26
NO172728B (no)	1993-05-24

Legal Events

Date	Code	Title	Description
2004-04-28	IF04	In force in the year 2004	Expiry date: 20070311

Publication	Publication Date	Title
DE3024416C2 (de)	1982-04-15	Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
DE60008912T2 (de)	2004-08-19	Direktverpressbare, ultrafeine acetaminophenzusammensetzungen und verfahren zu ihrer herstellung
DE3877764T2 (de)	1993-05-13	Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren.
EP0552227B2 (fr)	1998-11-04	Preparation pharmaceutique exempte de solvants, administree oralement, a liberation retardee du principe actif, ainsi que procede pour sa fabrication
DE60124077T2 (de)	2007-05-31	Verfahren und vorrichtung zum blasformen von kapseln aus polyvinylalkohol und blasgeformte polyvinylalkoholkapseln
DE69123075T2 (de)	1997-03-20	Ueberzogene Zusammensetzung sowie Verfahren zu ihrer Herstellung
DE2813146A1 (de)	1978-10-19	Tablettieren von mikrokapseln
EP0956004B1 (fr)	2004-09-15	Procede de preparation de compositions polyol faconnees ou non fac onnees et compositions obtenues
DE10046541A1 (de)	2002-03-28	Mechanisch stabile darreichungsformen, enthaltend Ubichinone
DE2360796A1 (de)	1975-06-12	Arzneimittel mit verzoegerter abgabe des wirkstoffs im darm und verfahren zu seiner herstellung
DE60019550T2 (de)	2006-05-04	Dämpfwachsperlen zur herstellung von festen formgegenständen
EP0537110B1 (fr)	1994-12-14	Méthode pour produire des articles moulés à partir de compositions façonnables comme des matières thermoplastiques
DE69527711T2 (de)	2002-12-05	Verfahren und apparat zur herstellung von schnelllöslichen dosierungseinheiten und daraus erhältliches produkt
WO2001000175A1 (fr)	2001-01-04	Formes d'administration pharmaceutiques mecaniquement stables, contenant des agents tensioactifs liquides ou semi-solides
DE68912515T2 (de)	1994-09-29	Granulierungsmittel und Verfahren.
DE2940041C2 (de)	1982-04-01	Grundmischungen zur Verformung von aufgeschäumtem Polyamid
DD258940A5 (de)	1988-08-10	Verfahren zur herstellung von arzneipillen-formulierungen mit langzeitwirkung
US4994227A (en)	1991-02-19	Method for the preparation of sustained released bolus formulation
DE4002257C2 (fr)	1992-02-13
DE2439538C3 (de)	1980-07-17	Verfahren zur Herstellung von oral zu verabreichenden Arzneimitteln mit verzögerter Wirkungsfreigabe
DE1766546A1 (de)	1971-09-30	Verfahren zur Herstellung von Arzneipillen oder Tabletten
DE2129646C3 (de)	1978-04-20	Verfahren zur Herstellung von Tabletten einheitlicher Form und einheitlicher Größe
DE1492123A1 (de)	1969-07-17	Verfahren zur Herstellung von Arzneipraeparaten in Tablettenform
DE10341264A1 (de)	2005-03-24	Schmelzformulierte, multipartikuläre orale Darreichungsform
DD277176A3 (de)	1990-03-28	Verfahren zur herstellung von trockensorbit mit einem definierten anteil an weiteren zuckeralkoholen